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Items: 29


KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma.

Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E.

N Engl J Med. 2017 May 18;376(20):1911-1920. doi: 10.1056/NEJMoa1613125.


Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial.

Wechsler ME, Yawn BP, Fuhlbrigge AL, Pace WD, Pencina MJ, Doros G, Kazani S, Raby BA, Lanzillotti J, Madison S, Israel E; BELT Investigators.

JAMA. 2015 Oct 27;314(16):1720-30. doi: 10.1001/jama.2015.13277.


Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.

Israel E, Lasky-Su J, Markezich A, Damask A, Szefler SJ, Schuemann B, Klanderman B, Sylvia J, Kazani S, Wu R, Martinez F, Boushey HA, Chinchilli VM, Mauger D, Weiss ST, Tantisira KG; SHARP Investigators.

Am J Respir Crit Care Med. 2015 Mar 1;191(5):530-7. doi: 10.1164/rccm.201408-1426OC.


LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.

Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E.

Springerplus. 2014 Nov 6;3:661. doi: 10.1186/2193-1801-3-661. eCollection 2014.


Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma.

Ono E, Dutile S, Kazani S, Wechsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland ER, Castro M, Jarjour NN, Israel E, Levy BD; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network.

Am J Respir Crit Care Med. 2014 Oct 15;190(8):886-97. doi: 10.1164/rccm.201403-0544OC.


Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.

Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA, LaForce C, Lazarus SC, Lemanske R, Lugogo N, Martin RJ, Mauger DT, Naureckas E, Peters SP, Phipatanakul W, Que LG, Sheshadri A, Smith L, Solway J, Sullivan-Vedder L, Sumino K, Wechsler ME, Wenzel S, White SR, Sutherland ER; National Heart, Lung, and Blood Institute’s AsthmaNet.

JAMA. 2014 May;311(20):2083-91. doi: 10.1001/jama.2014.5052.


Reply: "The intrinsic bias of generalizations" and "Far from 'disappointing'".

Kazani S, Israel E.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):361-2. doi: 10.1164/rccm.201308-1410LE. No abstract available.


Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.

Li C, Lee PS, Sun Y, Gu X, Zhang E, Guo Y, Wu CL, Auricchio N, Priolo C, Li J, Csibi A, Parkhitko A, Morrison T, Planaguma A, Kazani S, Israel E, Xu KF, Henske EP, Blenis J, Levy BD, Kwiatkowski D, Yu JJ.

J Exp Med. 2014 Jan 13;211(1):15-28. doi: 10.1084/jem.20131080. Epub 2014 Jan 6.


Loss of salmeterol bronchoprotection against exercise in relation to ADRB2 Arg16Gly polymorphism and exhaled nitric oxide.

Bonini M, Permaul P, Kulkarni T, Kazani S, Segal A, Sorkness CA, Wechsler ME, Israel E.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1407-12. doi: 10.1164/rccm.201307-1323OC.


What doesn't kill may not make you stronger. β-blockers for asthma.

Kazani S, Israel E.

Am J Respir Crit Care Med. 2013 Jun 15;187(12):1281. doi: 10.1164/rccm.201305-0815ED. No abstract available.


Exhaled breath condensate eicosanoid levels associate with asthma and its severity.

Kazani S, Planaguma A, Ono E, Bonini M, Zahid M, Marigowda G, Wechsler ME, Levy BD, Israel E.

J Allergy Clin Immunol. 2013 Sep;132(3):547-553. doi: 10.1016/j.jaci.2013.01.058. Epub 2013 Apr 19.


Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.

Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, Wechsler ME, Israel E, Levy BD.

Sci Transl Med. 2013 Feb 27;5(174):174ra26. doi: 10.1126/scitranslmed.3004812.


Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial.

Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA; Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute.

JAMA. 2012 Sep 12;308(10):987-97. doi: 10.1001/2012.jama.10893.


Update in asthma 2011.

Kazani S, Israel E.

