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Items: 1 to 50 of 105

1.

An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells.

Ohira T, Miyauchi K, Uno N, Shimizu N, Kazuki Y, Oshimura M, Kugoh H.

Sci Rep. 2019 Nov 18;9(1):16954. doi: 10.1038/s41598-019-53116-2.

2.

Dynamics of host and graft after cell sheet transplantation: Basic study for the application of amyotrophic lateral sclerosis.

Nakanishi M, Watanabe Y, Honda N, Une M, Kazuki K, Kazuki Y, Terashima T, Katagi M, Nakashima K, Hanajima R.

Brain Res. 2019 Dec 1;1724:146444. doi: 10.1016/j.brainres.2019.146444. Epub 2019 Sep 10.

PMID:
31518575
3.

CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.

Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y.

Mol Pharmacol. 2019 Nov;96(5):600-608. doi: 10.1124/mol.119.117333. Epub 2019 Aug 27.

PMID:
31455676
4.

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.

Kanatsu-Shinohara M, Yamamoto T, Toh H, Kazuki Y, Kazuki K, Imoto J, Ikeo K, Oshima M, Shirahige K, Iwama A, Nabeshima Y, Sasaki H, Shinohara T.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16404-16409. doi: 10.1073/pnas.1904980116. Epub 2019 Jul 29.

PMID:
31358627
5.

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4.

6.

Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo.

Minegishi G, Kazuki Y, Yamasaki Y, Okuya F, Akita H, Oshimura M, Kobayashi K.

Xenobiotica. 2019 Nov;49(11):1303-1310. doi: 10.1080/00498254.2018.1560516. Epub 2019 Jun 14.

PMID:
30561249
7.

Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transfer.

Hiramatsu K, Abe S, Kazuki K, Osaki M, Kajitani N, Yakura Y, Oshimura M, Kazuki Y.

Biochem Biophys Res Commun. 2019 Jan 8;508(2):603-607. doi: 10.1016/j.bbrc.2018.11.138. Epub 2018 Dec 1.

PMID:
30509488
8.

A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein-protein interactions mediated by G protein-coupled receptors.

Uno N, Fujimoto T, Komoto S, Kurosawa G, Sawa M, Suzuki T, Kazuki Y, Oshimura M.

Cytotechnology. 2018 Dec;70(6):1499-1508. doi: 10.1007/s10616-018-0231-7. Epub 2018 Jul 31.

9.

Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.

Nitta SI, Hashimoto M, Kazuki Y, Takehara S, Suzuki H, Oshimura M, Akita H, Chiba K, Kobayashi K.

AAPS J. 2018 Apr 9;20(3):61. doi: 10.1208/s12248-018-0186-9.

PMID:
29858698
10.

Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.

Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y.

Drug Metab Dispos. 2018 Nov;46(11):1756-1766. doi: 10.1124/dmd.118.081216. Epub 2018 May 18.

PMID:
29777024
11.

Production of a Human Cell Line with a Plant Chromosome.

Wada N, Kazuki Y, Kazuki K, Inoue T, Fukui K, Oshimura M.

Methods Mol Biol. 2018;1772:289-296. doi: 10.1007/978-1-4939-7795-6_16.

PMID:
29754235
12.

Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9.

Honma K, Abe S, Endo T, Uno N, Oshimura M, Ohbayashi T, Kazuki Y.

PLoS One. 2018 Mar 5;13(3):e0193642. doi: 10.1371/journal.pone.0193642. eCollection 2018.

13.

Bioluminescence-based cytotoxicity assay for simultaneous evaluation of cell viability and membrane damage in human hepatoma HepG2 cells.

Uno K, Murotomi K, Kazuki Y, Oshimura M, Nakajima Y.

Luminescence. 2018 May;33(3):616-624. doi: 10.1002/bio.3454. Epub 2018 Feb 8.

PMID:
29424036
14.

Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics.

Satoh D, Abe S, Kobayashi K, Nakajima Y, Oshimura M, Kazuki Y.

