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Items: 33

1.

Approaching infinite affinity through engineering of peptide-protein interaction.

Keeble AH, Turkki P, Stokes S, Khairil Anuar INA, Rahikainen R, Hytönen VP, Howarth M.

Proc Natl Acad Sci U S A. 2019 Dec 10. pii: 201909653. doi: 10.1073/pnas.1909653116. [Epub ahead of print]

2.

Potato ingestion is as effective as carbohydrate gels to support prolonged cycling performance.

Salvador AF, McKenna CF, Alamilla RA, Cloud RMT, Keeble AR, Miltko A, Scaroni SE, Beals JW, Ulanov AV, Dilger RN, Bauer LL, Broad EM, Burd NA.

J Appl Physiol (1985). 2019 Dec 1;127(6):1651-1659. doi: 10.1152/japplphysiol.00567.2019. Epub 2019 Oct 17.

3.

Spy&Go purification of SpyTag-proteins using pseudo-SpyCatcher to access an oligomerization toolbox.

Khairil Anuar INA, Banerjee A, Keeble AH, Carella A, Nikov GI, Howarth M.

Nat Commun. 2019 Apr 15;10(1):1734. doi: 10.1038/s41467-019-09678-w.

4.

Insider information on successful covalent protein coupling with help from SpyBank.

Keeble AH, Howarth M.

Methods Enzymol. 2019;617:443-461. doi: 10.1016/bs.mie.2018.12.010. Epub 2019 Jan 25.

PMID:
30784412
5.

Evolving Accelerated Amidation by SpyTag/SpyCatcher to Analyze Membrane Dynamics.

Keeble AH, Banerjee A, Ferla MP, Reddington SC, Anuar INAK, Howarth M.

Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16521-16525. doi: 10.1002/anie.201707623. Epub 2017 Dec 5.

6.

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.

Davies AM, Allan EG, Keeble AH, Delgado J, Cossins BP, Mitropoulou AN, Pang MOY, Ceska T, Beavil AJ, Craggs G, Westwood M, Henry AJ, McDonnell JM, Sutton BJ.

J Biol Chem. 2017 Jun 16;292(24):9975-9987. doi: 10.1074/jbc.M117.776476. Epub 2017 Apr 24.

7.

IgE binds asymmetrically to its B cell receptor CD23.

Dhaliwal B, Pang MO, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ.

Sci Rep. 2017 Mar 31;7:45533. doi: 10.1038/srep45533.

8.

Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.

Rhodes DA, Chen HC, Price AJ, Keeble AH, Davey MS, James LC, Eberl M, Trowsdale J.

J Immunol. 2015 Mar 1;194(5):2390-8. doi: 10.4049/jimmunol.1401064. Epub 2015 Jan 30.

9.

Human immunoglobulin E flexes between acutely bent and extended conformations.

Drinkwater N, Cossins B, Keeble AH, Wright M, Cain K, Hailu H, Oxbrow A, Delgado J, Shuttleworth LK, Kao MW, McDonnell JM, Beavil AJ, Henry AJ, Sutton BJ.

Nat Struct Mol Biol. 2014 Apr;21(4):397-404. doi: 10.1038/nsmb.2795. Epub 2014 Mar 16.

10.

Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.

Yuan D, Keeble AH, Hibbert RG, Fabiane S, Gould HJ, McDonnell JM, Beavil AJ, Sutton BJ, Dhaliwal B.

J Biol Chem. 2013 Jul 26;288(30):21667-77. doi: 10.1074/jbc.M113.480657. Epub 2013 Jun 17.

11.

Cytokinergic IgE Action in Mast Cell Activation.

Bax HJ, Keeble AH, Gould HJ.

Front Immunol. 2012 Aug 6;3:229. doi: 10.3389/fimmu.2012.00229. eCollection 2012.

12.

A fluorescent biosensor reveals conformational changes in human immunoglobulin E Fc: implications for mechanisms of receptor binding, inhibition, and allergen recognition.

Hunt J, Keeble AH, Dale RE, Corbett MK, Beavil RL, Levitt J, Swann MJ, Suhling K, Ameer-Beg S, Sutton BJ, Beavil AJ.

J Biol Chem. 2012 May 18;287(21):17459-70. doi: 10.1074/jbc.M111.331967. Epub 2012 Mar 22.

13.

Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation.

Gingras AR, Girija UV, Keeble AH, Panchal R, Mitchell DA, Moody PC, Wallis R.

Structure. 2011 Nov 9;19(11):1635-43. doi: 10.1016/j.str.2011.08.014.

14.

Perioperative mortality score: data collection and cost.

Achuthan S, Smirk A, Keeble A, Leslie K.

Anaesth Intensive Care. 2011 Mar;39(2):274-8.

15.

Engineering novel complement activity into a pulmonary surfactant protein.

Venkatraman Girija U, Furze C, Toth J, Schwaeble WJ, Mitchell DA, Keeble AH, Wallis R.

