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Items: 30

1.

Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target.

Brown DG, Brown GA, Centrella P, Certel K, Cooke RM, Cuozzo JW, Dekker N, Dumelin CE, Ferguson A, Fiez-Vandal C, Geschwindner S, Guié MA, Habeshian S, Keefe AD, Schlenker O, Sigel EA, Snijder A, Soutter HT, Sundström L, Troast DM, Wiggin G, Zhang J, Zhang Y, Clark MA.

SLAS Discov. 2018 Jun;23(5):429-436. doi: 10.1177/2472555217749847. Epub 2018 Jan 9.

PMID:
29316408
2.

Corrigendum: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNAEncoded Chemical Library.

Cuozzo JW, Centrella PA, Gikunju D, Habeshian S, Hupp CD, Keefe AD, Sigel EA, Soutter HH, Thomson HA, Zhang Y, Clark MA.

Chembiochem. 2017 Dec 14;18(24):2441. doi: 10.1002/cbic.201700610. Epub 2017 Nov 22. No abstract available.

PMID:
29239533
3.

Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors".

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.

ACS Med Chem Lett. 2017 Oct 18;8(11):1204. doi: 10.1021/acsmedchemlett.7b00397. eCollection 2017 Nov 9.

4.

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action.

Fernández-Montalván AE, Berger M, Kuropka B, Koo SJ, Badock V, Weiske J, Puetter V, Holton SJ, Stöckigt D, Ter Laak A, Centrella PA, Clark MA, Dumelin CE, Sigel EA, Soutter HH, Troast DM, Zhang Y, Cuozzo JW, Keefe AD, Roche D, Rodeschini V, Chaikuad A, Díaz-Sáez L, Bennett JM, Fedorov O, Huber KVM, Hübner J, Weinmann H, Hartung IV, Gorjánácz M.

ACS Chem Biol. 2017 Nov 17;12(11):2730-2736. doi: 10.1021/acschembio.7b00708. Epub 2017 Oct 24.

5.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.

ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 9. Erratum in: ACS Med Chem Lett. 2017 Oct 18;8(11):1204.

6.

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.

Cuozzo JW, Centrella PA, Gikunju D, Habeshian S, Hupp CD, Keefe AD, Sigel EA, Soutter HH, Thomson HA, Zhang Y, Clark MA.

Chembiochem. 2017 May 4;18(9):864-871. doi: 10.1002/cbic.201600573. Epub 2017 Feb 8. Erratum in: Chembiochem. 2017 Dec 14;18(24):2441.

PMID:
28056160
7.

DNA-encoded chemistry: enabling the deeper sampling of chemical space.

Goodnow RA Jr, Dumelin CE, Keefe AD.

Nat Rev Drug Discov. 2017 Feb;16(2):131-147. doi: 10.1038/nrd.2016.213. Epub 2016 Dec 9. Review.

PMID:
27932801
8.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.

Soutter HH, Centrella P, Clark MA, Cuozzo JW, Dumelin CE, Guie MA, Habeshian S, Keefe AD, Kennedy KM, Sigel EA, Troast DM, Zhang Y, Ferguson AD, Davies G, Stead ER, Breed J, Madhavapeddi P, Read JA.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7880-E7889. Epub 2016 Nov 18.

9.

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library.

Litovchick A, Dumelin CE, Habeshian S, Gikunju D, Guié MA, Centrella P, Zhang Y, Sigel EA, Cuozzo JW, Keefe AD, Clark MA.

Sci Rep. 2015 Jun 10;5:10916. doi: 10.1038/srep10916.

10.

Chemical ligation methods for the tagging of DNA-encoded chemical libraries.

Keefe AD, Clark MA, Hupp CD, Litovchick A, Zhang Y.

Curr Opin Chem Biol. 2015 Jun;26:80-8. doi: 10.1016/j.cbpa.2015.02.015. Epub 2015 Mar 8. Review.

PMID:
25756406
11.

Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags.

Litovchick A, Clark MA, Keefe AD.

Artif DNA PNA XNA. 2014;5(1):e27896. doi: 10.4161/adna.27896.

12.

Aptamers as therapeutics.

Keefe AD, Pai S, Ellington A.

Nat Rev Drug Discov. 2010 Jul;9(7):537-50. doi: 10.1038/nrd3141. Review. Erratum in: Nat Rev Drug Discov. 2010 Aug;9(8):660.