Drug Metab Pharmacokinet. 2018 Feb;33(1):17-30. doi: 10.1016/j.dmpk.2018.01.002. Epub 2018 Jan 11. Review.

15.

Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.

Benedetti S, Uno N, Hoshiya H, Ragazzi M, Ferrari G, Kazuki Y, Moyle LA, Tonlorenzi R, Lombardo A, Chaouch S, Mouly V, Moore M, Popplewell L, Kazuki K, Katoh M, Naldini L, Dickson G, Messina G, Oshimura M, Cossu G, Tedesco FS.

EMBO Mol Med. 2018 Feb;10(2):254-275. doi: 10.15252/emmm.201607284.

16.

Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models.

Uno N, Abe S, Oshimura M, Kazuki Y.

J Hum Genet. 2018 Feb;63(2):145-156. doi: 10.1038/s10038-017-0378-7. Epub 2017 Nov 27. Review.

PMID:
29180645
17.

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology.

Abe S, Kobayashi K, Oji A, Sakuma T, Kazuki K, Takehara S, Nakamura K, Okada A, Tsukazaki Y, Senda N, Honma K, Yamamoto T, Ikawa M, Chiba K, Oshimura M, Kazuki Y.

Sci Rep. 2017 Nov 9;7(1):15189. doi: 10.1038/s41598-017-15033-0.

18.

Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies.

Satoh D, Iwado S, Abe S, Kazuki K, Wakuri S, Oshimura M, Kazuki Y.

PLoS One. 2017 Oct 24;12(10):e0187072. doi: 10.1371/journal.pone.0187072. eCollection 2017.

19.

CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells.

Uno N, Hiramatsu K, Uno K, Komoto S, Kazuki Y, Oshimura M.

Sci Rep. 2017 Oct 6;7(1):12739. doi: 10.1038/s41598-017-10418-7.

20.

Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice.

Shinohara T, Kazuki K, Ogonuki N, Morimoto H, Matoba S, Hiramatsu K, Honma K, Suzuki T, Hara T, Ogura A, Oshimura M, Kanatsu-Shinohara M, Kazuki Y.

Stem Cell Reports. 2017 Oct 10;9(4):1180-1191. doi: 10.1016/j.stemcr.2017.08.012. Epub 2017 Sep 21.

21.

Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.

Murayama N, Kazuki Y, Satoh D, Arata K, Harada T, Shibata N, Guengerich FP, Yamazaki H.

J Toxicol Sci. 2017;42(3):343-348. doi: 10.2131/jts.42.343.

22.

Gender Difference of Hepatic and Intestinal CYP3A4 in CYP3AHumanized Mice Generated by a Human Chromosome-engineering Technique.

Kobayashi K, Abe C, Endo M, Kazuki Y, Oshimura M, Chiba K.

Drug Metab Lett. 2017 Nov 17;11(1):60-67. doi: 10.2174/1872312811666170404153804.

PMID:
28393714
23.

Multiple expression cassette exchange via TP901-1, R4, and Bxb1 integrase systems on a mouse artificial chromosome.

Tomimatsu K, Kokura K, Nishida T, Yoshimura Y, Kazuki Y, Narita M, Oshimura M, Ohbayashi T.

FEBS Open Bio. 2017 Jan 28;7(3):306-317. doi: 10.1002/2211-5463.12169. eCollection 2017 Mar.

24.

Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates.

Takenaka T, Kazuki K, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T, Abe S, Oshimura M, Kazuki Y.

Drug Metab Pharmacokinet. 2017 Feb;32(1):61-68. doi: 10.1016/j.dmpk.2016.08.004. Epub 2016 Aug 26.

PMID:
28139373
25.

Correlation between luminescence intensity and cytotoxicity in cell-based cytotoxicity assay using luciferase.

Wakuri S, Yamakage K, Kazuki Y, Kazuki K, Oshimura M, Aburatani S, Yasunaga M, Nakajima Y.

