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Items: 1 to 50 of 245

1.

Antigenic variation in Neisseria gonorrhoeae occurs independently of RecQ-mediated unwinding of the pilE G-quadruplex.

Voter AF, Callaghan MM, Tippana R, Myong S, Dillard JP, Keck JL.

J Bacteriol. 2019 Nov 18. pii: JB.00607-19. doi: 10.1128/JB.00607-19. [Epub ahead of print]

PMID:
31740492
2.

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction.

Anderson BW, Liu K, Wolak C, Dubiel K, She F, Satyshur KA, Keck JL, Wang JD.

Elife. 2019 Sep 25;8. pii: e47534. doi: 10.7554/eLife.47534.

3.

A modified method for rapid quantification of Chlamydia muridarum using Fluorospot.

Keck J, Chambers JP, Forsthuber T, Gupta R, Arulanandam BP.

MethodsX. 2019 Aug 30;6:1925-1932. doi: 10.1016/j.mex.2019.08.005. eCollection 2019.

4.

Clarifying the Mechanism of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα and IIβ.

Keck JM, Conner JD, Wilson JT, Jiang X, Lisic EC, Deweese JE.

Chem Res Toxicol. 2019 Oct 21;32(10):2135-2143. doi: 10.1021/acs.chemrestox.9b00311. Epub 2019 Sep 20.

PMID:
31512855
5.

Prediabetes Knowledge, Attitudes, and Practices at an Academic Family Medicine Practice.

Keck JW, Thomas AR, Hieronymus L, Roper KL.

J Am Board Fam Med. 2019 Jul-Aug;32(4):505-512. doi: 10.3122/jabfm.2019.04.180375.

6.

Action-Dependent Processing of Touch in the Human Parietal Operculum and Posterior Insula.

Limanowski J, Lopes P, Keck J, Baudisch P, Friston K, Blankenburg F.

Cereb Cortex. 2019 Jun 18. pii: bhz111. doi: 10.1093/cercor/bhz111. [Epub ahead of print]

PMID:
31211363
7.

Preclinical rationale for entinostat in embryonal rhabdomyosarcoma.

Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Pal R, Davies AM, Ashok A, Bushby D, Mancini M, Noakes C, Goodwin NC, Ordentlich P, Keck J, Hawkins DS, Rudzinski ER, Mansoor A, Perkins TJ, Vakoc CR, Michalek JE, Keller C.

Skelet Muscle. 2019 May 21;9(1):12. doi: 10.1186/s13395-019-0198-x.

8.

Daunorubicin-containing CLL1-targeting nanomicelles have anti-leukemia stem cell activity in acute myeloid leukemia.

Lin TY, Zhu Y, Li Y, Zhang H, Ma AH, Long Q, Keck J, Lam KS, Pan CX, Jonas BA.

Nanomedicine. 2019 Aug;20:102004. doi: 10.1016/j.nano.2019.04.007. Epub 2019 May 2.

PMID:
31055076
9.

Patient and Clinician Perceptions of Prediabetes: A Mixed-Methods Primary Care Study.

Roper KL, Thomas AR, Hieronymus L, Brock A, Keck J.

Diabetes Educ. 2019 Jun;45(3):302-314. doi: 10.1177/0145721719845347. Epub 2019 Apr 25.

PMID:
31018784
10.

Creation of PDX-Bearing Humanized Mice to Study Immuno-oncology.

Yao LC, Aryee KE, Cheng M, Kaur P, Keck JG, Brehm MA.

Methods Mol Biol. 2019;1953:241-252. doi: 10.1007/978-1-4939-9145-7_15.

PMID:
30912026
11.

Humanized mouse models of immunological diseases and precision medicine.

Shultz LD, Keck J, Burzenski L, Jangalwe S, Vaidya S, Greiner DL, Brehm MA.

