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Items: 1 to 50 of 75

1.

Caspase-1 Inhibition Attenuates Hyperoxia-induced Lung and Brain Injury in Neonatal Mice.

Dapaah-Siakwan F, Zambrano R, Luo S, Duncan MR, Kerr N, Donda K, Vaccari JPR, Keane RW, Dietrich WD, Benny M, Young K, Wu S.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):341-354. doi: 10.1165/rcmb.2018-0192OC.

PMID:
30897338
2.

The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury.

Lee SW, de Rivero Vaccari JP, Truettner JS, Dietrich WD, Keane RW.

J Neuroinflammation. 2019 Feb 8;16(1):27. doi: 10.1186/s12974-019-1423-6.

3.

Human Lung Cell Pyroptosis Following Traumatic Brain Injury.

Kerr NA, de Rivero Vaccari JP, Umland O, Bullock MR, Conner GE, Dietrich WD, Keane RW.

Cells. 2019 Jan 18;8(1). pii: E69. doi: 10.3390/cells8010069.

4.

Inflammasome proteins as biomarkers of traumatic brain injury.

Kerr N, Lee SW, Perez-Barcena J, Crespi C, Ibañez J, Bullock MR, Dietrich WD, Keane RW, de Rivero Vaccari JP.

PLoS One. 2018 Dec 31;13(12):e0210128. doi: 10.1371/journal.pone.0210128. eCollection 2018.

5.

Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke.

Kerr N, García-Contreras M, Abbassi S, Mejias NH, Desousa BR, Ricordi C, Dietrich WD, Keane RW, de Rivero Vaccari JP.

Front Mol Neurosci. 2018 Sep 4;11:309. doi: 10.3389/fnmol.2018.00309. eCollection 2018.

6.

Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response.

Syed SA, Beurel E, Loewenstein DA, Lowell JA, Craighead WE, Dunlop BW, Mayberg HS, Dhabhar F, Dietrich WD, Keane RW, de Rivero Vaccari JP, Nemeroff CB.

Neuron. 2018 Sep 5;99(5):914-924.e3. doi: 10.1016/j.neuron.2018.08.001. Epub 2018 Aug 23.

7.

Traumatic Brain Injury-Induced Acute Lung Injury: Evidence for Activation and Inhibition of a Neural-Respiratory-Inflammasome Axis.

Kerr NA, de Rivero Vaccari JP, Abbassi S, Kaur H, Zambrano R, Wu S, Dietrich WD, Keane RW.

J Neurotrauma. 2018 Sep 1;35(17):2067-2076. doi: 10.1089/neu.2017.5430. Epub 2018 Jun 8.

8.

Inflammasome Proteins As Biomarkers of Multiple Sclerosis.

Keane RW, Dietrich WD, de Rivero Vaccari JP.

Front Neurol. 2018 Mar 19;9:135. doi: 10.3389/fneur.2018.00135. eCollection 2018.

9.

Microglial Inflammasome Activation in Penetrating Ballistic-Like Brain Injury.

Lee SW, Gajavelli S, Spurlock MS, Andreoni C, de Rivero Vaccari JP, Bullock MR, Keane RW, Dietrich WD.

J Neurotrauma. 2018 Jul 15;35(14):1681-1693. doi: 10.1089/neu.2017.5530. Epub 2018 Apr 2.

10.

Inhibition of Rac1 Signaling Downregulates Inflammasome Activation and Attenuates Lung Injury in Neonatal Rats Exposed to Hyperoxia.

Hummler JK, Dapaah-Siakwan F, Vaidya R, Zambrano R, Luo S, Chen S, Kerr N, de Rivero Vaccari JP, Keane RW, Dietrich WD, Bancalari E, Young KC, Wu S.

Neonatology. 2017;111(3):280-288. doi: 10.1159/000450918. Epub 2016 Dec 24.

PMID:
28013306
11.

Myeloid cell transmigration across the CNS vasculature triggers IL-1β-driven neuroinflammation during autoimmune encephalomyelitis in mice.

