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Antigenic variation in Neisseria gonorrhoeae occurs independently of RecQ-mediated unwinding of the pilE G-quadruplex.

Voter AF, Callaghan MM, Tippana R, Myong S, Dillard JP, Keck JL.

J Bacteriol. 2019 Nov 18. pii: JB.00607-19. doi: 10.1128/JB.00607-19. [Epub ahead of print]


Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction.

Anderson BW, Liu K, Wolak C, Dubiel K, She F, Satyshur KA, Keck JL, Wang JD.

Elife. 2019 Sep 25;8. pii: e47534. doi: 10.7554/eLife.47534.


Function of a strand-separation pin element in the PriA DNA replication restart helicase.

Windgassen TA, Leroux M, Sandler SJ, Keck JL.

J Biol Chem. 2019 Feb 22;294(8):2801-2814. doi: 10.1074/jbc.RA118.006870. Epub 2018 Dec 28.


Practical Model Selection for Prospective Virtual Screening.

Liu S, Alnammi M, Ericksen SS, Voter AF, Ananiev GE, Keck JL, Hoffmann FM, Wildman SA, Gitter A.

J Chem Inf Model. 2019 Jan 28;59(1):282-293. doi: 10.1021/acs.jcim.8b00363. Epub 2018 Dec 18.


Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins.

Dubiel K, Myers AR, Kozlov AG, Yang O, Zhang J, Ha T, Lohman TM, Keck JL.

J Mol Biol. 2019 Jan 18;431(2):178-195. doi: 10.1016/j.jmb.2018.11.019. Epub 2018 Nov 22.


A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases.

Voter AF, Qiu Y, Tippana R, Myong S, Keck JL.

Nat Commun. 2018 Oct 10;9(1):4201. doi: 10.1038/s41467-018-06751-8.


Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase.

Windgassen TA, Leroux M, Satyshur KA, Sandler SJ, Keck JL.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9075-E9084. doi: 10.1073/pnas.1809842115. Epub 2018 Sep 10.


Single molecule kinetics uncover roles for E. coli RecQ DNA helicase domains and interaction with SSB.

Bagchi D, Manosas M, Zhang W, Manthei KA, Hodeib S, Ducos B, Keck JL, Croquette V.

Nucleic Acids Res. 2018 Sep 19;46(16):8500-8515. doi: 10.1093/nar/gky647.


Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases.

Voter AF, Keck JL.

Adv Protein Chem Struct Biol. 2018;111:197-222. doi: 10.1016/bs.apcsb.2017.07.005. Epub 2017 Aug 24. Review.


Mechanisms of bacterial DNA replication restart.

Windgassen TA, Wessel SR, Bhattacharyya B, Keck JL.

Nucleic Acids Res. 2018 Jan 25;46(2):504-519. doi: 10.1093/nar/gkx1203. Review.


A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein-Protein Interactions in an Academic Screening Facility.

Voter AF, Killoran MP, Ananiev GE, Wildman SA, Hoffmann FM, Keck JL.

SLAS Discov. 2018 Jan;23(1):94-101. doi: 10.1177/2472555217712001. Epub 2017 Jun 1.


An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase.

Windgassen TA, Keck JL.

Nucleic Acids Res. 2016 Nov 16;44(20):9745-9757. Epub 2016 Aug 2.


Structural and Functional Studies of H. seropedicae RecA Protein - Insights into the Polymerization of RecA Protein as Nucleoprotein Filament.

Leite WC, Galvão CW, Saab SC, Iulek J, Etto RM, Steffens MB, Chitteni-Pattu S, Stanage T, Keck JL, Cox MM.

PLoS One. 2016 Jul 22;11(7):e0159871. doi: 10.1371/journal.pone.0159871. eCollection 2016.


Structure and Function of the PriC DNA Replication Restart Protein.

Wessel SR, Cornilescu CC, Cornilescu G, Metz A, Leroux M, Hu K, Sandler SJ, Markley JL, Keck JL.

J Biol Chem. 2016 Aug 26;291(35):18384-96. doi: 10.1074/jbc.M116.738781. Epub 2016 Jul 5.


A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.

Voter AF, Manthei KA, Keck JL.

J Biomol Screen. 2016 Jul;21(6):626-33. doi: 10.1177/1087057116635503. Epub 2016 Mar 8.


Interaction with Single-stranded DNA-binding Protein Stimulates Escherichia coli Ribonuclease HI Enzymatic Activity.

Petzold C, Marceau AH, Miller KH, Marqusee S, Keck JL.

J Biol Chem. 2015 Jun 5;290(23):14626-36. doi: 10.1074/jbc.M115.655134. Epub 2015 Apr 22.


Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases.