Mamm Genome. 2019 Jun;30(5-6):123-142. doi: 10.1007/s00335-019-09796-2. Epub 2019 Mar 7. Review.

PMID:
30847553
12.

Function of a strand-separation pin element in the PriA DNA replication restart helicase.

Windgassen TA, Leroux M, Sandler SJ, Keck JL.

J Biol Chem. 2019 Feb 22;294(8):2801-2814. doi: 10.1074/jbc.RA118.006870. Epub 2018 Dec 28.

PMID:
30593500
13.

High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts.

Kim H, Kumar P, Menghi F, Noorbakhsh J, Cerveira E, Ryan M, Zhu Q, Ananda G, George J, Chen HC, Mockus S, Zhang C, Yang Y, Keck J, Karuturi RKM, Bult CJ, Lee C, Liu ET, Chuang JH.

Sci Rep. 2018 Dec 18;8(1):17937. doi: 10.1038/s41598-018-36184-8.

14.

Implementing a comprehensive translational oncology platform: from molecular testing to actionability.

Mitri ZI, Parmar S, Johnson B, Kolodzie A, Keck JM, Morris M, Guimaraes AR, Beckett BR, Borate U, Lopez CD, Kemmer KA, Alumkal JJ, Beer TM, Corless CL, Mills GB, Gray JW, Bergan RC.

J Transl Med. 2018 Dec 14;16(1):358. doi: 10.1186/s12967-018-1733-y.

15.

Practical Model Selection for Prospective Virtual Screening.

Liu S, Alnammi M, Ericksen SS, Voter AF, Ananiev GE, Keck JL, Hoffmann FM, Wildman SA, Gitter A.

J Chem Inf Model. 2019 Jan 28;59(1):282-293. doi: 10.1021/acs.jcim.8b00363. Epub 2018 Dec 18.

16.

Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins.

Dubiel K, Myers AR, Kozlov AG, Yang O, Zhang J, Ha T, Lohman TM, Keck JL.

J Mol Biol. 2019 Jan 18;431(2):178-195. doi: 10.1016/j.jmb.2018.11.019. Epub 2018 Nov 22.

PMID:
30472092
17.

The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma.

Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Ishikawa Y, Zientek K, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Rudek MA, Xu L, Anders NM, Pal R, Harrold AP, Davies AM, Ashok A, Bushby D, Mancini M, Noakes C, Goodwin NC, Ordentlich P, Keck J, Hawkins DS, Rudzinski ER, Chatterjee B, Bächinger HP, Barr FG, Liddle J, Garcia BA, Mansoor A, Perkins TJ, Vakoc CR, Michalek JE, Keller C.

Sci Signal. 2018 Nov 20;11(557). pii: eaau7632. doi: 10.1126/scisignal.aau7632.

18.

A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases.

Voter AF, Qiu Y, Tippana R, Myong S, Keck JL.

Nat Commun. 2018 Oct 10;9(1):4201. doi: 10.1038/s41467-018-06751-8.

19.

Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase.

Windgassen TA, Leroux M, Satyshur KA, Sandler SJ, Keck JL.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9075-E9084. doi: 10.1073/pnas.1809842115. Epub 2018 Sep 10.

20.

Single molecule kinetics uncover roles for E. coli RecQ DNA helicase domains and interaction with SSB.

Bagchi D, Manosas M, Zhang W, Manthei KA, Hodeib S, Ducos B, Keck JL, Croquette V.

Nucleic Acids Res. 2018 Sep 19;46(16):8500-8515. doi: 10.1093/nar/gky647.

21.

'Watch and wait' after chemoradiotherapy for rectal cancer.

Mullaney TG, Lightner AL, Johnston M, Keck J, Wattchow D.

ANZ J Surg. 2018 Sep;88(9):836-841. doi: 10.1111/ans.14352. Epub 2018 Jul 25. Review.

PMID:
30047201
22.

Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice.

