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Items: 31

1.

Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6).

Motoyama K, Nagata T, Kobayashi J, Nakamura A, Miyoshi N, Kazui M, Sakurai K, Sakakura T.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2222-2227. doi: 10.1016/j.bmcl.2018.03.056. Epub 2018 Mar 22.

PMID:
29752182
2.

Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase.

Kazui M, Ogura Y, Hagihara K, Kubota K, Kurihara A.

Drug Metab Dispos. 2016 Jan;44(1):115-23. doi: 10.1124/dmd.115.066290. Epub 2015 Nov 11.

3.

Pharmacokinetics of loxoprofen and its active metabolite after dermal application of loxoprofen gel to rats.

Sawamura R, Kazui M, Kurihara A, Izumi T.

Pharmazie. 2015 Feb;70(2):74-80.

PMID:
25997245
4.

Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin.

Sawamura R, Sakurai H, Wada N, Nishiya Y, Honda T, Kazui M, Kurihara A, Shinagawa A, Izumi T.

Biopharm Drug Dispos. 2015 Sep;36(6):352-363. doi: 10.1002/bdd.1945. Epub 2015 Apr 21.

PMID:
25765700
5.

Absorption, distribution, metabolism and excretion of loxoprofen after dermal application of loxoprofen gel to rats.

Sawamura R, Kazui M, Kurihara A, Izumi T.

Xenobiotica. 2014 Nov;44(11):1026-38. doi: 10.3109/00498254.2014.926571. Epub 2014 Jun 11.

PMID:
24916900
6.

Hepatic microsomal thiol methyltransferase is involved in stereoselective methylation of pharmacologically active metabolite of prasugrel.

Kazui M, Hagihara K, Izumi T, Ikeda T, Kurihara A.

Drug Metab Dispos. 2014 Jul;42(7):1138-45. doi: 10.1124/dmd.114.057661. Epub 2014 Apr 14.

7.

Glutaredoxin is involved in the formation of the pharmacologically active metabolite of clopidogrel from its GSH conjugate.

Hagihara K, Kazui M, Kurihara A, Ikeda T, Izumi T.

Drug Metab Dispos. 2012 Sep;40(9):1854-9. doi: 10.1124/dmd.112.045914. Epub 2012 Jun 25.

8.

The intestine as an important contributor to prasugrel active metabolite formation in vivo.

Hagihara K, Kazui M, Ikenaga H, Nanba T, Fusegawa K, Izumi T, Ikeda T, Kurihara A.

Drug Metab Dispos. 2011 Apr;39(4):565-70. doi: 10.1124/dmd.110.035956. Epub 2010 Dec 28.

9.

Glutaredoxin and thioredoxin can be involved in producing the pharmacologically active metabolite of a thienopyridine antiplatelet agent, prasugrel.

Hagihara K, Kazui M, Kurihara A, Kubota K, Ikeda T.

Drug Metab Dispos. 2011 Feb;39(2):208-14. doi: 10.1124/dmd.110.035196. Epub 2010 Oct 29.

10.

Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite.

Hagihara K, Kazui M, Kurihara A, Iwabuchi H, Ishikawa M, Kobayashi H, Tanaka N, Okazaki O, Farid NA, Ikeda T.

Drug Metab Dispos. 2010 Jun;38(6):898-904. doi: 10.1124/dmd.110.032086. Epub 2010 Mar 12.

11.

Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.

Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A.

Drug Metab Dispos. 2010 Jan;38(1):92-9. doi: 10.1124/dmd.109.029132.

12.

A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.

Hagihara K, Kazui M, Kurihara A, Yoshiike M, Honda K, Okazaki O, Farid NA, Ikeda T.

Drug Metab Dispos. 2009 Nov;37(11):2145-52. doi: 10.1124/dmd.109.028498. Epub 2009 Aug 24.

13.

Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs.

Hagihara K, Kazui M, Ikenaga H, Nanba T, Fusegawa K, Takahashi M, Kurihara A, Okazaki O, Farid NA, Ikeda T.

Xenobiotica. 2009 Mar;39(3):218-26. doi: 10.1080/00498250802650077.

PMID:
19280520
14.

Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine.

Hagihara K, Nishiya Y, Kurihara A, Kazui M, Farid NA, Ikeda T.

Drug Metab Pharmacokinet. 2008;23(6):412-20.

15.

The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2.

Williams ET, Jones KO, Ponsler GD, Lowery SM, Perkins EJ, Wrighton SA, Ruterbories KJ, Kazui M, Farid NA.

Drug Metab Dispos. 2008 Jul;36(7):1227-32. doi: 10.1124/dmd.107.020248. Epub 2008 Mar 27.

16.

Absorption, distribution and excretion of the new thienopyridine agent prasugrel in rats.

Hagihara K, Kurihara A, Kawai K, Kazui M, Takahashi M, Kawabata K, Farid NA, Ikeda T.

Xenobiotica. 2007 Jul;37(7):788-801.

PMID:
17620223
17.

