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Items: 1 to 50 of 139

1.

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer.

Witwicki RM, Ekram MB, Qiu X, Janiszewska M, Shu S, Kwon M, Trinh A, Frias E, Ramadan N, Hoffman G, Yu K, Xie Y, McAllister G, McDonald R, Golji J, Schlabach M, deWeck A, Keen N, Chan HM, Ruddy D, Rejtar T, Sovath S, Silver S, Sellers WR, Jagani Z, Hogarty MD, Roberts C, Brown M, Stegmaier K, Long H, Shivdasani RA, Pellman D, Polyak K.

Cell Rep. 2018 Oct 30;25(5):1255-1267.e5. doi: 10.1016/j.celrep.2018.10.023.

2.

Clinical Utility of Diffusion-Weighted Imaging in Spinal Infections.

Dumont RA, Keen NN, Bloomer CW, Schwartz BS, Talbott J, Clark AJ, Wilson DM, Chin CT.

Clin Neuroradiol. 2019 Sep;29(3):515-522. doi: 10.1007/s00062-018-0681-5. Epub 2018 Mar 26.

PMID:
29582111
3.

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.

Shao W, Mishina YM, Feng Y, Caponigro G, Cooke VG, Rivera S, Wang Y, Shen F, Korn JM, Mathews Griner LA, Nishiguchi G, Rico A, Tellew J, Haling JR, Aversa R, Polyakov V, Zang R, Hekmat-Nejad M, Amiri P, Singh M, Keen N, Dillon MP, Lees E, Ramurthy S, Sellers WR, Stuart DD.

Cancer Res. 2018 Mar 15;78(6):1537-1548. doi: 10.1158/0008-5472.CAN-17-2033. Epub 2018 Jan 17.

4.

Capturing Collaborative Challenges: Designing Complexity-Sensitive Theories of Change for Cross-Sector Partnerships.

van Tulder R, Keen N.

J Bus Ethics. 2018;150(2):315-332. doi: 10.1007/s10551-018-3857-7. Epub 2018 Apr 9.

5.

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

McDonald ER 3rd, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, Ramadan N, Ruddy DA, Silver SJ, Sovath S, Stump M, Weber O, Widmer R, Yu J, Yu K, Yue Y, Abramowski D, Ackley E, Barrett R, Berger J, Bernard JL, Billig R, Brachmann SM, Buxton F, Caothien R, Caushi JX, Chung FS, Cortés-Cros M, deBeaumont RS, Delaunay C, Desplat A, Duong W, Dwoske DA, Eldridge RS, Farsidjani A, Feng F, Feng J, Flemming D, Forrester W, Galli GG, Gao Z, Gauter F, Gibaja V, Haas K, Hattenberger M, Hood T, Hurov KE, Jagani Z, Jenal M, Johnson JA, Jones MD, Kapoor A, Korn J, Liu J, Liu Q, Liu S, Liu Y, Loo AT, Macchi KJ, Martin T, McAllister G, Meyer A, Mollé S, Pagliarini RA, Phadke T, Repko B, Schouwey T, Shanahan F, Shen Q, Stamm C, Stephan C, Stucke VM, Tiedt R, Varadarajan M, Venkatesan K, Vitari AC, Wallroth M, Weiler J, Zhang J, Mickanin C, Myer VE, Porter JA, Lai A, Bitter H, Lees E, Keen N, Kauffmann A, Stegmeier F, Hofmann F, Schmelzle T, Sellers WR.

Cell. 2017 Jul 27;170(3):577-592.e10. doi: 10.1016/j.cell.2017.07.005.

6.
7.

Psychological Interventions for Post-traumatic Stress Symptoms in Psychosis: A Systematic Review of Outcomes.

Swan S, Keen N, Reynolds N, Onwumere J.

Front Psychol. 2017 Mar 14;8:341. doi: 10.3389/fpsyg.2017.00341. eCollection 2017. Review.

8.

The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.

Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR.

Nature. 2017 Mar 30;543(7647):733-737. doi: 10.1038/nature21702. Epub 2017 Mar 22.

