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Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease.

Keaney J, Gasser J, Gillet G, Scholz D, Kadiu I.

J Neuroimmune Pharmacol. 2019 Feb 13. doi: 10.1007/s11481-019-09839-0. [Epub ahead of print]


Age-related changes in eye morphology and aqueous humor dynamics in DBA/2J mice using contrast-enhanced ocular MRI.

Crosbie DE, Keaney J, Tam LCS, Daniel Stamer W, Campbell M, Humphries P.

Magn Reson Imaging. 2019 Jan 17. pii: S0730-725X(18)30501-0. doi: 10.1016/j.mri.2019.01.016. [Epub ahead of print]


Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study.

Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF Jr, Vasan RS, Benjamin EJ, Mittleman MA.

Environ Res. 2018 Oct 28;171:36-43. doi: 10.1016/j.envres.2018.10.027. [Epub ahead of print]


Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction.

Kröller-Schön S, Jansen T, Tran TLP, Kvandová M, Kalinovic S, Oelze M, Keaney JF Jr, Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E.

Basic Res Cardiol. 2019 Jan 14;114(2):8. doi: 10.1007/s00395-019-0717-2.


Mitral Valve Repair Versus Replacement in Elderly With Degenerative Disease: Analysis of the STS Adult Cardiac Surgery Database.

Hendrix RJ, Bello RA, Flahive JM, Kakouros N, Aurigemma GP, Keaney JF, Hoffman W, Vassileva CM.

Ann Thorac Surg. 2018 Oct 26. pii: S0003-4975(18)31533-9. doi: 10.1016/j.athoracsur.2018.09.018. [Epub ahead of print]


VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease.

Keaney JF Jr, Rosen CJ.

N Engl J Med. 2019 Jan 3;380(1):91-93. doi: 10.1056/NEJMe1814933. Epub 2018 Nov 10. No abstract available.


Neuropolypathology as a result of severe traumatic brain injury?

Doherty CP, O'Keeffe E, Keaney J, Lawlor B, Coen RF, Farrell M, Campbell M.

Clin Neuropathol. 2019 Jan/Feb;38(1):14-22. doi: 10.5414/NP301131.


A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.

Srivastava PK, van Eyll J, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, Gressens P, Danis B, Vandenplas C, Foerch P, Leclercq K, Mairet-Coello G, Cardenas A, Vanclef F, Laaniste L, Niespodziany I, Keaney J, Gasser J, Gillet G, Shkura K, Chong SA, Behmoaras J, Kadiu I, Petretto E, Kaminski RM, Johnson MR.

Nat Commun. 2018 Sep 3;9(1):3561. doi: 10.1038/s41467-018-06008-4.


α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction.

Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandová M, Kalinovic S, Lagrange J, Keaney JF Jr, Münzel T, Wenzel P, Schulz E.

Cardiovasc Res. 2018 Dec 1;114(14):1883-1893. doi: 10.1093/cvr/cvy172.


First experience with zero-fluoroscopic ablation for supraventricular tachycardias using a novel impedance and magnetic-field-based mapping system.

Walsh KA, Galvin J, Keaney J, Keelan E, Szeplaki G.

Clin Res Cardiol. 2018 Jul;107(7):578-585. doi: 10.1007/s00392-018-1220-8. Epub 2018 Feb 23.


Evaluation of the Tp-Te Interval, QTc and P-Wave Dispersion in Patients With Coronary Artery Ectasia.

Conlon R, Tanner R, David S, Szeplaki G, Galvin J, Keaney J, Keelan E, Boles U.

Cardiol Res. 2017 Dec;8(6):280-285. doi: 10.14740/cr631w. Epub 2017 Dec 22.


Automated ultra-high-density mapping of peri-sinus node premature atrial contractions.

Walsh KA, Galvin J, Keaney J, Keelan E, Szeplaki G.

Clin Res Cardiol. 2018 Apr;107(4):368-370. doi: 10.1007/s00392-017-1191-1. Epub 2017 Dec 8. No abstract available.


