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Items: 47

1.

Pictet-Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis.

Roddan R, Ward JM, Keep NH, Hailes HC.

Curr Opin Chem Biol. 2020 Jan 21;55:69-76. doi: 10.1016/j.cbpa.2019.12.003. [Epub ahead of print] Review.

PMID:
31978651
2.

Critical Role of a Sheath Phosphorylation Site On the Assembly and Function of an Atypical Type VI Secretion System.

Ziveri J, Chhuon C, Jamet A, Rytter H, Prigent G, Tros F, Barel M, Coureuil M, Lays C, Henry T, Keep NH, Guerrera IC, Charbit A.

Mol Cell Proteomics. 2019 Dec;18(12):2418-2432. doi: 10.1074/mcp.RA119.001532. Epub 2019 Oct 2.

PMID:
31578219
3.

Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen.

Maitra A, Munshi T, Healy J, Martin LT, Vollmer W, Keep NH, Bhakta S.

FEMS Microbiol Rev. 2019 Sep 1;43(5):548-575. doi: 10.1093/femsre/fuz016.

4.

Terminal Regions Confer Plasticity to the Tetrameric Assembly of Human HspB2 and HspB3.

Clark AR, Vree Egberts W, Kondrat FDL, Hilton GR, Ray NJ, Cole AR, Carver JA, Benesch JLP, Keep NH, Boelens WC, Slingsby C.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3297-3310. doi: 10.1016/j.jmb.2018.06.047. Epub 2018 Jun 30.

5.

Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase.

Lichman BR, Sula A, Pesnot T, Hailes HC, Ward JM, Keep NH.

Biochemistry. 2017 Oct 10;56(40):5274-5277. doi: 10.1021/acs.biochem.7b00769. Epub 2017 Sep 20.

6.

Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.

Densham RM, Garvin AJ, Stone HR, Strachan J, Baldock RA, Daza-Martin M, Fletcher A, Blair-Reid S, Beesley J, Johal B, Pearl LH, Neely R, Keep NH, Watts FZ, Morris JR.

Nat Struct Mol Biol. 2016 Jul;23(7):647-55. doi: 10.1038/nsmb.3236. Epub 2016 May 30.

7.

Crystal Structures and Binding Dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri.

Northey T, Venthur H, De Biasio F, Chauviac FX, Cole A, Ribeiro KA Junior, Grossi G, Falabella P, Field LM, Keep NH, Zhou JJ.

Sci Rep. 2016 Apr 22;6:24739. doi: 10.1038/srep24739.

8.

Structure of the stationary phase survival protein YuiC from B.subtilis.

Quay DH, Cole AR, Cryar A, Thalassinos K, Williams MA, Bhakta S, Keep NH.

BMC Struct Biol. 2015 Jul 11;15:12. doi: 10.1186/s12900-015-0039-z.

9.

'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile.

Lichman BR, Gershater MC, Lamming ED, Pesnot T, Sula A, Keep NH, Hailes HC, Ward JM.

FEBS J. 2015 Mar;282(6):1137-51. doi: 10.1111/febs.13208. Epub 2015 Feb 9.

10.

The RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation-promoting factor catalytic domain.

Chauviac FX, Robertson G, Quay DH, Bagnéris C, Dumas C, Henderson B, Ward J, Keep NH, Cohen-Gonsaud M.

Acta Crystallogr F Struct Biol Commun. 2014 Aug;70(Pt 8):1022-6. doi: 10.1107/S2053230X1401317X. Epub 2014 Jul 23.

11.

Crystal structures of the human Dysferlin inner DysF domain.

Sula A, Cole AR, Yeats C, Orengo C, Keep NH.

BMC Struct Biol. 2014 Jan 17;14:3. doi: 10.1186/1472-6807-14-3.

12.

Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation.

Zihni C, Munro PM, Elbediwy A, Keep NH, Terry SJ, Harris J, Balda MS, Matter K.

J Cell Biol. 2014 Jan 6;204(1):111-27. doi: 10.1083/jcb.201304064. Epub 2013 Dec 30.

13.

Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis.

Munshi T, Gupta A, Evangelopoulos D, Guzman JD, Gibbons S, Keep NH, Bhakta S.

