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The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic.

Casado-Medrano V, Baker MJ, Lopez-Haber C, Cooke M, Wang S, Caloca MJ, Kazanietz MG.

Biochem Soc Trans. 2018 Aug 20;46(4):1003-1012. doi: 10.1042/BST20170519. Epub 2018 Jul 31. Review.


P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer.

Barrio-Real L, Lopez-Haber C, Casado-Medrano V, Goglia AG, Toettcher JE, Caloca MJ, Kazanietz MG.

Oncotarget. 2018 Jun 19;9(47):28612-28624. doi: 10.18632/oncotarget.25584. eCollection 2018 Jun 19.


COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer.

Garg R, Blando JM, Perez CJ, Lal P, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG.

Oncogene. 2018 Aug;37(34):4735-4749. doi: 10.1038/s41388-018-0318-9. Epub 2018 May 16.


Characterization of AJH-836, a diacylglycerol-lactone with selectivity for novel PKC isozymes.

Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG.

J Biol Chem. 2018 Jun 1;293(22):8330-8341. doi: 10.1074/jbc.RA117.000235. Epub 2018 Apr 10.


Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

Bessa C, Soares J, Raimundo L, Loureiro JB, Gomes C, Reis F, Soares ML, Santos D, Dureja C, Chaudhuri SR, Lopez-Haber C, Kazanietz MG, Gonçalves J, Simões MF, Rijo P, Saraiva L.

Cell Death Dis. 2018 Jan 18;9(2):23. doi: 10.1038/s41419-017-0154-9.


The Rac GTPase in Cancer: From Old Concepts to New Paradigms.

Kazanietz MG, Caloca MJ.

Cancer Res. 2017 Oct 15;77(20):5445-5451. doi: 10.1158/0008-5472.CAN-17-1456. Epub 2017 Aug 14. Review.


Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway.

Garg R, Blando JM, Perez CJ, Abba MC, Benavides F, Kazanietz MG.

Cell Rep. 2017 Apr 11;19(2):375-388. doi: 10.1016/j.celrep.2017.03.042.


Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis.

Baker MJ, Cooke M, Kazanietz MG.

Cancer Cell. 2017 Feb 13;31(2):167-169. doi: 10.1016/j.ccell.2017.01.008.


Protein kinase C in cancer: The top five unanswered questions.

Cooke M, Magimaidas A, Casado-Medrano V, Kazanietz MG.

Mol Carcinog. 2017 Jun;56(6):1531-1542. doi: 10.1002/mc.22617. Epub 2017 Mar 10. Review.


The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses.

Kazanietz MG, Barrio-Real L, Casado-Medrano V, Baker MJ, Lopez-Haber C.

Small GTPases. 2018 Jul 4;9(4):297-303. doi: 10.1080/21541248.2016.1221273. Epub 2016 Sep 2. Review.


Characterization of a P-Rex1 gene signature in breast cancer cells.

Barrio-Real L, Wertheimer E, Garg R, Abba MC, Kazanietz MG.

Oncotarget. 2016 Aug 9;7(32):51335-51348. doi: 10.18632/oncotarget.10285.


C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.

Priego N, Arechederra M, Sequera C, Bragado P, Vázquez-Carballo A, Gutiérrez-Uzquiza Á, Martín-Granado V, Ventura JJ, Kazanietz MG, Guerrero C, Porras A.

Oncotarget. 2016 Jul 19;7(29):45060-45078. doi: 10.18632/oncotarget.9911.


Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α.

Lopez-Haber C, Barrio-Real L, Casado-Medrano V, Kazanietz MG.

Mol Cell Biol. 2016 Jul 14;36(15):2011-26. doi: 10.1128/MCB.00180-16. Print 2016 Aug 1.


PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis.

Gutierrez-Uzquiza A, Lopez-Haber C, Jernigan DL, Fatatis A, Kazanietz MG.

Mol Cancer Res. 2015 Sep;13(9):1336-46. doi: 10.1158/1541-7786.MCR-15-0111. Epub 2015 May 28.


Protein kinase Cα mediates erlotinib resistance in lung cancer cells.

Abera MB, Kazanietz MG.

Mol Pharmacol. 2015 May;87(5):832-41. doi: 10.1124/mol.115.097725. Epub 2015 Feb 27.


Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.

Barrio-Real L, Benedetti LG, Engel N, Tu Y, Cho S, Sukumar S, Kazanietz MG.

Breast Cancer Res. 2014 Sep 24;16(5):441. doi: 10.1186/s13058-014-0441-7.


Transcriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins.

Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, Kazanietz MG.

J Biol Chem. 2014 Jul 11;289(28):19823-38. doi: 10.1074/jbc.M114.548446. Epub 2014 May 13.


β3-chimaerin, a novel member of the chimaerin Rac-GAP family.

Zubeldia-Brenner L, Gutierrez-Uzquiza A, Barrio-Real L, Wang H, Kazanietz MG, Leskow FC.

Mol Biol Rep. 2014;41(4):2067-76. doi: 10.1007/s11033-014-3055-3. Epub 2014 Jan 16.


Protein kinase C and cancer: what we know and what we do not.

Garg R, Benedetti LG, Abera MB, Wang H, Abba M, Kazanietz MG.

Oncogene. 2014 Nov 6;33(45):5225-37. doi: 10.1038/onc.2013.524. Epub 2013 Dec 16. Review.


Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes.

Garg R, Caino MC, Kazanietz MG.

PLoS One. 2013 Jun 27;8(6):e67319. doi: 10.1371/journal.pone.0067319. Print 2013.


Modulation of pancreatic tumor potential by overexpression of protein kinase C β1.

Cirigliano SM, Mauro LV, Grossoni VC, Colombo LL, Diament MJ, Kazanietz MG, Bal de Kier Joffé ED, Puricelli LI, Urtreger AJ.

Pancreas. 2013 Oct;42(7):1060-9. doi: 10.1097/MPA.0b013e31828fd141.


Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells.

Dipaolo BC, Davidovich N, Kazanietz MG, Margulies SS.

Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L141-53. doi: 10.1152/ajplung.00298.2012. Epub 2013 May 17.


Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.

Gutierrez-Uzquiza A, Colon-Gonzalez F, Leonard TA, Canagarajah BJ, Wang H, Mayer BJ, Hurley JH, Kazanietz MG.

Nat Commun. 2013;4:1849. doi: 10.1038/ncomms2834.


Differential signaling of the GnRH receptor in pituitary gonadotrope cell lines and prostate cancer cell lines.

Sviridonov L, Dobkin-Bekman M, Shterntal B, Przedecki F, Formishell L, Kravchook S, Rahamim-Ben Navi L, Bar-Lev TH, Kazanietz MG, Yao Z, Seger R, Naor Z.

Mol Cell Endocrinol. 2013 Apr 30;369(1-2):107-18. doi: 10.1016/j.mce.2013.01.010. Epub 2013 Feb 1.


A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites.

Millholland MG, Mishra S, Dupont CD, Love MS, Patel B, Shilling D, Kazanietz MG, Foskett JK, Hunter CA, Sinnis P, Greenbaum DC.

Cell Host Microbe. 2013 Jan 16;13(1):15-28. doi: 10.1016/j.chom.2012.12.001. Epub 2013 Jan 16.


Rho GEFs and cancer: linking gene expression and metastatic dissemination.

Barrio-Real L, Kazanietz MG.

Sci Signal. 2012 Oct 2;5(244):pe43. doi: 10.1126/scisignal.2003543.


Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C epsilon (PKCepsilon).

Garg R, Blando J, Perez CJ, Wang H, Benavides FJ, Kazanietz MG.

J Biol Chem. 2012 Oct 26;287(44):37570-82. doi: 10.1074/jbc.M112.398925. Epub 2012 Sep 6.


The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.

Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL.

Cell. 2012 Jun 22;149(7):1594-606. doi: 10.1016/j.cell.2012.05.018.


Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon.

Caino MC, Lopez-Haber C, Kissil JL, Kazanietz MG.

PLoS One. 2012;7(2):e31714. doi: 10.1371/journal.pone.0031714. Epub 2012 Feb 27.


Contribution of individual PKC isoforms to breast cancer progression.

Urtreger AJ, Kazanietz MG, Bal de Kier Joffé ED.

IUBMB Life. 2012 Jan;64(1):18-26. doi: 10.1002/iub.574. Epub 2011 Nov 17.


Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes.

Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG.

Oncogene. 2012 May 17;31(20):2593-600. doi: 10.1038/onc.2011.428. Epub 2011 Sep 26.


Rac signaling in breast cancer: a tale of GEFs and GAPs.

Wertheimer E, Gutierrez-Uzquiza A, Rosemblit C, Lopez-Haber C, Sosa MS, Kazanietz MG.

Cell Signal. 2012 Feb;24(2):353-62. doi: 10.1016/j.cellsig.2011.08.011. Epub 2011 Aug 27. Review.


Rac1 takes center stage in pancreatic cancer and ulcerative colitis: quantity matters.

Wertheimer E, Kazanietz MG.

Gastroenterology. 2011 Aug;141(2):427-30. doi: 10.1053/j.gastro.2011.06.027. Epub 2011 Jun 24. No abstract available.


p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function.

Wang H, Xiao L, Kazanietz MG.

J Biol Chem. 2011 May 6;286(18):15821-31. doi: 10.1074/jbc.M111.227991. Epub 2011 Mar 16.


Protein kinase C regulation: C1 meets C-tail.

Kazanietz MG, Lemmon MA.

Structure. 2011 Feb 9;19(2):144-6. doi: 10.1016/j.str.2011.01.004.


Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis.

Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG.

J Biol Chem. 2011 Apr 1;286(13):11254-64. doi: 10.1074/jbc.M110.194332. Epub 2011 Jan 20.


Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions.

Benavides F, Blando J, Perez CJ, Garg R, Conti CJ, DiGiovanni J, Kazanietz MG.

Cell Cycle. 2011 Jan 15;10(2):268-77. Epub 2011 Jan 15.


Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG.

Mol Cell. 2010 Dec 22;40(6):877-92. doi: 10.1016/j.molcel.2010.11.029.


Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway.

Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG.

J Biol Chem. 2010 Aug 20;285(34):26033-40. doi: 10.1074/jbc.M110.128371. Epub 2010 Jun 21.


A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.

Griner EM, Caino MC, Sosa MS, Colón-González F, Chalmers MJ, Mischak H, Kazanietz MG.

J Biol Chem. 2010 May 28;285(22):16931-41. doi: 10.1074/jbc.M109.099036. Epub 2010 Mar 24.


p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domains.

Wang H, Kazanietz MG.

Mol Biol Cell. 2010 Apr 15;21(8):1398-408. doi: 10.1091/mbc.E09-08-0735. Epub 2010 Feb 17.


Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways.

Chinchilla P, Xiao L, Kazanietz MG, Riobo NA.

Cell Cycle. 2010 Feb 1;9(3):570-79.


PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer.

Mauro LV, Grossoni VC, Urtreger AJ, Yang C, Colombo LL, Morandi A, Pallotta MG, Kazanietz MG, Bal de Kier Joffé ED, Puricelli LL.

Pancreas. 2010 Jan;39(1):e31-41. doi: 10.1097/MPA.0b013e3181bce796.


Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways.

Notcovich C, Diez F, Tubio MR, Baldi A, Kazanietz MG, Davio C, Shayo C.

Exp Cell Res. 2010 Feb 1;316(3):401-11. doi: 10.1016/j.yexcr.2009.11.002. Epub 2009 Nov 11.


ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK.

Xiao L, Eto M, Kazanietz MG.

J Biol Chem. 2009 Oct 23;284(43):29365-75. doi: 10.1074/jbc.M109.007971. Epub 2009 Aug 10.


Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.

Sosa MS, Lewin NE, Choi SH, Blumberg PM, Kazanietz MG.

Biochemistry. 2009 Sep 1;48(34):8171-8. doi: 10.1021/bi9010623.


Hallmarks for senescence in carcinogenesis: novel signaling players.

Caino MC, Meshki J, Kazanietz MG.

Apoptosis. 2009 Apr;14(4):392-408. doi: 10.1007/s10495-009-0316-z. Review.


Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model.

Grossoni VC, Todaro LB, Kazanietz MG, de Kier Joffé ED, Urtreger AJ.

Breast Cancer Res Treat. 2009 Dec;118(3):469-80. doi: 10.1007/s10549-008-0299-4. Epub 2009 Jan 9.


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