Hdac3 regulates lymphovenous and lymphatic valve formation.

Janardhan HP, Milstone ZJ, Shin M, Lawson ND, Keaney JF Jr, Trivedi CM.

J Clin Invest. 2017 Nov 1;127(11):4193-4206. doi: 10.1172/JCI92852. Epub 2017 Oct 16.


Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy.

Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF Jr, Zile MR, Aurigemma GP.

Front Cardiovasc Med. 2017 Aug 3;4:49. doi: 10.3389/fcvm.2017.00049. eCollection 2017.


Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study.

Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF Jr, Vasan RS, Benjamin EJ, Mittleman MA.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1793-1800. doi: 10.1161/ATVBAHA.117.309799. Epub 2017 Jul 27.


Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study.

Zachariah JP, Quiroz R, Nelson KP, Teng Z, Keaney JF Jr, Sullivan LM, Vasan RS.

J Am Heart Assoc. 2017 Jul 16;6(7). pii: e004974. doi: 10.1161/JAHA.116.004974.


Association of Parental Obesity and Diabetes Mellitus With Circulating Adipokines in Nonobese Nondiabetic Offspring.

Zachariah JP, Quiroz R, Enserro D, Andersson C, Keaney JF Jr, Sullivan LM, Vasan RS.

J Am Heart Assoc. 2017 Jul 16;6(7). pii: e004973. doi: 10.1161/JAHA.116.004973.


CHIP-ping Away at Atherosclerosis.

Keaney JF Jr.

N Engl J Med. 2017 Jul 13;377(2):184-185. doi: 10.1056/NEJMe1706173. Epub 2017 Jun 21. No abstract available.


Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression.

Nam M, Akie TE, Sanosaka M, Craige SM, Kant S, Keaney JF Jr, Cooper MP.

Sci Rep. 2017 May 17;7(1):2013. doi: 10.1038/s41598-017-01879-x.


Isolation of the superior vena cava to block unidirectional exit conduction from the right-sided pulmonary veins during atrial fibrillation ablation.

Szeplaki G, Keaney J, Keelan E, Valentine J, Galvin J.

J Interv Card Electrophysiol. 2017 Aug;49(2):127-128. doi: 10.1007/s10840-017-0251-9. Epub 2017 Apr 8. No abstract available.


PGC-1α dictates endothelial function through regulation of eNOS expression.

Craige SM, Kröller-Schön S, Li C, Kant S, Cai S, Chen K, Contractor MM, Pei Y, Schulz E, Keaney JF Jr.

Sci Rep. 2016 Dec 2;6:38210. doi: 10.1038/srep38210.


Common Statistical Pitfalls in Basic Science Research.

Sullivan LM, Weinberg J, Keaney JF Jr.

J Am Heart Assoc. 2016 Sep 29;5(10). pii: e004142. Review. No abstract available.


Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.

Ramo K, Sugamura K, Craige S, Keaney JF, Davis RJ.

Elife. 2016 Aug 9;5. pii: e18414. doi: 10.7554/eLife.18414.


Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy.

Doherty CP, O'Keefe E, Wallace E, Loftus T, Keaney J, Kealy J, Humphries MM, Molloy MG, Meaney JF, Farrell M, Campbell M.

J Neuropathol Exp Neurol. 2016 Jul;75(7):656-62. doi: 10.1093/jnen/nlw036. Epub 2016 May 31.


Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation.

Lee JJ, Britton KA, Pedley A, Massaro JM, Speliotes EK, Murabito JM, Hoffmann U, Ingram C, Keaney JF Jr, Vasan RS, Fox CS.

J Am Heart Assoc. 2016 May 4;5(5). pii: e002936. doi: 10.1161/JAHA.115.002936.


Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study.

Li W, Wilker EH, Dorans KS, Rice MB, Schwartz J, Coull BA, Koutrakis P, Gold DR, Keaney JF Jr, Lin H, Vasan RS, Benjamin EJ, Mittleman MA.

J Am Heart Assoc. 2016 Apr 28;5(5). pii: e002742. doi: 10.1161/JAHA.115.002742.