J Biol Chem. 2010 Apr 2;285(14):10546-52. doi: 10.1074/jbc.M109.097493. Epub 2010 Jan 29.

16.

Paths reunited: Initiation of the classical and lectin pathways of complement activation.

Wallis R, Mitchell DA, Schmid R, Schwaeble WJ, Keeble AH.

Immunobiology. 2010;215(1):1-11. doi: 10.1016/j.imbio.2009.08.006. Epub 2009 Sep 27. Review.

17.

Following evolutionary paths to protein-protein interactions with high affinity and selectivity.

Levin KB, Dym O, Albeck S, Magdassi S, Keeble AH, Kleanthous C, Tawfik DS.

Nat Struct Mol Biol. 2009 Oct;16(10):1049-55. doi: 10.1038/nsmb.1670. Epub 2009 Sep 13.

PMID:
19749752
18.

Analogous interactions in initiating complexes of the classical and lectin pathways of complement.

Phillips AE, Toth J, Dodds AW, Girija UV, Furze CM, Pala E, Sim RB, Reid KB, Schwaeble WJ, Schmid R, Keeble AH, Wallis R.

J Immunol. 2009 Jun 15;182(12):7708-17. doi: 10.4049/jimmunol.0900666.

19.

Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases.

Keeble AH, Joachimiak LA, Maté MJ, Meenan N, Kirkpatrick N, Baker D, Kleanthous C.

J Mol Biol. 2008 Jun 13;379(4):745-59. doi: 10.1016/j.jmb.2008.03.055. Epub 2008 Apr 3.

PMID:
18471830
20.

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.

Keeble AH, Khan Z, Forster A, James LC.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6045-50. doi: 10.1073/pnas.0800159105. Epub 2008 Apr 17.

21.

Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.

James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6200-5. Epub 2007 Mar 30.

22.

Calorimetric dissection of colicin DNase--immunity protein complex specificity.

Keeble AH, Kirkpatrick N, Shimizu S, Kleanthous C.

Biochemistry. 2006 Mar 14;45(10):3243-54.

PMID:
16519519
23.

The kinetic basis for dual recognition in colicin endonuclease-immunity protein complexes.

Keeble AH, Kleanthous C.

J Mol Biol. 2005 Sep 23;352(3):656-71.

PMID:
16109424
24.

A problem with a PCA pump handset.

Keeble A, Humble L.

Anaesth Intensive Care. 2005 Feb;33(1):140; author reply 140-1. No abstract available.

25.

Metal induced selectivity in phosphate ion binding in E9 DNase.

van den Bremer ET, Keeble AH, Kleanthous C, Heck AJ.

Chem Commun (Camb). 2005 Mar 7;(9):1137-9. Epub 2005 Jan 13.

PMID:
15726170
26.

Distinct conformational stability and functional activity of four highly homologous endonuclease colicins.

van den Bremer ET, Keeble AH, Jiskoot W, Spelbrink RE, Maier CS, van Hoek A, Visser AJ, James R, Moore GR, Kleanthous C, Heck AJ.

Protein Sci. 2004 May;13(5):1391-401.

27.

Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease.

van den Bremer ET, Keeble AH, Visser AJ, van Hoek A, Kleanthous C, Heck AJ, Jiskoot W.

Biochemistry. 2004 Apr 13;43(14):4347-55.

PMID:
15065879
28.

Highly discriminating protein-protein interaction specificities in the context of a conserved binding energy hotspot.

Li W, Keeble AH, Giffard C, James R, Moore GR, Kleanthous C.

J Mol Biol. 2004 Mar 26;337(3):743-59.

PMID:
15019791
29.

Multistep binding of transition metals to the H-N-H endonuclease toxin colicin E9.

Keeble AH, Hemmings AM, James R, Moore GR, Kleanthous C.

Biochemistry. 2002 Aug 13;41(32):10234-44.

PMID:
12162738
30.

The cytotoxic domain of colicin E9 is a channel-forming endonuclease.

Mosbahi K, Lemaître C, Keeble AH, Mobasheri H, Morel B, James R, Moore GR, Lea EJ, Kleanthous C.

Nat Struct Biol. 2002 Jun;9(6):476-84.

PMID:
12021774
31.

Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9.

Pommer AJ, Cal S, Keeble AH, Walker D, Evans SJ, Kühlmann UC, Cooper A, Connolly BA, Hemmings AM, Moore GR, James R, Kleanthous C.

J Mol Biol. 2001 Dec 7;314(4):735-49.

PMID:
11733993
32.

Satisfaction with the NHS: what is it and can we measure it?

Keeble B, Keeble A.

J R Coll Gen Pract. 1989 Jul;39(324):269-70. No abstract available.

33.

Combined tomography and bronchography (tomobronchography).

GANDEVIA B, KEEBLE A.

Radiography. 1957 Jul;23(271):181-3. No abstract available.

PMID:
13441886

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