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Items: 1 to 50 of 70

1.

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.

Rotter D, Peiris H, Grinsfelder DB, Martin AM, Burchfield J, Parra V, Hull C, Morales CR, Jessup CF, Matusica D, Parks BW, Lusis AJ, Nguyen NUN, Oh M, Iyoke I, Jakkampudi T, McMillan DR, Sadek HA, Watt MJ, Gupta RK, Pritchard MA, Keating DJ, Rothermel BA.

EMBO Rep. 2018 Nov 2. pii: e44706. doi: 10.15252/embr.201744706. [Epub ahead of print]

PMID:
30389725
2.

What is the role of endogenous gut serotonin in the control of gastrointestinal motility?

Keating DJ, Spencer NJ.

Pharmacol Res. 2018 Jun 21. pii: S1043-6618(18)30571-1. doi: 10.1016/j.phrs.2018.06.017. [Epub ahead of print] Review.

PMID:
29935946
3.

Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle.

Spencer NJ, Hibberd TJ, Travis L, Wiklendt L, Costa M, Hu H, Brookes SJ, Wattchow DA, Dinning PG, Keating DJ, Sorensen J.

J Neurosci. 2018 Jun 13;38(24):5507-5522. doi: 10.1523/JNEUROSCI.3489-17.2018. Epub 2018 May 28.

PMID:
29807910
4.

ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells.

Lumsden AL, Ma Y, Ashander LM, Stempel AJ, Keating DJ, Smith JR, Appukuttan B.

BMC Res Notes. 2018 May 9;11(1):285. doi: 10.1186/s13104-018-3384-8.

5.

Augmented capacity for peripheral serotonin release in human obesity.

Young RL, Lumsden AL, Martin AM, Schober G, Pezos N, Thazhath SS, Isaacs NJ, Cvijanovic N, Sun EWL, Wu T, Rayner CK, Nguyen NQ, Fontgalland D, Rabbitt P, Hollington P, Sposato L, Due SL, Wattchow DA, Liou AP, Jackson VM, Keating DJ.

Int J Obes (Lond). 2018 Mar 1. doi: 10.1038/s41366-018-0047-8. [Epub ahead of print]

PMID:
29568107
6.

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes.

Chen L, Liu C, Gao J, Xie Z, Chan LWC, Keating DJ, Yang Y, Sun J, Zhou F, Wei Y, Men X, Yang S.

Oncotarget. 2017 Sep 16;8(53):90693-90705. doi: 10.18632/oncotarget.20963. eCollection 2017 Oct 31.

7.

The neuronal and endocrine roles of RCAN1 in health and disease.

Peiris H, Keating DJ.

Clin Exp Pharmacol Physiol. 2018 Apr;45(4):377-383. doi: 10.1111/1440-1681.12884. Epub 2017 Nov 29.

PMID:
29094385
8.

Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

Grøndahl MF, Keating DJ, Vilsbøll T, Knop FK.

Curr Diab Rep. 2017 Oct 28;17(12):128. doi: 10.1007/s11892-017-0967-z. Review.

PMID:
29080075
9.

Synaptic activation of putative sensory neurons by hexamethonium-sensitive nerve pathways in mouse colon.

Hibberd TJ, Travis L, Wiklendt L, Costa M, Brookes SJH, Hu H, Keating DJ, Spencer NJ.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G53-G64. doi: 10.1152/ajpgi.00234.2017. Epub 2017 Sep 21.

PMID:
28935683
10.

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.

Saadipour K, Mañucat-Tan NB, Lim Y, Keating DJ, Smith KS, Zhong JH, Liao H, Bobrovskaya L, Wang YJ, Chao MV, Zhou XF.

J Neurochem. 2018 Feb;144(3):302-317. doi: 10.1111/jnc.14206. Epub 2017 Sep 27.

PMID:
28869759
11.

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine.

Sun EW, de Fontgalland D, Rabbitt P, Hollington P, Sposato L, Due SL, Wattchow DA, Rayner CK, Deane AM, Young RL, Keating DJ.

Diabetes. 2017 Aug;66(8):2144-2149. doi: 10.2337/db17-0058. Epub 2017 Apr 6.

12.

