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Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome.

Tran KV, Tanriverdi K, Aurigemma GP, Lessard D, Sardana M, Parker M, Shaikh A, Gottbrecht M, Milstone Z, Tanriverdi S, Vitseva O, Keaney JF, Kiefe CI, McManus DD, Freedman JE.

J Clin Transl Res. 2019 Jun 8;5(1):33-43. eCollection 2019 Sep 8.


Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis.

Kant S, Craige SM, Chen K, Reif MM, Learnard H, Kelly M, Caliz AD, Tran KV, Ramo K, Peters OM, Freeman M, Davis RJ, Keaney JF Jr.

Nat Commun. 2019 Sep 17;10(1):4223. doi: 10.1038/s41467-019-11982-4.


JNK and cardiometabolic dysfunction.

Craige SM, Chen K, Blanton RM, Keaney JF Jr, Kant S.

Biosci Rep. 2019 Jul 18;39(7). pii: BSR20190267. doi: 10.1042/BSR20190267. Print 2019 Jul 31. Review.


Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue.

Min SY, Learnard H, Kant S, Gealikman O, Rojas-Rodriguez R, DeSouza T, Desai A, Keaney JF Jr, Corvera S, Craige SM.

Int J Mol Sci. 2019 Apr 25;20(8). pii: E2046. doi: 10.3390/ijms20082046.


Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study.

Münzel T, Hahad O, Gori T, Hollmann S, Arnold N, Prochaska JH, Schulz A, Beutel M, Pfeiffer N, Schmidtmann I, Lackner KJ, Keaney JF Jr, Wild PS.

Clin Res Cardiol. 2019 Apr 5. doi: 10.1007/s00392-019-01466-2. [Epub ahead of print]


Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study.

Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF Jr, Vasan RS, Benjamin EJ, Mittleman MA.

Environ Res. 2019 Apr;171:36-43. doi: 10.1016/j.envres.2018.10.027. Epub 2018 Oct 28.


Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction.

Kröller-Schön S, Jansen T, Tran TLP, Kvandová M, Kalinovic S, Oelze M, Keaney JF Jr, Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E.

Basic Res Cardiol. 2019 Jan 14;114(2):8. doi: 10.1007/s00395-019-0717-2.


Mitral Valve Repair Versus Replacement in Elderly With Degenerative Disease: Analysis of the STS Adult Cardiac Surgery Database.

Hendrix RJ, Bello RA, Flahive JM, Kakouros N, Aurigemma GP, Keaney JF, Hoffman W, Vassileva CM.

Ann Thorac Surg. 2019 Mar;107(3):747-753. doi: 10.1016/j.athoracsur.2018.09.018. Epub 2018 Oct 26.


VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease.

Keaney JF Jr, Rosen CJ.

N Engl J Med. 2019 Jan 3;380(1):91-93. doi: 10.1056/NEJMe1814933. Epub 2018 Nov 10. No abstract available.


α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction.

Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandová M, Kalinovic S, Lagrange J, Keaney JF Jr, Münzel T, Wenzel P, Schulz E.

Cardiovasc Res. 2018 Dec 1;114(14):1883-1893. doi: 10.1093/cvr/cvy172.


Hdac3 regulates lymphovenous and lymphatic valve formation.

Janardhan HP, Milstone ZJ, Shin M, Lawson ND, Keaney JF Jr, Trivedi CM.

J Clin Invest. 2017 Nov 1;127(11):4193-4206. doi: 10.1172/JCI92852. Epub 2017 Oct 16.


Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy.

Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF Jr, Zile MR, Aurigemma GP.

Front Cardiovasc Med. 2017 Aug 3;4:49. doi: 10.3389/fcvm.2017.00049. eCollection 2017.


Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study.

Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF Jr, Vasan RS, Benjamin EJ, Mittleman MA.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1793-1800. doi: 10.1161/ATVBAHA.117.309799. Epub 2017 Jul 27.


Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study.

Zachariah JP, Quiroz R, Nelson KP, Teng Z, Keaney JF Jr, Sullivan LM, Vasan RS.

J Am Heart Assoc. 2017 Jul 16;6(7). pii: e004974. doi: 10.1161/JAHA.116.004974.


Association of Parental Obesity and Diabetes Mellitus With Circulating Adipokines in Nonobese Nondiabetic Offspring.

Zachariah JP, Quiroz R, Enserro D, Andersson C, Keaney JF Jr, Sullivan LM, Vasan RS.

J Am Heart Assoc. 2017 Jul 16;6(7). pii: e004973. doi: 10.1161/JAHA.116.004973.


CHIP-ping Away at Atherosclerosis.

Keaney JF Jr.

N Engl J Med. 2017 Jul 13;377(2):184-185. doi: 10.1056/NEJMe1706173. Epub 2017 Jun 21. No abstract available.


Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression.

Nam M, Akie TE, Sanosaka M, Craige SM, Kant S, Keaney JF Jr, Cooper MP.

Sci Rep. 2017 May 17;7(1):2013. doi: 10.1038/s41598-017-01879-x.


PGC-1α dictates endothelial function through regulation of eNOS expression.

Craige SM, Kröller-Schön S, Li C, Kant S, Cai S, Chen K, Contractor MM, Pei Y, Schulz E, Keaney JF Jr.

Sci Rep. 2016 Dec 2;6:38210. doi: 10.1038/srep38210.


Common Statistical Pitfalls in Basic Science Research.

Sullivan LM, Weinberg J, Keaney JF Jr.

J Am Heart Assoc. 2016 Sep 29;5(10). pii: e004142. Review. No abstract available.


Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.

Ramo K, Sugamura K, Craige S, Keaney JF, Davis RJ.

Elife. 2016 Aug 9;5. pii: e18414. doi: 10.7554/eLife.18414.


Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation.

Lee JJ, Britton KA, Pedley A, Massaro JM, Speliotes EK, Murabito JM, Hoffmann U, Ingram C, Keaney JF Jr, Vasan RS, Fox CS.

J Am Heart Assoc. 2016 May 4;5(5). pii: e002936. doi: 10.1161/JAHA.115.002936.


Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study.

Li W, Wilker EH, Dorans KS, Rice MB, Schwartz J, Coull BA, Koutrakis P, Gold DR, Keaney JF Jr, Lin H, Vasan RS, Benjamin EJ, Mittleman MA.

J Am Heart Assoc. 2016 Apr 28;5(5). pii: e002742. doi: 10.1161/JAHA.115.002742.


The molecular basis of the genesis of basal tone in internal anal sphincter.

Zhang CH, Wang P, Liu DH, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Lu P, Zheng K, Craige SM, Lifshitz LM, Keaney JF Jr, Fogarty KE, ZhuGe R, Zhu MS.

Nat Commun. 2016 Apr 22;7:11358. doi: 10.1038/ncomms11358.


Postmenopausal Hormone Therapy and Atherosclerosis--Time Is of the Essence.

Keaney JF Jr, Solomon CG.

N Engl J Med. 2016 Mar 31;374(13):1279-80. doi: 10.1056/NEJMe1602846. No abstract available.


Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling.

Li C, Reif MM, Craige SM, Kant S, Keaney JF Jr.

Nitric Oxide. 2016 May 1;55-56:45-53. doi: 10.1016/j.niox.2016.03.003. Epub 2016 Mar 14.


Cross-Sectional Associations of Computed Tomography (CT)-Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study.

Lee JJ, Pedley A, Hoffmann U, Massaro JM, Keaney JF Jr, Vasan RS, Fox CS.

J Am Heart Assoc. 2016 Feb 29;5(3):e002545. doi: 10.1161/JAHA.115.002545.


Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.

Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF 3rd, Klei L, Mandell JD, Moreno-De-Luca D, Poultney CS, Robinson EB, Smith L, Solli-Nowlan T, Su MY, Teran NA, Walker MF, Werling DM, Beaudet AL, Cantor RM, Fombonne E, Geschwind DH, Grice DE, Lord C, Lowe JK, Mane SM, Martin DM, Morrow EM, Talkowski ME, Sutcliffe JS, Walsh CA, Yu TW; Autism Sequencing Consortium, Ledbetter DH, Martin CL, Cook EH, Buxbaum JD, Daly MJ, Devlin B, Roeder K, State MW.

Neuron. 2015 Sep 23;87(6):1215-1233. doi: 10.1016/j.neuron.2015.09.016.


Creating and Maintaining a Successful Service Line in an Academic Medical Center at the Dawn of Value-Based Care: Lessons Learned From the Heart and Vascular Service Line at UMass Memorial Health Care.

Phillips RA, Cyr J, Keaney JF Jr, Messina LM, Meyer TE, Tam SK, Korenda K, Darrigo M, Kumar P, Challapalli S.

Acad Med. 2015 Oct;90(10):1340-6. doi: 10.1097/ACM.0000000000000839.


Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions.

Craige SM, Kant S, Reif M, Chen K, Pei Y, Angoff R, Sugamura K, Fitzgibbons T, Keaney JF Jr.

Free Radic Biol Med. 2015 Dec;89:1-7. doi: 10.1016/j.freeradbiomed.2015.07.004. Epub 2015 Jul 10.


Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.

Münzel T, Gori T, Keaney JF Jr, Maack C, Daiber A.

Eur Heart J. 2015 Oct 7;36(38):2555-64. doi: 10.1093/eurheartj/ehv305. Epub 2015 Jul 4. Review.


Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT.

Jarcho JA, Keaney JF Jr.

N Engl J Med. 2015 Jun 18;372(25):2448-50. doi: 10.1056/NEJMe1507041. Epub 2015 Jun 3. No abstract available.


Reactive oxygen species in endothelial function - from disease to adaptation - .

Craige SM, Kant S, Keaney JF Jr.

Circ J. 2015;79(6):1145-55. doi: 10.1253/circj.CJ-15-0464. Epub 2015 May 18. Review.


Balancing the risks and benefits of dual platelet inhibition.

Keaney JF Jr.

N Engl J Med. 2015 May 7;372(19):1854-6. doi: 10.1056/NEJMe1502137. Epub 2015 Mar 14. No abstract available.


Joseph A. Vita, MD, 1956-2014.

Keaney JF, Loscalzo J.

J Am Heart Assoc. 2015 Jan 26;4(1):e001778. doi: 10.1161/JAHA.115.001778. No abstract available.


Joseph A. Vita, MD, 1956-2014.

Keaney JF Jr, Loscalzo J.

Circulation. 2015 Jan 27;131(4):432-3. doi: 10.1161/CIRCULATIONAHA.114.014964. No abstract available.


De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder.

Dong S, Walker MF, Carriero NJ, DiCola M, Willsey AJ, Ye AY, Waqar Z, Gonzalez LE, Overton JD, Frahm S, Keaney JF 3rd, Teran NA, Dea J, Mandell JD, Hus Bal V, Sullivan CA, DiLullo NM, Khalil RO, Gockley J, Yuksel Z, Sertel SM, Ercan-Sencicek AG, Gupta AR, Mane SM, Sheldon M, Brooks AI, Roeder K, Devlin B, State MW, Wei L, Sanders SJ.

Cell Rep. 2014 Oct 9;9(1):16-23. doi: 10.1016/j.celrep.2014.08.068. Epub 2014 Oct 2.


Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).

McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF Jr, Donahue JK, Benjamin EJ, Freedman JE.

