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Items: 5


AMPK directly activates mTORC2 to promote cell survival during acute energetic stress.

Kazyken D, Magnuson B, Bodur C, Acosta-Jaquez HA, Zhang D, Tong X, Barnes TM, Steinl GK, Patterson NE, Altheim CH, Sharma N, Inoki K, Cartee GD, Bridges D, Yin L, Riddle SM, Fingar DC.

Sci Signal. 2019 Jun 11;12(585). pii: eaav3249. doi: 10.1126/scisignal.aav3249.


The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.

Bodur C, Kazyken D, Huang K, Ekim Ustunel B, Siroky KA, Tooley AS, Gonzalez IE, Foley DH, Acosta-Jaquez HA, Barnes TM, Steinl GK, Cho KW, Lumeng CN, Riddle SM, Myers MG Jr, Fingar DC.

EMBO J. 2018 Jan 4;37(1):19-38. doi: 10.15252/embj.201696164. Epub 2017 Nov 17.


The nuclear import of ribosomal proteins is regulated by mTOR.

Kazyken D, Kaz Y, Kiyan V, Zhylkibayev AA, Chen CH, Agarwal NK, Sarbassov dos D.

Oncotarget. 2014 Oct 30;5(20):9577-93.


Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov dos D.

J Biol Chem. 2013 Sep 20;288(38):27019-30. doi: 10.1074/jbc.M113.498055. Epub 2013 Aug 8.


Rictor encounters RhoGDI2: the second pilot is taking a lead.

Agarwal NK, Kazyken D, Sarbassov dos D.

Small GTPases. 2013 Apr-Jun;4(2):102-5. doi: 10.4161/sgtp.23346. Epub 2013 Jan 25.

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