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Items: 1 to 50 of 53

1.

BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells.

Mita P, Sun X, Fenyö D, Kahler DJ, Li D, Agmon N, Wudzinska A, Keegan S, Bader JS, Yun C, Boeke JD.

Nat Struct Mol Biol. 2020 Feb;27(2):179-191. doi: 10.1038/s41594-020-0374-z. Epub 2020 Feb 10.

PMID:
32042152
2.

Hair nicotine concentration of cats with gastrointestinal lymphoma and unaffected control cases.

Smith V, Knottenbelt C, Watson D, Mellor DJ, Guillen Martinez A, Philp H, Keegan S, Marrington M, Giannasi C, Cave T, McBrearty AR.

Vet Rec. 2020 Jan 23. pii: vetrec-2019-105564. doi: 10.1136/vr.105564. [Epub ahead of print]

PMID:
31974267
3.

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.

Clark DJ, Dhanasekaran SM, Petralia F, Pan J, Song X, Hu Y, da Veiga Leprevost F, Reva B, Lih TM, Chang HY, Ma W, Huang C, Ricketts CJ, Chen L, Krek A, Li Y, Rykunov D, Li QK, Chen LS, Ozbek U, Vasaikar S, Wu Y, Yoo S, Chowdhury S, Wyczalkowski MA, Ji J, Schnaubelt M, Kong A, Sethuraman S, Avtonomov DM, Ao M, Colaprico A, Cao S, Cho KC, Kalayci S, Ma S, Liu W, Ruggles K, Calinawan A, Gümüş ZH, Geiszler D, Kawaler E, Teo GC, Wen B, Zhang Y, Keegan S, Li K, Chen F, Edwards N, Pierorazio PM, Chen XS, Pavlovich CP, Hakimi AA, Brominski G, Hsieh JJ, Antczak A, Omelchenko T, Lubinski J, Wiznerowicz M, Linehan WM, Kinsinger CR, Thiagarajan M, Boja ES, Mesri M, Hiltke T, Robles AI, Rodriguez H, Qian J, Fenyö D, Zhang B, Ding L, Schadt E, Chinnaiyan AM, Zhang Z, Omenn GS, Cieslik M, Chan DW, Nesvizhskii AI, Wang P, Zhang H; Clinical Proteomic Tumor Analysis Consortium.

Cell. 2020 Jan 9;180(1):207. doi: 10.1016/j.cell.2019.12.026. No abstract available.

4.

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.

Clark DJ, Dhanasekaran SM, Petralia F, Pan J, Song X, Hu Y, da Veiga Leprevost F, Reva B, Lih TM, Chang HY, Ma W, Huang C, Ricketts CJ, Chen L, Krek A, Li Y, Rykunov D, Li QK, Chen LS, Ozbek U, Vasaikar S, Wu Y, Yoo S, Chowdhury S, Wyczalkowski MA, Ji J, Schnaubelt M, Kong A, Sethuraman S, Avtonomov DM, Ao M, Colaprico A, Cao S, Cho KC, Kalayci S, Ma S, Liu W, Ruggles K, Calinawan A, Gümüş ZH, Geiszler D, Kawaler E, Teo GC, Wen B, Zhang Y, Keegan S, Li K, Chen F, Edwards N, Pierorazio PM, Chen XS, Pavlovich CP, Hakimi AA, Brominski G, Hsieh JJ, Antczak A, Omelchenko T, Lubinski J, Wiznerowicz M, Linehan WM, Kinsinger CR, Thiagarajan M, Boja ES, Mesri M, Hiltke T, Robles AI, Rodriguez H, Qian J, Fenyö D, Zhang B, Ding L, Schadt E, Chinnaiyan AM, Zhang Z, Omenn GS, Cieslik M, Chan DW, Nesvizhskii AI, Wang P, Zhang H; Clinical Proteomic Tumor Analysis Consortium.

Cell. 2019 Oct 31;179(4):964-983.e31. doi: 10.1016/j.cell.2019.10.007. Erratum in: Cell. 2020 Jan 9;180(1):207.

5.

The Experience of Caregivers Following a Moderate to Severe Traumatic Brain Injury Requiring ICU Admission.

Kreitzer N, Bakas T, Kurowski B, Lindsell CJ, Ferioli S, Foreman B, Ngwenya LB, Thomas S, Keegan S, Adeoye O.

