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Analysis of Global Pediatric Cancer Research and Publications.

Syrimi E, Lewison G, Sullivan R, Kearns P.

JCO Glob Oncol. 2020 Feb;6:9-18. doi: 10.1200/JGO.19.00227.


Host-associated microbiomes are predicted by immune system complexity and climate.

Woodhams DC, Bletz MC, Becker CG, Bender HA, Buitrago-Rosas D, Diebboll H, Huynh R, Kearns PJ, Kueneman J, Kurosawa E, LaBumbard BC, Lyons C, McNally K, Schliep K, Shankar N, Tokash-Peters AG, Vences M, Whetstone R.

Genome Biol. 2020 Feb 3;21(1):23. doi: 10.1186/s13059-019-1908-8.


Effective delivery of Complex Innovative Design (CID) cancer trials-A consensus statement.

Blagden SP, Billingham L, Brown LC, Buckland SW, Cooper AM, Ellis S, Fisher W, Hughes H, Keatley DA, Maignen FM, Morozov A, Navaie W, Pearson S, Shaaban A, Wydenbach K, Kearns PR; Experimental Cancer Medicine Centres (ECMC) CID trials working group.

Br J Cancer. 2020 Jan 6. doi: 10.1038/s41416-019-0653-9. [Epub ahead of print] Review.


A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas.

Gatz SA, Aladowicz E, Casanova M, Chisholm JC, Kearns PR, Fulda S, Geoerger B, Schäfer BW, Shipley JM.

Front Oncol. 2019 Nov 22;9:1271. doi: 10.3389/fonc.2019.01271. eCollection 2019. Review.


What could be a cancer mission objective if we join our forces in the fight against cancer?

Philip T, Karjalainen S, De Lorenzo F, Apostolidis K, Lombardo C, Nilbert M, Lacombe D, Poortmans P, Albreht T, Kearns P, Vassal G.

Tumori. 2019 Dec;105(6):447-455. doi: 10.1177/0300891619886351. Epub 2019 Nov 13.


Pharmacokinetics of Nilotinib in Pediatric Patients with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia or Acute Lymphoblastic Leukemia.

Hijiya N, Zwaan CM, Rizzari C, Foà R, Abbink F, Lancaster D, Landman-Parker J, Millot F, Moppett J, Nelken B, Caterina Putti M, Tian X, Sinclair K, Santanastasio H, Buchbinder A, Kearns P.

Clin Cancer Res. 2020 Feb 15;26(4):812-820. doi: 10.1158/1078-0432.CCR-19-0090. Epub 2019 Nov 1.


Impact of dose and duration of therapy on dexamethasone pharmacokinetics in childhood acute lymphoblastic leukaemia-a report from the UKALL 2011 trial.

Jackson RK, Liebich M, Berry P, Errington J, Liu J, Parker C, Moppett J, Samarasinghe S, Hough R, Rowntree C, Goulden NJ, Vora A, Kearns PR, Saha V, Hempel G, Irving JAE, Veal GJ.

Eur J Cancer. 2019 Oct;120:75-85. doi: 10.1016/j.ejca.2019.07.026. Epub 2019 Sep 6.


A European paediatric cancer mission: aspiration or reality?

Kearns PR, Vassal G, Ladenstein R, Schrappe M, Biondi A, Blanc P, Eggert A, Kienesberger A, Kozhaeva O, Pieters R, Schmiegelow K.

Lancet Oncol. 2019 Sep;20(9):1200-1202. doi: 10.1016/S1470-2045(19)30487-5. No abstract available.


Trends in Conservative Management for Low-risk Prostate Cancer in a Population-based Cohort of Australian Men Diagnosed Between 2009 and 2016.

Ong WL, Evans SM, Evans M, Tacey M, Dodds L, Kearns P, Milne RL, Foroudi F, Millar J.

Eur Urol Oncol. 2019 May 6. pii: S2588-9311(19)30055-0. doi: 10.1016/j.euo.2019.04.006. [Epub ahead of print]


An overview of OECD activities related to modern techniques of biotechnology and genome editing : OECD conference on genome editing, June 2018.