Lévesque SA, Paré A, Mailhot B, Bellver-Landete V, Kébir H, Lécuyer MA, Alvarez JI, Prat A, de Rivero Vaccari JP, Keane RW, Lacroix S.

J Exp Med. 2016 May 30;213(6):929-49. doi: 10.1084/jem.20151437. Epub 2016 May 2.

12.

Therapeutics targeting the inflammasome after central nervous system injury.

de Rivero Vaccari JP, Dietrich WD, Keane RW.

Transl Res. 2016 Jan;167(1):35-45. doi: 10.1016/j.trsl.2015.05.003. Epub 2015 May 12. Review.

13.

Exosome-mediated inflammasome signaling after central nervous system injury.

de Rivero Vaccari JP, Brand F 3rd, Adamczak S, Lee SW, Perez-Barcena J, Wang MY, Bullock MR, Dietrich WD, Keane RW.

J Neurochem. 2016 Jan;136 Suppl 1:39-48. doi: 10.1111/jnc.13036. Epub 2015 Mar 1.

14.

Neutralization of ASC improves sperm motility in men with spinal cord injury.

Ibrahim E, Castle SM, Aballa TC, Keane RW, de Rivero Vaccari JP, Lynne CM, Brackett NL.

Hum Reprod. 2014 Nov;29(11):2368-73. doi: 10.1093/humrep/deu230. Epub 2014 Sep 8.

PMID:
25205754
15.

Pattern recognition receptors and central nervous system repair.

Kigerl KA, de Rivero Vaccari JP, Dietrich WD, Popovich PG, Keane RW.

Exp Neurol. 2014 Aug;258:5-16. doi: 10.1016/j.expneurol.2014.01.001. Review.

16.

The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis.

Dumas A, Amiable N, de Rivero Vaccari JP, Chae JJ, Keane RW, Lacroix S, Vallières L.

PLoS Pathog. 2014 May 29;10(5):e1004150. doi: 10.1371/journal.ppat.1004150. eCollection 2014 May.

17.

ATP and potassium ions: a deadly combination for astrocytes.

Jackson DG, Wang J, Keane RW, Scemes E, Dahl G.

Sci Rep. 2014 Apr 3;4:4576. doi: 10.1038/srep04576.

18.

RIG-1 receptor expression in the pathology of Alzheimer's disease.

de Rivero Vaccari JP, Brand FJ 3rd, Sedaghat C, Mash DC, Dietrich WD, Keane RW.

J Neuroinflammation. 2014 Apr 2;11:67. doi: 10.1186/1742-2094-11-67.

19.

Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury.

de Rivero Vaccari JP, Dietrich WD, Keane RW.

J Cereb Blood Flow Metab. 2014 Mar;34(3):369-75. doi: 10.1038/jcbfm.2013.227. Epub 2014 Jan 8. Review.

20.

Pyroptotic neuronal cell death mediated by the AIM2 inflammasome.

Adamczak SE, de Rivero Vaccari JP, Dale G, Brand FJ 3rd, Nonner D, Bullock MR, Dahl GP, Dietrich WD, Keane RW.

J Cereb Blood Flow Metab. 2014 Apr;34(4):621-9. doi: 10.1038/jcbfm.2013.236. Epub 2014 Jan 8. Erratum in: J Cereb Blood Flow Metab. 2016 Feb;36(2):456.

21.

Deep tissue injury in development of pressure ulcers: a decrease of inflammasome activation and changes in human skin morphology in response to aging and mechanical load.

Stojadinovic O, Minkiewicz J, Sawaya A, Bourne JW, Torzilli P, de Rivero Vaccari JP, Dietrich WD, Keane RW, Tomic-Canic M.

PLoS One. 2013 Aug 14;8(8):e69223. doi: 10.1371/journal.pone.0069223. eCollection 2013.

22.

Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse.

Bigford GE, Bracchi-Ricard VC, Keane RW, Nash MS, Bethea JR.

ASN Neuro. 2013 Sep 4;5(4):243-55. doi: 10.1042/AN20130021.

23.