J Head Trauma Rehabil. 2019 Aug 29. doi: 10.1097/HTR.0000000000000525. [Epub ahead of print]

PMID:
31479080
6.

Low frequency of pre-treatment and post-treatment haematological abnormalities in dogs with non-infectious meningoencephalitis treated with cytosine arabinoside and prednisolone.

Keegan S, Rose JH, Khan Z, Liebel FX.

Vet Rec Open. 2019 Feb 27;6(1):e000315. doi: 10.1136/vetreco-2018-000315. eCollection 2019.

7.

Transcription shapes DNA replication initiation and termination in human cells.

Chen YH, Keegan S, Kahli M, Tonzi P, Fenyö D, Huang TT, Smith DJ.

Nat Struct Mol Biol. 2019 Jan;26(1):67-77. doi: 10.1038/s41594-018-0171-0. Epub 2018 Dec 31.

8.

The ULK1-FBXW5-SEC23B nexus controls autophagy.

Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyö D, Cuervo AM, Rossi M, Pagano M.

Elife. 2018 Dec 31;7. pii: e42253. doi: 10.7554/eLife.42253.

9.

Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks.

Whelan DR, Lee WTC, Yin Y, Ofri DM, Bermudez-Hernandez K, Keegan S, Fenyo D, Rothenberg E.

Nat Commun. 2018 Sep 24;9(1):3882. doi: 10.1038/s41467-018-06435-3.

10.

A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors.

Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang Z, Xue L, Ghosh D, Liu S, Ramos P, Hu S, Bayron Kain D, Keegan S, Saul R, Colantonio S, Zhang H, Behn FP, Song G, Albino E, Asencio L, Ramos L, Lugo L, Morell G, Rivera J, Ruiz K, Almodovar R, Nazario L, Murphy K, Vargas I, Rivera-Pacheco ZA, Rosa C, Vargas M, McDade J, Clark BS, Yoo S, Khambadkone SG, de Melo J, Stevanovic M, Jiang L, Li Y, Yap WY, Jones B, Tandon A, Campbell E, Montelione GT, Anderson S, Myers RM, Boeke JD, Fenyö D, Whiteley G, Bader JS, Pino I, Eichinger DJ, Zhu H, Blackshaw S.

Nat Methods. 2018 May;15(5):330-338. doi: 10.1038/nmeth.4632. Epub 2018 Mar 19.

11.

Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration.

McLaughlin T, Falkowski M, Park JW, Keegan S, Elliott M, Wang JJ, Zhang SX.

Mol Neurodegener. 2018 Apr 4;13(1):16. doi: 10.1186/s13024-018-0250-z.

12.

National survey of patch testing in the United Kingdom and Republic of Ireland: what proportion of the population is and should be tested?

Bhoyrul B, Keegan S, Mughal A.

Contact Dermatitis. 2018 Jun;78(6):393-398. doi: 10.1111/cod.12961. Epub 2018 Feb 14.

PMID:
29441604
13.

A Method for Quantifying Molecular Interactions Using Stochastic Modelling and Super-Resolution Microscopy.

Bermudez-Hernandez K, Keegan S, Whelan DR, Reid DA, Zagelbaum J, Yin Y, Ma S, Rothenberg E, Fenyö D.

Sci Rep. 2017 Nov 1;7(1):14882. doi: 10.1038/s41598-017-14922-8.

14.

Single Molecule Localization Microscopy of DNA Damage Response Pathways in Cancer.

Whelan DR, Yin Y, Bermudez-Hernandez K, Keegan S, Fenyö D, Rothenberg E.

Microsc Microanal. 2016 Jul;22(Suppl 3):1016-1017. doi: 10.1017/S1431927616005924. Epub 2016 Jul 25. No abstract available.

15.

HIV-host interactome revealed directly from infected cells.

Luo Y, Jacobs EY, Greco TM, Mohammed KD, Tong T, Keegan S, Binley JM, Cristea IM, Fenyö D, Rout MP, Chait BT, Muesing MA.

Nat Microbiol. 2016 Jul;1(7):16068. Epub 2016 May 23.

16.

Erratum: Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.

Leo-Macias A, Agullo-Pascual E, Sanchez-Alonso JL, Keegan S, Lin X, Arcos T, Feng-Xia-Liang, Korchev YE, Gorelik J, Fenyö D, Rothenberg E, Delmar M.

Nat Commun. 2016 Feb 22;7:10919. doi: 10.1038/ncomms10919. No abstract available.

