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Items: 1 to 50 of 121

1.

Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans.

Isenmann E, Ambrosio G, Joseph JF, Mazzarino M, de la Torre X, Zimmer P, Kazlauskas R, Goebel C, Botrè F, Diel P, Parr MK.

Arch Toxicol. 2019 Jul;93(7):1807-1816. doi: 10.1007/s00204-019-02490-x. Epub 2019 May 23.

PMID:
31123801
2.

Engineering more stable proteins.

Kazlauskas R.

Chem Soc Rev. 2018 Dec 21;47(24):9026-9045. doi: 10.1039/c8cs00014j. Epub 2018 Oct 11. Review.

PMID:
30306986
3.

Developmental evolution facilitates rapid adaptation.

Lin H, Kazlauskas RJ, Travisano M.

Sci Rep. 2017 Nov 21;7(1):15891. doi: 10.1038/s41598-017-16229-0.

4.

Comparison of Five Protein Engineering Strategies for Stabilizing an α/β-Hydrolase.

Jones BJ, Lim HY, Huang J, Kazlauskas RJ.

Biochemistry. 2017 Dec 19;56(50):6521-6532. doi: 10.1021/acs.biochem.7b00571. Epub 2017 Nov 14.

5.

Biosynthesis of (-)-5-Hydroxy-equol and 5-Hydroxy-dehydroequol from Soy Isoflavone, Genistein Using Microbial Whole Cell Bioconversion.

Lee PG, Kim J, Kim EJ, Lee SH, Choi KY, Kazlauskas RJ, Kim BG.

ACS Chem Biol. 2017 Nov 17;12(11):2883-2890. doi: 10.1021/acschembio.7b00624. Epub 2017 Oct 23.

PMID:
28985044
6.

One-step pretreatment of yellow poplar biomass using peracetic acid to enhance enzymatic digestibility.

Lee HR, Kazlauskas RJ, Park TH.

Sci Rep. 2017 Sep 22;7(1):12216. doi: 10.1038/s41598-017-12542-w.

7.

Identical active sites in hydroxynitrile lyases show opposite enantioselectivity and reveal possible ancestral mechanism.

Jones BJ, Bata Z, Kazlauskas RJ.

ACS Catal. 2017 Jun 2;7(6):4221-4229. doi: 10.1021/acscatal.7b01108. Epub 2017 May 15.

8.

The Fungus Trichoderma Regulates Submerged Conidiation Using the Steroid Pregnenolone.

Lin H, Travisano M, Kazlauskas RJ.

ACS Chem Biol. 2016 Sep 16;11(9):2568-75. doi: 10.1021/acschembio.6b00376. Epub 2016 Jul 22.

PMID:
27413801
9.

The use of tandem yeast and mammalian cell in vitro androgen bioassays to detect androgens in internet-sourced sport supplements.

Cooper ER, McGrath KC, Li X, Akram O, Kasz R, Kazlauskas R, McLeod MD, Handelsman DJ, Heather AK.

Drug Test Anal. 2017 Apr;9(4):545-552. doi: 10.1002/dta.2000. Epub 2016 Jun 27.

PMID:
27346668
10.

Experimental Evolution of Trichoderma citrinoviride for Faster Deconstruction of Cellulose.

Lin H, Travisano M, Kazlauskas RJ.

PLoS One. 2016 Jan 28;11(1):e0147024. doi: 10.1371/journal.pone.0147024. eCollection 2016.

11.

Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases.

Devamani T, Rauwerdink AM, Lunzer M, Jones BJ, Mooney JL, Tan MA, Zhang ZJ, Xu JH, Dean AM, Kazlauskas RJ.

J Am Chem Soc. 2016 Jan 27;138(3):1046-56. doi: 10.1021/jacs.5b12209. Epub 2016 Jan 15.

12.

Production of p-hydroxybenzoic acid from p-coumaric acid by Burkholderia glumae BGR1.

Jung DH, Kim EJ, Jung E, Kazlauskas RJ, Choi KY, Kim BG.

Biotechnol Bioeng. 2016 Jul;113(7):1493-503. doi: 10.1002/bit.25908. Epub 2015 Dec 31.

PMID:
26693833
13.

Evolution of a Catalytic Mechanism.

