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Items: 1 to 50 of 109

1.

Role of Liquid-Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins.

Muiznieks LD, Sharpe S, Pomès R, Keeley FW.

J Mol Biol. 2018 Jun 8. pii: S0022-2836(18)30587-4. doi: 10.1016/j.jmb.2018.06.010. [Epub ahead of print] Review.

PMID:
29886015
2.

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

Reuter MS, Walker S, Thiruvahindrapuram B, Whitney J, Cohn I, Sondheimer N, Yuen RKC, Trost B, Paton TA, Pereira SL, Herbrick JA, Wintle RF, Merico D, Howe J, MacDonald JR, Lu C, Nalpathamkalam T, Sung WWL, Wang Z, Patel RV, Pellecchia G, Wei J, Strug LJ, Bell S, Kellam B, Mahtani MM, Bassett AS, Bombard Y, Weksberg R, Shuman C, Cohn RD, Stavropoulos DJ, Bowdin S, Hildebrandt MR, Wei W, Romm A, Pasceri P, Ellis J, Ray P, Meyn MS, Monfared N, Hosseini SM, Joseph-George AM, Keeley FW, Cook RA, Fiume M, Lee HC, Marshall CR, Davies J, Hazell A, Buchanan JA, Szego MJ, Scherer SW.

CMAJ. 2018 Feb 5;190(5):E126-E136. doi: 10.1503/cmaj.171151.

3.

Direct observation of structure and dynamics during phase separation of an elastomeric protein.

Reichheld SE, Muiznieks LD, Keeley FW, Sharpe S.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4408-E4415. doi: 10.1073/pnas.1701877114. Epub 2017 May 15.

4.
5.

Phase separation and mechanical properties of an elastomeric biomaterial from spider wrapping silk and elastin block copolymers.

Muiznieks LD, Keeley FW.

Biopolymers. 2016 Oct;105(10):693-703. doi: 10.1002/bip.22888.

PMID:
27272259
6.

Evolution of the fish heart by sub/neofunctionalization of an elastin gene.

Moriyama Y, Ito F, Takeda H, Yano T, Okabe M, Kuraku S, Keeley FW, Koshiba-Takeuchi K.

Nat Commun. 2016 Jan 19;7:10397. doi: 10.1038/ncomms10397.

7.

Contribution of domain 30 of tropoelastin to elastic fiber formation and material elasticity.

Muiznieks LD, Miao M, Sitarz EE, Keeley FW.

Biopolymers. 2016 May;105(5):267-75. doi: 10.1002/bip.22804.

PMID:
26763595
8.

Proline-poor hydrophobic domains modulate the assembly and material properties of polymeric elastin.

Muiznieks LD, Reichheld SE, Sitarz EE, Miao M, Keeley FW.

Biopolymers. 2015 Oct;103(10):563-73. doi: 10.1002/bip.22663.

PMID:
25924982
9.

Molecular-level characterization of elastin-like constructs and human aortic elastin.

Heinz A, Schräder CU, Baud S, Keeley FW, Mithieux SM, Weiss AS, Neubert RH, Schmelzer CE.

Matrix Biol. 2014 Sep;38:12-21. doi: 10.1016/j.matbio.2014.07.006. Epub 2014 Jul 25.

10.

Modulated growth, stability and interactions of liquid-like coacervate assemblies of elastin.

Muiznieks LD, Cirulis JT, van der Horst A, Reinhardt DP, Wuite GJ, Pomès R, Keeley FW.

Matrix Biol. 2014 Jun;36:39-50. doi: 10.1016/j.matbio.2014.03.008. Epub 2014 Apr 12.

11.

Conformational transitions of the cross-linking domains of elastin during self-assembly.

Reichheld SE, Muiznieks LD, Stahl R, Simonetti K, Sharpe S, Keeley FW.

J Biol Chem. 2014 Apr 4;289(14):10057-68. doi: 10.1074/jbc.M113.533893. Epub 2014 Feb 18.

12.

Elastin binding protein and FKBP65 modulate in vitro self-assembly of human tropoelastin.

Miao M, Reichheld SE, Muiznieks LD, Huang Y, Keeley FW.

Biochemistry. 2013 Nov 5;52(44):7731-41. doi: 10.1021/bi400760f. Epub 2013 Oct 24.

PMID:
24106871
13.

Sequence and domain arrangements influence mechanical properties of elastin-like polymeric elastomers.

Miao M, Sitarz E, Bellingham CM, Won E, Muiznieks LD, Keeley FW.

