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Items: 1 to 50 of 94

1.

Clinical and Epidemiological Aspects of Diphtheria:A Systematic Review and Pooled Analysis.

Truelove SA, Keegan LT, Moss WJ, Chaisson LH, Macher E, Azman AS, Lessler J.

Clin Infect Dis. 2019 Aug 19. pii: ciz808. doi: 10.1093/cid/ciz808. [Epub ahead of print]

PMID:
31425581
2.

The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

Piskacek M, Havelka M, Jendruchova K, Knight A, Keegan LP.

Cell Mol Life Sci. 2019 Aug 2. doi: 10.1007/s00018-019-03251-w. [Epub ahead of print]

PMID:
31375868
3.

Perfect counterfactuals for epidemic simulations.

Kaminsky J, Keegan LT, Metcalf CJE, Lessler J.

Philos Trans R Soc Lond B Biol Sci. 2019 Jul 8;374(1776):20180279. doi: 10.1098/rstb.2018.0279.

PMID:
31104612
4.

Improving natural social interaction: Group rehabilitation after Traumatic Brain Injury.

Keegan LC, Murdock M, Suger C, Togher L.

Neuropsychol Rehabil. 2019 Mar 24:1-26. doi: 10.1080/09602011.2019.1591464. [Epub ahead of print]

PMID:
30905263
5.

Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein.

Wiatrek DM, Candela ME, Sedmík J, Oppelt J, Keegan LP, O'Connell MA.

RNA. 2019 Jun;25(6):713-726. doi: 10.1261/rna.069625.118. Epub 2019 Mar 20.

PMID:
30894411
6.

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep.

Sinigaglia K, Wiatrek D, Khan A, Michalik D, Sambrani N, Sedmík J, Vukić D, O'Connell MA, Keegan LP.

Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):356-369. doi: 10.1016/j.bbagrm.2018.10.011. Epub 2018 Oct 31. Review.

PMID:
30391332
7.

Prospective forecasts of annual dengue hemorrhagic fever incidence in Thailand, 2010-2014.

Lauer SA, Sakrejda K, Ray EL, Keegan LT, Bi Q, Suangtho P, Hinjoy S, Iamsirithaworn S, Suthachana S, Laosiritaworn Y, Cummings DAT, Lessler J, Reich NG.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2175-E2182. doi: 10.1073/pnas.1714457115. Epub 2018 Feb 20.

8.

Quantifying Zika: Advancing the Epidemiology of Zika With Quantitative Models.

Keegan LT, Lessler J, Johansson MA.

J Infect Dis. 2017 Dec 16;216(suppl_10):S884-S890. doi: 10.1093/infdis/jix437. Review.

9.

Dynamic landscape and regulation of RNA editing in mammals.

Tan MH, Li Q, Shanmugam R, Piskol R, Kohler J, Young AN, Liu KI, Zhang R, Ramaswami G, Ariyoshi K, Gupte A, Keegan LP, George CX, Ramu A, Huang N, Pollina EA, Leeman DS, Rustighi A, Goh YPS; GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group; Statistical Methods groups—Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site—NDRI; Biospecimen Collection Source Site—RPCI; Biospecimen Core Resource—VARI; Brain Bank Repository—University of Miami Brain Endowment Bank; Leidos Biomedical—Project Management; ELSI Study; Genome Browser Data Integration &Visualization—EBI; Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz, Chawla A, Del Sal G, Peltz G, Brunet A, Conrad DF, Samuel CE, O'Connell MA, Walkley CR, Nishikura K, Li JB.

Nature. 2017 Oct 11;550(7675):249-254. doi: 10.1038/nature24041.

10.

ADAR RNA editing in human disease; more to it than meets the I.

Gallo A, Vukic D, Michalík D, O'Connell MA, Keegan LP.

Hum Genet. 2017 Sep;136(9):1265-1278. doi: 10.1007/s00439-017-1837-0. Epub 2017 Sep 14. Review.

PMID:
28913566
11.

Expression of masculine identity in individuals with a traumatic brain injury.

Keegan LC, Togher L, Murdock M, Hendry E.

Brain Inj. 2017;31(12):1632-1641. doi: 10.1080/02699052.2017.1332389. Epub 2017 Jul 7.

PMID:
28686072
12.

ADAR RNA editing below the backbone.

Keegan L, Khan A, Vukic D, O'Connell M.

RNA. 2017 Sep;23(9):1317-1328. doi: 10.1261/rna.060921.117. Epub 2017 May 30. Review.

13.

A to I editing in disease is not fake news.

Bajad P, Jantsch MF, Keegan L, O'Connell M.

RNA Biol. 2017 Sep 2;14(9):1223-1231. doi: 10.1080/15476286.2017.1306173. Epub 2017 Mar 27. Review.

14.

Estimating finite-population reproductive numbers in heterogeneous populations.

Keegan LT, Dushoff J.

J Theor Biol. 2016 May 21;397:1-12. doi: 10.1016/j.jtbi.2016.01.022. Epub 2016 Feb 15.