17.

g2pDB: A Database Mapping Protein Post-Translational Modifications to Genomic Coordinates.

Keegan S, Cortens JP, Beavis RC, Fenyö D.

J Proteome Res. 2016 Mar 4;15(3):983-90. doi: 10.1021/acs.jproteome.5b01018. Epub 2016 Feb 18.

PMID:
26842767
18.

Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.

Leo-Macias A, Agullo-Pascual E, Sanchez-Alonso JL, Keegan S, Lin X, Arcos T, Feng-Xia-Liang, Korchev YE, Gorelik J, Fenyö D, Rothenberg E, Rothenberg E, Delmar M.

Nat Commun. 2016 Jan 20;7:10342. doi: 10.1038/ncomms10342. Erratum in: Nat Commun. 2016;7:10919. Rothenberg, Eli [Added].

19.

Optimizing selection of large animals for antibody production by screening immune response to standard vaccines.

Thompson MK, Fridy PC, Keegan S, Chait BT, Fenyö D, Rout MP.

J Immunol Methods. 2016 Mar;430:56-60. doi: 10.1016/j.jim.2016.01.006. Epub 2016 Jan 9.

20.

Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair.

Reid DA, Keegan S, Leo-Macias A, Watanabe G, Strande NT, Chang HH, Oksuz BA, Fenyo D, Lieber MR, Ramsden DA, Rothenberg E.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2575-84. doi: 10.1073/pnas.1420115112. Epub 2015 May 4.

21.

Rapid, optimized interactomic screening.

Hakhverdyan Z, Domanski M, Hough LE, Oroskar AA, Oroskar AR, Keegan S, Dilworth DJ, Molloy KR, Sherman V, Aitchison JD, Fenyö D, Chait BT, Jensen TH, Rout MP, LaCava J.

Nat Methods. 2015 Jun;12(6):553-60. doi: 10.1038/nmeth.3395. Epub 2015 May 4.

22.

What kids think about boys getting the HPV vaccine as well as girls.

Keegan SM.

Paediatr Child Health. 2015 Jan-Feb;20(1):21-2. No abstract available.

23.

What is your neurologic diagnosis? Partial rupture of the calcaneal tendon.

Keegan S, Kuehn K, Danielski A, Smith PM.

J Am Vet Med Assoc. 2015 Jan 1;246(1):59-61. doi: 10.2460/javma.246.1.59. No abstract available.

PMID:
25517326
24.

A robust pipeline for rapid production of versatile nanobody repertoires.

Fridy PC, Li Y, Keegan S, Thompson MK, Nudelman I, Scheid JF, Oeffinger M, Nussenzweig MC, Fenyö D, Chait BT, Rout MP.

Nat Methods. 2014 Dec;11(12):1253-60. doi: 10.1038/nmeth.3170. Epub 2014 Nov 2.

25.

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

Agullo-Pascual E, Lin X, Leo-Macias A, Zhang M, Liang FX, Li Z, Pfenniger A, Lübkemeier I, Keegan S, Fenyö D, Willecke K, Rothenberg E, Delmar M.

Cardiovasc Res. 2014 Nov 1;104(2):371-81. doi: 10.1093/cvr/cvu195. Epub 2014 Aug 18.

26.

Modeling the clinical phenotype of BTK inhibition in the mature murine immune system.

Benson MJ, Rodriguez V, von Schack D, Keegan S, Cook TA, Edmonds J, Benoit S, Seth N, Du S, Messing D, Nickerson-Nutter CL, Dunussi-Joannopoulos K, Rankin AL, Ruzek M, Schnute ME, Douhan J 3rd.

J Immunol. 2014 Jul 1;193(1):185-97. doi: 10.4049/jimmunol.1302570. Epub 2014 Jun 4.

27.

Effect of a dalteparin prophylaxis protocol using anti-factor Xa concentrations on venous thromboembolism in high-risk trauma patients.

Droege ME, Mueller EW, Besl KM, Lemmink JA, Kramer EA, Athota KP, Droege CA, Ernst NE, Keegan SP, Lutomski DM, Hanseman DJ, Robinson BR.

J Trauma Acute Care Surg. 2014 Feb;76(2):450-6. doi: 10.1097/TA.0000000000000087.

PMID:
24458050
28.