PMID:
28329763
9.

The role of shame in people with a diagnosis of schizophrenia.

Keen N, George D, Scragg P, Peters E.

Br J Clin Psychol. 2017 Jun;56(2):115-129. doi: 10.1111/bjc.12125. Epub 2017 Jan 19.

PMID:
28105670
10.

Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.

Cowen SD, Russell D, Dakin LA, Chen H, Larsen NA, Godin R, Throner S, Zheng X, Molina A, Wu J, Cheung T, Howard T, Garcia-Arenas R, Keen N, Pendleton CS, Pietenpol JA, Ferguson AD.

J Med Chem. 2016 Dec 22;59(24):11079-11097. Epub 2016 Dec 1.

PMID:
28002961
11.

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Fei F, Firestone B, Fodor M, Fridrich C, Gao H, Grunenfelder D, Hao HX, Jacob J, Ho S, Hsiao K, Kang ZB, Karki R, Kato M, Larrow J, La Bonte LR, Lenoir F, Liu G, Liu S, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Price E, Quinn C, Shakya S, Shultz MD, Slisz J, Venkatesan K, Wang P, Warmuth M, Williams S, Yang G, Yuan J, Zhang JH, Zhu P, Ramsey T, Keen NJ, Sellers WR, Stams T, Fortin PD.

Nature. 2016 Jul 7;535(7610):148-52. Epub 2016 Jun 29.

PMID:
27362227
12.

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

Garcia Fortanet J, Chen CH, Chen YN, Chen Z, Deng Z, Firestone B, Fekkes P, Fodor M, Fortin PD, Fridrich C, Grunenfelder D, Ho S, Kang ZB, Karki R, Kato M, Keen N, LaBonte LR, Larrow J, Lenoir F, Liu G, Liu S, Lombardo F, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Ramsey T, Sellers WR, Shultz MD, Stams T, Towler C, Wang P, Williams SL, Zhang JH, LaMarche MJ.

J Med Chem. 2016 Sep 8;59(17):7773-82. doi: 10.1021/acs.jmedchem.6b00680. Epub 2016 Jul 12.

PMID:
27347692
13.

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.

Munoz DM, Cassiani PJ, Li L, Billy E, Korn JM, Jones MD, Golji J, Ruddy DA, Yu K, McAllister G, DeWeck A, Abramowski D, Wan J, Shirley MD, Neshat SY, Rakiec D, de Beaumont R, Weber O, Kauffmann A, McDonald ER 3rd, Keen N, Hofmann F, Sellers WR, Schmelzle T, Stegmeier F, Schlabach MR.

Cancer Discov. 2016 Aug;6(8):900-13. doi: 10.1158/2159-8290.CD-16-0178. Epub 2016 Jun 3.

14.

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor.

Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, Schoumacher M, Meyer R, Deeds J, Buchwalter G, Stams T, Keen N, Sellers WR, Brown M, Pagliarini RA.

Elife. 2016 May 16;5. pii: e13964. doi: 10.7554/eLife.13964.

15.

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.

Mavrakis KJ, McDonald ER 3rd, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, Yan-Neale Y, Yang G, Lin F, Yin H, Gao H, Kipp DR, Zhao S, McNamara JT, Sprague ER, Zheng B, Lin Y, Cho YS, Gu J, Crawford K, Ciccone D, Vitari AC, Lai A, Capka V, Hurov K, Porter JA, Tallarico J, Mickanin C, Lees E, Pagliarini R, Keen N, Schmelzle T, Hofmann F, Stegmeier F, Sellers WR.

Science. 2016 Mar 11;351(6278):1208-13. doi: 10.1126/science.aad5944. Epub 2016 Feb 11.

17.

The long-term effectiveness of cognitive behavior therapy for psychosis within a routine psychological therapies service.

Peters E, Crombie T, Agbedjro D, Johns LC, Stahl D, Greenwood K, Keen N, Onwumere J, Hunter E, Smith L, Kuipers E.