Spengler JR, McElroy AK, Harmon JR, Coleman-McCray JD, Welch SR, Keck JG, Nichol ST, Spiropoulou CF.

PLoS One. 2018 Jul 20;13(7):e0201104. doi: 10.1371/journal.pone.0201104. eCollection 2018.

23.

Stage-based Variation in the Effect of Primary Tumor Side on All Stages of Colorectal Cancer Recurrence and Survival.

Lee MM, MacKinlay A, Semira C, Schieber C, Jimeno Yepes AJ, Lee B, Wong R, Hettiarachchige CKH, Gunn N, Tie J, Wong HL, Skinner I, Jones IT, Keck J, Kosmider S, Tran B, Field K, Gibbs P.

Clin Colorectal Cancer. 2018 Sep;17(3):e569-e577. doi: 10.1016/j.clcc.2018.05.008. Epub 2018 May 26.

PMID:
29980491
24.

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions.

Floc'h N, Martin MJ, Riess JW, Orme JP, Staniszewska AD, Ménard L, Cuomo ME, O'Neill DJ, Ward RA, Finlay MRV, McKerrecher D, Cheng M, Vang DP, Burich RA, Keck JG, Gandara DR, Mack PC, Cross DAE.

Mol Cancer Ther. 2018 May;17(5):885-896. doi: 10.1158/1535-7163.MCT-17-0758. Epub 2018 Feb 26.

25.

Alterations in the Rho pathway contribute to Epstein-Barr virus-induced lymphomagenesis in immunosuppressed environments.

Cho SY, Sung CO, Chae J, Lee J, Na D, Kang W, Kang J, Min S, Lee A, Kwak E, Kim J, Choi B, Kim H, Chuang JH, Pak HK, Park CS, Park S, Ko YH, Lee D, Roh J, Cho MS, Park S, Ju YS, Suh YS, Kong SH, Lee HJ, Keck J, Banchereau J, Liu ET, Kim WH, Park H, Yang HK, Kim JI, Lee C.

Blood. 2018 Apr 26;131(17):1931-1941. doi: 10.1182/blood-2017-07-797209. Epub 2018 Feb 23.

26.

Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases.

Voter AF, Keck JL.

Adv Protein Chem Struct Biol. 2018;111:197-222. doi: 10.1016/bs.apcsb.2017.07.005. Epub 2017 Aug 24. Review.

27.

Mechanisms of bacterial DNA replication restart.

Windgassen TA, Wessel SR, Bhattacharyya B, Keck JL.

Nucleic Acids Res. 2018 Jan 25;46(2):504-519. doi: 10.1093/nar/gkx1203. Review.

28.

Invasive Haemophilus influenzae Serotype a Infection in Children: Clinical Description of an Emerging Pathogen-Alaska, 2002-2014.

Plumb ID, Lecy KD, Singleton R, Engel MC, Hirschfeld M, Keck JW, Klejka J, Rudolph KM, Hennessy TW, Bruce MG.

Pediatr Infect Dis J. 2018 Apr;37(4):298-303. doi: 10.1097/INF.0000000000001764.

29.

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.

Wang M, Yao LC, Cheng M, Cai D, Martinek J, Pan CX, Shi W, Ma AH, De Vere White RW, Airhart S, Liu ET, Banchereau J, Brehm MA, Greiner DL, Shultz LD, Palucka K, Keck JG.

FASEB J. 2018 Mar;32(3):1537-1549. doi: 10.1096/fj.201700740R. Epub 2018 Jan 3.

30.

Ischaemic colitis: uncertainty in diagnosis, pathophysiology and management.

Nikolic AL, Keck JO.

ANZ J Surg. 2018 Apr;88(4):278-283. doi: 10.1111/ans.14237. Epub 2017 Nov 9. Review.

PMID:
29124893
31.

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver.

Spengler JR, Saturday G, Lavender KJ, Martellaro C, Keck JG, Nichol ST, Spiropoulou CF, Feldmann H, Prescott J.