PLoS One. 2013;8(3):e60143. doi: 10.1371/journal.pone.0060143. Epub 2013 Mar 21.

14.

Crystal structure of reduced MsAcg, a putative nitroreductase from Mycobacterium smegmatis and a close homologue of Mycobacterium tuberculosis Acg.

Chauviac FX, Bommer M, Yan J, Parkin G, Daviter T, Lowden P, Raven EL, Thalassinos K, Keep NH.

J Biol Chem. 2012 Dec 28;287(53):44372-83. doi: 10.1074/jbc.M112.406264. Epub 2012 Nov 12.

15.

Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatis.

Evangelopoulos D, Cronin N, Daviter T, Sim E, Keep NH, Bhakta S.

FEBS J. 2011 Dec;278(24):4824-32. doi: 10.1111/j.1742-4658.2011.08382.x. Epub 2011 Oct 31.

16.

Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove.

Clark AR, Naylor CE, Bagnéris C, Keep NH, Slingsby C.

J Mol Biol. 2011 Apr 22;408(1):118-34. doi: 10.1016/j.jmb.2011.02.020. Epub 2011 Feb 15.

17.

Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis.

Basavannacharya C, Moody PR, Munshi T, Cronin N, Keep NH, Bhakta S.

Protein Cell. 2010 Nov;1(11):1011-22. doi: 10.1007/s13238-010-0132-9. Epub 2010 Dec 10.

18.

ATP-dependent MurE ligase in Mycobacterium tuberculosis: biochemical and structural characterisation.

Basavannacharya C, Robertson G, Munshi T, Keep NH, Bhakta S.

Tuberculosis (Edinb). 2010 Jan;90(1):16-24. doi: 10.1016/j.tube.2009.10.007. Epub 2009 Nov 27.

PMID:
19945347
19.

Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.

Bagnéris C, Bateman OA, Naylor CE, Cronin N, Boelens WC, Keep NH, Slingsby C.

J Mol Biol. 2009 Oct 9;392(5):1242-52. doi: 10.1016/j.jmb.2009.07.069. Epub 2009 Jul 30. Erratum in: J Mol Biol. 2009 Dec 4;394(3):588.

PMID:
19646995
20.

Characterisation of Bombyx mori Odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components.

Zhou JJ, Robertson G, He X, Dufour S, Hooper AM, Pickett JA, Keep NH, Field LM.

J Mol Biol. 2009 Jun 12;389(3):529-45. doi: 10.1016/j.jmb.2009.04.015. Epub 2009 Apr 14.

PMID:
19371749
21.

Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b.

Patel P, Harris R, Geddes SM, Strehle EM, Watson JD, Bashir R, Bushby K, Driscoll PC, Keep NH.

J Mol Biol. 2008 Jun 20;379(5):981-90. doi: 10.1016/j.jmb.2008.04.046. Epub 2008 Apr 26.

PMID:
18495154
22.
23.

Bacterial resuscitation factors: revival of viable but non-culturable bacteria.

Keep NH, Ward JM, Robertson G, Cohen-Gonsaud M, Henderson B.

Cell Mol Life Sci. 2006 Nov;63(22):2555-9. No abstract available.

PMID:
17013561
24.

Wake up! Peptidoglycan lysis and bacterial non-growth states.

Keep NH, Ward JM, Cohen-Gonsaud M, Henderson B.

Trends Microbiol. 2006 Jun;14(6):271-6. Epub 2006 May 3. Review.

PMID:
16675219
25.

Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.

Morris JR, Pangon L, Boutell C, Katagiri T, Keep NH, Solomon E.

Hum Mol Genet. 2006 Feb 15;15(4):599-606. Epub 2006 Jan 10.

PMID:
16403807
26.

Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis.

Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH.

J Biol Chem. 2005 Sep 30;280(39):33419-25. Epub 2005 Jul 26. Erratum in: J Biol Chem. 2005 Nov 18;280(46):38888. Saibi, Helen R [corrected to Saibil, Helen R].

27.

(1)H, (15)N, and (13)C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis.

Cohen-Gonsaud M, Barthe P, Pommier F, Harris R, Driscoll PC, Keep NH, Roumestand C.

J Biomol NMR. 2004 Nov;30(3):373-4. No abstract available.