Front Psychol. 2015 Oct 29;6:1658. doi: 10.3389/fpsyg.2015.01658. eCollection 2015.

18.

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR.

Nat Med. 2015 Nov;21(11):1318-25. doi: 10.1038/nm.3954. Epub 2015 Oct 19.

PMID:
26479923
19.

Nightmares in Patients With Psychosis: The Relation With Sleep, Psychotic, Affective, and Cognitive Symptoms.

Sheaves B, Onwumere J, Keen N, Stahl D, Kuipers E.

Can J Psychiatry. 2015 Aug;60(8):354-61.

20.

Posttraumatic stress symptoms (PTSS) in caregivers of people with psychosis and associations with caregiving experiences.

Kingston C, Onwumere J, Keen N, Ruffell T, Kuipers E.

J Trauma Dissociation. 2016 May-Jun;17(3):307-21. doi: 10.1080/15299732.2015.1089969. Epub 2015 Sep 20.

PMID:
26387937
21.

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors.

Gibaja V, Shen F, Harari J, Korn J, Ruddy D, Saenz-Vash V, Zhai H, Rejtar T, Paris CG, Yu Z, Lira M, King D, Qi W, Keen N, Hassan AQ, Chan HM.

Oncogene. 2016 Feb 4;35(5):558-66. doi: 10.1038/onc.2015.114. Epub 2015 Apr 20.

22.

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

Bhang HE, Ruddy DA, Krishnamurthy Radhakrishna V, Caushi JX, Zhao R, Hims MM, Singh AP, Kao I, Rakiec D, Shaw P, Balak M, Raza A, Ackley E, Keen N, Schlabach MR, Palmer M, Leary RJ, Chiang DY, Sellers WR, Michor F, Cooke VG, Korn JM, Stegmeier F.

Nat Med. 2015 May;21(5):440-8. doi: 10.1038/nm.3841. Epub 2015 Apr 13.

PMID:
25849130
23.

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.

Hoffman GR, Rahal R, Buxton F, Xiang K, McAllister G, Frias E, Bagdasarian L, Huber J, Lindeman A, Chen D, Romero R, Ramadan N, Phadke T, Haas K, Jaskelioff M, Wilson BG, Meyer MJ, Saenz-Vash V, Zhai H, Myer VE, Porter JA, Keen N, McLaughlin ME, Mickanin C, Roberts CW, Stegmeier F, Jagani Z.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3128-33. doi: 10.1073/pnas.1316793111. Epub 2014 Feb 11.

24.

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

Jaffe JD, Wang Y, Chan HM, Zhang J, Huether R, Kryukov GV, Bhang HE, Taylor JE, Hu M, Englund NP, Yan F, Wang Z, Robert McDonald E 3rd, Wei L, Ma J, Easton J, Yu Z, deBeaumount R, Gibaja V, Venkatesan K, Schlegel R, Sellers WR, Keen N, Liu J, Caponigro G, Barretina J, Cooke VG, Mullighan C, Carr SA, Downing JR, Garraway LA, Stegmeier F.

Nat Genet. 2013 Nov;45(11):1386-91. doi: 10.1038/ng.2777. Epub 2013 Sep 29.

25.

The use of rescripting imagery for people with psychosis who hear voices.

Ison R, Medoro L, Keen N, Kuipers E.

Behav Cogn Psychother. 2014 Mar;42(2):129-42. doi: 10.1017/S135246581300057X. Epub 2013 Aug 7.

PMID:
23920004
26.

Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1.

Wu J, Mikule K, Wang W, Su N, Petteruti P, Gharahdaghi F, Code E, Zhu X, Jacques K, Lai Z, Yang B, Lamb ML, Chuaqui C, Keen N, Chen H.

ACS Chem Biol. 2013 Oct 18;8(10):2201-8. doi: 10.1021/cb400186w. Epub 2013 Aug 16.

PMID:
23895133
27.

Diagnosing ulnar neuropathy at the elbow using magnetic resonance neurography.

