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The health risk for seafood consumers under future ocean acidification (OA) scenarios: OA alters bioaccumulation of three pollutants in an edible bivalve species through affecting the in vivo metabolism.

Su W, Shi W, Han Y, Hu Y, Ke A, Wu H, Liu G.

Sci Total Environ. 2019 Feb 10;650(Pt 2):2987-2995. doi: 10.1016/j.scitotenv.2018.10.056. Epub 2018 Oct 5.


Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.

Dillard KE, Brown MW, Johnson NV, Xiao Y, Dolan A, Hernandez E, Dahlhauser SD, Kim Y, Myler LR, Anslyn EV, Ke A, Finkelstein IJ.

Cell. 2018 Nov 1;175(4):934-946.e15. doi: 10.1016/j.cell.2018.09.039. Epub 2018 Oct 18.


Development of novel affinity reagents for detecting protein tyrosine phosphorylation based on superbinder SH2 domain in tumor cells.

Ke AQ, Liu AD, Gao YN, Luo DN, Li ZF, Yu YQ, Liu JY, Xu H, Cao X.

Anal Chim Acta. 2018 Nov 22;1032:138-146. doi: 10.1016/j.aca.2018.05.045. Epub 2018 May 18.


LncRNA SNHG3 induces EMT and sorafenib resistance by modulating the miR-128/CD151 pathway in hepatocellular carcinoma.

Zhang PF, Wang F, Wu J, Wu Y, Huang W, Liu D, Huang XY, Zhang XM, Ke AW.

J Cell Physiol. 2018 Aug 21. doi: 10.1002/jcp.27095. [Epub ahead of print]


CCL15 recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma.

Liu LZ, Zhang Z, Zheng BH, Shi Y, Duan M, Ma LJ, Wang ZC, Dong LQ, Dong PP, Shi JY, Zhang S, Ding ZB, Ke AW, Cao Y, Zhang XM, Xi R, Zhou J, Fan J, Wang XY, Gao Q.

Hepatology. 2018 Aug 2. doi: 10.1002/hep.30134. [Epub ahead of print]


Canonical Wnt Signaling Remodels Lipid Metabolism in Zebrafish Hepatocytes following Ras Oncogenic Insult.

Yao Y, Sun S, Wang J, Fei F, Dong Z, Ke AW, He R, Wang L, Zhang L, Ji MB, Li Q, Yu M, Shi GM, Fan J, Gong Z, Wang X.

Cancer Res. 2018 Oct 1;78(19):5548-5560. doi: 10.1158/0008-5472.CAN-17-3964. Epub 2018 Jul 31.


Bioheat transfer model of transcutaneous spinal cord stimulation-induced temperature changes.

Chen L, Ke A, Zhang P, Gao Z, Zou X, He J.

PeerJ. 2018 Jun 4;6:e4921. doi: 10.7717/peerj.4921. eCollection 2018. Retraction in: PeerJ. 2018 Aug 10;6:.


Structure basis for RNA-guided DNA degradation by Cascade and Cas3.

Xiao Y, Luo M, Dolan AE, Liao M, Ke A.

Science. 2018 Jul 6;361(6397). pii: eaat0839. doi: 10.1126/science.aat0839. Epub 2018 Jun 7.


Improving Generalization Based on l1-Norm Regularization for EEG-Based Motor Imagery Classification.

Zhao Y, Han J, Chen Y, Sun H, Chen J, Ke A, Han Y, Zhang P, Zhang Y, Zhou J, Wang C.

Front Neurosci. 2018 May 9;12:272. doi: 10.3389/fnins.2018.00272. eCollection 2018.


A Fast, Open EEG Classification Framework Based on Feature Compression and Channel Ranking.

Han J, Zhao Y, Sun H, Chen J, Ke A, Xu G, Zhang H, Zhou J, Wang C.

Front Neurosci. 2018 Apr 16;12:217. doi: 10.3389/fnins.2018.00217. eCollection 2018.


Guanidine-sensing riboswitches: How do they work and what do they regulate?

Battaglia RA, Ke A.

Wiley Interdiscip Rev RNA. 2018 Apr 26:e1482. doi: 10.1002/wrna.1482. [Epub ahead of print] Review.


Acting in tandem.

Battaglia RA, Ke A.

Elife. 2018 Apr 23;7. pii: e36489. doi: 10.7554/eLife.36489.


Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.

Dong LQ, Shi Y, Ma LJ, Yang LX, Wang XY, Zhang S, Wang ZC, Duan M, Zhang Z, Liu LZ, Zheng BH, Ding ZB, Ke AW, Gao DM, Yuan K, Zhou J, Fan J, Xi R, Gao Q.

J Hepatol. 2018 Jul;69(1):89-98. doi: 10.1016/j.jhep.2018.02.029. Epub 2018 Mar 16.


Model-Informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor.

Gupta N, Hanley MJ, Diderichsen PM, Yang H, Ke A, Teng Z, Labotka R, Berg D, Patel C, Liu G, van de Velde H, Venkatakrishnan K.

Clin Pharmacol Ther. 2018 Feb 15. doi: 10.1002/cpt.1047. [Epub ahead of print] Review.


Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations.

Ke AB, Greupink R, Abduljalil K.

CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):103-110. doi: 10.1002/psp4.12274. Epub 2018 Jan 31. Review.


Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma.

Zhan H, Jiang J, Sun Q, Ke A, Hu J, Hu Z, Zhu K, Luo C, Ren N, Fan J, Zhou J, Huang X.

Gastroenterol Res Pract. 2017;2017:2029315. doi: 10.1155/2017/2029315. Epub 2017 Nov 29.


Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing.

Duan M, Hao J, Cui S, Worthley DL, Zhang S, Wang Z, Shi J, Liu L, Wang X, Ke A, Cao Y, Xi R, Zhang X, Zhou J, Fan J, Li C, Gao Q.

Cell Res. 2018 Mar;28(3):359-373. doi: 10.1038/cr.2018.11. Epub 2018 Jan 12.


Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma.

Xie N, Cai JB, Zhang L, Zhang PF, Shen YH, Yang X, Lu JC, Gao DM, Kang Q, Liu LX, Zhang C, Huang XY, Zou H, Zhang XY, Song ZJ, Sun HX, Fu BM, Ke AW, Shi GM.

Cell Death Dis. 2017 Dec 13;8(12):3205. doi: 10.1038/s41419-017-0015-6.


The Quantificational Domain of dou: An Experimental Study.

Ke AH, Epstein SD, Lewis R, Pires A.

J Psycholinguist Res. 2018 Jun;47(3):537-556. doi: 10.1007/s10936-017-9532-9.


In vitro to in vivo extrapolation for high throughput prioritization and decision making.

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC.

Toxicol In Vitro. 2018 Mar;47:213-227. doi: 10.1016/j.tiv.2017.11.016. Epub 2017 Dec 5. Review.


Preoperative Albumin-Bilirubin Score for Postoperative Solitary Hepatocellular Carcinoma within the Milan Criteria and Child-Pugh A Cirrhosis.

Dong ZR, Zou J, Sun D, Shi GM, Ke AW, Cai JB, Sun HC, Qiu SJ, Li T, Zhou J, Zhi XT, Fan J.

J Cancer. 2017 Oct 17;8(18):3862-3867. doi: 10.7150/jca.21313. eCollection 2017.


Sphingolipids in marine microalgae: Development and application of a mass spectrometric method for global structural characterization of ceramides and glycosphingolipids in three major phyla.

Li Y, Lou Y, Mu T, Ke A, Ran Z, Xu J, Chen J, Zhou C, Yan X, Xu Q, Tan Y.

Anal Chim Acta. 2017 Sep 15;986:82-94. doi: 10.1016/j.aca.2017.07.039. Epub 2017 Jul 21.


How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.

Xiao Y, Ng S, Nam KH, Ke A.

Nature. 2017 Oct 5;550(7674):137-141. doi: 10.1038/nature24020. Epub 2017 Sep 4.


Telomere length variation in tumor cells and cancer-associated fibroblasts: potential biomarker for hepatocellular carcinoma.

Ma LJ, Wang XY, Duan M, Liu LZ, Shi JY, Dong LQ, Yang LX, Wang ZC, Ding ZB, Ke AW, Cao Y, Zhang XM, Zhou J, Fan J, Gao Q.

J Pathol. 2017 Dec;243(4):407-417. doi: 10.1002/path.4961. Epub 2017 Oct 13.


Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis.