Kearns P.

Transgenic Res. 2019 Aug;28(Suppl 2):41-44. doi: 10.1007/s11248-019-00131-8. No abstract available.



Kearns P.

Transgenic Res. 2019 Aug;28(Suppl 2):39-40. doi: 10.1007/s11248-019-00130-9. No abstract available.


Meeting report of the OECD conference on "Genome Editing: Applications in Agriculture-Implications for Health, Environment and Regulation".

Friedrichs S, Takasu Y, Kearns P, Dagallier B, Oshima R, Schofield J, Moreddu C.

Transgenic Res. 2019 Aug;28(3-4):419-463. doi: 10.1007/s11248-019-00154-1.


Policy Considerations Regarding Genome Editing.

Friedrichs S, Takasu Y, Kearns P, Dagallier B, Oshima R, Schofield J, Moreddu C.

Trends Biotechnol. 2019 Oct;37(10):1029-1032. doi: 10.1016/j.tibtech.2019.05.005. Epub 2019 Jun 19.


Regional variation in the incidence rate and sex ratio of multiple sclerosis in Scotland 2010-2017: findings from the Scottish Multiple Sclerosis Register.

Kearns PKA, Paton M, O'Neill M, Waters C, Colville S, McDonald J, Young IJB, Pugh D, O'Riordan J, Weller B, MacDougall N, Clemens T, Dibben C, Wilson JF, Castro MC, Ascherio A, Chandran S, Connick P.

J Neurol. 2019 Oct;266(10):2376-2386. doi: 10.1007/s00415-019-09413-x. Epub 2019 Jun 11.


Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.

Nat Rev Clin Oncol. 2019 Aug;16(8):522-523. doi: 10.1038/s41571-019-0236-y. No abstract available.


Recommendations for the organisation of care in paediatric radiation oncology across Europe: a SIOPE-ESTRO-PROS-CCI-Europe collaborative project in the framework of the JARC.

Janssens GO, Timmermann B, Laprie A, Mandeville H, Padovani L, Chargari C, Journy N, Kameric L, Kienesberger A, Brunhofer M, Kozhaeva O, Gasparotto C, Kearns P, Boterberg T, Lievens Y, Vassal G.

Eur J Cancer. 2019 Jun;114:47-54. doi: 10.1016/j.ejca.2019.03.003. Epub 2019 May 3.


Establishment Limitation Constrains the Abundance of Lactic Acid Bacteria in the Napa Cabbage Phyllosphere.

Miller ER, Kearns PJ, Niccum BA, O'Mara Schwartz J, Ornstein A, Wolfe BE.

Appl Environ Microbiol. 2019 Jun 17;85(13). pii: e00269-19. doi: 10.1128/AEM.00269-19. Print 2019 Jul 1.


Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model.

Pais H, Ruggero K, Zhang J, Al-Assar O, Bery N, Bhuller R, Weston V, Kearns PR, Mecucci C, Miller A, Rabbitts TH.

Sci Rep. 2019 Apr 8;9(1):5760. doi: 10.1038/s41598-019-42214-w.


16S rRNA/rRNA Gene Ratios and Cell Activity Staining Reveal Consistent Patterns of Microbial Activity in Plant-Associated Soil.

Bowsher AW, Kearns PJ, Shade A.

mSystems. 2019 Apr 2;4(2). pii: e00003-19. doi: 10.1128/mSystems.00003-19. eCollection 2019 Mar-Apr.


Phase 1-2 safety, efficacy and pharmacokinetic study of decitabine in sequential administration with cytarabine in children with relapsed or refractory acute myeloid leukaemia.

Kearns P, Zwaan CM, Reinhardt D, Gibson B, Moreno L, Nysom K, Nakahara S, Huang F, Zhou W, Parasrampuria DA, Nemat S.

Br J Haematol. 2019 Aug;186(3):e7-e11. doi: 10.1111/bjh.15847. Epub 2019 Mar 7. No abstract available.


Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data.