The molecular basis of the genesis of basal tone in internal anal sphincter.

Zhang CH, Wang P, Liu DH, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Lu P, Zheng K, Craige SM, Lifshitz LM, Keaney JF Jr, Fogarty KE, ZhuGe R, Zhu MS.

Nat Commun. 2016 Apr 22;7:11358. doi: 10.1038/ncomms11358.


Postmenopausal Hormone Therapy and Atherosclerosis--Time Is of the Essence.

Keaney JF Jr, Solomon CG.

N Engl J Med. 2016 Mar 31;374(13):1279-80. doi: 10.1056/NEJMe1602846. No abstract available.


Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling.

Li C, Reif MM, Craige SM, Kant S, Keaney JF Jr.

Nitric Oxide. 2016 May 1;55-56:45-53. doi: 10.1016/j.niox.2016.03.003. Epub 2016 Mar 14.


Cross-Sectional Associations of Computed Tomography (CT)-Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study.

Lee JJ, Pedley A, Hoffmann U, Massaro JM, Keaney JF Jr, Vasan RS, Fox CS.

J Am Heart Assoc. 2016 Feb 29;5(3):e002545. doi: 10.1161/JAHA.115.002545.


A Simple and Portable Algorithm for Identifying Atrial Fibrillation in the Electronic Medical Record.

Khurshid S, Keaney J, Ellinor PT, Lubitz SA.

Am J Cardiol. 2016 Jan 15;117(2):221-5. doi: 10.1016/j.amjcard.2015.10.031. Epub 2015 Nov 6.


Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier.

Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M.

Sci Adv. 2015 Sep 4;1(8):e1500472.


Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.

Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF 3rd, Klei L, Mandell JD, Moreno-De-Luca D, Poultney CS, Robinson EB, Smith L, Solli-Nowlan T, Su MY, Teran NA, Walker MF, Werling DM, Beaudet AL, Cantor RM, Fombonne E, Geschwind DH, Grice DE, Lord C, Lowe JK, Mane SM, Martin DM, Morrow EM, Talkowski ME, Sutcliffe JS, Walsh CA, Yu TW; Autism Sequencing Consortium, Ledbetter DH, Martin CL, Cook EH, Buxbaum JD, Daly MJ, Devlin B, Roeder K, State MW.

Neuron. 2015 Sep 23;87(6):1215-1233. doi: 10.1016/j.neuron.2015.09.016.


The dynamic blood-brain barrier.

Keaney J, Campbell M.

FEBS J. 2015 Nov;282(21):4067-79. doi: 10.1111/febs.13412. Epub 2015 Sep 8. Review.


Creating and Maintaining a Successful Service Line in an Academic Medical Center at the Dawn of Value-Based Care: Lessons Learned From the Heart and Vascular Service Line at UMass Memorial Health Care.

Phillips RA, Cyr J, Keaney JF Jr, Messina LM, Meyer TE, Tam SK, Korenda K, Darrigo M, Kumar P, Challapalli S.

Acad Med. 2015 Oct;90(10):1340-6. doi: 10.1097/ACM.0000000000000839.


Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions.

Craige SM, Kant S, Reif M, Chen K, Pei Y, Angoff R, Sugamura K, Fitzgibbons T, Keaney JF Jr.

Free Radic Biol Med. 2015 Dec;89:1-7. doi: 10.1016/j.freeradbiomed.2015.07.004. Epub 2015 Jul 10.


Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.

Münzel T, Gori T, Keaney JF Jr, Maack C, Daiber A.

Eur Heart J. 2015 Oct 7;36(38):2555-64. doi: 10.1093/eurheartj/ehv305. Epub 2015 Jul 4. Review.


Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT.

Jarcho JA, Keaney JF Jr.

N Engl J Med. 2015 Jun 18;372(25):2448-50. doi: 10.1056/NEJMe1507041. Epub 2015 Jun 3. No abstract available.


Reactive oxygen species in endothelial function - from disease to adaptation - .

