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Items: 28


Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC.

Nature. 2019 Jun;570(7762):468-473. doi: 10.1038/s41586-019-1250-z. Epub 2019 May 29.


A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.

Keeffe JR, Van Rompay KKA, Olsen PC, Wang Q, Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MR, Bjorkman PJ, Nussenzweig MC, Robbiani DF.

Cell Rep. 2018 Nov 6;25(6):1385-1394.e7. doi: 10.1016/j.celrep.2018.10.031.


Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.

Robbiani DF, Bozzacco L, Keeffe JR, Khouri R, Olsen PC, Gazumyan A, Schaefer-Babajew D, Avila-Rios S, Nogueira L, Patel R, Azzopardi SA, Uhl LFK, Saeed M, Sevilla-Reyes EE, Agudelo M, Yao KH, Golijanin J, Gristick HB, Lee YE, Hurley A, Caskey M, Pai J, Oliveira T, Wunder EA Jr, Sacramento G, Nery N Jr, Orge C, Costa F, Reis MG, Thomas NM, Eisenreich T, Weinberger DM, de Almeida ARP, West AP Jr, Rice CM, Bjorkman PJ, Reyes-Teran G, Ko AI, MacDonald MR, Nussenzweig MC.

Cell. 2017 May 4;169(4):597-609.e11. doi: 10.1016/j.cell.2017.04.024.


Are copper(I) carbenes capable intermediates for cyclopropanations? The case for ylide intermediates.

Aldajaei JT, Keeffe JR, Swift CA, Gronert S.

Chemistry. 2015 Sep 1;21(36):12702-8. doi: 10.1002/chem.201501550. Epub 2015 Jul 14.


Design and characterization of structured protein linkers with differing flexibilities.

Klein JS, Jiang S, Galimidi RP, Keeffe JR, Bjorkman PJ.

Protein Eng Des Sel. 2014 Oct;27(10):325-30. doi: 10.1093/protein/gzu043.


Reactivity in the nucleophilic aromatic substitution reactions of pyridinium ions.

Bowler JT, Wong FM, Gronert S, Keeffe JR, Wu W.

Org Biomol Chem. 2014 Aug 28;12(32):6175-80. doi: 10.1039/c4ob00946k.


Effect of allylic groups on S(N)2 reactivity.

Erden I, Gronert S, Keeffe JR, Ma J, Ocal N, Gärtner C, Soukup LL.

J Org Chem. 2014 Jul 18;79(14):6410-8. doi: 10.1021/jo501157s. Epub 2014 Jul 7.


The element effect revisited: factors determining leaving group ability in activated nucleophilic aromatic substitution reactions.

Senger NA, Bo B, Cheng Q, Keeffe JR, Gronert S, Wu W.

J Org Chem. 2012 Nov 2;77(21):9535-40. doi: 10.1021/jo301134q. Epub 2012 Oct 17.


Base-catalyzed dehydration of 3-substituted benzene cis-1,2-dihydrodiols: stabilization of a cyclohexadienide anion intermediate by negative aromatic hyperconjugation.

Kudavalli JS, Rao SN, Bean DE, Sharma ND, Boyd DR, Fowler PW, Gronert S, Kamerlin SC, Keeffe JR, More O'Ferrall RA.

J Am Chem Soc. 2012 Aug 29;134(34):14056-69. doi: 10.1021/ja304366j. Epub 2012 Aug 16.


Hyperaromatic stabilization of arenium ions: cyclohexa- and cycloheptadienyl cations-experimental and calculated stabilities and ring currents.

Lawlor DA, Bean DE, Fowler PW, Keeffe JR, Kudavalli JS, O'Ferrall RA, Rao SN.

J Am Chem Soc. 2011 Dec 14;133(49):19729-42. doi: 10.1021/ja2071626. Epub 2011 Nov 17.


Designed oligomers of cyanovirin-N show enhanced HIV neutralization.

Keeffe JR, Gnanapragasam PN, Gillespie SK, Yong J, Bjorkman PJ, Mayo SL.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14079-84. doi: 10.1073/pnas.1108777108. Epub 2011 Jul 28.


Stabilities of carbenes: independent measures for singlets and triplets.

Gronert S, Keeffe JR, More O'Ferrall RA.

J Am Chem Soc. 2011 Mar 16;133(10):3381-9. doi: 10.1021/ja1071493. Epub 2011 Feb 22. Erratum in: J Am Chem Soc. 2011 Aug 3;133(30):11817-8.


Hyperaromatic stabilization of arenium ions.

Kudavalli JS, Boyd DR, Coyne D, Keeffe JR, Lawlor DA, MacCormac AC, More O'Ferrall RA, Rao SN, Sharma ND.

Org Lett. 2010 Dec 3;12(23):5550-3. doi: 10.1021/ol1014027. Epub 2010 Nov 5.


Characterization of the arsenate respiratory reductase from Shewanella sp. strain ANA-3.

Malasarn D, Keeffe JR, Newman DK.

J Bacteriol. 2008 Jan;190(1):135-42. Epub 2007 Oct 19.


The protonation of allene and some heteroallenes, a computational study.

Gronert S, Keeffe JR.

J Org Chem. 2007 Aug 17;72(17):6343-52. Epub 2007 Jul 26.


The 2-oxocyclobutanecarboxylic acid keto-enol system in aqueous solution: a remarkable acid-strengthening effect of the cyclobutane ring.

Chang JA, Chiang Y, Keeffe JR, Kresge AJ, Nikolaev VA, Popik VV.

J Org Chem. 2006 Jun 9;71(12):4460-7.


Computationally designed variants of Escherichia coli chorismate mutase show altered catalytic activity.

Lassila JK, Keeffe JR, Oelschlaeger P, Mayo SL.

Protein Eng Des Sel. 2005 Apr;18(4):161-3. Epub 2005 Apr 8.


Unexpectedly small ortho-oxygen substituent effects on stabilities of benzylic carbocations.

Fujio M, Keeffe JR, More O'Ferrall RA, O'Donoghue AC.

J Am Chem Soc. 2004 Aug 18;126(32):9982-92.


Identity proton-transfer reactions from C-H, N-H, and O-H acids. An ab initio, DFT, and CPCM-B3LYP aqueous solvent model study.

Keeffe JR, Gronert S, Colvin ME, Tran NL.

J Am Chem Soc. 2003 Sep 24;125(38):11730-45.


Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex.

Brzovic PS, Keeffe JR, Nishikawa H, Miyamoto K, Fox D 3rd, Fukuda M, Ohta T, Klevit R.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):5646-51. Epub 2003 May 5.


A circularly permuted myoglobin possesses a folded structure and ligand binding similar to those of the wild-type protein but with a reduced thermodynamic stability.

Fishburn AL, Keeffe JR, Lissounov AV, Peyton DH, Anthony-Cahill SJ.

Biochemistry. 2002 Nov 5;41(44):13318-27.


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