Keen NN, Chin CT, Engstrom JW, Saloner D, Steinbach LS.

Skeletal Radiol. 2012 Apr;41(4):401-7. doi: 10.1007/s00256-011-1251-y. Epub 2011 Aug 16.

PMID:
21845447
28.

Structural basis of substrate methylation and inhibition of SMYD2.

Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N.

Structure. 2011 Sep 7;19(9):1262-73. doi: 10.1016/j.str.2011.06.011. Epub 2011 Jul 21.

29.

Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferase.

Wu J, Cheung T, Grande C, Ferguson AD, Zhu X, Theriault K, Code E, Birr C, Keen N, Chen H.

Biochemistry. 2011 Jul 26;50(29):6488-97. doi: 10.1021/bi200725p. Epub 2011 Jun 29.

PMID:
21678921
30.

Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.

Glasner JD, Yang CH, Reverchon S, Hugouvieux-Cotte-Pattat N, Condemine G, Bohin JP, Van Gijsegem F, Yang S, Franza T, Expert D, Plunkett G 3rd, San Francisco MJ, Charkowski AO, Py B, Bell K, Rauscher L, Rodriguez-Palenzuela P, Toussaint A, Holeva MC, He SY, Douet V, Boccara M, Blanco C, Toth I, Anderson BD, Biehl BS, Mau B, Flynn SM, Barras F, Lindeberg M, Birch PR, Tsuyumu S, Shi X, Hibbing M, Yap MN, Carpentier M, Dassa E, Umehara M, Kim JF, Rusch M, Soni P, Mayhew GF, Fouts DE, Gill SR, Blattner FR, Keen NT, Perna NT.

J Bacteriol. 2011 Apr;193(8):2076-7. doi: 10.1128/JB.01513-10. Epub 2011 Jan 7.

31.

Reducing the cost of proton pump inhibitors by adopting best practice.

Hughes JD, Tanpurekul W, Keen NC, Ee HC.

Qual Prim Care. 2009;17(1):15-21.

PMID:
19281670
32.

Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780.

Nair JS, Ho AL, Tse AN, Coward J, Cheema H, Ambrosini G, Keen N, Schwartz GK.

Mol Biol Cell. 2009 Apr;20(8):2218-28. doi: 10.1091/mbc.E08-08-0885. Epub 2009 Feb 18.

33.

Mitotic drivers--inhibitors of the Aurora B Kinase.

Keen N, Taylor S.

Cancer Metastasis Rev. 2009 Jun;28(1-2):185-95. doi: 10.1007/s10555-009-9184-9. Review.

PMID:
19189202
34.

A critical shortage in u.s. Agricultural research funding: a time for action.

Keen NT, Fletcher J.

Phytopathology. 2003 Jan;93(1):18-9. doi: 10.1094/PHYTO.2003.93.1.18. No abstract available.

35.

Agricultural microbes genome 2.

Johnson PJ, Keen NT, Lunney JK, Sadowsky MJ.

Comp Funct Genomics. 2001;2(1):10-3. doi: 10.1002/cfg.64. No abstract available.

36.

Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity.

Foote KM, Mortlock AA, Heron NM, Jung FH, Hill GB, Pasquet G, Brady MC, Green S, Heaton SP, Kearney S, Keen NJ, Odedra R, Wedge SR, Wilkinson RW.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1904-9. doi: 10.1016/j.bmcl.2008.02.002. Epub 2008 Feb 7.

PMID:
18294849
37.

Obsessive compulsive symptoms and the simulation of future negative events.

Keen N, Brown GP, Wheatley J.

Br J Clin Psychol. 2008 Sep;47(Pt 3):265-79. doi: 10.1348/014466508X282833. Epub 2008 Feb 11.

PMID:
18269783
38.

AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis.

Wilkinson RW, Odedra R, Heaton SP, Wedge SR, Keen NJ, Crafter C, Foster JR, Brady MC, Bigley A, Brown E, Byth KF, Barrass NC, Mundt KE, Foote KM, Heron NM, Jung FH, Mortlock AA, Boyle FT, Green S.