Rasmussen K, Rauscher H, Kearns P, González M, Riego Sintes J.

Regul Toxicol Pharmacol. 2019 Jun;104:74-83. doi: 10.1016/j.yrtph.2019.02.008. Epub 2019 Mar 1.


Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.

Ferrari A, Brecht IB, Gatta G, Schneider DT, Orbach D, Cecchetto G, Godzinski J, Reguerre Y, Bien E, Stachowicz-Stencel T, Ost M, Magni C, Kearns P, Vassal G, Massimino M, Biondi A, Bisogno G, Trama A.

Eur J Cancer. 2019 Mar;110:120-126. doi: 10.1016/j.ejca.2018.12.031. Epub 2019 Feb 19.


Community richness of amphibian skin bacteria correlates with bioclimate at the global scale.

Kueneman JG, Bletz MC, McKenzie VJ, Becker CG, Joseph MB, Abarca JG, Archer H, Arellano AL, Bataille A, Becker M, Belden LK, Crottini A, Geffers R, Haddad CFB, Harris RN, Holden WM, Hughey M, Jarek M, Kearns PJ, Kerby JL, Kielgast J, Kurabayashi A, Longo AV, Loudon A, Medina D, Nuñez JJ, Perl RGB, Pinto-Tomás A, Rabemananjara FCE, Rebollar EA, Rodríguez A, Rollins-Smith L, Stevenson R, Tebbe CC, Vargas Asensio G, Waldman B, Walke JB, Whitfield SM, Zamudio KR, Zúñiga Chaves I, Woodhams DC, Vences M.

Nat Ecol Evol. 2019 Mar;3(3):381-389. doi: 10.1038/s41559-019-0798-1. Epub 2019 Feb 18.


Challenges to curing primary brain tumours.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.

Nat Rev Clin Oncol. 2019 Aug;16(8):509-520. doi: 10.1038/s41571-019-0177-5. Review.


Primary transitional cell carcinoma of penis - A rare presentation.

Teh J, Kearns P, Lawrentschuk N.

Urol Case Rep. 2018 Nov 23;23:25-26. doi: 10.1016/j.eucr.2018.11.016. eCollection 2019 Mar.


Long-term analysis of children with metastatic neuroblastoma treated in the ENSG5 randomised clinical trial.

Moreno L, Vaidya SJ, Schrey D, Pinkerton CR, Lewis IJ, Kearns PR, Machin D, Pearson ADJ; European Neuroblastoma Study Group and the Children's Cancer and Leukaemia Group (CCLG) (formerly UKCCSG).

Pediatr Blood Cancer. 2019 Apr;66(4):e27565. doi: 10.1002/pbc.27565. Epub 2018 Dec 5.


Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.

Mussai F, Wheat R, Sarrou E, Booth S, Stavrou V, Fultang L, Perry T, Kearns P, Cheng P, Keeshan K, Craddock C, De Santo C.

Int J Cancer. 2019 Oct 15;145(8):2201-2208. doi: 10.1002/ijc.32028. Epub 2019 Jan 11.


The utility of routine surveillance screening with magnetic resonance imaging to detect tumor recurrence/progression in children with high-grade central nervous system tumors: a systematic review.

Stevens SP, Main C, Bailey S, Pizer B, English M, Phillips B, Peet A, Avula S, Wilne S, Wheatley K, Kearns PR, Wilson JS.

Pediatr Blood Cancer. 2019 Feb;66(2):e27509. doi: 10.1002/pbc.27509. Epub 2018 Nov 8.


Nitrifying and Denitrifying Bacterial Communities in Advanced Nitrogen-Removal Onsite Wastewater Treatment Systems.

Wigginton S, Brannon E, Kearns PJ, Lancellotti B, Cox A, Loomis GW, Amador JA.

J Environ Qual. 2018 Sep;47(5):1163-1171. doi: 10.2134/jeq2018.03.0116.


Hypothesis: Multiple sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons.

Kearns PKA, Casey HA, Leach JP.

