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Items: 1 to 50 of 85

1.

Correction: Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts (doi:10.1242/jcs.180539).

Zhang K, Grither WR, Van Hove S, Biswas H, Ponik SM, Eliceiri KW, Keely PJ, Longmore GD.

J Cell Sci. 2019 May 2;132(9). pii: jcs232348. doi: 10.1242/jcs.232348. No abstract available.

2.

Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma.

Tomko LA, Hill RC, Barrett A, Szulczewski JM, Conklin MW, Eliceiri KW, Keely PJ, Hansen KC, Ponik SM.

Sci Rep. 2018 Aug 28;8(1):12941. doi: 10.1038/s41598-018-31126-w.

3.

The Presence of Cyclooxygenase 2, Tumor-Associated Macrophages, and Collagen Alignment as Prognostic Markers for Invasive Breast Carcinoma Patients.

Esbona K, Yi Y, Saha S, Yu M, Van Doorn RR, Conklin MW, Graham DS, Wisinski KB, Ponik SM, Eliceiri KW, Wilke LG, Keely PJ.

Am J Pathol. 2018 Mar;188(3):559-573. doi: 10.1016/j.ajpath.2017.10.025.

4.

Review of quantitative multiscale imaging of breast cancer.

Pinkert MA, Salkowski LR, Keely PJ, Hall TJ, Block WF, Eliceiri KW.

J Med Imaging (Bellingham). 2018 Jan;5(1):010901. doi: 10.1117/1.JMI.5.1.010901. Epub 2018 Jan 22. Review.

5.

Collagen Alignment as a Predictor of Recurrence after Ductal Carcinoma In Situ.

Conklin MW, Gangnon RE, Sprague BL, Van Gemert L, Hampton JM, Eliceiri KW, Bredfeldt JS, Liu Y, Surachaicharn N, Newcomb PA, Friedl A, Keely PJ, Trentham-Dietz A.

Cancer Epidemiol Biomarkers Prev. 2018 Feb;27(2):138-145. doi: 10.1158/1055-9965.EPI-17-0720. Epub 2017 Nov 15.

6.

Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells.

Ishihara S, Inman DR, Li WJ, Ponik SM, Keely PJ.

Cancer Res. 2017 Nov 15;77(22):6179-6189. doi: 10.1158/0008-5472.CAN-17-0569. Epub 2017 Sep 28.

7.

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments.

Fluegen G, Avivar-Valderas A, Wang Y, Padgen MR, Williams JK, Nobre AR, Calvo V, Cheung JF, Bravo-Cordero JJ, Entenberg D, Castracane J, Verkhusha V, Keely PJ, Condeelis J, Aguirre-Ghiso JA.

Nat Cell Biol. 2017 Feb;19(2):120-132. doi: 10.1038/ncb3465. Epub 2017 Jan 23.

8.

Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells.

Barcus CE, O'Leary KA, Brockman JL, Rugowski DE, Liu Y, Garcia N, Yu M, Keely PJ, Eliceiri KW, Schuler LA.

Breast Cancer Res. 2017 Jan 19;19(1):9. doi: 10.1186/s13058-017-0801-1.

9.

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells.

Morris BA, Burkel B, Ponik SM, Fan J, Condeelis JS, Aguirre-Ghiso JA, Castracane J, Denu JM, Keely PJ.

EBioMedicine. 2016 Nov;13:146-156. doi: 10.1016/j.ebiom.2016.10.012. Epub 2016 Oct 8.

10.

Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells.

Barcus CE, Keely PJ, Eliceiri KW, Schuler LA.

Oncotarget. 2016 Jul 26;7(30):48093-48106. doi: 10.18632/oncotarget.10137.

11.

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis.

Corsa CA, Brenot A, Grither WR, Van Hove S, Loza AJ, Zhang K, Ponik SM, Liu Y, DeNardo DG, Eliceiri KW, Keely PJ, Longmore GD.

Cell Rep. 2016 Jun 14;15(11):2510-23. doi: 10.1016/j.celrep.2016.05.033. Epub 2016 Jun 2.

12.

In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging.

Szulczewski JM, Inman DR, Entenberg D, Ponik SM, Aguirre-Ghiso J, Castracane J, Condeelis J, Eliceiri KW, Keely PJ.

Sci Rep. 2016 May 25;6:25086. doi: 10.1038/srep25086.

13.

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo.

Burkel B, Morris BA, Ponik SM, Riching KM, Eliceiri KW, Keely PJ.

J Vis Exp. 2016 May 9;(111). doi: 10.3791/53989.

14.

Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment.

García-Mendoza MG, Inman DR, Ponik SM, Jeffery JJ, Sheerar DS, Van Doorn RR, Keely PJ.

Breast Cancer Res. 2016 May 11;18(1):49. doi: 10.1186/s13058-016-0703-7.

15.

Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts.

