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Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1.

Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A, Keegan AD.

Immunohorizons. 2019 Feb;3(2):71-87. doi: 10.4049/immunohorizons.1800026.


Oxaliplatin disrupts pathological features of glioma cells and associated macrophages independent of apoptosis induction.

Roberts NB, Alqazzaz A, Hwang JR, Qi X, Keegan AD, Kim AJ, Winkles JA, Woodworth GF.

J Neurooncol. 2018 Dec;140(3):497-507. doi: 10.1007/s11060-018-2979-1. Epub 2018 Aug 21.


CD8+ T cells promote cytokine responses to stress.

Clark SM, Song C, Li X, Keegan AD, Tonelli LH.

Cytokine. 2019 Jan;113:256-264. doi: 10.1016/j.cyto.2018.07.015. Epub 2018 Jul 19.


IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View.

Keegan AD, Zamorano J, Keselman A, Heller NM.

Front Immunol. 2018 May 15;9:1037. doi: 10.3389/fimmu.2018.01037. eCollection 2018. Review.


The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation.

Dasgupta P, Dorsey NJ, Li J, Qi X, Smith EP, Yamaji-Kegan K, Keegan AD.

Sci Signal. 2016 Jun 21;9(433):ra63. doi: 10.1126/scisignal.aad6724.


Enhanced allergic responsiveness after early childhood infection with respiratory viruses: Are long-lived alternatively activated macrophages the missing link?

Keegan AD, Shirey KA, Bagdure D, Blanco J, Viscardi RM, Vogel SN.

Pathog Dis. 2016 Jul;74(5). pii: ftw047. doi: 10.1093/femspd/ftw047. Epub 2016 May 12.


Expansion of brain T cells in homeostatic conditions in lymphopenic Rag2(-/-) mice.

Song C, Nicholson JD, Clark SM, Li X, Keegan AD, Tonelli LH.

Brain Behav Immun. 2016 Oct;57:161-172. doi: 10.1016/j.bbi.2016.03.017. Epub 2016 Mar 21.


IL-4 and IL-13: from "supe" to nuts.

Keegan AD.

Cytokine. 2015 Sep;75(1):1-2. doi: 10.1016/j.cyto.2015.06.001. Epub 2015 Jul 11. No abstract available.


Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation.

Palaniyandi S, Liu X, Periasamy S, Ma A, Tang J, Jenkins M, Tuo W, Song W, Keegan AD, Conrad DH, Zhu X.

Mucosal Immunol. 2015 Nov;8(6):1262-74. doi: 10.1038/mi.2015.16. Epub 2015 Mar 18.


Immune status influences fear and anxiety responses in mice after acute stress exposure.

Clark SM, Sand J, Francis TC, Nagaraju A, Michael KC, Keegan AD, Kusnecov A, Gould TD, Tonelli LH.

Brain Behav Immun. 2014 May;38:192-201. doi: 10.1016/j.bbi.2014.02.001. Epub 2014 Feb 10.


Neuroimmune semaphorin 4A as a drug and drug target for asthma.

Mogie G, Shanks K, Nkyimbeng-Takwi EH, Smith E, Davila E, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP.

Int Immunopharmacol. 2013 Nov;17(3):568-75. doi: 10.1016/j.intimp.2013.08.005. Epub 2013 Aug 28.


Absence of the common gamma chain (γ(c)), a critical component of the Type I IL-4 receptor, increases the severity of allergic lung inflammation.

Dasgupta P, Qi X, Smith EP, Keegan AD.

PLoS One. 2013 Aug 5;8(8):e71344. doi: 10.1371/journal.pone.0071344. Print 2013.


Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation.

Shanks K, Nkyimbeng-Takwi EH, Smith E, Lipsky MM, DeTolla LJ, Scott DW, Keegan AD, Chapoval SP.

Mol Immunol. 2013 Dec;56(4):480-7. doi: 10.1016/j.molimm.2013.05.228. Epub 2013 Aug 1.


STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation.

Dorsey NJ, Chapoval SP, Smith EP, Skupsky J, Scott DW, Keegan AD.