The Diverse Metabolic Roles of Peripheral Serotonin.

Martin AM, Young RL, Leong L, Rogers GB, Spencer NJ, Jessup CF, Keating DJ.

Endocrinology. 2017 May 1;158(5):1049-1063. doi: 10.1210/en.2016-1839. Review.

PMID:
28323941
13.

Regional differences in nutrient-induced secretion of gut serotonin.

Martin AM, Lumsden AL, Young RL, Jessup CF, Spencer NJ, Keating DJ.

Physiol Rep. 2017 Mar;5(6). pii: e13199. doi: 10.14814/phy2.13199.

14.

Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins.

Mackenzie KD, Lim Y, Duffield MD, Chataway T, Zhou XF, Keating DJ.

Cell Signal. 2017 Jul;35:176-187. doi: 10.1016/j.cellsig.2017.02.023. Epub 2017 Mar 1.

PMID:
28259758
15.

The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon.

Martin AM, Lumsden AL, Young RL, Jessup CF, Spencer NJ, Keating DJ.

Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13046. Epub 2017 Mar 2.

PMID:
28251760
16.

Local Sphingosine Kinase 1 Activity Improves Islet Transplantation.

Rojas-Canales D, Penko D, Myo Min KK, Parham KA, Peiris H, Haberberger RV, Pitson SM, Drogemuller C, Keating DJ, Grey ST, Coates PT, Bonder CS, Jessup CF.

Diabetes. 2017 May;66(5):1301-1311. doi: 10.2337/db16-0837. Epub 2017 Feb 7.

18.

Is There a Role for Endogenous 5-HT in Gastrointestinal Motility? How Recent Studies Have Changed Our Understanding.

Spencer NJ, Keating DJ.

Adv Exp Med Biol. 2016;891:113-22. doi: 10.1007/978-3-319-27592-5_11. Review.

PMID:
27379639
19.

Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking.

Mackenzie KD, Lumsden AL, Guo F, Duffield MD, Chataway T, Lim Y, Zhou XF, Keating DJ.

J Neurochem. 2016 Sep;138(5):710-21. doi: 10.1111/jnc.13703. Epub 2016 Jul 18.

20.

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ.

PLoS Genet. 2016 May 19;12(5):e1006033. doi: 10.1371/journal.pgen.1006033. eCollection 2016 May.

21.

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways.

Rogers GB, Keating DJ, Young RL, Wong ML, Licinio J, Wesselingh S.

Mol Psychiatry. 2016 Jun;21(6):738-48. doi: 10.1038/mp.2016.50. Epub 2016 Apr 19. Review.

22.

The 18th International Symposia on Chromaffin Cell Biology.

Meunier FA, Keating DJ.

J Neurochem. 2016 Jun;137(6):847-8. doi: 10.1111/jnc.13631. No abstract available.

23.

Exocytosis in non-neuronal cells.

Thorn P, Zorec R, Rettig J, Keating DJ.

J Neurochem. 2016 Jun;137(6):849-59. doi: 10.1111/jnc.13602. Epub 2016 May 2. Review.

24.

Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules.

Han YC, Lim Y, Duffieldl MD, Li H, Liu J, Abdul Manaph NP, Yang M, Keating DJ, Zhou XF.

Stem Cells Int. 2016;2016:4304916. doi: 10.1155/2016/4304916. Epub 2015 Dec 16.

25.

Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability.

Zelkas L, Raghupathi R, Lumsden AL, Martin AM, Sun E, Spencer NJ, Young RL, Keating DJ.

Nutr Metab (Lond). 2015 Dec 15;12:55. doi: 10.1186/s12986-015-0051-0. eCollection 2015.

26.

Fusion Pore Size Limits 5-HT Release From Single Enterochromaffin Cell Vesicles.

Raghupathi R, Jessup CF, Lumsden AL, Keating DJ.

J Cell Physiol. 2016 Jul;231(7):1593-600. doi: 10.1002/jcp.25256. Epub 2015 Dec 10.

PMID:
26574734
27.

Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating.

Spencer NJ, Sia TC, Brookes SJ, Costa M, Keating DJ.

J Physiol. 2015 Aug 1;593(15):3235. doi: 10.1113/JP270684. No abstract available.

