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Items: 1 to 50 of 201


Widespread Transcriptional Scanning in the Testis Modulates Gene Evolution Rates.

Xia B, Yan Y, Baron M, Wagner F, Barkley D, Chiodin M, Kim SY, Keefe DL, Alukal JP, Boeke JD, Yanai I.

Cell. 2020 Jan 23;180(2):248-262.e21. doi: 10.1016/j.cell.2019.12.015.


Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.

Taroc EZM, Naik AS, Lin JM, Peterson NB, Keefe DL Jr, Genis E, Fuchs G, Balasubramanian R, Forni PE.

J Neurosci. 2020 Jan 8;40(2):311-326. doi: 10.1523/JNEUROSCI.1977-19.2019. Epub 2019 Nov 25.


Epigenetics and Female Reproductive Aging.

Chamani IJ, Keefe DL.

Front Endocrinol (Lausanne). 2019 Aug 29;10:473. doi: 10.3389/fendo.2019.00473. eCollection 2019. Review.


Easing US restrictions on mitochondrial replacement therapy would protect research interests but grease the slippery slope.

Keefe DL.

J Assist Reprod Genet. 2019 Sep;36(9):1781-1785. doi: 10.1007/s10815-019-01529-3. Epub 2019 Aug 28. No abstract available.


Proceedings of the New York University School of Medicine Reproductive Ethics Conference: Challenges and Solutions.

Sampson A, Sutter M, Caplan AL, Keefe DL, Quinn GP.

J Assist Reprod Genet. 2019 Sep;36(9):1767-1769. doi: 10.1007/s10815-019-01522-w. Epub 2019 Jul 25. No abstract available.


Amyloid-like substance in mice and human oocytes and embryos.

Pimentel RN, Navarro PA, Wang F, Robinson LG Jr, Cammer M, Liang F, Kramer Y, Keefe DL.

J Assist Reprod Genet. 2019 Sep;36(9):1877-1890. doi: 10.1007/s10815-019-01530-w. Epub 2019 Jul 22.


Telomeres and genomic instability during early development.

Keefe DL.

Eur J Med Genet. 2019 Mar 9:103638. doi: 10.1016/j.ejmg.2019.03.002. [Epub ahead of print] Review.


Uterus transplantation in women who are genetically XY.

Sampson A, Kimberly LL, Goldman KN, Keefe DL, Quinn GP.

J Med Ethics. 2019 Oct;45(10):687-689. doi: 10.1136/medethics-2018-105222. Epub 2019 Feb 25.


Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence.

Liao Y, Chang HC, Liang FX, Chung PJ, Wei Y, Nguyen TP, Zhou G, Talebian S, Krey LC, Deng FM, Wong TW, Chicote JU, Grifo JA, Keefe DL, Shapiro E, Lepor H, Wu XR, DeSalle R, Garcia-EspaƱa A, Kim SY, Sun TT.

Mol Biol Cell. 2018 Oct 10:mbcE18080496. doi: 10.1091/mbc.E18-08-0496. [Epub ahead of print]


Telomere length and early trauma in schizophrenia.

Riley G, Perrin M, Vaez-Azizi LM, Ruby E, Goetz RR, Dracxler R, Walsh-Messinger J, Keefe DL, Buckley PF, Szeszko PR, Malaspina D.

Schizophr Res. 2018 Sep;199:426-430. doi: 10.1016/j.schres.2018.02.059. Epub 2018 Apr 2.


Contemporary Hormonal Contraception and the Risk of Breast Cancer.

Nachtigall L, Naftolin F, Keefe DL.

N Engl J Med. 2018 Mar 29;378(13):1265. doi: 10.1056/NEJMc1800054. No abstract available.


Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications.

Da Broi MG, Giorgi VSI, Wang F, Keefe DL, Albertini D, Navarro PA.