PMID:
15754060
28.

The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes.

Cohen-Gonsaud M, Barthe P, Bagnéris C, Henderson B, Ward J, Roumestand C, Keep NH.

Nat Struct Mol Biol. 2005 Mar;12(3):270-3. Epub 2005 Feb 20.

PMID:
15723078
29.

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.

Harvey K, Duguid IC, Alldred MJ, Beatty SE, Ward H, Keep NH, Lingenfelter SE, Pearce BR, Lundgren J, Owen MJ, Smart TG, Lüscher B, Rees MI, Harvey RJ.

J Neurosci. 2004 Jun 23;24(25):5816-26.

30.

Resuscitation-promoting factors possess a lysozyme-like domain.

Cohen-Gonsaud M, Keep NH, Davies AP, Ward J, Henderson B, Labesse G.

Trends Biochem Sci. 2004 Jan;29(1):7-10.

PMID:
14729326
31.

Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein.

Garavini H, Riento K, Phelan JP, McAlister MS, Ridley AJ, Keep NH.

Biochemistry. 2002 May 21;41(20):6303-10.

PMID:
12009891
32.

Identification of residues required for the interaction of BARD1 with BRCA1.

Morris JR, Keep NH, Solomon E.

J Biol Chem. 2002 Mar 15;277(11):9382-6. Epub 2001 Dec 31.

33.

The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein.

Knight D, Harris R, McAlister MS, Phelan JP, Geddes S, Moss SJ, Driscoll PC, Keep NH.

J Biol Chem. 2002 Feb 15;277(7):5556-61. Epub 2001 Nov 29.

34.

Backbone 1H, 13C, and 15N resonance assignments for a 14 kD protein, GABA(A) receptor associated protein (GABARAP).

Harris R, McAlister MS, Sankar A, Phelan JP, Moss SJ, Keep NH, Driscoll PC.

J Biomol NMR. 2001 Oct;21(2):185-6. No abstract available.

PMID:
11727986
35.
36.

Structural comparison of actin binding in utrophin and dystrophin.

Keep NH.

Neurol Sci. 2000;21(5 Suppl):S929-37. Review.

PMID:
11382192
37.
38.

Structure of the utrophin actin-binding domain bound to F-actin reveals binding by an induced fit mechanism.

Moores CA, Keep NH, Kendrick-Jones J.

J Mol Biol. 2000 Mar 24;297(2):465-80.

PMID:
10715214
39.

Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.

Lian LY, Barsukov I, Golovanov AP, Hawkins DI, Badii R, Sze KH, Keep NH, Bokoch GM, Roberts GC.

Structure. 2000 Jan 15;8(1):47-55.

40.

Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer.

Keep NH, Winder SJ, Moores CA, Walke S, Norwood FL, Kendrick-Jones J.

Structure. 1999 Dec 15;7(12):1539-46.

41.

The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin.

Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J.

J Mol Biol. 1999 Jan 22;285(3):1257-64.

PMID:
9887274
42.

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.

Keep NH, Barnes M, Barsukov I, Badii R, Lian LY, Segal AW, Moody PC, Roberts GC.

Structure. 1997 May 15;5(5):623-33.

43.

How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution.

Mancia F, Keep NH, Nakagawa A, Leadlay PF, McSweeney S, Rasmussen B, Bösecke P, Diat O, Evans PR.

Structure. 1996 Mar 15;4(3):339-50.

44.

Molecular analysis in three cases of X91- variant chronic granulomatous disease.

Bu-Ghanim HN, Segal AW, Keep NH, Casimir CM.

Blood. 1995 Nov 1;86(9):3575-82.

PMID:
7579466
45.

Chronic granulomatous disease.

Thrasher AJ, Keep NH, Wientjes F, Segal AW.

Biochim Biophys Acta. 1994 Oct 21;1227(1-2):1-24. Review. No abstract available.

PMID:
7918677
46.

The synthetic substrate succinyl(carbadethia)-CoA generates cob(II)alamin on adenosylcobalamin-dependent methylmalonyl-CoA mutase.

Keep NH, Smith GA, Evans MC, Diakun GP, Leadlay PF.

Biochem J. 1993 Oct 15;295 ( Pt 2):387-92.

47.

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