PMID:
20592747
13.

SELEX with modified nucleotides.

Keefe AD, Cload ST.

Curr Opin Chem Biol. 2008 Aug;12(4):448-56. doi: 10.1016/j.cbpa.2008.06.028. Epub 2008 Jul 21. Review.

PMID:
18644461
14.

Random mutagenesis by PCR.

Wilson DS, Keefe AD.

Curr Protoc Mol Biol. 2001 May;Chapter 8:Unit8.3. doi: 10.1002/0471142727.mb0803s51.

PMID:
18265275
15.

Protein selection using mRNA display.

Keefe AD.

Curr Protoc Mol Biol. 2001 May;Chapter 24:Unit 24.5. doi: 10.1002/0471142727.mb2405s53.

PMID:
18265212
16.

Aptamers as candidate therapeutics for cardiovascular indications.

Keefe AD, Schaub RG.

Curr Opin Pharmacol. 2008 Apr;8(2):147-52. doi: 10.1016/j.coph.2007.12.005. Epub 2008 Jan 28. Review.

PMID:
18222730
17.

2'-Deoxy purine, 2'-O-methyl pyrimidine (dRmY) aptamers as candidate therapeutics.

Burmeister PE, Wang C, Killough JR, Lewis SD, Horwitz LR, Ferguson A, Thompson KM, Pendergrast PS, McCauley TG, Kurz M, Diener J, Cload ST, Wilson C, Keefe AD.

Oligonucleotides. 2006 Winter;16(4):337-51.

PMID:
17155909
18.

Building oligonucleotide therapeutics using non-natural chemistries.

Wilson C, Keefe AD.

Curr Opin Chem Biol. 2006 Dec;10(6):607-14. Epub 2006 Oct 16. Review.

PMID:
17049298
19.

Direct in vitro selection of a 2'-O-methyl aptamer to VEGF.

Burmeister PE, Lewis SD, Silva RF, Preiss JR, Horwitz LR, Pendergrast PS, McCauley TG, Kurz JC, Epstein DM, Wilson C, Keefe AD.

Chem Biol. 2005 Jan;12(1):25-33.

20.

A novel strategy for selection of allosteric ribozymes yields RiboReporter sensors for caffeine and aspartame.

Ferguson A, Boomer RM, Kurz M, Keene SC, Diener JL, Keefe AD, Wilson C, Cload ST.

Nucleic Acids Res. 2004 Mar 16;32(5):1756-66. Print 2004.

21.

One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag.

Keefe AD, Wilson DS, Seelig B, Szostak JW.

Protein Expr Purif. 2001 Dec;23(3):440-6.

PMID:
11722181
22.

Functional proteins from a random-sequence library.

Keefe AD, Szostak JW.

Nature. 2001 Apr 5;410(6829):715-8.

23.

The use of mRNA display to select high-affinity protein-binding peptides.

Wilson DS, Keefe AD, Szostak JW.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3750-5. Epub 2001 Mar 13.

24.

Constructing high complexity synthetic libraries of long ORFs using in vitro selection.

Cho G, Keefe AD, Liu R, Wilson DS, Szostak JW.

J Mol Biol. 2000 Mar 24;297(2):309-19.

PMID:
10715203
25.

Was ferrocyanide a prebiotic reagent?

Keefe AD, Miller SL.

Orig Life Evol Biosph. 1996 Apr;26(2):111-29.

PMID:
11536749
26.

Potentially prebiotic syntheses of condensed phosphates.

Keefe AD, Miller SL.

Orig Life Evol Biosph. 1996 Feb;26(1):15-25.

PMID:
11536744
27.

Investigation of the prebiotic synthesis of amino acids and RNA bases from CO2 using FeS/H2S as a reducing agent.

Keefe AD, Miller SL, McDonald G, Bada J.

Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11904-6.

28.

Are polyphosphates or phosphate esters prebiotic reagents?

Keefe AD, Miller SL.

J Mol Evol. 1995 Dec;41(6):693-702.

PMID:
11536719
29.

Evolution of the biosynthesis of the branched-chain amino acids.

Keefe AD, Lazcano A, Miller SL.

Orig Life Evol Biosph. 1995 Jun;25(1-3):99-110.

PMID:
11536684
30.

A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A.

Keefe AD, Newton GL, Miller SL.

Nature. 1995 Feb 23;373(6516):683-5.

PMID:
7854449

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