Anal Biochem. 2017 Apr 1;522:18-29. doi: 10.1016/j.ab.2017.01.015. Epub 2017 Jan 20.

PMID:
28111305
26.

A kidney injury molecule-1 (Kim-1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells.

Kokura K, Kuromi Y, Endo T, Anzai N, Kazuki Y, Oshimura M, Ohbayashi T.

J Gene Med. 2016 Oct;18(10):273-281. doi: 10.1002/jgm.2925.

27.

Maintenance and Function of a Plant Chromosome in Human Cells.

Wada N, Kazuki Y, Kazuki K, Inoue T, Fukui K, Oshimura M.

ACS Synth Biol. 2017 Feb 17;6(2):301-310. doi: 10.1021/acssynbio.6b00180. Epub 2016 Oct 17.

PMID:
27696824
28.

Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts.

Shiba Y, Gomibuchi T, Seto T, Wada Y, Ichimura H, Tanaka Y, Ogasawara T, Okada K, Shiba N, Sakamoto K, Ido D, Shiina T, Ohkura M, Nakai J, Uno N, Kazuki Y, Oshimura M, Minami I, Ikeda U.

Nature. 2016 Oct 20;538(7625):388-391. doi: 10.1038/nature19815. Epub 2016 Oct 10.

PMID:
27723741
29.

Effects of duration of electric pulse on in vitro development of cloned cat embryos with human artificial chromosome vector.

Do L, Wittayarat M, Terazono T, Sato Y, Taniguchi M, Tanihara F, Takemoto T, Kazuki Y, Kazuki K, Oshimura M, Otoi T.

Reprod Domest Anim. 2016 Dec;51(6):1039-1043. doi: 10.1111/rda.12766. Epub 2016 Aug 28.

PMID:
27568550
30.

The effect of supplementation of amino acids and taurine to modified KSOM culture medium on rat embryo development.

Nakamura K, Morimoto K, Shima K, Yoshimura Y, Kazuki Y, Suzuki O, Matsuda J, Ohbayashi T.

Theriogenology. 2016 Nov;86(8):2083-90. doi: 10.1016/j.theriogenology.2016.07.001. Epub 2016 Jul 13.

PMID:
27527405
31.

Evaluation of an Hprt-Luciferase Reporter Gene on a Mammalian Artificial Chromosome in Response to Cytotoxicity.

Endo T, Noda N, Kuromi Y, Kokura K, Kazuki Y, Oshimura M, Ohbayashi T.

Yonago Acta Med. 2016 Jun 29;59(2):174-82. eCollection 2016 Jun.

32.

Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.

Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP.

Chem Res Toxicol. 2016 Aug 15;29(8):1279-81. doi: 10.1021/acs.chemrestox.6b00210. Epub 2016 Jul 29.

33.

Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins.

Suzuki T, Kazuki Y, Oshimura M, Hara T.

PLoS One. 2016 Jun 7;11(6):e0157187. doi: 10.1371/journal.pone.0157187. eCollection 2016.

34.

Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model.

Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim H, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, Maragakis N, Wagner KR, Lee G.

Cell Rep. 2016 Jun 7;15(10):2301-2312. doi: 10.1016/j.celrep.2016.05.016. Epub 2016 May 26.

35.

Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.

Hashimoto M, Kobayashi K, Yamazaki M, Kazuki Y, Takehara S, Oshimura M, Chiba K.

J Steroid Biochem Mol Biol. 2016 Oct;163:121-8. doi: 10.1016/j.jsbmb.2016.04.018. Epub 2016 Apr 29.

PMID:
27137100
36.

Dynamics of epigenetic regulation at the single-cell level.

Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB.

Science. 2016 Feb 12;351(6274):720-4. doi: 10.1126/science.aab2956.

37.

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.

Kazuki Y, Akita M, Kobayashi K, Osaki M, Satoh D, Ohta R, Abe S, Takehara S, Kazuki K, Yamazaki H, Kamataki T, Oshimura M.

