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Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection.

Eshleman EM, Delgado C, Kearney SJ, Friedman RS, Lenz LL.

PLoS Pathog. 2017 May 22;13(5):e1006388. doi: 10.1371/journal.ppat.1006388. eCollection 2017 May.


Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.

Kearney SJ, Delgado C, Eshleman EM, Hill KK, O'Connor BP, Lenz LL.

J Immunol. 2013 Sep 15;191(6):3384-92. doi: 10.4049/jimmunol.1203510. Epub 2013 Aug 9.

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