Mult Scler Relat Disord. 2018 Aug;24:157-174. doi: 10.1016/j.msard.2018.06.014. Epub 2018 Jul 4.


Nutrient Enrichment Alters Salt Marsh Fungal Communities and Promotes Putative Fungal Denitrifiers.

Kearns PJ, Bulseco-McKim AN, Hoyt H, Angell JH, Bowen JL.

Microb Ecol. 2019 Feb;77(2):358-369. doi: 10.1007/s00248-018-1223-z. Epub 2018 Jul 6.


Trait-based patterns of microbial dynamics in dormancy potential and heterotrophic strategy: case studies of resource-based and post-press succession.

Kearns PJ, Shade A.

ISME J. 2018 Nov;12(11):2575-2581. doi: 10.1038/s41396-018-0194-x. Epub 2018 Jun 29. Review.


The utility of routine surveillance screening with magnetic resonance imaging (MRI) to detect tumour recurrence in children with low-grade central nervous system (CNS) tumours: a systematic review.

Stevens SP, Main C, Bailey S, Pizer B, English M, Phillips R, Peet A, Avula S, Wilne S, Wheatley K, Kearns PR, Wilson JS.

J Neurooncol. 2018 Sep;139(3):507-522. doi: 10.1007/s11060-018-2901-x. Epub 2018 Jun 9. Review.


Genetic Analysis of Flooding Tolerance in an Andean Diversity Panel of Dry Bean (Phaseolus vulgaris L.).

Soltani A, MafiMoghaddam S, Oladzad-Abbasabadi A, Walter K, Kearns PJ, Vasquez-Guzman J, Mamidi S, Lee R, Shade AL, Jacobs JL, Chilivers MI, Lowry DB, McClean P, Osorno JM.

Front Plant Sci. 2018 Jun 6;9:767. doi: 10.3389/fpls.2018.00767. eCollection 2018.


Active surveillance of men with low risk prostate cancer: evidence from the Prostate Cancer Outcomes Registry-Victoria.

Evans MA, Millar JL, Earnest A, Frydenberg M, Davis ID, Murphy DG, Kearns PA, Evans SM.

Med J Aust. 2018 Jun 4;208(10):439-443. Epub 2018 May 28.


Stigma and Its Association With Glycemic Control and Hypoglycemia in Adolescents and Young Adults With Type 1 Diabetes: Cross-Sectional Study.

Brazeau AS, Nakhla M, Wright M, Henderson M, Panagiotopoulos C, Pacaud D, Kearns P, Rahme E, Da Costa D, Dasgupta K.

J Med Internet Res. 2018 Apr 20;20(4):e151. doi: 10.2196/jmir.9432.


Synergistic action of dual IGF1/R and MEK inhibition sensitizes childhood acute lymphoblastic leukemia (ALL) cells to cytotoxic agents and involves downregulation of STAT6 and PDAP1.

Weston VJ, Wei W, Stankovic T, Kearns P.

Exp Hematol. 2018 Jul;63:52-63.e5. doi: 10.1016/j.exphem.2018.04.002. Epub 2018 Apr 12.


The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.

Furness CL, Mansur MB, Weston VJ, Ermini L, van Delft FW, Jenkinson S, Gale R, Harrison CJ, Pombo-de-Oliveira MS, Sanchez-Martin M, Ferrando AA, Kearns P, Titley I, Ford AM, Potter NE, Greaves M.

Leukemia. 2018 Sep;32(9):1984-1993. doi: 10.1038/s41375-018-0046-8. Epub 2018 Mar 20.


10-year report on the European Paediatric Regulation and its impact on new drugs for children's cancers.

Pearson AD, Heenen D, Kearns PR, Goeres A, Marshall LV, Blanc P, Vassal G.

Lancet Oncol. 2018 Mar;19(3):285-287. doi: 10.1016/S1470-2045(18)30105-0. No abstract available.


Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial.

Gore L, Kearns PR, de Martino ML, Lee, De Souza CA, Bertrand Y, Hijiya N, Stork LC, Chung NG, Cardos RC, Saikia T, Fagioli F, Seo JJ, Landman-Parker J, Lancaster D, Place AE, Rabin KR, Sacchi M, Swanink R, Zwaan CM.

