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Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model.

Uchida N, Nassehi T, Drysdale CM, Gamer J, Yapundich M, Bonifacino AC, Krouse AE, Linde N, Hsieh MM, Donahue RE, Dunbar CE, Kean LS, Tisdale JF.

Mol Ther. 2019 Sep 4;27(9):1586-1596. doi: 10.1016/j.ymthe.2019.05.022. Epub 2019 Jun 5.


Characterization of natural killer cells expressing markers associated with maturity and cytotoxicity in children and young adults with sickle cell disease.

Abraham AA, Lang H, Meier ER, Nickel RS, Dean M, Lawal N, Speller-Brown B, Wang Y, Kean L, Bollard CM.

Pediatr Blood Cancer. 2019 May;66(5):e27601. doi: 10.1002/pbc.27601. Epub 2019 Jan 4.


Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.

Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS.

Nat Commun. 2018 Oct 25;9(1):4438. doi: 10.1038/s41467-018-06736-7.


CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.

Watkins BK, Tkachev V, Furlan SN, Hunt DJ, Betz K, Yu A, Brown M, Poirier N, Zheng HB, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou JP, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert E, Hamby K, Garrett A, Deane T, Blazar BR, Vanhove B, Kean LS.

J Clin Invest. 2018 Aug 31;128(9):3991-4007. doi: 10.1172/JCI98793. Epub 2018 Aug 13.


Reduced-intensity conditioning for hematopoietic cell transplant for HLH and primary immune deficiencies.

Allen CE, Marsh R, Dawson P, Bollard CM, Shenoy S, Roehrs P, Hanna R, Burroughs L, Kean L, Talano JA, Schultz KR, Pai SY, Baker KS, Andolina JR, Stenger EO, Connelly J, Ramirez A, Bryant C, Eapen M, Pulsipher MA.

Blood. 2018 Sep 27;132(13):1438-1451. doi: 10.1182/blood-2018-01-828277. Epub 2018 Jul 11.


Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice.

Pennell CA, Barnum JL, McDonald-Hyman CS, Panoskaltsis-Mortari A, Riddle MJ, Xiong Z, Loschi M, Thangavelu G, Campbell HM, Storlie MD, Refaeli Y, Furlan SN, Jensen MC, Kean LS, Miller JS, Tolar J, Osborn MJ, Blazar BR.

Mol Ther. 2018 Jun 6;26(6):1423-1434. doi: 10.1016/j.ymthe.2018.04.006. Epub 2018 Apr 7.


Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis.

Kean LS.

Blood. 2018 Jun 14;131(24):2630-2639. doi: 10.1182/blood-2018-02-785881. Epub 2018 May 4. Review.


Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates.

Taraseviciute A, Tkachev V, Ponce R, Turtle CJ, Snyder JM, Liggitt HD, Myerson D, Gonzalez-Cuyar L, Baldessari A, English C, Yu A, Zheng H, Furlan SN, Hunt DJ, Hoglund V, Finney O, Brakke H, Blazar BR, Berger C, Riddell SR, Gardner R, Kean LS, Jensen MC.

Cancer Discov. 2018 Jun;8(6):750-763. doi: 10.1158/2159-8290.CD-17-1368. Epub 2018 Mar 21.


The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future.

Andermann TM, Peled JU, Ho C, Reddy P, Riches M, Storb R, Teshima T, van den Brink MRM, Alousi A, Balderman S, Chiusolo P, Clark WB, Holler E, Howard A, Kean LS, Koh AY, McCarthy PL, McCarty JM, Mohty M, Nakamura R, Rezvani K, Segal BH, Shaw BE, Shpall EJ, Sung AD, Weber D, Whangbo J, Wingard JR, Wood WA, Perales MA, Jenq RR, Bhatt AS; Blood and Marrow Transplant Clinical Trials Network.

Biol Blood Marrow Transplant. 2018 Jul;24(7):1322-1340. doi: 10.1016/j.bbmt.2018.02.009. Epub 2018 Feb 19. Review. No abstract available.


Reprint of: Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR.

Perales MA, Kebriaei P, Kean LS, Sadelain M.

Biol Blood Marrow Transplant. 2018 Mar;24(3S):S15-S19. doi: 10.1016/j.bbmt.2017.12.789. Review.


Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR.

Perales MA, Kebriaei P, Kean LS, Sadelain M.