Manthei KA, Hill MC, Burke JE, Butcher SE, Keck JL.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4292-7. doi: 10.1073/pnas.1416746112. Epub 2015 Mar 23.


Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp.

Liu K, Myers AR, Pisithkul T, Claas KR, Satyshur KA, Amador-Noguez D, Keck JL, Wang JD.

Mol Cell. 2015 Feb 19;57(4):735-749. doi: 10.1016/j.molcel.2014.12.037. Epub 2015 Feb 5.


Grip it and rip it: structural mechanisms of DNA helicase substrate binding and unwinding.

Bhattacharyya B, Keck JL.

Protein Sci. 2014 Nov;23(11):1498-507. doi: 10.1002/pro.2533. Epub 2014 Aug 22. Review.


RecD2 helicase limits replication fork stress in Bacillus subtilis.

Walsh BW, Bolz SA, Wessel SR, Schroeder JW, Keck JL, Simmons LA.

J Bacteriol. 2014 Apr;196(7):1359-68. doi: 10.1128/JB.01475-13. Epub 2014 Jan 17.


Structural mechanisms of PriA-mediated DNA replication restart.

Bhattacharyya B, George NP, Thurmes TM, Zhou R, Jani N, Wessel SR, Sandler SJ, Ha T, Keck JL.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1373-8. doi: 10.1073/pnas.1318001111. Epub 2013 Dec 30.


PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein.

Wessel SR, Marceau AH, Massoni SC, Zhou R, Ha T, Sandler SJ, Keck JL.

J Biol Chem. 2013 Jun 14;288(24):17569-78. doi: 10.1074/jbc.M113.478156. Epub 2013 Apr 29.


The BLM dissolvasome in DNA replication and repair.

Manthei KA, Keck JL.

Cell Mol Life Sci. 2013 Nov;70(21):4067-84. doi: 10.1007/s00018-013-1325-1. Epub 2013 Mar 31. Review.


Protein interactions in genome maintenance as novel antibacterial targets.

Marceau AH, Bernstein DA, Walsh BW, Shapiro W, Simmons LA, Keck JL.

PLoS One. 2013;8(3):e58765. doi: 10.1371/journal.pone.0058765. Epub 2013 Mar 11.


Neisseria gonorrhoeae RecQ helicase HRDC domains are essential for efficient binding and unwinding of the pilE guanine quartet structure required for pilin antigenic variation.

Cahoon LA, Manthei KA, Rotman E, Keck JL, Seifert HS.

J Bacteriol. 2013 May;195(10):2255-61. doi: 10.1128/JB.02217-12. Epub 2013 Mar 8.


The Deinococcus radiodurans DR1245 protein, a DdrB partner homologous to YbjN proteins and reminiscent of type III secretion system chaperones.

Norais C, Servant P, Bouthier-de-la-Tour C, Coureux PD, Ithurbide S, Vannier F, Guerin PP, Dulberger CL, Satyshur KA, Keck JL, Armengaud J, Cox MM, Sommer S.

PLoS One. 2013;8(2):e56558. doi: 10.1371/journal.pone.0056558. Epub 2013 Feb 18.


Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases.

Rymer RU, Solorio FA, Tehranchi AK, Chu C, Corn JE, Keck JL, Wang JD, Berger JM.

Structure. 2012 Sep 5;20(9):1478-89. doi: 10.1016/j.str.2012.05.017. Epub 2012 Jul 12.


Structure and cellular dynamics of Deinococcus radiodurans single-stranded DNA (ssDNA)-binding protein (SSB)-DNA complexes.

George NP, Ngo KV, Chitteni-Pattu S, Norais CA, Battista JR, Cox MM, Keck JL.

J Biol Chem. 2012 Jun 22;287(26):22123-32. doi: 10.1074/jbc.M112.367573. Epub 2012 May 7.


Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome.

Hoadley KA, Xue Y, Ling C, Takata M, Wang W, Keck JL.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4437-42. doi: 10.1073/pnas.1117279109. Epub 2012 Mar 5.


Genetic recombination in Bacillus subtilis: a division of labor between two single-strand DNA-binding proteins.

Yadav T, Carrasco B, Myers AR, George NP, Keck JL, Alonso JC.

Nucleic Acids Res. 2012 Jul;40(12):5546-59. doi: 10.1093/nar/gks173. Epub 2012 Feb 28.


Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae.

Smith BC, Anderson MA, Hoadley KA, Keck JL, Cleland WW, Denu JM.

Biochemistry. 2012 Jan 10;51(1):243-56. doi: 10.1021/bi2015508. Epub 2011 Dec 29.


Structure of the SSB-DNA polymerase III interface and its role in DNA replication.

Marceau AH, Bahng S, Massoni SC, George NP, Sandler SJ, Marians KJ, Keck JL.