J Assist Reprod Genet. 2018 May;35(5):735-751. doi: 10.1007/s10815-018-1143-3. Epub 2018 Mar 2. Review.


Reconstitution of ovarian function following transplantation of primordial germ cells.

Zeng M, Sheng X, Keefe DL, Liu L.

Sci Rep. 2017 May 3;7(1):1427. doi: 10.1038/s41598-017-01648-w.


mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy.

Goldman KN, Chenette D, Arju R, Duncan FE, Keefe DL, Grifo JA, Schneider RJ.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3186-3191. doi: 10.1073/pnas.1617233114. Epub 2017 Mar 7.


Telomeres, Reproductive Aging, and Genomic Instability During Early Development.

Keefe DL.

Reprod Sci. 2016 Dec;23(12):1612-1615. Review.


Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs.

Yang J, Guo R, Wang H, Ye X, Zhou Z, Dan J, Wang H, Gong P, Deng W, Yin Y, Mao S, Wang L, Ding J, Li J, Keefe DL, Dawlaty MM, Wang J, Xu G, Liu L.

Cell Rep. 2016 May 24;15(8):1809-21. doi: 10.1016/j.celrep.2016.04.058. Epub 2016 May 12.


Telomeres and Female Reproductive Aging.

Kalmbach KH, Antunes DM, Kohlrausch F, Keefe DL.

Semin Reprod Med. 2015 Nov;33(6):389-95. doi: 10.1055/s-0035-1567823. Epub 2015 Dec 2. Review.


A single-cell assay for telomere DNA content shows increasing telomere length heterogeneity, as well as increasing mean telomere length in human spermatozoa with advancing age.

Antunes DM, Kalmbach KH, Wang F, Dracxler RC, Seth-Smith ML, Kramer Y, Buldo-Licciardi J, Kohlrausch FB, Keefe DL.

J Assist Reprod Genet. 2015 Nov;32(11):1685-90. doi: 10.1007/s10815-015-0574-3. Epub 2015 Sep 28.


Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey.

Zhang D, Zhang X, Zeng M, Yuan J, Liu M, Yin Y, Wu X, Keefe DL, Liu L.

J Assist Reprod Genet. 2015 Jul;32(7):1069-78. doi: 10.1007/s10815-015-0483-5. Epub 2015 May 10.


Telomere length variability is related to symptoms and cognition in schizophrenia.

Vaez-Azizi LM, Ruby E, Dracxler R, Rothman K, Perrin M, Walsh-Messinger J, Antonius D, Goetz RR, Goetz DM, Keefe DL, Malaspina D.

Schizophr Res. 2015 May;164(1-3):268-9. doi: 10.1016/j.schres.2015.03.011. Epub 2015 Apr 1. No abstract available.


Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome.

Pedroso DC, Miranda-Furtado CL, Kogure GS, Meola J, Okuka M, Silva C, Calado RT, Ferriani RA, Keefe DL, dos Reis RM.

Fertil Steril. 2015 Feb;103(2):542-7.e2. doi: 10.1016/j.fertnstert.2014.10.035. Epub 2014 Nov 20.


Telomere elongation and naive pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer.

Sung LY, Chang WF, Zhang Q, Liu CC, Liou JY, Chang CC, Ou-Yang H, Guo R, Fu H, Cheng WTK, Ding ST, Chen CM, Okuka M, Keefe DL, Chen YE, Liu L, Xu J.

Cell Rep. 2014 Dec 11;9(5):1603-1609. doi: 10.1016/j.celrep.2014.10.052. Epub 2014 Nov 20.


In every end there is a beginning--telomeres in male reproduction.

Keefe DL.

Fertil Steril. 2014 Sep;102(3):690-1. doi: 10.1016/j.fertnstert.2014.07.1236. Epub 2014 Aug 6. No abstract available.


Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing.

Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A, Liu L.

Dev Cell. 2014 Apr 14;29(1):7-19. doi: 10.1016/j.devcel.2014.03.004.