Gupta N, Hanley MJ, Venkatakrishnan K, Bessudo A, Rasco DW, Sharma S, O'Neil BH, Wang B, Liu G, Ke A, Patel C, Rowland Yeo K, Xia C, Zhang X, Esseltine DL, Nemunaitis J.

J Clin Pharmacol. 2018 Feb;58(2):180-192. doi: 10.1002/jcph.988. Epub 2017 Aug 11.


Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.

Xiao Y, Luo M, Hayes RP, Kim J, Ng S, Ding F, Liao M, Ke A.

Cell. 2017 Jun 29;170(1):48-60.e11. doi: 10.1016/j.cell.2017.06.012.


Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips.

Jung C, Hawkins JA, Jones SK Jr, Xiao Y, Rybarski JR, Dillard KE, Hussmann J, Saifuddin FA, Savran CA, Ellington AD, Ke A, Press WH, Finkelstein IJ.

Cell. 2017 Jun 29;170(1):35-47.e13. doi: 10.1016/j.cell.2017.05.044.


Functional characterization and crystal structure of thermostable amylase from Thermotoga petrophila, reveals high thermostability and an unusual form of dimerization.

Hameed U, Price I, Ikram-Ul-Haq, Ke A, Wilson DB, Mirza O.

Biochim Biophys Acta Proteins Proteom. 2017 Oct;1865(10):1237-1245. doi: 10.1016/j.bbapap.2017.06.015. Epub 2017 Jun 22.


Building the Class 2 CRISPR-Cas Arsenal.

Lewis KM, Ke A.

Mol Cell. 2017 Feb 2;65(3):377-379. doi: 10.1016/j.molcel.2017.01.024.


Structural basis for guanidine sensing by the ykkC family of riboswitches.

Battaglia RA, Price IR, Ke A.

RNA. 2017 Apr;23(4):578-585. doi: 10.1261/rna.060186.116. Epub 2017 Jan 17.


Mortalin promotes cell proliferation and epithelial mesenchymal transition of intrahepatic cholangiocarcinoma cells in vitro.

Kang Q, Cai JB, Dong RZ, Liu LX, Zhang C, Zhang PF, Zou H, Xie N, Zhang L, Zhang XY, Song ZJ, Dong ZR, Hu MY, Huang XY, Zhang XW, Ke AW, Shi GM.

J Clin Pathol. 2017 Aug;70(8):677-683. doi: 10.1136/jclinpath-2016-204251. Epub 2017 Jan 17.


Wortmannilactones I-L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilide hydroxamic acid to the culture medium of Talaromyces wortmannii.

Liu WC, Wang YY, Liu JH, Ke AB, Zheng ZH, Lu XH, Luan YS, Xiu ZL, Dong YS.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5328-5333. doi: 10.1016/j.bmcl.2016.09.032. Epub 2016 Sep 14.


PIWI Takes a Giant Step.

Xiao Y, Ke A.

Cell. 2016 Oct 6;167(2):310-312. doi: 10.1016/j.cell.2016.09.043.


Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6.

Ke A, Barter Z, Rowland-Yeo K, Almond L.

CPT Pharmacometrics Syst Pharmacol. 2016 Jul;5(7):367-76. doi: 10.1002/psp4.12088. Epub 2016 Jul 20.


UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2.

Bai DS, Wu C, Yang LX, Zhang C, Zhang PF, He YZ, Cai JB, Song ZJ, Dong ZR, Huang XY, Ke AW, Shi GM.

Oncotarget. 2016 May 31;7(22):32946-55. doi: 10.18632/oncotarget.8783.


Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling.

Zhang PF, Li KS, Shen YH, Gao PT, Dong ZR, Cai JB, Zhang C, Huang XY, Tian MX, Hu ZQ, Gao DM, Fan J, Ke AW, Shi GM.

Cell Death Dis. 2016 Apr 21;7:e2201. doi: 10.1038/cddis.2015.324.


Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.

Hayes RP, Xiao Y, Ding F, van Erp PB, Rajashankar K, Bailey S, Wiedenheft B, Ke A.

Nature. 2016 Feb 25;530(7591):499-503. doi: 10.1038/nature16995. Epub 2016 Feb 10.


Tumour-suppressive role of PTPN13 in hepatocellular carcinoma and its clinical significance.

Zhan H, Jiang J, Luo C, Sun Q, Ke A, Sun C, Hu J, Hu Z, Hu B, Zhu K, Fan J, Zhou J, Huang X.