EMBO J. 2011 Aug 19;30(20):4236-47. doi: 10.1038/emboj.2011.305.


The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast.

Lindner SE, Llinás M, Keck JL, Kappe SH.

Mol Biochem Parasitol. 2011 Dec;180(2):69-75. doi: 10.1016/j.molbiopara.2011.08.002. Epub 2011 Aug 11.


Mechanism of Exonuclease I stimulation by the single-stranded DNA-binding protein.

Lu D, Myers AR, George NP, Keck JL.

Nucleic Acids Res. 2011 Aug;39(15):6536-45. doi: 10.1093/nar/gkr315. Epub 2011 May 13.


Structure and biochemical activities of Escherichia coli MgsA.

Page AN, George NP, Marceau AH, Cox MM, Keck JL.

J Biol Chem. 2011 Apr 8;286(14):12075-85. doi: 10.1074/jbc.M110.210187. Epub 2011 Feb 5.


Creating directed double-strand breaks with the Ref protein: a novel RecA-dependent nuclease from bacteriophage P1.

Gruenig MC, Lu D, Won SJ, Dulberger CL, Manlick AJ, Keck JL, Cox MM.

J Biol Chem. 2011 Mar 11;286(10):8240-51. doi: 10.1074/jbc.M110.205088. Epub 2010 Dec 30.


Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone.

Kolonko EM, Albaugh BN, Lindner SE, Chen Y, Satyshur KA, Arnold KM, Kaufman PD, Keck JL, Denu JM.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20275-80. doi: 10.1073/pnas.1009860107. Epub 2010 Nov 5.


Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.

Hoadley KA, Xu D, Xue Y, Satyshur KA, Wang W, Keck JL.

Structure. 2010 Sep 8;18(9):1149-58. doi: 10.1016/j.str.2010.06.009.


X-ray crystal structure of the bacterial conjugation factor PsiB, a negative regulator of RecA.

Petrova V, Satyshur KA, George NP, McCaslin D, Cox MM, Keck JL.

J Biol Chem. 2010 Oct 1;285(40):30615-21. doi: 10.1074/jbc.M110.152298. Epub 2010 Jul 21.


Werner helicase wings DNA binding.

Hoadley KA, Keck JL.

Structure. 2010 Feb 10;18(2):149-51. doi: 10.1016/j.str.2010.01.007.


Rising from the Ashes: DNA Repair in Deinococcus radiodurans.

Cox MM, Keck JL, Battista JR.

PLoS Genet. 2010 Jan 15;6(1):e1000815. doi: 10.1371/journal.pgen.1000815. No abstract available.


Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance.

Lu D, Bernstein DA, Satyshur KA, Keck JL.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):633-8. doi: 10.1073/pnas.0909191107. Epub 2009 Dec 16.


Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator.

Lindner SE, De Silva EK, Keck JL, Llinás M.

J Mol Biol. 2010 Jan 22;395(3):558-67. doi: 10.1016/j.jmb.2009.11.004. Epub 2009 Nov 10.


Molecular biology: Slip sliding on DNA.

George NP, Keck JL.

Nature. 2009 Oct 22;461(7267):1067-8. doi: 10.1038/4611067a. No abstract available.


Peptide inhibitors identify roles for SSB C-terminal residues in SSB/exonuclease I complex formation.

Lu D, Windsor MA, Gellman SH, Keck JL.

Biochemistry. 2009 Jul 28;48(29):6764-71. doi: 10.1021/bi900361r.


Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75.

Berndsen CE, Tsubota T, Lindner SE, Lee S, Holton JM, Kaufman PD, Keck JL, Denu JM.

Nat Struct Mol Biol. 2008 Sep;15(9):948-56.


Identification of the SSB binding site on E. coli RecQ reveals a conserved surface for binding SSB's C terminus.

Shereda RD, Reiter NJ, Butcher SE, Keck JL.

J Mol Biol. 2009 Feb 27;386(3):612-25. doi: 10.1016/j.jmb.2008.12.065. Epub 2009 Jan 3.


RecQ DNA helicase HRDC domains are critical determinants in Neisseria gonorrhoeae pilin antigenic variation and DNA repair.

Killoran MP, Kohler PL, Dillard JP, Keck JL.

Mol Microbiol. 2009 Jan;71(1):158-71. doi: 10.1111/j.1365-2958.2008.06513.x. Epub 2008 Nov 11.


SSB as an organizer/mobilizer of genome maintenance complexes.

Shereda RD, Kozlov AG, Lohman TM, Cox MM, Keck JL.

Crit Rev Biochem Mol Biol. 2008 Sep-Oct;43(5):289-318. doi: 10.1080/10409230802341296 . Review.


Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I.

Lu D, Keck JL.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9169-74. doi: 10.1073/pnas.0800741105. Epub 2008 Jun 30.

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