Biol Blood Marrow Transplant. 2018 Jan;24(1):27-31. doi: 10.1016/j.bbmt.2017.10.017. Epub 2017 Oct 13. Review.


Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.

Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaan3085. doi: 10.1126/scitranslmed.aan3085.


In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines.

Hippen KL, O'Connor RS, Lemire AM, Saha A, Hanse EA, Tennis NC, Merkel SC, Kelekar A, Riley JL, Levine BL, June CH, Turka LA, Kean LS, MacMillan ML, Miller JS, Wagner JE, Munn DH, Blazar BR.

Am J Transplant. 2017 Dec;17(12):3098-3113. doi: 10.1111/ajt.14338. Epub 2017 Jun 14.


Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy.

Kean LS, Turka LA, Blazar BR.

Immunol Rev. 2017 Mar;276(1):192-212. doi: 10.1111/imr.12523. Review.


A Canine Model of Chronic Graft-versus-Host Disease.

Graves SS, Rezvani A, Sale G, Stone D, Parker M, Rosinski S, Spector M, Swearingen B, Kean L, Storb R.

Biol Blood Marrow Transplant. 2017 Mar;23(3):420-427. doi: 10.1016/j.bbmt.2016.12.629. Epub 2016 Dec 21.


Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.

Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR.

Transplantation. 2016 Dec;100(12):2630-2639. doi: 10.1097/TP.0000000000001465.


Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells.

Furlan SN, Watkins B, Tkachev V, Cooley S, Panoskaltsis-Mortari A, Betz K, Brown M, Hunt DJ, Schell JB, Zeleski K, Yu A, Giver CR, Waller EK, Miller JS, Blazar BR, Kean LS.

Blood. 2016 Nov 24;128(21):2568-2579. Epub 2016 Oct 6.


The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.

Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS.

Am J Transplant. 2017 Mar;17(3):657-670. doi: 10.1111/ajt.14006. Epub 2016 Sep 19.


Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR.

J Clin Invest. 2016 Jul 1;126(7):2642-60. doi: 10.1172/JCI85796. Epub 2016 Jun 13.


Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.

Furlan SN, Watkins B, Tkachev V, Flynn R, Cooley S, Ramakrishnan S, Singh K, Giver C, Hamby K, Stempora L, Garrett A, Chen J, Betz KM, Ziegler CG, Tharp GK, Bosinger SE, Promislow DE, Miller JS, Waller EK, Blazar BR, Kean LS.

Sci Transl Med. 2015 Nov 25;7(315):315ra191. doi: 10.1126/scitranslmed.aad3231.


Immunophenotypic parameters and RBC alloimmunization in children with sickle cell disease on chronic transfusion.

Nickel RS, Horan JT, Fasano RM, Meyer E, Josephson CD, Winkler AM, Yee ME, Kean LS, Hendrickson JE.

Am J Hematol. 2015 Dec;90(12):1135-41. doi: 10.1002/ajh.24188. Epub 2015 Oct 6.


Use of Alefacept for Preconditioning in Multiply Transfused Pediatric Patients with Nonmalignant Diseases.

Stenger EO, Chiang KY, Haight A, Qayed M, Kean L, Horan J.

Biol Blood Marrow Transplant. 2015 Oct;21(10):1845-52. doi: 10.1016/j.bbmt.2015.06.005. Epub 2015 Jun 19.


Red blood cell transfusions are associated with HLA class I but not H-Y alloantibodies in children with sickle cell disease.

Nickel RS, Hendrickson JE, Yee MM, Bray RA, Gebel HM, Kean LS, Miklos DB, Horan JT.

Br J Haematol. 2015 Jul;170(2):247-56. doi: 10.1111/bjh.13424. Epub 2015 Apr 19.


CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire.

Suessmuth Y, Mukherjee R, Watkins B, Koura DT, Finstermeier K, Desmarais C, Stempora L, Horan JT, Langston A, Qayed M, Khoury HJ, Grizzle A, Cheeseman JA, Conger JA, Robertson J, Garrett A, Kirk AD, Waller EK, Blazar BR, Mehta AK, Robins HS, Kean LS.

Blood. 2015 Jun 18;125(25):3835-50. doi: 10.1182/blood-2015-03-631853. Epub 2015 Apr 7.


Immune parameter analysis of children with sickle cell disease on hydroxycarbamide or chronic transfusion therapy.

Nickel RS, Osunkwo I, Garrett A, Robertson J, Archer DR, Promislow DE, Horan JT, Hendrickson JE, Kean LS.