Response to "Characterization of unbound phenytoin concentrations in neurointensive care unit patients using a revised Winter-Tozer equation" by Sean P. Kane, Adam P. Bress, and Eljim P. Tesoro.

Brown AL, Sangha KS, Mueller EW, Kaur D, Keegan SP.

Ann Pharmacother. 2013 Oct;47(10):1374-5. doi: 10.1177/1060028013503625. No abstract available.

PMID:
24259705
29.

Quantitative analysis of target coverage and germinal center response by a CXCL13 neutralizing antibody in a T-dependent mouse immunization model.

Brodfuehrer J, Rankin A, Edmonds J, Keegan S, Andreyeva T, Lawrence-Henderson R, Ozer J, Gao H, Bloom L, Boisvert A, Lam K, Lee J, LaBranche T, Syed J, Miao W, Singh P.

Pharm Res. 2014 Mar;31(3):635-48. doi: 10.1007/s11095-013-1185-2. Epub 2013 Nov 5.

PMID:
24190631
30.

Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.

Rankin AL, Seth N, Keegan S, Andreyeva T, Cook TA, Edmonds J, Mathialagan N, Benson MJ, Syed J, Zhan Y, Benoit SE, Miyashiro JS, Wood N, Mohan S, Peeva E, Ramaiah SK, Messing D, Homer BL, Dunussi-Joannopoulos K, Nickerson-Nutter CL, Schnute ME, Douhan J 3rd.

J Immunol. 2013 Nov 1;191(9):4540-50. doi: 10.4049/jimmunol.1301553. Epub 2013 Sep 25.

31.

Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque.

Agullo-Pascual E, Reid DA, Keegan S, Sidhu M, Fenyö D, Rothenberg E, Delmar M.

Cardiovasc Res. 2013 Nov 1;100(2):231-40. doi: 10.1093/cvr/cvt191. Epub 2013 Aug 8.

32.

The incidence of seizures in patients undergoing therapeutic hypothermia after resuscitation from cardiac arrest.

Knight WA, Hart KW, Adeoye OM, Bonomo JB, Keegan SP, Ficker DM, Szaflarski JP, Privitera MD, Lindsell CJ.

Epilepsy Res. 2013 Oct;106(3):396-402. doi: 10.1016/j.eplepsyres.2013.06.018. Epub 2013 Jul 29.

33.

Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells.

Carrier Y, Whitters MJ, Miyashiro JS, LaBranche TP, Ramon HE, Benoit SE, Ryan MS, Keegan SP, Guay H, Douhan J, Collins M, Dunussi-Joannopoulos K, Medley QG.

Eur J Immunol. 2012 Jun;42(6):1393-404. doi: 10.1002/eji.201142162.

34.

IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.

Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K.

J Immunol. 2012 Feb 15;188(4):1656-67. doi: 10.4049/jimmunol.1003871. Epub 2012 Jan 9.

35.

The impact of uniform and mixed species blood meals on the fitness of the mosquito vector Anopheles gambiae s.s: does a specialist pay for diversifying its host species diet?

Lyimo IN, Keegan SP, Ranford-Cartwright LC, Ferguson HM.

J Evol Biol. 2012 Mar;25(3):452-60. doi: 10.1111/j.1420-9101.2011.02442.x. Epub 2012 Jan 4.

36.

Global assessment of psychosocial functioning and predictors of outcome in schizophrenia.

Stefanopoulou E, Lafuente AR, Fonseca AS, Keegan S, Vishnick C, Huxley A.

Int J Psychiatry Clin Pract. 2011 Mar;15(1):62-8. doi: 10.3109/13651501.2010.519035. Epub 2010 Oct 15.

PMID:
22122691
37.

Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis.

Kim KH, Maderna A, Schnute ME, Hegen M, Mohan S, Miyashiro J, Lin L, Li E, Keegan S, Lussier J, Wrocklage C, Nickerson-Nutter CL, Wittwer AJ, Soutter H, Caspers N, Han S, Kurumbail R, Dunussi-Joannopoulos K, Douhan J 3rd, Wissner A.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6258-63. doi: 10.1016/j.bmcl.2011.09.008. Epub 2011 Sep 10.

PMID:
21958547
38.

IL-21 receptor is critical for the development of memory B cell responses.

Rankin AL, MacLeod H, Keegan S, Andreyeva T, Lowe L, Bloom L, Collins M, Nickerson-Nutter C, Young D, Guay H.