J Infect Dis. 2017 Dec 27;217(1):58-63. doi: 10.1093/infdis/jix562.

32.

Distance to care, enrollment and loss to follow-up of HIV patients during decentralization of antiretroviral therapy in Neno District, Malawi: A retrospective cohort study.

Bilinski A, Birru E, Peckarsky M, Herce M, Kalanga N, Neumann C, Bronson G, Po-Chedley S, Kachimanga C, McBain R, Keck J.

PLoS One. 2017 Oct 3;12(10):e0185699. doi: 10.1371/journal.pone.0185699. eCollection 2017.

33.

Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma.

Bharathy N, Svalina MN, Settelmeyer TP, Cleary MM, Berlow NE, Airhart SD, Xiang S, Keck J, Hayden JB, Shern JF, Mansoor A, Lathara M, Srinivasa G, Langenau DM, Keller C.

Oncotarget. 2017 Jun 16;8(38):62976-62983. doi: 10.18632/oncotarget.18520. eCollection 2017 Sep 8.

34.

EphB4/EphrinB2 therapeutics in Rhabdomyosarcoma.

Randolph ME, Cleary MM, Bajwa Z, Svalina MN, Young MC, Mansoor A, Kaur P, Bult CJ, Goros MW, Michalek JE, Xiang S, Keck J, Krasnoperov V, Gill P, Keller C.

PLoS One. 2017 Aug 17;12(8):e0183161. doi: 10.1371/journal.pone.0183161. eCollection 2017.

35.

MicroRNA mediated regulation of immunity against gram-negative bacteria.

Keck J, Gupta R, Christenson LK, Arulanandam BP.

Int Rev Immunol. 2017 Sep 3;36(5):287-299. doi: 10.1080/08830185.2017.1347649. Epub 2017 Aug 11. Review.

PMID:
28800263
36.

A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein-Protein Interactions in an Academic Screening Facility.

Voter AF, Killoran MP, Ananiev GE, Wildman SA, Hoffmann FM, Keck JL.

SLAS Discov. 2018 Jan;23(1):94-101. doi: 10.1177/2472555217712001. Epub 2017 Jun 1.

37.

Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection.

Spengler JR, Kelly Keating M, McElroy AK, Zivcec M, Coleman-McCray JD, Harmon JR, Bollweg BC, Goldsmith CS, Bergeron É, Keck JG, Zaki SR, Nichol ST, Spiropoulou CF.

J Infect Dis. 2017 Dec 12;216(11):1386-1397. doi: 10.1093/infdis/jix215.

38.

A Point System as Catalyst to Increase Resident Scholarship: An MPCRN Study.

Seehusen DA, Ledford CJ, Grogan S, Kim E, Johnson JJ, Stackle ME, Runser LA, Fargo MV, Keck JW, Oberhofer AL, Shoemaker R.

Fam Med. 2017 Mar;49(3):222-224.

39.

Optical interference coating design contest 2016: a dispersive mirror and coating uniformity challenge.

Kruschwitz JD, Pervak V, Keck J, Bolshakov I, Gerig Z, Lemarchand F, Sato K, Southwell W, Sugiura M, Trubetskov M, Yuan W.

Appl Opt. 2017 Feb 1;56(4):C151-C162. doi: 10.1364/AO.56.00C151.

PMID:
28158062
40.

Impact of Surgical Complications Following Resection of Locally Advanced Rectal Adenocarcinoma on Adjuvant Chemotherapy Delivery and Survival Outcomes.

Jamnagerwalla M, Tay R, Steel M, Keck J, Jones I, Faragher I, Gibbs P, Wong R.

Dis Colon Rectum. 2016 Oct;59(10):916-24. doi: 10.1097/DCR.0000000000000659.

PMID:
27602922
41.

Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment.

