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Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells.

Cross EW, Blain TJ, Mathew D, Kedl RM.

PLoS One. 2019 Feb 8;14(2):e0211446. doi: 10.1371/journal.pone.0211446. eCollection 2019.


Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis.

Klarquist J, Chitrakar A, Pennock ND, Kilgore AM, Blain T, Zheng C, Danhorn T, Walton K, Jiang L, Sun J, Hunter CA, D'Alessandro A, Kedl RM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaas9822. doi: 10.1126/sciimmunol.aas9822.


Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity.

Atif SM, Gibbings SL, Redente EF, Camp FA, Torres RM, Kedl RM, Henson PM, Jakubzick CV.

Am J Respir Cell Mol Biol. 2018 Nov;59(5):580-591. doi: 10.1165/rcmb.2018-0159OC.


Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation.

Vartuli RL, Zhou H, Zhang L, Powers RK, Klarquist J, Rudra P, Vincent MY, Ghosh D, Costello JC, Kedl RM, Slansky JE, Zhao R, Ford HL.

J Clin Invest. 2018 Jun 1;128(6):2535-2550. doi: 10.1172/JCI96784. Epub 2018 May 14.


Dimensions of immunologic memory.

Homann D, Kedl RM.

Immunol Rev. 2018 May;283(1):5-6. doi: 10.1111/imr.12658. No abstract available.


Foreign antigen-independent memory-phenotype CD4+ T cells: a new player in innate immunity?

Kedl RM, White JT.

Nat Rev Immunol. 2018 Feb 26;18(3):1. doi: 10.1038/nri.2018.13. No abstract available.


IL-27p28 Production by XCR1+ Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8+ T Cell Responses.

Kilgore AM, Welsh S, Cheney EE, Chitrakar A, Blain TJ, Kedl BJ, Hunter CA, Pennock ND, Kedl RM.

Immunohorizons. 2018 Jan 1;2(1):1-11. doi: 10.4049/immunohorizons.1700054.


Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction.

Kedl RM, Lindsay RS, Finlon JM, Lucas ED, Friedman RS, Tamburini BAJ.

Nat Commun. 2017 Dec 11;8(1):2034. doi: 10.1038/s41467-017-02247-z.


Editorial overview: Vaccines.

Kedl RM, Seder R.

Curr Opin Immunol. 2017 Aug;47:A1-A2. doi: 10.1016/j.coi.2017.09.001. No abstract available.


Corrigendum: Spontaneous partial loss of the OT-I transgene.

Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.

Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951b. No abstract available.


Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them.

White JT, Cross EW, Kedl RM.

Nat Rev Immunol. 2017 Jun;17(6):391-400. doi: 10.1038/nri.2017.34. Epub 2017 May 8.


Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.

Barrett BS, Harper MS, Jones ST, Guo K, Heilman KJ, Kedl RM, Hasenkrug KJ, Santiago ML.

Retrovirology. 2017 Apr 17;14(1):25. doi: 10.1186/s12977-017-0349-2.


Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory.

Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG.

Am J Transplant. 2017 Jul;17(7):1742-1753. doi: 10.1111/ajt.14194. Epub 2017 Feb 21.


Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner.

White JT, Cross EW, Burchill MA, Danhorn T, McCarter MD, Rosen HR, O'Connor B, Kedl RM.

Nat Commun. 2016 Apr 21;7:11291. doi: 10.1038/ncomms11291.


Spontaneous partial loss of the OT-I transgene.

Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.

Nat Immunol. 2016 May;17(5):471. doi: 10.1038/ni.3411. No abstract available. Erratum in: Nat Immunol. 2017 Jul 19;18(8):951.


T Cell Vaccinology: Beyond the Reflection of Infectious Responses.

Pennock ND, Kedl JD, Kedl RM.

Trends Immunol. 2016 Mar;37(3):170-180. doi: 10.1016/ Epub 2016 Jan 30. Review.


Correction: Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates.

Thompson EA, Liang F, Lindgren G, Sandgren KJ, Quinn KM, Darrah PA, Koup RA, Seder RA, Kedl RM, Loré K.

J Immunol. 2015 Oct 1;195(7):3497-8. doi: 10.4049/jimmunol.1501682. No abstract available.


Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium.

Kedl RM, Tamburini BA.

Eur J Immunol. 2015 Oct;45(10):2721-9. doi: 10.1002/eji.201545739. Epub 2015 Sep 10. Review.


T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs.

Burchill MA, Tamburini BA, Kedl RM.

Eur J Immunol. 2015 Nov;45(11):3140-9. doi: 10.1002/eji.201545749. Epub 2015 Aug 3.


Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates.

Thompson EA, Liang F, Lindgren G, Sandgren KJ, Quinn KM, Darrah PA, Koup RA, Seder RA, Kedl RM, Loré K.

J Immunol. 2015 Aug 1;195(3):1015-24. doi: 10.4049/jimmunol.1500078. Epub 2015 Jun 29. Erratum in: J Immunol. 2015 Oct 1;195(7):3497-8.


Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts.

Atif SM, Nelsen MK, Gibbings SL, Desch AN, Kedl RM, Gill RG, Marrack P, Murphy KM, Grazia TJ, Henson PM, Jakubzick CV.

J Immunol. 2015 Jul 1;195(1):46-50. doi: 10.4049/jimmunol.1500669. Epub 2015 Jun 1.


Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency.

Zhang Y, Tian S, Liu Z, Zhang J, Zhang M, Bosenberg MW, Kedl RM, Waldmann TA, Storkus WJ, Falo LD Jr, You Z.

Oncoimmunology. 2014 Dec 15;3(10):e959321. eCollection 2014 Nov.


How squalene GLAdly helps generate antigen-specific T cells via antigen-carrying neutrophils and IL-18.

Kedl JD, Kedl RM.

Eur J Immunol. 2015 Feb;45(2):376-9. doi: 10.1002/eji.201445379.


General parity between trio and pairwise breeding of laboratory mice in static caging.

Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D.

J Immunol. 2014 Nov 15;193(10):4757-60. doi: 10.4049/jimmunol.1402306.


IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization.

Pennock ND, Gapin L, Kedl RM.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16472-7. doi: 10.1073/pnas.1407393111. Epub 2014 Sep 29.


Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction.

Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C.

Nat Commun. 2014 Aug 19;5:4674. doi: 10.1038/ncomms5674.


Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration.

Christie M, Torres RM, Kedl RM, Randolph TW, Carpenter JF.

J Pharm Sci. 2014 Jan;103(1):128-39. Epub 2013 Nov 25.


Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection.

Tamburini BA, Burchill MA, Kedl RM.

Nat Commun. 2014 Jun 6;5:3989. doi: 10.1038/ncomms4989.


T cell responses: naive to memory and everything in between.

Pennock ND, White JT, Cross EW, Cheney EE, Tamburini BA, Kedl RM.

Adv Physiol Educ. 2013 Dec;37(4):273-83. doi: 10.1152/advan.00066.2013. No abstract available.


CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.

Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM.

J Immunol. 2013 Mar 1;190(5):1936-47. doi: 10.4049/jimmunol.1203149. Epub 2013 Jan 25.


Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation.

Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R.

J Immunol. 2013 Mar 1;190(5):2090-101. doi: 10.4049/jimmunol.1202810. Epub 2013 Jan 18.


Antigen-specific regulation of IgE antibodies by non-antigen-specific γδ T cells.

Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK.

J Immunol. 2013 Feb 1;190(3):913-21. doi: 10.4049/jimmunol.1202230. Epub 2012 Dec 28.


T cell vaccinology: exploring the known unknowns.

Burchill MA, Tamburini BA, Pennock ND, White JT, Kurche JS, Kedl RM.

Vaccine. 2013 Jan 2;31(2):297-305. doi: 10.1016/j.vaccine.2012.10.096. Epub 2012 Nov 6. Review.


SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells.

Friend SF, Peterson LK, Kedl RM, Dragone LL.

Immunol Res. 2013 Mar;55(1-3):116-24. doi: 10.1007/s12026-012-8354-y.


Phenotype and function of protective, CD4-independent CD8 T cell memory.

Edwards LE, Haluszczak C, Kedl RM.

Immunol Res. 2013 Mar;55(1-3):135-45. doi: 10.1007/s12026-012-8356-9.


An alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling.

Sanchez PJ, Kedl RM.

Vaccine. 2012 Feb 1;30(6):1154-61. doi: 10.1016/j.vaccine.2011.12.017. Epub 2011 Dec 14.


Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression.

Kurche JS, Haluszczak C, McWilliams JA, Sanchez PJ, Kedl RM.

J Immunol. 2012 Jan 15;188(2):585-93. doi: 10.4049/jimmunol.1102550. Epub 2011 Dec 7.


IL-6-inducing whole yeast-based immunotherapy directly controls IL-12-dependent CD8 T-cell responses.

Tamburini BA, Kedl RM, Bellgrau D.

J Immunother. 2012 Jan;35(1):14-22. doi: 10.1097/CJI.0b013e3182356888.


Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses.

Kemmler CB, Clambey ET, Kedl RM, Slansky JE.

J Immunol. 2011 Nov 1;187(9):4431-9. doi: 10.4049/jimmunol.1101555. Epub 2011 Sep 21.


CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen.

Desch AN, Randolph GJ, Murphy K, Gautier EL, Kedl RM, Lahoud MH, Caminschi I, Shortman K, Henson PM, Jakubzick CV.

J Exp Med. 2011 Aug 29;208(9):1789-97. doi: 10.1084/jem.20110538. Epub 2011 Aug 22.


TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway.

Oh JZ, Kurche JS, Burchill MA, Kedl RM.

Blood. 2011 Sep 15;118(11):3028-38. doi: 10.1182/blood-2011-04-348839. Epub 2011 Aug 2.


The capacity to induce cross-presentation dictates the success of a TLR7 agonist-conjugate vaccine for eliciting cellular immunity.

Oh JZ, Kedl RM.

J Immunol. 2010 Oct 15;185(8):4602-8. doi: 10.4049/jimmunol.1001892. Epub 2010 Sep 15.


Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses.

Kurche JS, Burchill MA, Sanchez PJ, Haluszczak C, Kedl RM.

J Immunol. 2010 Aug 15;185(4):2106-15. doi: 10.4049/jimmunol.1000172. Epub 2010 Jul 16.


Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity.

McWilliams JA, Sanchez PJ, Haluszczak C, Gapin L, Kedl RM.

Vaccine. 2010 Feb 10;28(6):1468-76. doi: 10.1016/j.vaccine.2009.11.071. Epub 2009 Dec 6.


Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation.

Takeda K, Dow SW, Miyahara N, Kodama T, Koya T, Taube C, Joetham A, Park JW, Dakhama A, Kedl RM, Gelfand EW.

J Immunol. 2009 Jul 1;183(1):181-90. doi: 10.4049/jimmunol.0803967.


Revolving doors: from academia to industry and back again.

Kedl RM.

Nat Immunol. 2009 Mar;10(3):227-9. doi: 10.1038/ni0309-227. No abstract available.


The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion.

Haluszczak C, Akue AD, Hamilton SE, Johnson LD, Pujanauski L, Teodorovic L, Jameson SC, Kedl RM.

J Exp Med. 2009 Feb 16;206(2):435-48. doi: 10.1084/jem.20081829. Epub 2009 Feb 2.


CD40 ligation converts TGF-beta-secreting tolerogenic CD4-8- dendritic cells into IL-12-secreting immunogenic ones.

Zhang X, Kedl RM, Xiang J.

Biochem Biophys Res Commun. 2009 Feb 20;379(4):954-8. doi: 10.1016/j.bbrc.2008.12.179. Epub 2009 Jan 9.


Mechanism of T cell tolerance induction by murine hepatic Kupffer cells.

You Q, Cheng L, Kedl RM, Ju C.

Hepatology. 2008 Sep;48(3):978-90. doi: 10.1002/hep.22395.


Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.

Ahonen CL, Wasiuk A, Fuse S, Turk MJ, Ernstoff MS, Suriawinata AA, Gorham JD, Kedl RM, Usherwood EJ, Noelle RJ.

Blood. 2008 Mar 15;111(6):3116-25. doi: 10.1182/blood-2007-09-114371. Epub 2008 Jan 17.

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