28.

CrossTalk opposing view: 5-HT is not necessary for peristalsis.

Spencer NJ, Sia TC, Brookes SJ, Costa M, Keating DJ.

J Physiol. 2015 Aug 1;593(15):3229-31. doi: 10.1113/JP270183. No abstract available.

29.

Gut Serotonin Is a Regulator of Obesity and Metabolism.

Young RL, Lumsden AL, Keating DJ.

Gastroenterology. 2015 Jul;149(1):253-5. doi: 10.1053/j.gastro.2015.05.020. Epub 2015 May 27. No abstract available.

PMID:
26025313
30.

Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.

Jackson J, Papadopulos A, Meunier FA, McCluskey A, Robinson PJ, Keating DJ.

Mol Psychiatry. 2015 Jul;20(7):810-9. doi: 10.1038/mp.2015.56. Epub 2015 May 5.

PMID:
25939402
31.

Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking.

Papadopulos A, Gomez GA, Martin S, Jackson J, Gormal RS, Keating DJ, Yap AS, Meunier FA.

Nat Commun. 2015 Feb 24;6:6297. doi: 10.1038/ncomms7297.

PMID:
25708831
32.

Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder.

Kumar R, Corbett MA, Smith NJ, Jolly LA, Tan C, Keating DJ, Duffield MD, Utsumi T, Moriya K, Smith KR, Hoischen A, Abbott K, Harbord MG, Compton AG, Woenig JA, Arts P, Kwint M, Wieskamp N, Gijsen S, Veltman JA, Bahlo M, Gleeson JG, Haan E, Gecz J.

Hum Mol Genet. 2015 Apr 1;24(7):2000-10. doi: 10.1093/hmg/ddu614. Epub 2014 Dec 11.

PMID:
25504045
33.

RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells.

Peiris H, Dubach D, Jessup CF, Unterweger P, Raghupathi R, Muyderman H, Zanin MP, Mackenzie K, Pritchard MA, Keating DJ.

Oxid Med Cell Longev. 2014;2014:520316. doi: 10.1155/2014/520316. Epub 2014 Jun 9.

34.

Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells.

Mackenzie KD, Duffield MD, Peiris H, Phillips L, Zanin MP, Teo EH, Zhou XF, Keating DJ.

J Physiol. 2014 Apr 1;592(7):1505-18. doi: 10.1113/jphysiol.2013.268342. Epub 2013 Dec 23.

35.

The β-cell/EC axis: how do islet cells talk to each other?

Peiris H, Bonder CS, Coates PT, Keating DJ, Jessup CF.

Diabetes. 2014 Jan;63(1):3-11. doi: 10.2337/db13-0617. Review.

36.

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells.

Raghupathi R, Duffield MD, Zelkas L, Meedeniya A, Brookes SJ, Sia TC, Wattchow DA, Spencer NJ, Keating DJ.

J Physiol. 2013 Dec 1;591(23):5959-75. doi: 10.1113/jphysiol.2013.259796. Epub 2013 Oct 7.

37.

Endothelial progenitor cells enhance islet engraftment, influence β-cell function, and modulate islet connexin 36 expression.

Penko D, Rojas-Canales D, Mohanasundaram D, Peiris HS, Sun WY, Drogemuller CJ, Keating DJ, Coates PT, Bonder CS, Jessup CF.

Cell Transplant. 2015;24(1):37-48. doi: 10.3727/096368913X673423. Epub 2013 Sep 10.

PMID:
24069942
38.

The presence of 5-HT in myenteric varicosities is not due to uptake of 5-HT released from the mucosa during dissection: use of a novel method for quantifying 5-HT immunoreactivity in myenteric ganglia.

Keating DJ, Peiris H, Kyloh M, Brookes SJ, Spencer NJ.

Neurogastroenterol Motil. 2013 Oct;25(10):849-53. doi: 10.1111/nmo.12189. Epub 2013 Jul 31.

PMID:
23901879
39.

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

Duncan C, Bica L, Crouch PJ, Caragounis A, Lidgerwood GE, Parker SJ, Meyerowitz J, Volitakis I, Liddell JR, Raghupathi R, Paterson BM, Duffield MD, Cappai R, Donnelly PS, Grubman A, Camakaris J, Keating DJ, White AR.