Tumour Biol. 2016 Jul;37(7):9691-8. doi: 10.1007/s13277-016-4843-2. Epub 2016 Jan 23.


Generation and characterization of a tetraspanin CD151/integrin α6β1-binding domain competitively binding monoclonal antibody for inhibition of tumor progression in HCC.

Ke AW, Zhang PF, Shen YH, Gao PT, Dong ZR, Zhang C, Cai JB, Huang XY, Wu C, Zhang L, Kang Q, Liu LX, Xie N, Shen ZZ, Hu MY, Cao Y, Qiu SJ, Sun HC, Zhou J, Fan J, Shi GM.

Oncotarget. 2016 Feb 2;7(5):6314-22. doi: 10.18632/oncotarget.6833.


Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity.

Shi JY, Xing Q, Duan M, Wang ZC, Yang LX, Zhao YJ, Wang XY, Liu Y, Deng M, Ding ZB, Ke AW, Zhou J, Fan J, Cao Y, Wang J, Xi R, Gao Q.

Oncotarget. 2016 Jan 19;7(3):2867-77. doi: 10.18632/oncotarget.6558.


Mitogen-activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial-mesenchymal transition.

Yang LX, Gao Q, Shi JY, Wang ZC, Zhang Y, Gao PT, Wang XY, Shi YH, Ke AW, Shi GM, Cai JB, Liu WR, Duan M, Zhao YJ, Ji Y, Gao DM, Zhu K, Zhou J, Qiu SJ, Cao Y, Tang QQ, Fan J.

Hepatology. 2015 Dec;62(6):1804-16. doi: 10.1002/hep.28149. Epub 2015 Oct 17.


Structures of Large RNAs and RNA-Protein Complexes: Toward Structure Determination of Riboswitches.

Grigg JC, Ke A.

Methods Enzymol. 2015;558:213-32. doi: 10.1016/bs.mie.2015.02.009. Epub 2015 Apr 1.


Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.

Xie F, Ke AB, Bowers GD, Zamek-Gliszczynski MJ.

J Pharmacol Exp Ther. 2015 Aug;354(2):225-9. doi: 10.1124/jpet.115.225698. Epub 2015 Jun 10.


Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition.

Wang ZC, Gao Q, Shi JY, Guo WJ, Yang LX, Liu XY, Liu LZ, Ma LJ, Duan M, Zhao YJ, Wu YN, Gao DM, Wang XY, Shi GM, Ding ZB, Ke AW, Tang QQ, Cao Y, Zhou J, Fan J.

Hepatology. 2015 Oct;62(4):1201-14. doi: 10.1002/hep.27911. Epub 2015 Aug 13. Erratum in: Hepatology. 2016 Jan;63(1):349.


Characterizing Metal-Dependent Nucleases of CRISPR-Cas Prokaryotic Adaptive Immunity Systems.

Nam KH, DeLisa MP, Ke A.

Methods Mol Biol. 2015;1311:265-76. doi: 10.1007/978-1-4939-2687-9_17.


[Effects of acupuncture on distribution taxis of paclitaxel in mice with lung cancer].

Zhang ZX, Cheng ZD, Li CR, Ke AJ, Chen JL, Chen YG.

Zhongguo Zhen Jiu. 2014 Dec;34(12):1208-13. Chinese.


Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy.

Mizrachi D, Chen Y, Liu J, Peng HM, Ke A, Pollack L, Turner RJ, Auchus RJ, DeLisa MP.

Nat Commun. 2015 Apr 8;6:6826. doi: 10.1038/ncomms7826.


BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma.

Zhang P, Dong Z, Cai J, Zhang C, Shen Z, Ke A, Gao D, Fan J, Shi G.

Int J Immunopathol Pharmacol. 2015 Mar;28(1):36-44. doi: 10.1177/0394632015572070.


Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches.

Price IR, Gaballa A, Ding F, Helmann JD, Ke A.

Mol Cell. 2015 Mar 19;57(6):1110-1123. doi: 10.1016/j.molcel.2015.02.016.


Assessment of the persistence of anacetrapib and evacetrapib concentrations using two pharmacokinetic modeling approaches.

Small DS, Ke AB, Hall SD, Mantlo N, Rotelli M, Friedrich S.

J Clin Pharmacol. 2015 Jul;55(7):757-67. doi: 10.1002/jcph.472. Epub 2015 Feb 20.


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