Rauwerdink A, Lunzer M, Devamani T, Jones B, Mooney J, Zhang ZJ, Xu JH, Kazlauskas RJ, Dean AM.

Mol Biol Evol. 2016 Apr;33(4):971-9. doi: 10.1093/molbev/msv338. Epub 2015 Dec 16.

14.

How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.

Rauwerdink A, Kazlauskas RJ.

ACS Catal. 2015 Oct 2;5(10):6153-6176. doi: 10.1021/acscatal.5b01539. Epub 2015 Sep 9.

15.

Stabilization of an α/β-Hydrolase by Introducing Proline Residues: Salicylic Acid Binding Protein 2 from Tobacco.

Huang J, Jones BJ, Kazlauskas RJ.

Biochemistry. 2015 Jul 21;54(28):4330-41. doi: 10.1021/acs.biochem.5b00333. Epub 2015 Jul 9.

16.

Natural product biosynthesis: the road to L.

Jones B, Kazlauskas RJ.

Nat Chem. 2015 Jan;7(1):11-2. doi: 10.1038/nchem.2137. No abstract available.

PMID:
25515878
17.

N,N-dimethyl-2-phenylpropan-1-amine - new designer agent found in athlete urine and nutritional supplement.

Kwiatkowska D, Wójtowicz M, Jarek A, Goebel C, Chajewska K, Turek-Lepa E, Pokrywka A, Kazlauskas R.

Drug Test Anal. 2015 Apr;7(4):331-5. doi: 10.1002/dta.1741. Epub 2014 Oct 29.

PMID:
25355281
18.

Increasing the reaction rate of hydroxynitrile lyase from Hevea brasiliensis toward mandelonitrile by copying active site residues from an esterase that accepts aromatic esters.

von Langermann J, Nedrud DM, Kazlauskas RJ.

Chembiochem. 2014 Sep 5;15(13):1931-8. doi: 10.1002/cbic.201402081. Epub 2014 Jul 18.

19.

Development of colorimetric HTS assay of cytochrome p450 for ortho-specific hydroxylation, and engineering of CYP102D1 with enhanced catalytic activity and regioselectivity.

Choi KY, Jung EO, Yun H, Yang YH, Kazlauskas RJ, Kim BG.

Chembiochem. 2013 Jul 8;14(10):1231-8. doi: 10.1002/cbic.201300212. Epub 2013 Jun 18.

PMID:
23780920
20.

New structural motif for carboxylic acid perhydrolases.

Yin DT, Purpero VM, Fujii R, Jing Q, Kazlauskas RJ.

Chemistry. 2013 Feb 25;19(9):3037-46. doi: 10.1002/chem.201202027. Epub 2013 Jan 16.

21.

Bioconversion of p-coumaric acid to p-hydroxystyrene using phenolic acid decarboxylase from B. amyloliquefaciens in biphasic reaction system.

Jung DH, Choi W, Choi KY, Jung E, Yun H, Kazlauskas RJ, Kim BG.

Appl Microbiol Biotechnol. 2013 Feb;97(4):1501-11. doi: 10.1007/s00253-012-4358-8. Epub 2012 Oct 19.

PMID:
23081771
22.

Carbon isotope ratio analysis of endogenous glucocorticoid urinary metabolites after cortisone acetate and adrenosterone administration for doping control.

Brooker L, Cawley A, Kazlauskas R, Goebel C, George A.

Drug Test Anal. 2012 Dec;4(12):951-61. doi: 10.1002/dta.1403. Epub 2012 Sep 17.

PMID:
22987608
23.

Revised molecular basis of the promiscuous carboxylic acid perhydrolase activity in serine hydrolases.

Yin DT, Kazlauskas RJ.

Chemistry. 2012 Jun 25;18(26):8130-9. doi: 10.1002/chem.201200052. Epub 2012 May 22.

PMID:
22618813
24.

Engineering the third wave of biocatalysis.

Bornscheuer UT, Huisman GW, Kazlauskas RJ, Lutz S, Moore JC, Robins K.

Nature. 2012 May 9;485(7397):185-94. doi: 10.1038/nature11117. Review.

PMID:
22575958
25.

Biology evolves to fight chemistry.

Kazlauskas R.