Metallomics. 2013 Jun;5(6):700-14. doi: 10.1039/c3mt20231c.

PMID:
23661118
40.

Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors.

McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, Gorgani NN, Keating DJ, Cousin MA, van Dam EM, Mariana A, Whiting A, Perera S, Novelle A, Young KA, Deane FM, Gilbert J, Sakoff JA, Chircop M, McCluskey A, Robinson PJ.

ACS Chem Biol. 2013 Jul 19;8(7):1507-18. doi: 10.1021/cb400137p. Epub 2013 May 30.

PMID:
23642287
41.

RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity.

Zanin MP, Mackenzie KD, Peiris H, Pritchard MA, Keating DJ.

J Neurochem. 2013 Feb;124(3):290-9. doi: 10.1111/jnc.12086.

42.

Exocytosis is impaired in mucopolysaccharidosis IIIA mouse chromaffin cells.

Keating DJ, Winter MA, Hemsley KM, Mackenzie KD, Teo EH, Hopwood JJ, Brooks DA, Parkinson-Lawrence EJ.

Neuroscience. 2012 Dec 27;227:110-8. doi: 10.1016/j.neuroscience.2012.09.034. Epub 2012 Sep 25.

PMID:
23022219
43.

Increased expression of the glucose-responsive gene, RCAN1, causes hypoinsulinemia, β-cell dysfunction, and diabetes.

Peiris H, Raghupathi R, Jessup CF, Zanin MP, Mohanasundaram D, Mackenzie KD, Chataway T, Clarke JN, Brealey J, Coates PT, Pritchard MA, Keating DJ.

Endocrinology. 2012 Nov;153(11):5212-21. doi: 10.1210/en.2011-2149. Epub 2012 Sep 25.

PMID:
23011918
44.

Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARγ-dependent and PPARγ-independent mechanisms.

Rao JR, Keating DJ, Chen C, Parkington HC.

Diabetes Obes Metab. 2012 Nov;14(11):983-9. doi: 10.1111/j.1463-1326.2012.01626.x. Epub 2012 Jun 7.

PMID:
22594400
45.

Aging differentially affects multiple aspects of vesicle fusion kinetics.

Zanin MP, Phillips L, Mackenzie KD, Keating DJ.

PLoS One. 2011;6(11):e27820. doi: 10.1371/journal.pone.0027820. Epub 2011 Nov 18.

46.

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

Wen PJ, Osborne SL, Zanin M, Low PC, Wang HT, Schoenwaelder SM, Jackson SP, Wedlich-Söldner R, Vanhaesebroeck B, Keating DJ, Meunier FA.

Nat Commun. 2011 Oct 4;2:491. doi: 10.1038/ncomms1500.

PMID:
21971506
47.

A new 'dual' in the crown for electrochemistry.

Duffield MD, Keating DJ.

J Neurochem. 2011 Dec;119(5):899-900. doi: 10.1111/j.1471-4159.2011.07508.x. No abstract available.

48.

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

Spencer NJ, Nicholas SJ, Robinson L, Kyloh M, Flack N, Brookes SJ, Zagorodnyuk VP, Keating DJ.

Am J Physiol Gastrointest Liver Physiol. 2011 Sep;301(3):G519-27. doi: 10.1152/ajpgi.00101.2011. Epub 2011 Jun 23.

49.

Galanin receptor 3--a potential target for acute pancreatitis therapy.

Barreto SG, Bazargan M, Zotti M, Hussey DJ, Sukocheva OA, Peiris H, Leong M, Keating DJ, Schloithe AC, Carati CJ, Smith C, Toouli J, Saccone GT.

Neurogastroenterol Motil. 2011 Mar;23(3):e141-51. doi: 10.1111/j.1365-2982.2010.01662.x.

PMID:
21303427
50.

ClC-3--a granular anion transporter involved in insulin secretion?

Jentsch TJ, Maritzen T, Keating DJ, Zdebik AA, Thévenod F.

Cell Metab. 2010 Oct 6;12(4):307-308. doi: 10.1016/j.cmet.2010.08.014. No abstract available.

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