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Items: 40


Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers.

Mattox TE, Chen X, Maxuitenko YY, Keeton AB, Piazza GA.

Int J Mol Sci. 2019 Dec 24;21(1). pii: E141. doi: 10.3390/ijms21010141. Review.


Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins.

Almutairi MS, Hassan ES, Keeton AB, Piazza GA, Abdelhameed AS, Attia MI.

Drug Des Devel Ther. 2019 Aug 27;13:3069-3078. doi: 10.2147/DDDT.S208241. eCollection 2019.


Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.

Adamska A, Domenichini A, Capone E, Damiani V, Akkaya BG, Linton KJ, Di Sebastiano P, Chen X, Keeton AB, Ramirez-Alcantara V, Maxuitenko Y, Piazza GA, De Laurenzi V, Sala G, Falasca M.

J Exp Clin Cancer Res. 2019 Aug 5;38(1):312. doi: 10.1186/s13046-019-1308-7.


Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity.

Abd El-Aleam RH, George RF, Lee KJ, Keeton AB, Piazza GA, Kamel AA, El-Daly ME, Hassan GS, Abdel-Rahman HM.

Arch Pharm (Weinheim). 2019 Aug;352(8):e1900002. doi: 10.1002/ardp.201900002. Epub 2019 Jul 29.


Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents.

Eldehna WM, Al-Wabli RI, Almutairi MS, Keeton AB, Piazza GA, Abdel-Aziz HA, Attia MI.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):867-878. doi: 10.1080/14756366.2018.1462802.


Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.

Zhu B, Lindsey A, Li N, Lee K, Ramirez-Alcantara V, Canzoneri JC, Fajardo A, Madeira da Silva L, Thomas M, Piazza JT, Yet L, Eberhardt BT, Gurpinar E, Otali D, Grizzle W, Valiyaveettil J, Chen X, Keeton AB, Piazza GA.

Oncotarget. 2017 Aug 27;8(41):69264-69280. doi: 10.18632/oncotarget.20566. eCollection 2017 Sep 19.


Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling.

Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI.

Drug Des Devel Ther. 2017 Aug 9;11:2333-2346. doi: 10.2147/DDDT.S140164. eCollection 2017.


New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres.

Attia MI, Eldehna WM, Afifi SA, Keeton AB, Piazza GA, Abdel-Aziz HA.

PLoS One. 2017 Jul 25;12(7):e0181241. doi: 10.1371/journal.pone.0181241. eCollection 2017.


Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion.

Whitt JD, Keeton AB, Gary BD, Sklar LA, Sodani K, Chen ZS, Piazza GA.

J Biomed Res. 2016 Mar;30(2):120-133. doi: 10.7555/JBR.30.20150108. Epub 2015 Nov 20.


The RAS-Effector Interaction as a Drug Target.

Keeton AB, Salter EA, Piazza GA.

Cancer Res. 2017 Jan 15;77(2):221-226. doi: 10.1158/0008-5472.CAN-16-0938. Epub 2017 Jan 6. Review.


Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.

Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Brodsky JL, Sorscher EJ.

PLoS One. 2016 Oct 12;11(10):e0163615. doi: 10.1371/journal.pone.0163615. eCollection 2016.


Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells.

Prasain JK, Rajbhandari R, Keeton AB, Piazza GA, Barnes S.

Food Funct. 2016 Sep 14;7(9):4012-4019.


β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG.

Lee K, Lindsey AS, Li N, Gary B, Andrews J, Keeton AB, Piazza GA.

Oncotarget. 2016 Feb 2;7(5):5353-65. doi: 10.18632/oncotarget.6705.


Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.

Li N, Chen X, Zhu B, Ramírez-Alcántara V, Canzoneri JC, Lee K, Sigler S, Gary B, Li Y, Zhang W, Moyer MP, Salter EA, Wierzbicki A, Keeton AB, Piazza GA.

Oncotarget. 2015 Sep 29;6(29):27403-15. doi: 10.18632/oncotarget.4741.


Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention.

Aboul-Fadl T, Al-Hamad SS, Lee K, Li N, Gary BD, Keeton AB, Piazza GA, Abdel-Hamid MK.

Med Chem Res. 2014 Sep;23(9):4177-4188.


Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.

Li N, Lee K, Xi Y, Zhu B, Gary BD, Ramírez-Alcántara V, Gurpinar E, Canzoneri JC, Fajardo A, Sigler S, Piazza JT, Chen X, Andrews J, Thomas M, Lu W, Li Y, Laan DJ, Moyer MP, Russo S, Eberhardt BT, Yet L, Keeton AB, Grizzle WE, Piazza GA.

Oncogene. 2015 Mar 19;34(12):1499-509. doi: 10.1038/onc.2014.94. Epub 2014 Apr 7.


Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.

Awadallah FM, Piazza GA, Gary BD, Keeton AB, Canzoneri JC.

Eur J Med Chem. 2013;70:273-9. doi: 10.1016/j.ejmech.2013.10.003. Epub 2013 Oct 9.


Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW, Abadi AH.

Bioorg Med Chem. 2013 Dec 1;21(23):7343-56. doi: 10.1016/j.bmc.2013.09.055. Epub 2013 Oct 1.


6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.

Hamed MM, Abou El Ella DA, Keeton AB, Piazza GA, Abadi AH, Hartmann RW, Engel M.

ChemMedChem. 2013 Sep;8(9):1495-504. doi: 10.1002/cmdc.201300147. Epub 2013 Jul 11.


Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.

Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA.

Mol Cancer Ther. 2013 Sep;12(9):1848-59. doi: 10.1158/1535-7163.MCT-13-0048. Epub 2013 Jun 26.


A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.

Gurpinar E, Grizzle WE, Shacka JJ, Mader BJ, Li N, Piazza NA, Russo S, Keeton AB, Piazza GA.

Mol Cancer Ther. 2013 May;12(5):663-74. doi: 10.1158/1535-7163.MCT-12-0785. Epub 2013 Feb 26.


A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.

Whitt JD, Li N, Tinsley HN, Chen X, Zhang W, Li Y, Gary BD, Keeton AB, Xi Y, Abadi AH, Grizzle WE, Piazza GA.

Cancer Prev Res (Phila). 2012 Jun;5(6):822-33. doi: 10.1158/1940-6207.CAPR-11-0559. Epub 2012 May 3. Erratum in: Cancer Prev Res (Phila). 2013 Jan;6(1):70.


Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.

Tinsley HN, Gary BD, Keeton AB, Lu W, Li Y, Piazza GA.

Cancer Prev Res (Phila). 2011 Aug;4(8):1275-84. doi: 10.1158/1940-6207.CAPR-11-0095. Epub 2011 Apr 19.


Anti-Inflammatory Action of Insulin via Induction of Gadd45-β Transcription by the mTOR Signaling Pathway.

Bortoff KD, Keeton AB, Franklin JL, Messina JL.

Hepat Med. 2010 Jun 1;2001(2):79-85.


Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.

Tinsley HN, Gary BD, Thaiparambil J, Li N, Lu W, Li Y, Maxuitenko YY, Keeton AB, Piazza GA.

Cancer Prev Res (Phila). 2010 Oct;3(10):1303-13. doi: 10.1158/1940-6207.CAPR-10-0030. Epub 2010 Sep 28.


NSAIDs: Old Drugs Reveal New Anticancer Targets.

Piazza GA, Keeton AB, Tinsley HN, Whitt JD, Gary BD, Mathew B, Singh R, Grizzle WE, Reynolds RC.

Pharmaceuticals (Basel). 2010 May 25;3(5):1652-1667. Review.


Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.

Tinsley HN, Gary BD, Keeton AB, Zhang W, Abadi AH, Reynolds RC, Piazza GA.

Mol Cancer Ther. 2009 Dec;8(12):3331-40. doi: 10.1158/1535-7163.MCT-09-0758.


Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents.

Abadi AH, Abouel-Ella DA, Ahmed NS, Gary BD, Thaiparambil JT, Tinsley HN, Keeton AB, Piazza GA.

Arzneimittelforschung. 2009;59(8):415-21.


A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

Piazza GA, Keeton AB, Tinsley HN, Gary BD, Whitt JD, Mathew B, Thaiparambil J, Coward L, Gorman G, Li Y, Sani B, Hobrath JV, Maxuitenko YY, Reynolds RC.

Cancer Prev Res (Phila). 2009 Jun;2(6):572-80. doi: 10.1158/1940-6207.CAPR-09-0001. Epub 2009 May 26.


Assay for isolation of inhibitors of her2-kinase expression.

Chiosis G, Keeton AB.

Methods Mol Biol. 2009;486:139-49. doi: 10.1007/978-1-60327-545-3_10.


Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells.

Franklin JL, Keeton AB, Bortoff KD, Messina JL.

Int J Clin Exp Med. 2008;1(1):89-97. Epub 2008 Jan 25.


Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways.

Bennett WL, Keeton AB, Ji S, Xu J, Messina JL.

Endocrine. 2007 Oct;32(2):219-26. Epub 2007 Nov 27.


Insulin enhances growth hormone induction of the MEK/ERK signaling pathway.

Xu J, Keeton AB, Franklin JL, Li X, Venable DY, Frank SJ, Messina JL.

J Biol Chem. 2006 Jan 13;281(2):982-92. Epub 2005 Nov 4.


Gene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expression.

Xu J, Keeton AB, Wu L, Franklin JL, Cao X, Messina JL.

Breast Cancer Res Treat. 2005 Jun;91(3):207-15.


Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expression.

Keeton AB, Bortoff KD, Franklin JL, Messina JL.

Endocrinology. 2005 Jun;146(6):2716-25. Epub 2005 Feb 24.


Modulation of Elk-dependent-transcription by Gene33.

Keeton AB, Messina JL.

J Cell Biochem. 2005 Apr 15;94(6):1190-8.


Regulation of Gene33 expression by insulin requires MEK-ERK activation.

Keeton AB, Xu J, Franklin JL, Messina JL.

Biochim Biophys Acta. 2004 Sep 17;1679(3):248-55.


Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha.

Ma Y, Toth B, Keeton AB, Holland LT, Chaudry IH, Messina JL.

Endocrinology. 2004 Nov;145(11):5168-76. Epub 2004 Aug 5.


Insulin-regulated expression of Egr-1 and Krox20: dependence on ERK1/2 and interaction with p38 and PI3-kinase pathways.

Keeton AB, Bortoff KD, Bennett WL, Franklin JL, Venable DY, Messina JL.

Endocrinology. 2003 Dec;144(12):5402-10. Epub 2003 Sep 11.


Insulin signal transduction pathways and insulin-induced gene expression.

Keeton AB, Amsler MO, Venable DY, Messina JL.

J Biol Chem. 2002 Dec 13;277(50):48565-73. Epub 2002 Oct 2.

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