Clin Cancer Res. 2007 Jun 15;13(12):3682-8.

39.

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase.

Mortlock AA, Foote KM, Heron NM, Jung FH, Pasquet G, Lohmann JJ, Warin N, Renaud F, De Savi C, Roberts NJ, Johnson T, Dousson CB, Hill GB, Perkins D, Hatter G, Wilkinson RW, Wedge SR, Heaton SP, Odedra R, Keen NJ, Crafter C, Brown E, Thompson K, Brightwell S, Khatri L, Brady MC, Kearney S, McKillop D, Rhead S, Parry T, Green S.

J Med Chem. 2007 May 3;50(9):2213-24. Epub 2007 Mar 21.

PMID:
17373783
40.

Validating Aurora B as an anti-cancer drug target.

Girdler F, Gascoigne KE, Eyers PA, Hartmuth S, Crafter C, Foote KM, Keen NJ, Taylor SS.

J Cell Sci. 2006 Sep 1;119(Pt 17):3664-75. Epub 2006 Aug 15.

41.

Population behavior analysis of dspE and pelD regulation in Erwinia chrysanthemi 3937.

Peng Q, Yang S, Charkowski AO, Yap MN, Steeber DA, Keen NT, Yang CH.

Mol Plant Microbe Interact. 2006 Apr;19(4):451-7.

42.

Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.

Jung FH, Pasquet G, Lambert-van der Brempt C, Lohmann JJ, Warin N, Renaud F, Germain H, De Savi C, Roberts N, Johnson T, Dousson C, Hill GB, Mortlock AA, Heron N, Wilkinson RW, Wedge SR, Heaton SP, Odedra R, Keen NJ, Green S, Brown E, Thompson K, Brightwell S.

J Med Chem. 2006 Feb 9;49(3):955-70.

PMID:
16451062
43.

Progress in the development of selective inhibitors of aurora kinases.

Mortlock AA, Keen NJ, Jung FH, Heron NM, Foote KM, Wilkinson RW, Green S.

Curr Top Med Chem. 2005;5(8):807-21. Review.

PMID:
16101420
44.

Progress in the development of selective inhibitors of Aurora kinases.

Mortlock A, Keen NJ, Jung FH, Heron NM, Foote KM, Wilkinson R, Green S.

Curr Top Med Chem. 2005;5(2):199-213. Review. Erratum in: Curr Top Med Chem. 2005;5(8):805. Corrected and republished in: Curr Top Med Chem. 2005;5(8):807-21.

PMID:
15853647
45.

The Ipl1/Aurora kinase family: methods of inhibition and functional analysis in mammalian cells.

Ditchfield C, Keen N, Taylor SS.

Methods Mol Biol. 2005;296:371-81.

PMID:
15576945
46.

Aurora-kinase inhibitors as anticancer agents.

Keen N, Taylor S.

Nat Rev Cancer. 2004 Dec;4(12):927-36. Review.

PMID:
15573114
47.

Genome-wide identification of plant-upregulated genes of Erwinia chrysanthemi 3937 using a GFP-based IVET leaf array.

Yang S, Perna NT, Cooksey DA, Okinaka Y, Lindow SE, Ibekwe AM, Keen NT, Yang CH.

Mol Plant Microbe Interact. 2004 Sep;17(9):999-1008.

48.

First crystallographic structure of a xylanase from glycoside hydrolase family 5: implications for catalysis.

Larson SB, Day J, Barba de la Rosa AP, Keen NT, McPherson A.

Biochemistry. 2003 Jul 22;42(28):8411-22.

PMID:
12859186
49.

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.

Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS.

J Cell Biol. 2003 Apr 28;161(2):267-80.

50.

The P34 syringolide elicitor receptor interacts with a soybean photorespiration enzyme, NADH-dependent hydroxypyruvate reductase.

Okinaka Y, Yang CH, Herman E, Kinney A, Keen NT.

Mol Plant Microbe Interact. 2002 Dec;15(12):1213-8.

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