Zhang K, Grither WR, Van Hove S, Biswas H, Ponik SM, Eliceiri KW, Keely PJ, Longmore GD.

J Cell Sci. 2016 May 15;129(10):1989-2002. doi: 10.1242/jcs.180539. Epub 2016 Apr 12. Erratum in: J Cell Sci. 2019 May 2;132(9):.

16.

Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.

Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L.

J Cell Biol. 2016 Mar 14;212(6):707-19. doi: 10.1083/jcb.201507054.

17.

Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer.

Takabatake Y, Oxvig C, Nagi C, Adelson K, Jaffer S, Schmidt H, Keely PJ, Eliceiri KW, Mandeli J, Germain D.

EMBO Mol Med. 2016 Apr 1;8(4):388-406. doi: 10.15252/emmm.201606273.

18.

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.

Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB.

Cancer Discov. 2016 May;6(5):516-31. doi: 10.1158/2159-8290.CD-15-1183. Epub 2016 Jan 25.

19.

Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells.

Barcus CE, Holt EC, Keely PJ, Eliceiri KW, Schuler LA.

PLoS One. 2015 Jan 21;10(1):e0116891. doi: 10.1371/journal.pone.0116891. eCollection 2015.

20.

Tumor mechanics and metabolic dysfunction.

Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM.

Free Radic Biol Med. 2015 Feb;79:269-80. doi: 10.1016/j.freeradbiomed.2014.11.020. Epub 2014 Dec 19. Review.

21.

Collagen density regulates xenobiotic and hypoxic response of mammary epithelial cells.

Curran CS, Carrillo ER, Ponik SM, Keely PJ.

Environ Toxicol Pharmacol. 2015 Jan;39(1):114-24. doi: 10.1016/j.etap.2014.10.017. Epub 2014 Nov 1.

22.

Rho family GTPases: making it to the third dimension.

Riching KM, Keely PJ.

Int J Biochem Cell Biol. 2015 Feb;59:111-5. doi: 10.1016/j.biocel.2014.11.007. Epub 2014 Dec 3. Review.

23.

3D collagen alignment limits protrusions to enhance breast cancer cell persistence.

Riching KM, Cox BL, Salick MR, Pehlke C, Riching AS, Ponik SM, Bass BR, Crone WC, Jiang Y, Weaver AM, Eliceiri KW, Keely PJ.

Biophys J. 2014 Dec 2;107(11):2546-58. doi: 10.1016/j.bpj.2014.10.035. Epub 2014 Dec 2.

24.

A three-dimensional computational model of collagen network mechanics.

Lee B, Zhou X, Riching K, Eliceiri KW, Keely PJ, Guelcher SA, Weaver AM, Jiang Y.

PLoS One. 2014 Nov 11;9(11):e111896. doi: 10.1371/journal.pone.0111896. eCollection 2014.

25.

Automated quantification of aligned collagen for human breast carcinoma prognosis.

Bredfeldt JS, Liu Y, Conklin MW, Keely PJ, Mackie TR, Eliceiri KW.

J Pathol Inform. 2014 Aug 28;5(1):28. doi: 10.4103/2153-3539.139707. eCollection 2014.

26.

The importance of being a lumen.

Bischel LL, Sung KE, Jiménez-Torres JA, Mader B, Keely PJ, Beebe DJ.

FASEB J. 2014 Nov;28(11):4583-90. doi: 10.1096/fj.13-243733. Epub 2014 Jul 30.

27.

LPS modulates rhinovirus-induced chemokine secretion in monocytes and macrophages.

Karta MR, Gavala ML, Curran CS, Wickert LE, Keely PJ, Gern JE, Bertics PJ.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):125-34. doi: 10.1165/rcmb.2013-0404OC.

28.

Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer.

Bredfeldt JS, Liu Y, Pehlke CA, Conklin MW, Szulczewski JM, Inman DR, Keely PJ, Nowak RD, Mackie TR, Eliceiri KW.

J Biomed Opt. 2014 Jan;19(1):16007. doi: 10.1117/1.JBO.19.1.016007.

29.

Proteolytic remodeling of the ECM and the geometric control of stem cell fate.

Keely PJ.

Dev Cell. 2013 May 28;25(4):325-6. doi: 10.1016/j.devcel.2013.05.012.

30.

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.

Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD.

Nat Cell Biol. 2013 Jun;15(6):677-87. doi: 10.1038/ncb2743. Epub 2013 May 5.

31.

A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys.

Pugh TD, Conklin MW, Evans TD, Polewski MA, Barbian HJ, Pass R, Anderson BD, Colman RJ, Eliceiri KW, Keely PJ, Weindruch R, Beasley TM, Anderson RM.

Aging Cell. 2013 Aug;12(4):672-81. doi: 10.1111/acel.12091. Epub 2013 May 27.

32.

Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression.

Gehler S, Ponik SM, Riching KM, Keely PJ.