PMID:
26891919
15.

The Epitranscriptome and Innate Immunity.

O'Connell MA, Mannion NM, Keegan LP.

PLoS Genet. 2015 Dec 10;11(12):e1005687. doi: 10.1371/journal.pgen.1005687. eCollection 2015 Dec. Review.

16.

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins.

Mannion N, Arieti F, Gallo A, Keegan LP, O'Connell MA.

Biomolecules. 2015 Sep 30;5(4):2338-62. doi: 10.3390/biom5042338. Review.

17.

The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.

Mannion NM, Greenwood SM, Young R, Cox S, Brindle J, Read D, Nellåker C, Vesely C, Ponting CP, McLaughlin PJ, Jantsch MF, Dorin J, Adams IR, Scadden AD, Ohman M, Keegan LP, O'Connell MA.

Cell Rep. 2014 Nov 20;9(4):1482-94. doi: 10.1016/j.celrep.2014.10.041. Epub 2014 Nov 13.

18.

Conflict RNA modification, host-parasite co-evolution, and the origins of DNA and DNA-binding proteins1.

McLaughlin PJ, Keegan LP.

Biochem Soc Trans. 2014 Aug;42(4):1159-67. doi: 10.1042/BST20140147. Review.

PMID:
25110019
19.

Analytic calculation of finite-population reproductive numbers for direct- and vector-transmitted diseases with homogeneous mixing.

Keegan L, Dushoff J.

Bull Math Biol. 2014 May;76(5):1143-54. doi: 10.1007/s11538-014-9950-x. Epub 2014 Apr 23.

20.

Preparing community Level II neonatal intensive care unit nurses to deliver Level IIIA care.

Keegan LM, Fields W.

Neonatal Netw. 2013 Nov-Dec;32(6):390-8. doi: 10.1891/0730-0832.32.6.390.

PMID:
24195798
21.

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster.

Li X, Overton IM, Baines RA, Keegan LP, O'Connell MA.

Nucleic Acids Res. 2014 Jan;42(2):1139-51. doi: 10.1093/nar/gkt909. Epub 2013 Oct 16.

22.

Effectiveness of melatonin for sleep impairment post paediatric acquired brain injury: evidence from a systematic review.

Keegan LJ, Reed-Berendt R, Neilly E, Morrall MC, Murdoch-Eaton D.

Dev Neurorehabil. 2014 Oct;17(5):355-62. doi: 10.3109/17518423.2012.741147. Epub 2013 Oct 8. Review.

PMID:
24102301
23.

Population-level effects of clinical immunity to malaria.

Keegan LT, Dushoff J.

BMC Infect Dis. 2013 Sep 11;13:428. doi: 10.1186/1471-2334-13-428.

24.

Forest immersion experience: Mother Nature promotes introspection and healing.

Keegan L, Gilbert T.

Beginnings. 2013 Jun;33(3):10-2. No abstract available.

PMID:
23941039
25.

Quality of life through the end of life.

Keegan L, Drick CA.

Beginnings. 2013 Feb;33(1):14-7. No abstract available.

PMID:
23550378
26.

Identifying RNA editing sites using RNA sequencing data alone.

Ramaswami G, Zhang R, Piskol R, Keegan LP, Deng P, O'Connell MA, Li JB.

Nat Methods. 2013 Feb;10(2):128-32. doi: 10.1038/nmeth.2330. Epub 2013 Jan 6.

27.

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.

Rice GI, Kasher PR, Forte GM, Mannion NM, Greenwood SM, Szynkiewicz M, Dickerson JE, Bhaskar SS, Zampini M, Briggs TA, Jenkinson EM, Bacino CA, Battini R, Bertini E, Brogan PA, Brueton LA, Carpanelli M, De Laet C, de Lonlay P, del Toro M, Desguerre I, Fazzi E, Garcia-Cazorla A, Heiberg A, Kawaguchi M, Kumar R, Lin JP, Lourenco CM, Male AM, Marques W Jr, Mignot C, Olivieri I, Orcesi S, Prabhakar P, Rasmussen M, Robinson RA, Rozenberg F, Schmidt JL, Steindl K, Tan TY, van der Merwe WG, Vanderver A, Vassallo G, Wakeling EL, Wassmer E, Whittaker E, Livingston JH, Lebon P, Suzuki T, McLaughlin PJ, Keegan LP, O'Connell MA, Lovell SC, Crow YJ.

Nat Genet. 2012 Nov;44(11):1243-8. doi: 10.1038/ng.2414. Epub 2012 Sep 23.

28.

Death with dignity: a holistic approach.

Drick CA, Keegan L.

Beginnings. 2012 Jun;32(3):4-6. No abstract available.

PMID:
22852227
29.

Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects.

Marcucci R, Brindle J, Paro S, Casadio A, Hempel S, Morrice N, Bisso A, Keegan LP, Del Sal G, O'Connell MA.