Peripheral blood telomere content is greater in patients with endometriosis than in controls.

Dracxler RC, Oh C, Kalmbach K, Wang F, Liu L, Kallas EG, Giret MT, Seth-Smith ML, Antunes D, Keefe DL, Abrao MS.

Reprod Sci. 2014 Dec;21(12):1465-71. doi: 10.1177/1933719114527353. Epub 2014 Mar 27.


No evidence for neo-oogenesis may link to ovarian senescence in adult monkey.

Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L.

Stem Cells. 2013 Nov;31(11):2538-50. doi: 10.1002/stem.1480.


Robust measurement of telomere length in single cells.

Wang F, Pan X, Kalmbach K, Seth-Smith ML, Ye X, Antumes DM, Yin Y, Liu L, Keefe DL, Weissman SM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1906-12. doi: 10.1073/pnas.1306639110. Epub 2013 May 9.


Breastfeeding status and maternal cardiovascular variables across the postpartum.

Groer MW, Jevitt CM, Sahebzamani F, Beckstead JW, Keefe DL.

J Womens Health (Larchmt). 2013 May;22(5):453-9. doi: 10.1089/jwh.2012.3981.


Ovarian aging: breaking up is hard to fix.

Johnson J, Keefe DL.

Sci Transl Med. 2013 Feb 13;5(172):172fs5. doi: 10.1126/scitranslmed.3005579.


Resveratrol protects against age-associated infertility in mice.

Liu M, Yin Y, Ye X, Zeng M, Zhao Q, Keefe DL, Liu L.

Hum Reprod. 2013 Mar;28(3):707-17. doi: 10.1093/humrep/des437. Epub 2013 Jan 4.


Telomeres and human reproduction.

Kalmbach KH, Fontes Antunes DM, Dracxler RC, Knier TW, Seth-Smith ML, Wang F, Liu L, Keefe DL.

Fertil Steril. 2013 Jan;99(1):23-9. doi: 10.1016/j.fertnstert.2012.11.039. Review.


Antihypertensive treatment in patients with class 3 obesity.

Jordan J, Boye SW, Breton SL, Keefe DL, Engeli S, Prescott MF.

Ther Adv Endocrinol Metab. 2012 Jun;3(3):93-8. doi: 10.1177/2042018812445573.


Efficacy and safety of aliskiren and amlodipine combination therapy in patients with hypertension: a randomized, double-blind, multifactorial study.

Littlejohn TW 3rd, Jones SW, Zhang J, Hsu H, Keefe DL.

J Hum Hypertens. 2013 May;27(5):321-7. doi: 10.1038/jhh.2012.42. Epub 2012 Oct 18.


Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke.

Huang J, Okuka M, Lu W, Tsibris JC, McLean MP, Keefe DL, Liu L.

Reprod Toxicol. 2013 Jan;35:89-95. doi: 10.1016/j.reprotox.2012.07.003. Epub 2012 Jul 21.


Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC).

Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N, Tang X, Baltz JM, Keefe DL, Liu L.

Hum Reprod. 2012 May;27(5):1411-20. doi: 10.1093/humrep/des019. Epub 2012 Feb 21.


Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.

Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L.

Cell Res. 2012 Apr;22(4):757-68. doi: 10.1038/cr.2011.201. Epub 2011 Dec 20.


Efficacy, safety, and tolerability of aliskiren monotherapy administered with a light meal in elderly hypertensive patients: a randomized, double-blind, placebo-controlled, dose-response evaluation study.

Villa G, Le Breton S, Ibram G, Keefe DL.

J Clin Pharmacol. 2012 Dec;52(12):1901-11. doi: 10.1177/0091270011426432. Epub 2011 Dec 15.


Comparison of aliskiren/hydrochlorothiazide combination therapy and amlodipine monotherapy in patients with stage 2 systolic hypertension and type 2 diabetes mellitus.