Anti-HIV-1 activities and pharmacokinetics of new arylpiperazinyl fluoroquinolones.

Ohmine T, Katsube T, Tsuzaki Y, Kazui M, Kobayashi N, Komai T, Hagihara M, Nishigaki T, Iwamoto A, Kimura T, Kashiwase H, Yamashita M.

Bioorg Med Chem Lett. 2002 Mar 11;12(5):739-42.

PMID:
11858992
18.

Rapid, real-time sampling of R-84760 in blood by in vivo microdialysis with tandem mass spectrometry.

Kobayashi N, Kazui M, Ikeda T.

J Pharm Biomed Anal. 2000 Jan;21(6):1233-42.

PMID:
10708407
19.

Ethane: a marker of lipid peroxidation during cardiopulmonary bypass in humans.

Andreoni KA, Kazui M, Cameron DE, Nyhan D, Sehnert SS, Rohde CA, Bulkley GB, Risby TH.

Free Radic Biol Med. 1999 Feb;26(3-4):439-45.

PMID:
9895236
20.

Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs.

Kawai K, Kawasaki-Tokui Y, Odaka T, Tsuruta F, Kazui M, Iwabuchi H, Nakamura T, Kinoshita T, Ikeda T, Yoshioka T, Komai T, Nakamura K.

Arzneimittelforschung. 1997 Apr;47(4):356-68.

PMID:
9150855
21.

Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping.

Kazui M, Andreoni KA, Williams GM, Perler BA, Bulkley GB, Beattie C, Donham RT, Sehnert SS, Burdick JF, Risby TH.

J Vasc Surg. 1994 Mar;19(3):473-7.

PMID:
8126860
22.

Evidence for free radical-mediated lipid peroxidation at reperfusion of human orthotopic liver transplants.

Risby TH, Maley W, Scott RP, Bulkley GB, Kazui M, Sehnert SS, Schwarz KB, Potter J, Mezey E, Klein AS, et al.

Surgery. 1994 Jan;115(1):94-101.

PMID:
8284767
23.

Late results of coronary artery bypass surgery with maximal follow-up of 7 years: analysis of determinants affecting late survival.

Hosoda Y, Nukariya M, Watanabe M, Sasaguri S, Kazui M, Tahara M, Watanabe T, Sato T, Goto M, Takazawa K, et al.

Cardiovasc Surg. 1993 Aug;1(4):403-9.

PMID:
8076071
24.

[Immunocytochemical and ultrastructural study of saphenous vein, internal thoracic artery, and right gastroepiploic artery in coronary artery bypass grafting].

Sasaguri S, Hosoda Y, Tahara M, Watanabe T, Kazui M, Kikuchi N, Goto M, Yamamuro M, Yamamoto S, Nukariya M.

Nihon Kyobu Geka Gakkai Zasshi. 1993 Jul;41(7):1188-93. Japanese.

PMID:
8376887
25.

[Immunocytochemical investigations of occluded saphenous vein grafts].

Sasaguri S, Hosoda Y, Tahara M, Takazawa K, Watanabe T, Satoh T, Kazui M, Nukariya M.

Nihon Kyobu Geka Gakkai Zasshi. 1993 Mar;41(3):421-6. Japanese.

PMID:
8478570
26.

Breath ethane: a specific indicator of free-radical-mediated lipid peroxidation following reperfusion of the ischemic liver.

Kazui M, Andreoni KA, Norris EJ, Klein AS, Burdick JF, Beattie C, Sehnert SS, Bell WR, Bulkley GB, Risby TH.

Free Radic Biol Med. 1992 Nov;13(5):509-15.

PMID:
1459476
27.

Utility of breath ethane as a noninvasive biomarker of vitamin E status in children.

Refat M, Moore TJ, Kazui M, Risby TH, Perman JA, Schwarz KB.

Pediatr Res. 1991 Nov;30(5):396-403.

PMID:
1754293
28.

Transplantation of livers from non-heart-beating donors is possible by core cooling technique.

Hoshino T, Koyama I, Nagashima N, Kadokura M, Kazui M, Omoto R.

Transplant Proc. 1989 Jun;21(3):3519. No abstract available.

PMID:
2662504
29.

Liver transplantation from non-heart-beating donors by core cooling technique.

Hoshino T, Koyama I, Nagashima N, Kadokura M, Kazui M, Omoto R.

Transplant Proc. 1989 Feb;21(1 Pt 2):1206-8. No abstract available.

PMID:
2652398
30.

Experimental study of cervical heterotopic cardiac transplantation as a temporary left ventricular assist device.

Hirooka Y, Kazui M, Hosoda Y.

Transplant Proc. 1989 Feb;21(1 Pt 3):2563-6. No abstract available.

PMID:
2650336
31.

[Surgical treatment of cancers of the lung and esophagus with heart diseases].

Mishina H, Kusajima K, Takada K, Kazui M, Hosokawa H.

Rinsho Kyobu Geka. 1983 Nov;3(6):679-88. Japanese. No abstract available.

PMID:
6610197

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