Heart Rhythm. 2015 Jan;12(1):3-10. doi: 10.1016/j.hrthm.2014.09.050. Epub 2014 Oct 9.


The new cholesterol treatment guidelines.

Keaney JF Jr, Curfman GD, Jarcho JA.

N Engl J Med. 2014 May 15;370(20):1957. doi: 10.1056/NEJMc1403438. No abstract available.


Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes.

Cheng S, Enserro D, Xanthakis V, Sullivan LM, Murabito JM, Benjamin EJ, Polak JF, O'Donnell CJ, Wolf PA, O'Connor GT, Keaney JF, Vasan RS.

Eur Heart J. 2014 Nov 7;35(42):2980-7. doi: 10.1093/eurheartj/ehu052. Epub 2014 Feb 25.


Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction.

Ward JA, Esa N, Pidikiti R, Freedman JE, Keaney JF, Tanriverdi K, Vitseva O, Ambros V, Lee R, McManus DD.

Fam Med Med Sci Res. 2013 Oct 1;2(2):108.


Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.

Liu L, Nam M, Fan W, Akie TE, Hoaglin DC, Gao G, Keaney JF Jr, Cooper MP.

J Clin Invest. 2014 Feb;124(2):768-84. doi: 10.1172/JCI69413. Epub 2014 Jan 16.


A pragmatic view of the new cholesterol treatment guidelines.

Keaney JF Jr, Curfman GD, Jarcho JA.

N Engl J Med. 2014 Jan 16;370(3):275-8. doi: 10.1056/NEJMms1314569. Epub 2013 Nov 27. No abstract available.


Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study.

Hong SN, Gona P, Fontes JD, Oyama N, Chan RH, Kenchaiah S, Tsao CW, Yeon SB, Schnabel RB, Keaney JF, O'Donnell CJ, Benjamin EJ, Manning WJ.

J Am Heart Assoc. 2013 Nov 15;2(6):e000307. doi: 10.1161/JAHA.113.000307.


P2Y12 inhibition in patients with NSTEMI--can later be better?

Keaney JF Jr.

N Engl J Med. 2013 Sep 12;369(11):1056-7. doi: 10.1056/NEJMe1308820. Epub 2013 Sep 1. No abstract available.


Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk.

McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF Jr, Benjamin EJ, Freedman JE.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2666-73. doi: 10.1161/ATVBAHA.112.301112. Epub 2013 Aug 22.


Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics.

Shimasaki Y, Pan N, Messina LM, Li C, Chen K, Liu L, Cooper MP, Vita JA, Keaney JF Jr.

Circ Res. 2013 Sep 13;113(7):891-901. doi: 10.1161/CIRCRESAHA.113.301319. Epub 2013 Jul 2.


Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community.

Schnabel RB, Yin X, Larson MG, Yamamoto JF, Fontes JD, Kathiresan S, Rong J, Levy D, Keaney JF Jr, Wang TJ, Murabito JM, Vasan RS, Benjamin EJ.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1728-33. doi: 10.1161/ATVBAHA.112.301174. Epub 2013 May 2.


Vascular inflammation and sleep disordered breathing in a community-based cohort.

Chami HA, Fontes JD, Vasan RS, Keaney JF Jr, O'Connor GT, Larson MG, Benjamin EJ, Gottlieb DJ.

Sleep. 2013 May 1;36(5):763-768C. doi: 10.5665/sleep.2644.


Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study.

Fontes JD, Yamamoto JF, Larson MG, Wang N, Dallmeier D, Rienstra M, Schnabel RB, Vasan RS, Keaney JF Jr, Benjamin EJ.

Atherosclerosis. 2013 May;228(1):217-23. doi: 10.1016/j.atherosclerosis.2013.01.019. Epub 2013 Feb 4.


Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease.

Chen K, Keaney JF Jr.

Curr Atheroscler Rep. 2012 Oct;14(5):476-83. doi: 10.1007/s11883-012-0266-8. Review.

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