Townsend RR, Forker AD, Bhosekar V, Yadao A, Keefe DL.

J Clin Hypertens (Greenwich). 2011 Dec;13(12):889-97. doi: 10.1111/j.1751-7176.2011.00552.x. Epub 2011 Nov 11.


Aliskiren as add-on therapy in the treatment of hypertensive diabetic patients inadequately controlled with valsartan/HCT combination: a placebo-controlled study.

Drummond W, Sirenko YM, Ramos E, Baek I, Keefe DL.

Am J Cardiovasc Drugs. 2011 Oct 1;11(5):327-33. doi: 10.2165/11591970-000000000-00000.


Safety and tolerability of the direct renin inhibitor aliskiren in combination with angiotensin receptor blockers and thiazide diuretics: a pooled analysis of clinical experience of 12,942 patients.

White WB, Bresalier R, Kaplan AP, Palmer BF, Riddell RH, Lesogor A, Chang W, Keefe DL.

J Clin Hypertens (Greenwich). 2011 Jul;13(7):506-16. doi: 10.1111/j.1751-7176.2011.00438.x. Epub 2011 Mar 18.


Association of telomere length with authentic pluripotency of ES/iPS cells.

Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L.

Cell Res. 2011 May;21(5):779-92. doi: 10.1038/cr.2011.16. Epub 2011 Feb 1.


Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary.

Liu Z, Hu Z, Pan X, Li M, Togun TA, Tuck D, Pelizzola M, Huang J, Ye X, Yin Y, Liu M, Li C, Chen Z, Wang F, Zhou L, Chen L, Keefe DL, Liu L.

Hum Mol Genet. 2011 Apr 1;20(7):1339-52. doi: 10.1093/hmg/ddr016. Epub 2011 Jan 14.


Safety and tolerability of the direct renin inhibitor aliskiren: a pooled analysis of clinical experience in more than 12,000 patients with hypertension.

White WB, Bresalier R, Kaplan AP, Palmer BF, Riddell RH, Lesogor A, Chang W, Keefe DL.

J Clin Hypertens (Greenwich). 2010 Oct;12(10):765-75. doi: 10.1111/j.1751-7176.2010.00352.x.


Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis.

Liu N, Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L.

J Mol Cell Biol. 2010 Dec;2(6):333-44. doi: 10.1093/jmcb/mjq029. Epub 2010 Oct 6.


Comparative efficacy of aliskiren monotherapy and ramipril monotherapy in patients with stage 2 systolic hypertension: subgroup analysis of a double-blind, active comparator trial.

Andersen K, Weinberger MH, Egan B, Constance CM, Wright M, Lukashevich V, Keefe DL.

Cardiovasc Ther. 2010 Dec;28(6):344-9. doi: 10.1111/j.1755-5922.2010.00148.x.


Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro.

Huang J, Okuka M, McLean M, Keefe DL, Liu L.

Free Radic Biol Med. 2010 Jun 15;48(12):1663-76. doi: 10.1016/j.freeradbiomed.2010.03.026. Epub 2010 Apr 8.


Efficacy, safety and tolerability of aliskiren, a direct renin inhibitor, in women with hypertension: a pooled analysis of eight studies.

Gradman AH, Weir MR, Wright M, Bush CA, Keefe DL.

J Hum Hypertens. 2010 Nov;24(11):721-9. doi: 10.1038/jhh.2010.11. Epub 2010 Mar 4.


Frozen hope: fertility preservation for women with cancer.

Quinn GP, Vadaparampil ST, Jacobsen PB, Knapp C, Keefe DL, Bell GE; Moffitt Fertility Preservation Group.

J Midwifery Womens Health. 2010 Mar-Apr;55(2):175-80. doi: 10.1016/j.jmwh.2009.07.009.


Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.

Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, Dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ.

Nature. 2010 Mar 11;464(7286):292-6. doi: 10.1038/nature08792. Epub 2010 Feb 17.

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