Craige SM, Kant S, Keaney JF Jr.

Circ J. 2015;79(6):1145-55. doi: 10.1253/circj.CJ-15-0464. Epub 2015 May 18. Review.


Urban and rural differences in out-of-hospital cardiac arrest in Ireland.

Masterson S, Wright P, O'Donnell C, Vellinga A, Murphy AW, Hennelly D, Sinnott B, Egan J, O'Reilly M, Keaney J, Bury G, Deasy C.

Resuscitation. 2015 Jun;91:42-7. doi: 10.1016/j.resuscitation.2015.03.012. Epub 2015 Mar 26.


Balancing the risks and benefits of dual platelet inhibition.

Keaney JF Jr.

N Engl J Med. 2015 May 7;372(19):1854-6. doi: 10.1056/NEJMe1502137. Epub 2015 Mar 14. No abstract available.


Joseph A. Vita, MD, 1956-2014.

Keaney JF, Loscalzo J.

J Am Heart Assoc. 2015 Jan 26;4(1):e001778. doi: 10.1161/JAHA.115.001778. No abstract available.


Joseph A. Vita, MD, 1956-2014.

Keaney JF Jr, Loscalzo J.

Circulation. 2015 Jan 27;131(4):432-3. doi: 10.1161/CIRCULATIONAHA.114.014964. No abstract available.


No evidence for association of autism with rare heterozygous point mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins.

Murdoch JD, Gupta AR, Sanders SJ, Walker MF, Keaney J, Fernandez TV, Murtha MT, Anyanwu S, Ober GT, Raubeson MJ, DiLullo NM, Villa N, Waqar Z, Sullivan C, Gonzalez L, Willsey AJ, Choe SY, Neale BM, Daly MJ, State MW.

PLoS Genet. 2015 Jan 26;11(1):e1004852. doi: 10.1371/journal.pgen.1004852. eCollection 2015 Jan.


Increased perforation risk with an MRI-conditional pacing lead: a single-center study.

Acha MR, Keaney JJ, Lubitz SA, Milan DJ, Mansour M, Heist KE, Ptaszek LM, Singh JP, Blendea D, Mela T.

Pacing Clin Electrophysiol. 2015 Mar;38(3):334-42. doi: 10.1111/pace.12550. Epub 2014 Dec 2.


De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder.

Dong S, Walker MF, Carriero NJ, DiCola M, Willsey AJ, Ye AY, Waqar Z, Gonzalez LE, Overton JD, Frahm S, Keaney JF 3rd, Teran NA, Dea J, Mandell JD, Hus Bal V, Sullivan CA, DiLullo NM, Khalil RO, Gockley J, Yuksel Z, Sertel SM, Ercan-Sencicek AG, Gupta AR, Mane SM, Sheldon M, Brooks AI, Roeder K, Devlin B, State MW, Wei L, Sanders SJ.

Cell Rep. 2014 Oct 9;9(1):16-23. doi: 10.1016/j.celrep.2014.08.068. Epub 2014 Oct 2.


Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).

McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF Jr, Donahue JK, Benjamin EJ, Freedman JE.

Heart Rhythm. 2015 Jan;12(1):3-10. doi: 10.1016/j.hrthm.2014.09.050. Epub 2014 Oct 9.


The new cholesterol treatment guidelines.

Keaney JF Jr, Curfman GD, Jarcho JA.

N Engl J Med. 2014 May 15;370(20):1957. doi: 10.1056/NEJMc1403438. No abstract available.


IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.

Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M.

Sci Transl Med. 2014 Apr 2;6(230):230ra44. doi: 10.1126/scitranslmed.3007616.


Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes.

Cheng S, Enserro D, Xanthakis V, Sullivan LM, Murabito JM, Benjamin EJ, Polak JF, O'Donnell CJ, Wolf PA, O'Connor GT, Keaney JF, Vasan RS.

Eur Heart J. 2014 Nov 7;35(42):2980-7. doi: 10.1093/eurheartj/ehu052. Epub 2014 Feb 25.

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