J Immunol. 2011 Jan 15;186(2):667-74. doi: 10.4049/jimmunol.0903207. Epub 2010 Dec 17.

39.

Effect of accelerated rehabilitation on function after ankle sprain: randomised controlled trial.

Bleakley CM, O'Connor SR, Tully MA, Rocke LG, Macauley DC, Bradbury I, Keegan S, McDonough SM.

BMJ. 2010 May 10;340:c1964. doi: 10.1136/bmj.c1964.

PMID:
20457737
40.

Prevention of perioperative venous thromboembolism.

Keegan SP, Patrick DM, Ernst NE, Mueller EW.

Int Anesthesiol Clin. 2009 Fall;47(4):55-64. doi: 10.1097/AIA.0b013e3181b485af. Review. No abstract available.

PMID:
19820478
41.

Argatroban for anticoagulation in continuous renal replacement therapy.

Keegan SP, Ernst NE, Mueller EW.

Crit Care Med. 2009 Jun;37(6):2139; author reply 2139-40. doi: 10.1097/CCM.0b013e3181a60793. No abstract available.

PMID:
19448479
42.

Effects of critical illness and organ failure on therapeutic argatroban dosage requirements in patients with suspected or confirmed heparin-induced thrombocytopenia.

Keegan SP, Gallagher EM, Ernst NE, Young EJ, Mueller EW.

Ann Pharmacother. 2009 Jan;43(1):19-27. doi: 10.1345/aph.1L224. Epub 2008 Dec 30.

PMID:
19116377
43.

Where is all the pressure coming from? Messages from mothers and teachers about preschool children's appearance, diet and exercise.

McCabe MP, Ricciardelli LA, Stanford J, Holt K, Keegan S, Miller L.

Eur Eat Disord Rev. 2007 May;15(3):221-30.

PMID:
17676692
44.

RSV604, a novel inhibitor of respiratory syncytial virus replication.

Chapman J, Abbott E, Alber DG, Baxter RC, Bithell SK, Henderson EA, Carter MC, Chambers P, Chubb A, Cockerill GS, Collins PL, Dowdell VC, Keegan SJ, Kelsey RD, Lockyer MJ, Luongo C, Najarro P, Pickles RJ, Simmonds M, Taylor D, Tyms S, Wilson LJ, Powell KL.

Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. Epub 2007 Jun 18.

45.

1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.

Henderson EA, Alber DG, Baxter RC, Bithell SK, Budworth J, Carter MC, Chubb A, Cockerill GS, Dowdell VC, Fraser IJ, Harris RA, Keegan SJ, Kelsey RD, Lumley JA, Stables JN, Weerasekera N, Wilson LJ, Powell KL.

J Med Chem. 2007 Apr 5;50(7):1685-92. Epub 2007 Mar 7.

PMID:
17341059
46.

1,4-Benzodiazepines as inhibitors of respiratory syncytial virus.

Carter MC, Alber DG, Baxter RC, Bithell SK, Budworth J, Chubb A, Cockerill GS, Dowdell VC, Henderson EA, Keegan SJ, Kelsey RD, Lockyer MJ, Stables JN, Wilson LJ, Powell KL.

J Med Chem. 2006 Apr 6;49(7):2311-9.

PMID:
16570927
47.

Identification of natural antibodies to interleukin-18 in the sera of normal humans and three nonhuman primate species.

Soos JM, Polsky RM, Keegan SP, Bugelski P, Herzyk DJ.

Clin Immunol. 2003 Nov;109(2):188-96.

PMID:
14597217
48.

Characterization of Escherichia coli strains causing urinary tract infections in patients with transposed intestinal segments.

Keegan SJ, Graham C, Neal DE, Blum-Oehler G, N'Dow J, Pearson JP, Gally DL.

J Urol. 2003 Jun;169(6):2382-7.

PMID:
12771802
49.

Analysis of Escherichia coli strains causing bacteriuria during pregnancy: selection for strains that do not express type 1 fimbriae.

Graham JC, Leathart JB, Keegan SJ, Pearson J, Bint A, Gally DL.

Infect Immun. 2001 Feb;69(2):794-9.

50.

Characterisation and adherence mechanisms of Escherichia coli strains causing infections in patients with a reconstructed bladder.

Keegan SJ, Hormaeche CE, Pearson JP, Gally DL.

Adv Exp Med Biol. 2000;485:263-71. No abstract available.

PMID:
11109115

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