J Immunol. 2013 Aug 15;191(4):1517-28. doi: 10.4049/jimmunol.1300486. Epub 2013 Jul 3.


IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors.

Porter HA, Perry A, Kingsley C, Tran NL, Keegan AD.

Cancer Lett. 2013 Sep 28;338(2):239-48. doi: 10.1016/j.canlet.2013.03.030. Epub 2013 Apr 2.


Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.

Rajaiah R, Perkins DJ, Polumuri SK, Zhao A, Keegan AD, Vogel SN.

J Immunol. 2013 May 1;190(9):4763-72. doi: 10.4049/jimmunol.1202407. Epub 2013 Mar 29.


Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity.

Yang Z, Grinchuk V, Urban JF Jr, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan AD, Wynn TA, Shea-Donohue T, Zhao A.

PLoS One. 2013;8(3):e59441. doi: 10.1371/journal.pone.0059441. Epub 2013 Mar 25.


Cytokines in chronic respiratory diseases.

Atamas SP, Chapoval SP, Keegan AD.

F1000 Biol Rep. 2013;5:3. doi: 10.3410/B5-3. Epub 2013 Feb 1.


Regulation of inflammation by interleukin-4: a review of "alternatives".

Luzina IG, Keegan AD, Heller NM, Rook GA, Shea-Donohue T, Atamas SP.

J Leukoc Biol. 2012 Oct;92(4):753-64. doi: 10.1189/jlb.0412214. Epub 2012 Jul 10. Review.


IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro.

Heller NM, Gwinn WM, Donnelly RP, Constant SL, Keegan AD.

PLoS One. 2012;7(6):e39673. doi: 10.1371/journal.pone.0039673. Epub 2012 Jun 28.


Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death.

Porter HA, Carey GB, Keegan AD.

Exp Cell Res. 2012 Aug 15;318(14):1745-58. doi: 10.1016/j.yexcr.2012.04.020. Epub 2012 May 28.


Neuroimmune semaphorin 4A downregulates the severity of allergic response.

Nkyimbeng-Takwi EH, Shanks K, Smith E, Iyer A, Lipsky MM, Detolla LJ, Kikutani H, Keegan AD, Chapoval SP.

Mucosal Immunol. 2012 Jul;5(4):409-19. doi: 10.1038/mi.2012.18. Epub 2012 Apr 4.


Contribution of alternatively activated macrophages to allergic lung inflammation: a tale of mice and men.

Dasgupta P, Keegan AD.

J Innate Immun. 2012;4(5-6):478-88. doi: 10.1159/000336025. Epub 2012 Mar 21.


Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation.

Ford AQ, Dasgupta P, Mikhailenko I, Smith EM, Noben-Trauth N, Keegan AD.

BMC Immunol. 2012 Jan 31;13:6. doi: 10.1186/1471-2172-13-6.


Suppression of the inflammatory immune response prevents the development of chronic biofilm infection due to methicillin-resistant Staphylococcus aureus.

Prabhakara R, Harro JM, Leid JG, Keegan AD, Prior ML, Shirtliff ME.

Infect Immun. 2011 Dec;79(12):5010-8. doi: 10.1128/IAI.05571-11. Epub 2011 Sep 26.


NF-κB signaling participates in both RANKL- and IL-4-induced macrophage fusion: receptor cross-talk leads to alterations in NF-κB pathways.

Yu M, Qi X, Moreno JL, Farber DL, Keegan AD.

J Immunol. 2011 Aug 15;187(4):1797-806. doi: 10.4049/jimmunol.1002628. Epub 2011 Jul 6.


Transcriptional control of rapid recall by memory CD4 T cells.

Lai W, Yu M, Huang MN, Okoye F, Keegan AD, Farber DL.

J Immunol. 2011 Jul 1;187(1):133-40. doi: 10.4049/jimmunol.1002742. Epub 2011 Jun 3.


TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss.

Myneni SR, Settem RP, Connell TD, Keegan AD, Gaffen SL, Sharma A.

J Immunol. 2011 Jul 1;187(1):501-9. doi: 10.4049/jimmunol.1100683. Epub 2011 Jun 1.


Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor.

Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP.

BMC Immunol. 2011 May 19;12:30. doi: 10.1186/1471-2172-12-30.


A potential new target for asthma therapy: a disintegrin and metalloprotease 10 (ADAM10) involvement in murine experimental asthma.

Mathews JA, Ford J, Norton S, Kang D, Dellinger A, Gibb DR, Ford AQ, Massay H, Kepley CL, Scherle P, Keegan AD, Conrad DH.

Allergy. 2011 Sep;66(9):1193-200. doi: 10.1111/j.1398-9995.2011.02614.x. Epub 2011 May 10.


Alternatively spliced variants of interleukin-4 promote inflammation differentially.

Luzina IG, Lockatell V, Todd NW, Highsmith K, Keegan AD, Hasday JD, Atamas SP.

J Leukoc Biol. 2011 May;89(5):763-70. doi: 10.1189/jlb.0510271. Epub 2011 Feb 1.


STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease.

Chapoval SP, Dasgupta P, Smith EP, DeTolla LJ, Lipsky MM, Kelly-Welch AE, Keegan AD.

J Immunol. 2011 Feb 15;186(4):2571-83. doi: 10.4049/jimmunol.1002567. Epub 2011 Jan 17.


Splice isoforms of human interleukin-4 are functionally active in mice in vivo.

Luzina IG, Lockatell V, Todd NW, Keegan AD, Hasday JD, Atamas SP.

Immunology. 2011 Mar;132(3):385-93. doi: 10.1111/j.1365-2567.2010.03393.x. Epub 2011 Jan 10.


Hospital bed occupancy: more than queuing for a bed.

Keegan AD.

Med J Aust. 2010 Sep 6;193(5):291-3.


Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent.

Shirey KA, Pletneva LM, Puche AC, Keegan AD, Prince GA, Blanco JC, Vogel SN.

Mucosal Immunol. 2010 May;3(3):291-300. doi: 10.1038/mi.2010.6. Epub 2010 Mar 10.


Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6.

Chapoval S, Dasgupta P, Dorsey NJ, Keegan AD.

J Leukoc Biol. 2010 Jun;87(6):1011-8. doi: 10.1189/jlb.1209772. Epub 2010 Mar 24. Review.


An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation.

Ford AQ, Heller NM, Stephenson L, Boothby MR, Keegan AD.

J Immunol. 2009 Aug 1;183(3):1607-16. doi: 10.4049/jimmunol.0803266. Epub 2009 Jul 10.


Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.

Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA.

Clin Immunol. 2009 Sep;132(3):371-84. doi: 10.1016/j.clim.2009.05.016. Epub 2009 Jun 24.


Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

Heller NM, Qi X, Junttila IS, Shirey KA, Vogel SN, Paul WE, Keegan AD.

Sci Signal. 2008 Dec 23;1(51):ra17. doi: 10.1126/scisignal.1164795.


Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism.

Shirey KA, Cole LE, Keegan AD, Vogel SN.

J Immunol. 2008 Sep 15;181(6):4159-67.


Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC.

Cell. 2008 Jan 25;132(2):259-72. doi: 10.1016/j.cell.2007.12.030.


IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin.

Moreno JL, Mikhailenko I, Tondravi MM, Keegan AD.

J Leukoc Biol. 2007 Dec;82(6):1542-53. Epub 2007 Sep 12.


Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention.

Gwinn WM, Damsker JM, Falahati R, Okwumabua I, Kelly-Welch A, Keegan AD, Vanpouille C, Lee JJ, Dent LA, Leitenberg D, Bukrinsky MI, Constant SL.

J Immunol. 2006 Oct 1;177(7):4870-9.


Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13.

Yamada A, Sheikh F, Niimi T, DeMayo FJ, Keegan AD, Donnelly RP, Kimura S.

J Immunol. 2005 Nov 1;175(9):5708-15.


Interleukin-4 (IL-4) pathway.

Kelly-Welch A, Hanson EM, Keegan AD.

Sci STKE. 2005 Jul 19;2005(293):cm9.

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