Chem Biol. 2012 Apr 20;19(4):435-7. doi: 10.1016/j.chembiol.2012.04.004.

26.

Cloning, expression and characterization of CYP102D1, a self-sufficient P450 monooxygenase from Streptomyces avermitilis.

Choi KY, Jung E, Jung DH, Pandey BP, Yun H, Park HY, Kazlauskas RJ, Kim BG.

FEBS J. 2012 May;279(9):1650-62. doi: 10.1111/j.1742-4658.2011.08462.x. Epub 2012 Jan 23.

27.

Studies of methylhexaneamine in supplements and geranium oil.

Lisi A, Hasick N, Kazlauskas R, Goebel C.

Drug Test Anal. 2011 Nov-Dec;3(11-12):873-6. doi: 10.1002/dta.392. Epub 2011 Dec 6.

PMID:
22147493
28.

Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli.

Malla S, Koffas MA, Kazlauskas RJ, Kim BG.

Appl Environ Microbiol. 2012 Feb;78(3):684-94. doi: 10.1128/AEM.06274-11. Epub 2011 Nov 18.

29.

Survey of protein engineering strategies.

Bornscheuer U, Kazlauskas RJ.

Curr Protoc Protein Sci. 2011 Nov;Chapter 26:Unit26.7. doi: 10.1002/0471140864.ps2607s66.

PMID:
22045562
30.

Chemical biotechnology in progress.

Chen GQ, Kazlauskas R.

Curr Opin Biotechnol. 2011 Dec;22(6):747-8. doi: 10.1016/j.copbio.2011.08.003. Epub 2011 Aug 20. No abstract available.

PMID:
21862309
31.

External calibration in gas chromatography-combustion-isotope ratio mass spectrometry measurements of endogenous androgenic anabolic steroids in sports doping control.

Kioussi MK, Angelis YS, Cawley AT, Koupparis M, Kazlauskas R, Brenna JT, Georgakopoulos CG.

J Chromatogr A. 2011 Aug 19;1218(33):5675-82. doi: 10.1016/j.chroma.2011.06.014. Epub 2011 Jun 17.

PMID:
21752385
32.

The importance of reference materials in doping-control analysis.

Mackay LG, Kazlauskas R.

Anal Bioanal Chem. 2011 Aug;401(2):483-92. doi: 10.1007/s00216-011-5049-5. Epub 2011 May 12. Review.

PMID:
21562740
33.

Protein engineering of α/β-hydrolase fold enzymes.

Jochens H, Hesseler M, Stiba K, Padhi SK, Kazlauskas RJ, Bornscheuer UT.

Chembiochem. 2011 Jul 4;12(10):1508-17. doi: 10.1002/cbic.201000771. Epub 2011 Apr 19. Review.

PMID:
21506229
34.

Different active-site loop orientation in serine hydrolases versus acyltransferases.

Jiang Y, Morley KL, Schrag JD, Kazlauskas RJ.

Chembiochem. 2011 Mar 21;12(5):768-76. doi: 10.1002/cbic.201000693. Epub 2011 Feb 23.

PMID:
21351219
35.

Improved pretreatment of lignocellulosic biomass using enzymatically-generated peracetic acid.

Yin DT, Jing Q, AlDajani WW, Duncan S, Tschirner U, Schilling J, Kazlauskas RJ.

Bioresour Technol. 2011 Apr;102(8):5183-92. doi: 10.1016/j.biortech.2011.01.079. Epub 2011 Feb 2.

PMID:
21345668
36.

Evaluation of androgenic activity of nutraceutical-derived steroids using mammalian and yeast in vitro androgen bioassays.

Akram ON, Bursill C, Desai R, Heather AK, Kazlauskas R, Handelsman DJ, Lambert G.

Anal Chem. 2011 Mar 15;83(6):2065-74. doi: 10.1021/ac102845y. Epub 2011 Feb 18.

PMID:
21329390
37.

Advances in sports drug testing: an overview.

Kazlauskas R.

Drug Test Anal. 2010 Nov-Dec;2(11-12):523-5. doi: 10.1002/dta.251. No abstract available.

PMID:
21204284
38.

The potential of urinary androstdiene markers to identify 4-androstenediol (4-ADIOL) administration in athletes.

Cawley AT, Trout GJ, Kazlauskas R, George AV.