Biopolymers. 2013 Jun;99(6):392-407. doi: 10.1002/bip.22192. Erratum in: Biopolymers. 2014 Jan;101(1):129.

PMID:
23529691
14.

In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials.

Heinz A, Ruttkies CK, Jahreis G, Schräder CU, Wichapong K, Sippl W, Keeley FW, Neubert RH, Schmelzer CE.

Biochim Biophys Acta. 2013 Apr;1830(4):2994-3004. doi: 10.1016/j.bbagen.2013.01.014. Epub 2013 Jan 30.

PMID:
23375722
15.

Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective.

Muiznieks LD, Keeley FW.

Biochim Biophys Acta. 2013 Jul;1832(7):866-75. doi: 10.1016/j.bbadis.2012.11.022. Epub 2012 Dec 6. Review.

16.

Polymorphisms in the human tropoelastin gene modify in vitro self-assembly and mechanical properties of elastin-like polypeptides.

He D, Miao M, Sitarz EE, Muiznieks LD, Reichheld S, Stahl RJ, Keeley FW, Parkinson J.

PLoS One. 2012;7(9):e46130. doi: 10.1371/journal.pone.0046130. Epub 2012 Sep 25.

17.

Coacervation of tropoelastin.

Yeo GC, Keeley FW, Weiss AS.

Adv Colloid Interface Sci. 2011 Sep 14;167(1-2):94-103. doi: 10.1016/j.cis.2010.10.003. Epub 2010 Oct 21. Review.

PMID:
21081222
18.

Proline periodicity modulates the self-assembly properties of elastin-like polypeptides.

Muiznieks LD, Keeley FW.

J Biol Chem. 2010 Dec 17;285(51):39779-89. doi: 10.1074/jbc.M110.164467. Epub 2010 Oct 13.

19.

Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro.

Akhtar K, Broekelmann TJ, Miao M, Keeley FW, Starcher BC, Pierce RA, Mecham RP, Adair-Kirk TL.

J Biol Chem. 2010 Nov 26;285(48):37396-404. doi: 10.1074/jbc.M110.126789. Epub 2010 Sep 16.

20.

Kinetics and morphology of self-assembly of an elastin-like polypeptide based on the alternating domain arrangement of human tropoelastin.

Cirulis JT, Keeley FW.

Biochemistry. 2010 Jul 13;49(27):5726-33. doi: 10.1021/bi100468v.

PMID:
20527981
21.

Structural disorder and dynamics of elastin.

Muiznieks LD, Weiss AS, Keeley FW.

Biochem Cell Biol. 2010 Apr;88(2):239-50. doi: 10.1139/o09-161. Review.

PMID:
20453927
22.

Functional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastin.

Hubmacher D, Cirulis JT, Miao M, Keeley FW, Reinhardt DP.

J Biol Chem. 2010 Jan 8;285(2):1188-98. doi: 10.1074/jbc.M109.021246. Epub 2009 Nov 4.

23.

Characterization of an unusual tropoelastin with truncated C-terminus in the frog.

Miao M, Stahl RJ, Petersen LF, Reintsch WE, Davis EC, Keeley FW.

Matrix Biol. 2009 Sep;28(7):432-41. doi: 10.1016/j.matbio.2009.07.003. Epub 2009 Jul 26.

PMID:
19638308
24.

Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide.

Cirulis JT, Bellingham CM, Davis EC, Hubmacher D, Reinhardt DP, Mecham RP, Keeley FW.

Biochemistry. 2008 Nov 25;47(47):12601-13. doi: 10.1021/bi8005384.

25.

Effect of extracellular matrix elements on the transport of paclitaxel through an arterial wall tissue mimic.

Sirianni RW, Kremer J, Guler I, Chen YL, Keeley FW, Saltzman WM.

Biomacromolecules. 2008 Oct;9(10):2792-8. doi: 10.1021/bm800571s. Epub 2008 Sep 12.

PMID:
18785771
26.

Comparative genomics of elastin: Sequence analysis of a highly repetitive protein.

He D, Chung M, Chan E, Alleyne T, Ha KC, Miao M, Stahl RJ, Keeley FW, Parkinson J.

Matrix Biol. 2007 Sep;26(7):524-40. Epub 2007 May 25.

PMID:
17628459
27.

Differential expression of two tropoelastin genes in zebrafish.

Miao M, Bruce AE, Bhanji T, Davis EC, Keeley FW.

Matrix Biol. 2007 Mar;26(2):115-24. Epub 2006 Oct 3.

PMID:
17112714
28.