Br J Haematol. 2015 May;169(4):574-83. doi: 10.1111/bjh.13326. Epub 2015 Mar 5.


Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.

Singh K, Stempora L, Harvey RD, Kirk AD, Larsen CP, Blazar BR, Kean LS.

Am J Transplant. 2014 Dec;14(12):2691-703. doi: 10.1111/ajt.12934. Epub 2014 Oct 30.


Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant.

Mavigner M, Watkins B, Lawson B, Lee ST, Chahroudi A, Kean L, Silvestri G.

PLoS Pathog. 2014 Sep 25;10(9):e1004406. doi: 10.1371/journal.ppat.1004406. eCollection 2014 Sep.


Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.

Kirk AD, Guasch A, Xu H, Cheeseman J, Mead SI, Ghali A, Mehta AK, Wu D, Gebel H, Bray R, Horan J, Kean LS, Larsen CP, Pearson TC.

Am J Transplant. 2014 May;14(5):1142-51. doi: 10.1111/ajt.12712. Epub 2014 Mar 31.


CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis.

Kaliyaperumal S, Watkins B, Sharma P, Furlan S, Ramakrishnan S, Giver C, Garcia A, Courtney C, Knight H, Strobert E, Elder E, Crenshaw T, Blazar BR, Waller EK, Westmoreland S, Kean LS.

Blood. 2014 Mar 20;123(12):1967-9. doi: 10.1182/blood-2014-01-547612. No abstract available.


A rare case of a bipartite placenta with a transamniotic vascular connection.

Brighouse JR, Sfeir P, Kean LH.

J Obstet Gynaecol. 2014 Feb;34(2):201. doi: 10.3109/01443615.2013.843654. No abstract available.


Antidepressants for mothers: what are psychiatrists prescribing?

Kean LJ, Pasupuleti P, Shah P.

Scott Med J. 2013 Nov;58(4):228-33. doi: 10.1177/0036933013507871.


In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial.

Koura DT, Horan JT, Langston AA, Qayed M, Mehta A, Khoury HJ, Harvey RD, Suessmuth Y, Couture C, Carr J, Grizzle A, Johnson HR, Cheeseman JA, Conger JA, Robertson J, Stempora L, Johnson BE, Garrett A, Kirk AD, Larsen CP, Waller EK, Kean LS.

Biol Blood Marrow Transplant. 2013 Nov;19(11):1638-49. doi: 10.1016/j.bbmt.2013.09.003. Epub 2013 Sep 15.


Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection.

Beus JM, Hashmi SS, Selvaraj SA, Duan D, Stempora LL, Monday SA, Cheeseman JA, Hamby KM, Speck SH, Larsen CP, Kirk AD, Kean LS.

PLoS One. 2013 Aug 5;8(8):e71221. doi: 10.1371/journal.pone.0071221. Print 2013.


Pluripotent stem cells: immune to the immune system?

Pearl JI, Kean LS, Davis MM, Wu JC.

Sci Transl Med. 2012 Dec 12;4(164):164ps25. doi: 10.1126/scitranslmed.3005090. Review.


Viewing transplantation immunology through today's lens: new models, new imaging, and new insights.

Huang AY, Haining WN, Barkauskas DS, Myers JT, Petrosiute A, Garrett AP, Singh K, Cooke KR, Kean LS.

Biol Blood Marrow Transplant. 2013 Jan;19(1 Suppl):S44-51. doi: 10.1016/j.bbmt.2012.10.020. Epub 2012 Oct 22. Review. No abstract available.


Cooking up tolerance: has a new recipe been created?

Kean LS, Blazar BR.

Am J Transplant. 2012 Jul;12(7):1667-9. doi: 10.1111/j.1600-6143.2012.04154.x. Epub 2012 Jun 15. No abstract available.


Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques.

Ramakrishnan SK, Page A, Farris AB 3rd, Singh K, Leopardi F, Hamby K, Sen S, Polnett A, Deane T, Song M, Stempora L, Strobert E, Kirk AD, Larsen CP, Kean LS.

Am J Transplant. 2012 Jul;12(7):1755-64. doi: 10.1111/j.1600-6143.2012.04045.x. Epub 2012 May 29.


Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.

Singh K, Kozyr N, Stempora L, Kirk AD, Larsen CP, Blazar BR, Kean LS.

Am J Transplant. 2012 Jun;12(6):1441-57. doi: 10.1111/j.1600-6143.2011.03963.x. Epub 2012 Feb 2.


Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old.

Kean LS, Singh K, Blazar BR, Larsen CP.

Am J Transplant. 2012 Apr;12(4):812-9. doi: 10.1111/j.1600-6143.2011.03873.x. Epub 2011 Dec 17. Review.


Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets.

Johnson ZP, Eady RD, Ahmad SF, Agravat S, Morris T, Else J, Lank SM, Wiseman RW, O'Connor DH, Penedo MC, Larsen CP, Kean LS.

Immunogenetics. 2012 Apr;64(4):329-36. doi: 10.1007/s00251-011-0587-8. Epub 2011 Nov 15.


Significant mobilization of both conventional and regulatory T cells with AMD3100.

Kean LS, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, Bonifacino AC, Metzger ME, Promislow DE, Mattapallil JJ, Donahue RE.

Blood. 2011 Dec 15;118(25):6580-90. doi: 10.1182/blood-2011-06-359331. Epub 2011 Oct 11.


CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.

Page A, Srinivasan S, Singh K, Russell M, Hamby K, Deane T, Sen S, Stempora L, Leopardi F, Price AA, Strobert E, Reimann KA, Kirk AD, Larsen CP, Kean LS.

Am J Transplant. 2012 Jan;12(1):115-25. doi: 10.1111/j.1600-6143.2011.03737.x. Epub 2011 Sep 19.


Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease.

Hendrickson JE, Hod EA, Perry JR, Ghosh S, Chappa P, Adisa O, Kean LS, Ofori-Acquah SF, Archer DR, Spitalnik SL, Zimring JC.

Transfusion. 2012 Feb;52(2):231-40. doi: 10.1111/j.1537-2995.2011.03255.x. Epub 2011 Jul 25.


Antidepressants for mothers: what are we prescribing?

Kean LJ, Hamilton J, Shah P.

Scott Med J. 2011 May;56(2):94-7. doi: 10.1258/smj.2011.011034.


An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.

Larsen CP, Page A, Linzie KH, Russell M, Deane T, Stempora L, Strobert E, Penedo MC, Ward T, Wiseman R, O'Connor D, Miller W, Sen S, Singh K, Kean LS.

Am J Transplant. 2010 Nov;10(11):2396-409. doi: 10.1111/j.1600-6143.2010.03272.x. Epub 2010 Sep 17.


GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression.

Miller WP, Srinivasan S, Panoskaltsis-Mortari A, Singh K, Sen S, Hamby K, Deane T, Stempora L, Beus J, Turner A, Wheeler C, Anderson DC, Sharma P, Garcia A, Strobert E, Elder E, Crocker I, Crenshaw T, Penedo MC, Ward T, Song M, Horan J, Larsen CP, Blazar BR, Kean LS.

Blood. 2010 Dec 9;116(24):5403-18. doi: 10.1182/blood-2010-06-289272. Epub 2010 Sep 10.


Resources for genetic management and genomics research on non-human primates at the National Primate Research Centers (NPRCs).

Kanthaswamy S, Capitanio JP, Dubay CJ, Ferguson B, Folks T, Ha JC, Hotchkiss CE, Johnson ZP, Katze MG, Kean LS, Kubisch HM, Lank S, Lyons LA, Miller GM, Nylander J, O'Connor DH, Palermo RE, Smith DG, Vallender EJ, Wiseman RW, Rogers J.

J Med Primatol. 2009 Oct;38 Suppl 1:17-23. doi: 10.1111/j.1600-0684.2009.00371.x.


Resource brief: the National Non-Human Primate DNA Bank.

Ferguson B, Capitanio J, Folks T, Hotchkiss C, Johnson Z, Kean L, Kubisch HM, Lank S, Lyons L, Miller GM, Nylander J, O'Connor D, Vallender EJ, Wiseman R.

Methods. 2009 Sep;49(1):3-4. doi: 10.1016/j.ymeth.2009.07.011.


Electronic fetal heart rate monitoring.

Gandhi H, Kean L.

Br J Hosp Med (Lond). 2008 Jul;69(7):388-91.


Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.

Anderson A, Martens CL, Hendrix R, Stempora LL, Miller WP, Hamby K, Russell M, Strobert E, Blazar BR, Pearson TC, Larsen CP, Kean LS.

Am J Transplant. 2008 Nov;8(11):2252-64. doi: 10.1111/j.1600-6143.2008.02376.x. Epub 2008 Sep 17.

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