Forensic Sci Int. 2011 May 20;208(1-3):129-38. doi: 10.1016/j.forsciint.2010.11.016. Epub 2010 Dec 21.

PMID:
21177052
39.

Stable isotope ratio profiling of testosterone preparations.

Cawley A, Collins M, Kazlauskas R, Handelsman DJ, Heywood R, Longworth M, Arenas-Queralt A.

Drug Test Anal. 2010 Nov-Dec;2(11-12):557-67. doi: 10.1002/dta.175. Epub 2010 Oct 22.

PMID:
20967879
40.

Switching from an esterase to a hydroxynitrile lyase mechanism requires only two amino acid substitutions.

Padhi SK, Fujii R, Legatt GA, Fossum SL, Berchtold R, Kazlauskas RJ.

Chem Biol. 2010 Aug 27;17(8):863-71. doi: 10.1016/j.chembiol.2010.06.013.

41.

Development of criteria for the detection of adrenosterone administration by gas chromatography-mass spectrometry and gas chromatography-combustion-isotope ratio mass spectrometry for doping control.

Brooker L, Parr MK, Cawley A, Flenker U, Howe C, Kazlauskas R, Schänzer W, George A.

Drug Test Anal. 2009 Nov;1(11-12):587-95. doi: 10.1002/dta.108.

PMID:
20355175
42.

Screening for testosterone abuse in male athletes using the measurement of urinary LH, a revision of the paradigm.

Goebel C, Howe CJ, Ho KK, Nelson A, Kazlauskas R, Trout GJ.

Drug Test Anal. 2009 Nov;1(11-12):511-7. doi: 10.1002/dta.71.

PMID:
20355166
43.

Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.

Yin DL, Bernhardt P, Morley KL, Jiang Y, Cheeseman JD, Purpero V, Schrag JD, Kazlauskas RJ.

Biochemistry. 2010 Mar 9;49(9):1931-42. doi: 10.1021/bi9021268.

44.

Designer steroids.

Kazlauskas R.

Handb Exp Pharmacol. 2010;(195):155-85. doi: 10.1007/978-3-540-79088-4_7. Review.

PMID:
20020364
45.

Molecular basis for the stereoselective ammoniolysis of N-alkyl aziridine-2-carboxylates catalyzed by Candida antarctica lipase B.

Park JH, Ha HJ, Lee WK, Généreux-Vincent T, Kazlauskas RJ.

Chembiochem. 2009 Sep 4;10(13):2213-22. doi: 10.1002/cbic.200900343.

PMID:
19672908
46.

Finding better protein engineering strategies.

Kazlauskas RJ, Bornscheuer UT.

Nat Chem Biol. 2009 Aug;5(8):526-9. doi: 10.1038/nchembio0809-526. No abstract available.

PMID:
19620988
47.

Increased saccharification yields from aspen biomass upon treatment with enzymatically generated peracetic acid.

Duncan S, Jing Q, Katona A, Kazlauskas RJ, Schilling J, Tschirner U, Aldajani WW.

Appl Biochem Biotechnol. 2010 Mar;160(6):1637-52. doi: 10.1007/s12010-009-8639-3. Epub 2009 Jun 1.

PMID:
19484411
48.

Converting an esterase into an epoxide hydrolase.

Jochens H, Stiba K, Savile C, Fujii R, Yu JG, Gerassenkov T, Kazlauskas RJ, Bornscheuer UT.

Angew Chem Int Ed Engl. 2009;48(19):3532-5. doi: 10.1002/anie.200806276.

PMID:
19350592
49.

Engineering enzymes by 'intelligent' design.

Kazlauskas R, Lutz S.

Curr Opin Chem Biol. 2009 Feb;13(1):1-2. doi: 10.1016/j.cbpa.2009.02.022. Epub 2009 Mar 9. No abstract available.

50.

Effects of recombinant human LH and hCG on serum and urine LH and androgens in men.

Handelsman DJ, Goebel C, Idan A, Jimenez M, Trout G, Kazlauskas R.

Clin Endocrinol (Oxf). 2009 Sep;71(3):417-28. doi: 10.1111/j.1365-2265.2008.03516.x. Epub 2008 Dec 18.

PMID:
19170708

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