EMBO J. 2011 Aug 16;30(20):4211-22. doi: 10.1038/emboj.2011.303.

30.

Regulation and functions of ADAR in drosophila.

Paro S, Li X, O'Connell MA, Keegan LP.

Curr Top Microbiol Immunol. 2012;353:221-36. doi: 10.1007/82_2011_152. Review.

PMID:
21761288
31.

The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function.

Heale BS, Keegan LP, O'Connell MA.

Adv Exp Med Biol. 2011;700:76-84.

PMID:
21755475
32.

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects.

Keegan LP, McGurk L, Palavicini JP, Brindle J, Paro S, Li X, Rosenthal JJ, O'Connell MA.

Nucleic Acids Res. 2011 Sep 1;39(16):7249-62. doi: 10.1093/nar/gkr423. Epub 2011 May 27.

33.

Laser microdissection and pressure catapulting of single human motor neurons for RNA editing analysis.

Sun H, Raja A, O'Connell MA, Mann V, Noble B, Keegan LP.

Methods Mol Biol. 2011;718:75-87. doi: 10.1007/978-1-61779-018-8_4.

PMID:
21370042
34.

A new place for death with dignity: the golden room.

Keegan L, Drick CA.

J Holist Nurs. 2011 Dec;29(4):287-91. doi: 10.1177/0898010111398662. Epub 2011 Feb 28.

PMID:
21357182
35.

RNA editing by mammalian ADARs.

Hogg M, Paro S, Keegan LP, O'Connell MA.

Adv Genet. 2011;73:87-120. doi: 10.1016/B978-0-12-380860-8.00003-3. Review.

PMID:
21310295
36.

The effect of RNA editing and ADARs on miRNA biogenesis and function.

Heale BS, Keegan LP, O'Connell MA.

Adv Exp Med Biol. 2010;700:76-84. Review.

PMID:
21627032
37.

ADARs have effects beyond RNA editing.

Heale BS, Keegan LP, O'Connell MA.

Cell Cycle. 2009 Dec 15;8(24):4011-2. Epub 2009 Dec 30. No abstract available.

PMID:
19949296
38.

Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae).

Carpenter JA, Keegan LP, Wilfert L, O'Connell MA, Jiggins FM.

BMC Genet. 2009 Nov 26;10:75. doi: 10.1186/1471-2156-10-75.

39.

Human BLCAP transcript: new editing events in normal and cancerous tissues.

Galeano F, Leroy A, Rossetti C, Gromova I, Gautier P, Keegan LP, Massimi L, Di Rocco C, O'Connell MA, Gallo A.

Int J Cancer. 2010 Jul 1;127(1):127-37. doi: 10.1002/ijc.25022.

40.

Editing independent effects of ADARs on the miRNA/siRNA pathways.

Heale BS, Keegan LP, McGurk L, Michlewski G, Brindle J, Stanton CM, Caceres JF, O'Connell MA.

EMBO J. 2009 Oct 21;28(20):3145-56. doi: 10.1038/emboj.2009.244. Epub 2009 Aug 27.

41.

Three-dimensional imaging of Drosophila melanogaster.

McGurk L, Morrison H, Keegan LP, Sharpe J, O'Connell MA.

PLoS One. 2007 Sep 5;2(9):e834.

42.

Purification and assay of ADAR activity.

Keegan LP, Rosenthal JJ, Roberson LM, O'Connell MA.

Methods Enzymol. 2007;424:301-17.

PMID:
17662847
43.

Reflection on the universal nature of vulnerability.

Keegan L.

Explore (NY). 2006 Jul-Aug;2(4):365-7. Review. No abstract available.

PMID:
16846828
44.

Drosha versus ADAR: wrangling over pri-miRNA.

O'Connell MA, Keegan LP.

Nat Struct Mol Biol. 2006 Jan;13(1):3-4.

PMID:
16395313
45.

SUMO-1 modification alters ADAR1 editing activity.

Desterro JM, Keegan LP, Jaffray E, Hay RT, O'Connell MA, Carmo-Fonseca M.

Mol Biol Cell. 2005 Nov;16(11):5115-26. Epub 2005 Aug 24.

46.

Tuning of RNA editing by ADAR is required in Drosophila.

Keegan LP, Brindle J, Gallo A, Leroy A, Reenan RA, O'Connell MA.

EMBO J. 2005 Jun 15;24(12):2183-93. Epub 2005 May 26.

47.
48.

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes.

Keegan LP, Leroy A, Sproul D, O'Connell MA.

Genome Biol. 2004;5(2):209. Epub 2004 Feb 2. Review.

49.

Therapies to reduce stress and anxiety.

Keegan L.

Crit Care Nurs Clin North Am. 2003 Sep;15(3):321-7.

PMID:
12943138
50.

An ADAR that edits transcripts encoding ion channel subunits functions as a dimer.

Gallo A, Keegan LP, Ring GM, O'Connell MA.

EMBO J. 2003 Jul 1;22(13):3421-30.

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