Spengler JR, Lavender KJ, Martellaro C, Carmody A, Kurth A, Keck JG, Saturday G, Scott DP, Nichol ST, Hasenkrug KJ, Spiropoulou CF, Feldmann H, Prescott J.

J Infect Dis. 2016 Oct 15;214(suppl 3):S308-S318. Epub 2016 Sep 6. Erratum in: J Infect Dis. 2017 Nov 15;216(8):1048.

42.

Antigen specific immune response in Chlamydia muridarum genital infection is dependent on murine microRNAs-155 and -182.

Gupta R, Arkatkar T, Keck J, Koundinya GK, Castillo K, Hobel S, Chambers JP, Yu JJ, Guentzel MN, Aigner A, Christenson LK, Arulanandam BP.

Oncotarget. 2016 Oct 4;7(40):64726-64742. doi: 10.18632/oncotarget.11461.

43.

An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase.

Windgassen TA, Keck JL.

Nucleic Acids Res. 2016 Nov 16;44(20):9745-9757. Epub 2016 Aug 2.

44.

Structural and Functional Studies of H. seropedicae RecA Protein - Insights into the Polymerization of RecA Protein as Nucleoprotein Filament.

Leite WC, Galvão CW, Saab SC, Iulek J, Etto RM, Steffens MB, Chitteni-Pattu S, Stanage T, Keck JL, Cox MM.

PLoS One. 2016 Jul 22;11(7):e0159871. doi: 10.1371/journal.pone.0159871. eCollection 2016.

45.

Structure and Function of the PriC DNA Replication Restart Protein.

Wessel SR, Cornilescu CC, Cornilescu G, Metz A, Leroux M, Hu K, Sandler SJ, Markley JL, Keck JL.

J Biol Chem. 2016 Aug 26;291(35):18384-96. doi: 10.1074/jbc.M116.738781. Epub 2016 Jul 5.

46.

The tandem duplicator phenotype as a distinct genomic configuration in cancer.

Menghi F, Inaki K, Woo X, Kumar PA, Grzeda KR, Malhotra A, Yadav V, Kim H, Marquez EJ, Ucar D, Shreckengast PT, Wagner JP, MacIntyre G, Murthy Karuturi KR, Scully R, Keck J, Chuang JH, Liu ET.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2373-82. doi: 10.1073/pnas.1520010113. Epub 2016 Apr 7.

47.

A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.

Voter AF, Manthei KA, Keck JL.

J Biomol Screen. 2016 Jul;21(6):626-33. doi: 10.1177/1087057116635503. Epub 2016 Mar 8.

48.

The Chromosome-Encoded Hypothetical Protein TC0668 Is an Upper Genital Tract Pathogenicity Factor of Chlamydia muridarum.

Conrad TA, Gong S, Yang Z, Matulich P, Keck J, Beltrami N, Chen C, Zhou Z, Dai J, Zhong G.

Infect Immun. 2015 Nov 23;84(2):467-79. doi: 10.1128/IAI.01171-15. Print 2016 Feb.

49.

Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy.

Pan CX, Zhang H, Tepper CG, Lin TY, Davis RR, Keck J, Ghosh PM, Gill P, Airhart S, Bult C, Gandara DR, Liu E, de Vere White RW.

PLoS One. 2015 Aug 13;10(8):e0134346. doi: 10.1371/journal.pone.0134346. eCollection 2015.

50.

Excellent clinical outcomes and retention in care for adults with HIV-associated Kaposi sarcoma treated with systemic chemotherapy and integrated antiretroviral therapy in rural Malawi.

Herce ME, Kalanga N, Wroe EB, Keck JW, Chingoli F, Tengatenga L, Gopal S, Phiri A, Mailosi B, Bazile J, Beste JA, Elmore SN, Crocker JT, Rigodon J.

J Int AIDS Soc. 2015 May 29;18:19929. doi: 10.7448/IAS.18.1.19929. eCollection 2015.

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