Crit Rev Eukaryot Gene Expr. 2013;23(2):139-57. Review.

33.

RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.

Ponik SM, Trier SM, Wozniak MA, Eliceiri KW, Keely PJ.

Mol Biol Cell. 2013 Jun;24(11):1688-99, S1-3. doi: 10.1091/mbc.E12-05-0386. Epub 2013 Apr 3.

34.

Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells.

Barcus CE, Keely PJ, Eliceiri KW, Schuler LA.

J Biol Chem. 2013 May 3;288(18):12722-32. doi: 10.1074/jbc.M112.447631. Epub 2013 Mar 24.

35.

Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition.

Curran CS, Keely PJ.

Matrix Biol. 2013 Mar 11;32(2):95-105. doi: 10.1016/j.matbio.2012.11.016. Epub 2012 Dec 20. Review.

36.

Microtubules regulate GEF-H1 in response to extracellular matrix stiffness.

Heck JN, Ponik SM, Garcia-Mendoza MG, Pehlke CA, Inman DR, Eliceiri KW, Keely PJ.

Mol Biol Cell. 2012 Jul;23(13):2583-92. doi: 10.1091/mbc.E11-10-0876. Epub 2012 May 16.

37.

Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers.

Conklin MW, Keely PJ.

Cell Adh Migr. 2012 May-Jun;6(3):249-60. doi: 10.4161/cam.20567. Epub 2012 May 1. Review.

38.

Structural changes in mixed Col I/Col V collagen gels probed by SHG microscopy: implications for probing stromal alterations in human breast cancer.

Ajeti V, Nadiarnykh O, Ponik SM, Keely PJ, Eliceiri KW, Campagnola PJ.

Biomed Opt Express. 2011 Aug 1;2(8):2307-16. doi: 10.1364/BOE.2.002307. Epub 2011 Jul 20.

39.

Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion.

Keely PJ.

J Mammary Gland Biol Neoplasia. 2011 Sep;16(3):205-19. doi: 10.1007/s10911-011-9226-0. Epub 2011 Aug 7. Review.

40.

Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.

Lyons TR, O'Brien J, Borges VF, Conklin MW, Keely PJ, Eliceiri KW, Marusyk A, Tan AC, Schedin P.

Nat Med. 2011 Aug 7;17(9):1109-15. doi: 10.1038/nm.2416.

41.

Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis.

Goetz JG, Minguet S, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibáñez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, Sánchez-Mateos P, Cukierman E, Del Pozo MA.

Cell. 2011 Jul 8;146(1):148-63. doi: 10.1016/j.cell.2011.05.040.

42.

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.

Provenzano PP, Keely PJ.

J Cell Sci. 2011 Apr 15;124(Pt 8):1195-205. doi: 10.1242/jcs.067009.

43.

Aligned collagen is a prognostic signature for survival in human breast carcinoma.

Conklin MW, Eickhoff JC, Riching KM, Pehlke CA, Eliceiri KW, Provenzano PP, Friedl A, Keely PJ.

Am J Pathol. 2011 Mar;178(3):1221-32. doi: 10.1016/j.ajpath.2010.11.076.

44.

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects.

Sung KE, Yang N, Pehlke C, Keely PJ, Eliceiri KW, Friedl A, Beebe DJ.

Integr Biol (Camb). 2011 Apr;3(4):439-50. doi: 10.1039/c0ib00063a. Epub 2010 Dec 7.

45.

Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression.

Schedin P, Keely PJ.

Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a003228. doi: 10.1101/cshperspect.a003228. Review.

46.

Engineering three-dimensional collagen matrices to provide contact guidance during 3D cell migration.

Provenzano PP, Eliceiri KW, Inman DR, Keely PJ.

Curr Protoc Cell Biol. 2010 Jun;Chapter 10:Unit 10.17. doi: 10.1002/0471143030.cb1017s47.

47.

R-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis.

Conklin MW, Ada-Nguema A, Parsons M, Riching KM, Keely PJ.

BMC Cell Biol. 2010 Feb 18;11:14. doi: 10.1186/1471-2121-11-14.

48.

Nonlinear optical microscopy and computational analysis of intrinsic signatures in breast cancer.

Rueden CT, Conklin MW, Provenzano PP, Keely PJ, Eliceiri KW.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:4077-80. doi: 10.1109/IEMBS.2009.5334523.

49.

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage.

Provenzano PP, Inman DR, Eliceiri KW, Keely PJ.

Oncogene. 2009 Dec 10;28(49):4326-43. doi: 10.1038/onc.2009.299.

50.

Shining new light on 3D cell motility and the metastatic process.

Provenzano PP, Eliceiri KW, Keely PJ.

Trends Cell Biol. 2009 Nov;19(11):638-48. doi: 10.1016/j.tcb.2009.08.009. Epub 2009 Oct 8. Review.

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