Sci Rep. 2016 Feb 23;6:21419. doi: 10.1038/srep21419.

38.
39.

Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy.

Uno N, Uno K, Komoto S, Suzuki T, Hiratsuka M, Osaki M, Kazuki Y, Oshimura M.

Mol Ther Nucleic Acids. 2015 Dec 15;4:e272. doi: 10.1038/mtna.2015.45.

40.

Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis.

Watanabe Y, Kazuki Y, Kazuki K, Ebiki M, Nakanishi M, Nakamura K, Yoshida Yamakawa M, Hosokawa H, Ohbayashi T, Oshimura M, Nakashima K.

Mol Ther Nucleic Acids. 2015 Oct 6;4:e253. doi: 10.1038/mtna.2015.28.

41.

Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans.

Nakada N, Kawamura A, Kamimura H, Sato K, Kazuki Y, Kakuni M, Ohbuchi M, Kato K, Tateno C, Oshimura M, Usui T.

Biopharm Drug Dispos. 2016 Jan;37(1):3-14. doi: 10.1002/bdd.1990.

PMID:
26352195
42.

Construction of a Luciferase Reporter System to Monitor Osteogenic Differentiation of Mesenchymal Stem Cells by Using a Mammalian Artificial Chromosome Vector.

Narai T, Katoh M, Inoue T, Taniguchi M, Kazuki K, Kazuki Y, Sato K, Kodani I, Ryoke K, Oshimura M.

Yonago Acta Med. 2015 Mar;58(1):23-9. Epub 2015 Mar 27.

43.

Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome.

Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, Takehara S, Osaki M, Kazuki Y, Kurosawa Y, Nakamura T, Katoh M, Oshimura M.

BMC Biotechnol. 2015 Jun 19;15:58. doi: 10.1186/s12896-015-0142-z.

44.

Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation.

Yoshimura Y, Nakamura K, Endo T, Kajitani N, Kazuki K, Kazuki Y, Kugoh H, Oshimura M, Ohbayashi T.

Transgenic Res. 2015 Aug;24(4):717-27. doi: 10.1007/s11248-015-9884-6. Epub 2015 Jun 9.

45.

Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver.

Kato K, Ohbuchi M, Hamamura S, Ohshita H, Kazuki Y, Oshimura M, Sato K, Nakada N, Kawamura A, Usui T, Kamimura H, Tateno C.

Drug Metab Dispos. 2015 Aug;43(8):1208-17. doi: 10.1124/dmd.115.063479. Epub 2015 May 15.

PMID:
25979261
46.

Recurrent micronucleation through cell cycle progression in the presence of microtubule inhibitors.

Nakayama Y, Uno N, Uno K, Mizoguchi Y, Komoto S, Kazuki Y, Nanba E, Inoue T, Oshimura M.

Cell Struct Funct. 2015;40(1):51-9. doi: 10.1247/csf.14005. Epub 2015 Jan 9.

47.

A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges.

Oshimura M, Uno N, Kazuki Y, Katoh M, Inoue T.

Chromosome Res. 2015 Feb;23(1):111-33. doi: 10.1007/s10577-014-9459-z. Review.

48.

Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.

Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, Oshimura M, Ishigaki Y, Hamasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H.

PLoS One. 2014 Nov 12;9(11):e112900. doi: 10.1371/journal.pone.0112900. eCollection 2014.

49.

A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome.

Suzuki T, Kazuki Y, Oshimura M, Hara T.

PLoS One. 2014 Oct 10;9(10):e110404. doi: 10.1371/journal.pone.0110404. eCollection 2014.

50.

Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.

Kazuki Y, Yakura Y, Abe S, Osaki M, Kajitani N, Kazuki K, Takehara S, Honma K, Suemori H, Yamazaki S, Sakuma T, Toki T, Shimizu R, Nakauchi H, Yamamoto T, Oshimura M.

Sci Rep. 2014 Aug 27;4:6136. doi: 10.1038/srep06136.

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