Proline and glycine control protein self-organization into elastomeric or amyloid fibrils.

Rauscher S, Baud S, Miao M, Keeley FW, Pomès R.

Structure. 2006 Nov;14(11):1667-76.

29.

Microstructural and tensile properties of elastin-based polypeptides crosslinked with genipin and pyrroloquinoline quinone.

Vieth S, Bellingham CM, Keeley FW, Hodge SM, Rousseau D.

Biopolymers. 2007 Feb 15;85(3):199-206.

PMID:
17066474
30.

Sequences and domain structures of mammalian, avian, amphibian and teleost tropoelastins: Clues to the evolutionary history of elastins.

Chung MI, Miao M, Stahl RJ, Chan E, Parkinson J, Keeley FW.

Matrix Biol. 2006 Oct;25(8):492-504. Epub 2006 Aug 12.

PMID:
16982180
31.

Cooperativity between the hydrophobic and cross-linking domains of elastin.

Kumashiro KK, Ho JP, Niemczura WP, Keeley FW.

J Biol Chem. 2006 Aug 18;281(33):23757-65. Epub 2006 Jun 15.

33.

Structural determinants of cross-linking and hydrophobic domains for self-assembly of elastin-like polypeptides.

Miao M, Cirulis JT, Lee S, Keeley FW.

Biochemistry. 2005 Nov 1;44(43):14367-75.

PMID:
16245953
34.

Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain.

Broekelmann TJ, Kozel BA, Ishibashi H, Werneck CC, Keeley FW, Zhang L, Mecham RP.

J Biol Chem. 2005 Dec 9;280(49):40939-47. Epub 2005 Sep 27.

35.

Investigation of recombinant human elastin polypeptides as non-thrombogenic coatings.

Woodhouse KA, Klement P, Chen V, Gorbet MB, Keeley FW, Stahl R, Fromstein JD, Bellingham CM.

Biomaterials. 2004 Aug;25(19):4543-53.

PMID:
15120499
36.

Recombinant human elastin polypeptides self-assemble into biomaterials with elastin-like properties.

Bellingham CM, Lillie MA, Gosline JM, Wright GM, Starcher BC, Bailey AJ, Woodhouse KA, Keeley FW.

Biopolymers. 2003 Dec;70(4):445-55.

PMID:
14648756
37.

Sequence and structure determinants for the self-aggregation of recombinant polypeptides modeled after human elastin.

Miao M, Bellingham CM, Stahl RJ, Sitarz EE, Lane CJ, Keeley FW.

J Biol Chem. 2003 Dec 5;278(49):48553-62. Epub 2003 Sep 18.

38.

Codistribution analysis of elastin and related fibrillar proteins in early vertebrate development.

Visconti RP, Barth JL, Keeley FW, Little CD.

Matrix Biol. 2003 Apr;22(2):109-21.

PMID:
12782138
39.
40.

Self-aggregation characteristics of recombinantly expressed human elastin polypeptides.

Bellingham CM, Woodhouse KA, Robson P, Rothstein SJ, Keeley FW.

Biochim Biophys Acta. 2001 Nov 26;1550(1):6-19.

PMID:
11738083
41.

The unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebrates.

Wright GM, Keeley FW, Robson P.

Cell Tissue Res. 2001 May;304(2):165-74. Review.

PMID:
11396711
42.
43.

Distinct non-collagen based cartilages comprising the endoskeleton of the Atlantic hagfish, Myxine glutinosa.

Robson P, Wright GM, Keeley FW.

Anat Embryol (Berl). 2000 Oct;202(4):281-90.

PMID:
11000279
46.

Identification and characterization of a serpin with differential expression during the life cycle of the sea lamprey.

Robson P, Li F, Youson JH, Keeley FW.

Comp Biochem Physiol B Biochem Mol Biol. 1998 Jun;120(2):253-63.

PMID:
9787795
48.

Arterial vasodilation and vascular connective tissue changes in spontaneously hypertensive rats.

Tsoporis J, Keeley FW, Lee RM, Leenen FH.

J Cardiovasc Pharmacol. 1998 Jun;31(6):960-2.

PMID:
9641483
49.
50.

In vivo collagen turnover following experimental balloon angioplasty injury and the role of matrix metalloproteinases.

Strauss BH, Robinson R, Batchelor WB, Chisholm RJ, Ravi G, Natarajan MK, Logan RA, Mehta SR, Levy DE, Ezrin AM, Keeley FW.

Circ Res. 1996 Sep;79(3):541-50.

PMID:
8781487

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