Am J Respir Crit Care Med. 2012 Jul 1;186(1):35-40. doi: 10.1164/rccm.201204-0634UP. Review. No abstract available.


Utility of exhaled breath condensates across respiratory diseases.

Kazani S, Israel E.

Am J Respir Crit Care Med. 2012 Apr 15;185(8):791-2. doi: 10.1164/rccm.201202-0212ED. No abstract available.


Update in asthma 2010.

Kazani S, Israel E.

Am J Respir Crit Care Med. 2011 Aug 1;184(3):291-6. doi: 10.1164/rccm.201103-0557UP. No abstract available.


Treatment with beta blockers in people with COPD.

Kazani S, Israel E.

BMJ. 2011 May 10;342:d2655. doi: 10.1136/bmj.d2655. No abstract available.


The effects of an insertion in the 5'UTR of the AMCase on gene expression and pulmonary functions.

Birben E, Sackesen C, Kazani S, Tincer G, Karaaslan C, Durgunsu B, Gürsel I, Wechsler ME, Israel E, Kalayci O.

Respir Med. 2011 Aug;105(8):1160-9. doi: 10.1016/j.rmed.2011.03.017. Epub 2011 Apr 20.


Exhaled breath condensates in asthma: diagnostic and therapeutic implications.

Kazani S, Israel E.

J Breath Res. 2010 Dec;4(4):047001. doi: 10.1088/1752-7155/4/4/047001. Epub 2010 Nov 30. Review.


Cysteinyl leukotriene antagonism inhibits bronchoconstriction in response to hypertonic saline inhalation in asthma.

Kazani S, Sadeh J, Bunga S, Wechsler ME, Israel E.

Respir Med. 2011 May;105(5):667-73. doi: 10.1016/j.rmed.2010.11.025. Epub 2010 Dec 18.


Tiotropium bromide step-up therapy for adults with uncontrolled asthma.

Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske RF Jr, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER; National Heart, Lung, and Blood Institute Asthma Clinical Research Network.

N Engl J Med. 2010 Oct 28;363(18):1715-26. doi: 10.1056/NEJMoa1008770. Epub 2010 Sep 19.


The safety of long-acting beta-agonists: more evidence is needed.

Kazani S, Ware JH, Drazen JM, Taylor DR, Sears MR.

Respirology. 2010 Aug;15(6):881-5; discussion 885-6. doi: 10.1111/j.1440-1843.2010.01800.x. Epub 2010 Jul 6.


Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma.

Bhavsar PK, Levy BD, Hew MJ, Pfeffer MA, Kazani S, Israel E, Chung KF.

Respir Res. 2010 Jun 7;11:71. doi: 10.1186/1465-9921-11-71.


Long-acting beta-agonists and inhaled corticosteroids: is the whole greater than the sum of its parts?

Kazani S, Israel E.

J Allergy Clin Immunol. 2010 Feb;125(2):357-8. doi: 10.1016/j.jaci.2009.12.021. No abstract available.


The role of pharmacogenomics in improving the management of asthma.

Kazani S, Wechsler ME, Israel E.

J Allergy Clin Immunol. 2010 Feb;125(2):295-302; quiz 303-4. doi: 10.1016/j.jaci.2009.12.014. Review.


Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial.

Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF Jr, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman SI, Israel E; National Heart, Lung and Blood Institute's Asthma Clinical Research Network.

Lancet. 2009 Nov 21;374(9703):1754-64. doi: 10.1016/S0140-6736(09)61492-6.


Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.

Planagumà A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD.

Am J Respir Crit Care Med. 2008 Sep 15;178(6):574-82. doi: 10.1164/rccm.200801-061OC. Epub 2008 Jun 26.


Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness.

Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN.

J Immunol. 2007 Jan 1;178(1):496-502.


Relation between blood lead levels and childhood anemia in India.

Jain NB, Laden F, Guller U, Shankar A, Kazani S, Garshick E.

Am J Epidemiol. 2005 May 15;161(10):968-73.


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