Human astrocytes express a novel NLRP2 inflammasome.

Minkiewicz J, de Rivero Vaccari JP, Keane RW.

Glia. 2013 Jul;61(7):1113-21. doi: 10.1002/glia.22499. Epub 2013 Apr 26.

PMID:
23625868
24.

Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome: clinical article.

Adamczak S, Dale G, de Rivero Vaccari JP, Bullock MR, Dietrich WD, Keane RW.

J Neurosurg. 2012 Dec;117(6):1119-25. doi: 10.3171/2012.9.JNS12815. Epub 2012 Oct 12.

25.

Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury.

Zhang X, Ibrahim E, de Rivero Vaccari JP, Lotocki G, Aballa TC, Dietrich WD, Keane RW, Lynne CM, Brackett NL.

Fertil Steril. 2013 Jan;99(1):118-24. doi: 10.1016/j.fertnstert.2012.09.004. Epub 2012 Oct 3.

PMID:
23040525
26.

Effects of therapeutic hypothermia on inflammasome signaling after traumatic brain injury.

Tomura S, de Rivero Vaccari JP, Keane RW, Bramlett HM, Dietrich WD.

J Cereb Blood Flow Metab. 2012 Oct;32(10):1939-47. doi: 10.1038/jcbfm.2012.99. Epub 2012 Jul 11.

27.

Pannexin: from discovery to bedside in 11±4 years?

Dahl G, Keane RW.

Brain Res. 2012 Dec 3;1487:150-9. doi: 10.1016/j.brainres.2012.04.058. Epub 2012 Jul 4. Review.

28.

Caspase-1 level is higher in the scalp in androgenetic alopecia.

de Rivero Vaccari JP, Sawaya ME, Brand F 3rd, Nusbaum BP, Bauman AJ, Bramlett HM, Dietrich WD, Keane RW.

Dermatol Surg. 2012 Jul;38(7 Pt 1):1033-9. doi: 10.1111/j.1524-4725.2012.02378.x. Epub 2012 Mar 8.

PMID:
22404322
29.

P2X4 receptors influence inflammasome activation after spinal cord injury.

de Rivero Vaccari JP, Bastien D, Yurcisin G, Pineau I, Dietrich WD, De Koninck Y, Keane RW, Lacroix S.

J Neurosci. 2012 Feb 29;32(9):3058-66. doi: 10.1523/JNEUROSCI.4930-11.2012.

30.

5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization.

Bigford GE, Chaudhry NS, Keane RW, Holohean AM.

J Biol Chem. 2012 Mar 30;287(14):11049-59. doi: 10.1074/jbc.M111.277806. Epub 2012 Jan 30.

31.

Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury.

de Rivero Vaccari JP, Minkiewicz J, Wang X, De Rivero Vaccari JC, German R, Marcillo AE, Dietrich WD, Keane RW.

Glia. 2012 Mar;60(3):414-21. doi: 10.1002/glia.22275. Epub 2011 Dec 7.

32.

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats.

Mawhinney LJ, de Rivero Vaccari JP, Dale GA, Keane RW, Bramlett HM.

BMC Neurosci. 2011 Dec 1;12:123. doi: 10.1186/1471-2202-12-123.

33.

In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations.

Daftarian P, Chowdhury R, Ames P, Wei C, King AD, de Rivero Vaccari JP, Dillon L, Price J, Leung H, Ashlock B, Mesri E, Perez V, Züchner S, Reiser J, Lemmon V, Keane RW.

Hybridoma (Larchmt). 2011 Oct;30(5):409-18. doi: 10.1089/hyb.2010.0120.

34.

Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain.

Nadeau S, Filali M, Zhang J, Kerr BJ, Rivest S, Soulet D, Iwakura Y, de Rivero Vaccari JP, Keane RW, Lacroix S.

J Neurosci. 2011 Aug 31;31(35):12533-42. doi: 10.1523/JNEUROSCI.2840-11.2011.

35.

Activation of the nuclear factor E2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury.