J Clin Oncol. 2018 May 1;36(13):1330-1338. doi: 10.1200/JCO.2017.75.9597. Epub 2018 Mar 2.


Community Composition of Nitrous Oxide-Related Genes in Salt Marsh Sediments Exposed to Nitrogen Enrichment.

Angell JH, Peng X, Ji Q, Craick I, Jayakumar A, Kearns PJ, Ward BB, Bowen JL.

Front Microbiol. 2018 Feb 12;9:170. doi: 10.3389/fmicb.2018.00170. eCollection 2018.


Rationalizing governance of genetically modified products in developing countries.

Adenle AA, Morris EJ, Murphy DJ, Phillips PWB, Trigo E, Kearns P, Li YH, Quemada H, Falck-Zepeda J, Komen J.

Nat Biotechnol. 2018 Feb 6;36(2):137-139. doi: 10.1038/nbt.4069. No abstract available.


Fight Fungi with Fungi: Antifungal Properties of the Amphibian Mycobiome.

Kearns PJ, Fischer S, Fernández-Beaskoetxea S, Gabor CR, Bosch J, Bowen JL, Tlusty MF, Woodhams DC.

Front Microbiol. 2017 Dec 14;8:2494. doi: 10.3389/fmicb.2017.02494. eCollection 2017.


Nanomaterials: certain aspects of application, risk assessment and risk communication.

Laux P, Tentschert J, Riebeling C, Braeuning A, Creutzenberg O, Epp A, Fessard V, Haas KH, Haase A, Hund-Rinke K, Jakubowski N, Kearns P, Lampen A, Rauscher H, Schoonjans R, Störmer A, Thielmann A, Mühle U, Luch A.

Arch Toxicol. 2018 Jan;92(1):121-141. doi: 10.1007/s00204-017-2144-1. Epub 2017 Dec 22. Review.


The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.

De Santo C, Booth S, Vardon A, Cousins A, Tubb V, Perry T, Noyvert B, Beggs A, Ng M, Halsey C, Kearns P, Cheng P, Mussai F.

Int J Cancer. 2018 Apr 1;142(7):1490-1502. doi: 10.1002/ijc.31170. Epub 2017 Dec 26.


Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme.

Rasmussen K, Rauscher H, Mech A, Riego Sintes J, Gilliland D, González M, Kearns P, Moss K, Visser M, Groenewold M, Bleeker EAJ.

Regul Toxicol Pharmacol. 2018 Feb;92:8-28. doi: 10.1016/j.yrtph.2017.10.019. Epub 2017 Oct 23. Review.


Lineage overwhelms environmental conditions in determining rhizosphere bacterial community structure in a cosmopolitan invasive plant.

Bowen JL, Kearns PJ, Byrnes JEK, Wigginton S, Allen WJ, Greenwood M, Tran K, Yu J, Cronin JT, Meyerson LA.

Nat Commun. 2017 Sep 5;8(1):433. doi: 10.1038/s41467-017-00626-0.


Orphan Drug Regulation: A missed opportunity for children and adolescents with cancer.

Vassal G, Kearns P, Blanc P, Scobie N, Heenen D, Pearson A.

Eur J Cancer. 2017 Oct;84:149-158. doi: 10.1016/j.ejca.2017.07.021. Epub 2017 Sep 4.


From class waivers to precision medicine in paediatric oncology.

Pearson ADJ, Pfister SM, Baruchel A, Bourquin JP, Casanova M, Chesler L, Doz F, Eggert A, Geoerger B, Jones DTW, Kearns PR, Molenaar JJ, Morland B, Schleiermacher G, Schulte JH, Vormoor J, Marshall LV, Zwaan CM, Vassal G; Executive and Biology Committees of the Innovative Therapies for Children with Cancer European Consortium.

Lancet Oncol. 2017 Jul;18(7):e394-e404. doi: 10.1016/S1470-2045(17)30442-4. Review.


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