Wang X, de Rivero Vaccari JP, Wang H, Diaz P, German R, Marcillo AE, Keane RW.

J Neurotrauma. 2012 Mar 20;29(5):936-45. doi: 10.1089/neu.2011.1922. Epub 2011 Sep 21.

36.

Neuroprotective effects of bone morphogenetic protein 7 (BMP7) treatment after spinal cord injury.

de Rivero Vaccari JP, Marcillo A, Nonner D, Dietrich WD, Keane RW.

Neurosci Lett. 2009 Nov 20;465(3):226-9. doi: 10.1016/j.neulet.2009.09.013. Epub 2009 Sep 17.

PMID:
19765637
37.

Sex differences in XIAP cleavage after traumatic brain injury in the rat.

Bramlett HM, Furones-Alonso O, Lotocki G, Rodriguez-Paez A, Sanchez-Molano J, Keane RW.

Neurosci Lett. 2009 Sep 11;461(1):49-53. doi: 10.1016/j.neulet.2009.05.071. Epub 2009 Jun 9.

38.

The pannexin 1 channel activates the inflammasome in neurons and astrocytes.

Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G.

J Biol Chem. 2009 Jul 3;284(27):18143-51. doi: 10.1074/jbc.M109.004804. Epub 2009 May 5.

39.

Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury.

de Rivero Vaccari JP, Lotocki G, Alonso OF, Bramlett HM, Dietrich WD, Keane RW.

J Cereb Blood Flow Metab. 2009 Jul;29(7):1251-61. doi: 10.1038/jcbfm.2009.46. Epub 2009 Apr 29.

40.

A novel protein complex in membrane rafts linking the NR2B glutamate receptor and autophagy is disrupted following traumatic brain injury.

Bigford GE, Alonso OF, Dietrich D, Keane RW.

J Neurotrauma. 2009 May;26(5):703-20. doi: 10.1089/neu.2008.0783.

41.

Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice.

Abulafia DP, de Rivero Vaccari JP, Lozano JD, Lotocki G, Keane RW, Dietrich WD.

J Cereb Blood Flow Metab. 2009 Mar;29(3):534-44. doi: 10.1038/jcbfm.2008.143. Epub 2008 Dec 10.

PMID:
19066616
42.

A molecular platform in neurons regulates inflammation after spinal cord injury.

de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW.

J Neurosci. 2008 Mar 26;28(13):3404-14. doi: 10.1523/JNEUROSCI.0157-08.2008.

43.

Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.

Wang J, Ma M, Locovei S, Keane RW, Dahl G.

Am J Physiol Cell Physiol. 2007 Sep;293(3):C1112-9. Epub 2007 Jul 25.

44.

FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury.

Davis AR, Lotocki G, Marcillo AE, Dietrich WD, Keane RW.

J Neurotrauma. 2007 May;24(5):823-34.

PMID:
17518537
45.

Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage.

Lotocki G, de Rivero Vaccari JP, Perez ER, Alonso OF, Curbelo K, Keane RW, Dietrich WD.

Eur J Neurosci. 2006 Oct;24(8):2283-90.

PMID:
17074049
46.

Inflammatory and apoptotic signaling after spinal cord injury.

Keane RW, Davis AR, Dietrich WD.

J Neurotrauma. 2006 Mar-Apr;23(3-4):335-44. Review.

PMID:
16629620
47.
48.

Monoubiquitination and cellular distribution of XIAP in neurons after traumatic brain injury.

Lotocki G, Alonso OF, Frydel B, Dietrich WD, Keane RW.

J Cereb Blood Flow Metab. 2003 Oct;23(10):1129-36.

PMID:
14526223
49.

Inhibitors of apoptosis proteins in injury and disease.

Lotocki G, Keane RW.

IUBMB Life. 2002 Nov;54(5):231-40. Review.

50.

Therapeutic strategies targeting caspase inhibition following spinal cord injury in rats.

Ozawa H, Keane RW, Marcillo AE, Diaz PH, Dietrich WD.

Exp Neurol. 2002 Sep;177(1):306-13.

PMID:
12429232

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