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Items: 24

1.

Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase.

Baulig A, Helmle I, Bader M, Wolf F, Kulik A, Al-Dilaimi A, Wibberg D, Kalinowski J, Gross H, Kaysser L.

Chem Sci. 2019 Mar 21;10(16):4486-4490. doi: 10.1039/c9sc00641a. eCollection 2019 Apr 28.

2.

Built to bind: biosynthetic strategies for the formation of small-molecule protease inhibitors.

Kaysser L.

Nat Prod Rep. 2019 Apr 12. doi: 10.1039/c8np00095f. [Epub ahead of print] Review.

PMID:
30976762
3.

Characterization of the Actinonin Biosynthetic Gene Cluster.

Wolf F, Leipoldt F, Kulik A, Wibberg D, Kalinowski J, Kaysser L.

Chembiochem. 2018 Mar 30. doi: 10.1002/cbic.201800116. [Epub ahead of print]

PMID:
29600569
4.

Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors.

Leipoldt F, Santos-Aberturas J, Stegmann DP, Wolf F, Kulik A, Lacret R, Popadić D, Keinhörster D, Kirchner N, Bekiesch P, Gross H, Truman AW, Kaysser L.

Nat Commun. 2017 Dec 6;8(1):1965. doi: 10.1038/s41467-017-01975-6.

5.

Biosynthesis of the β-Lactone Proteasome Inhibitors Belactosin and Cystargolide.

Wolf F, Bauer JS, Bendel TM, Kulik A, Kalinowski J, Gross H, Kaysser L.

Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6665-6668. doi: 10.1002/anie.201612076. Epub 2017 Apr 28.

PMID:
28452105
6.

Epoxomicin and Eponemycin Biosynthesis Involves gem-Dimethylation and an Acyl-CoA Dehydrogenase-Like Enzyme.

Zettler J, Zubeil F, Kulik A, Grond S, Kaysser L.

Chembiochem. 2016 May 3;17(9):792-8. doi: 10.1002/cbic.201500567. Epub 2016 Feb 25.

PMID:
26789439
7.

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds.

Leipoldt F, Zeyhle P, Kulik A, Kalinowski J, Heide L, Kaysser L.

PLoS One. 2015 Dec 14;10(12):e0143237. doi: 10.1371/journal.pone.0143237. eCollection 2015.

8.

Complete genome sequence of Streptomyces sp. CNQ-509, a prolific producer of meroterpenoid chemistry.

Rückert C, Leipoldt F, Zeyhle P, Fenical W, Jensen PR, Kalinowski J, Heide L, Kaysser L.

J Biotechnol. 2015 Dec 20;216:140-1. doi: 10.1016/j.jbiotec.2015.08.009. Epub 2015 Aug 28.

PMID:
26319318
9.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

10.

A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins.

Diethelm S, Teufel R, Kaysser L, Moore BS.

Angew Chem Int Ed Engl. 2014 Oct 6;53(41):11023-6. doi: 10.1002/anie.201405696. Epub 2014 Aug 21.

11.

One-pot enzymatic synthesis of merochlorin A and B.

Teufel R, Kaysser L, Villaume MT, Diethelm S, Carbullido MK, Baran PS, Moore BS.

Angew Chem Int Ed Engl. 2014 Oct 6;53(41):11019-22. doi: 10.1002/anie.201405694. Epub 2014 Aug 12.

12.

Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.

Schorn M, Zettler J, Noel JP, Dorrestein PC, Moore BS, Kaysser L.

ACS Chem Biol. 2014 Jan 17;9(1):301-9. doi: 10.1021/cb400699p. Epub 2013 Nov 8.

13.

A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase.

Tang X, Eitel K, Kaysser L, Kulik A, Grond S, Gust B.

Nat Chem Biol. 2013 Oct;9(10):610-5. doi: 10.1038/nchembio.1310. Epub 2013 Aug 4.

PMID:
23912167
14.

Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases.

Kaysser L, Bernhardt P, Nam SJ, Loesgen S, Ruby JG, Skewes-Cox P, Jensen PR, Fenical W, Moore BS.

J Am Chem Soc. 2012 Jul 25;134(29):11988-91. doi: 10.1021/ja305665f. Epub 2012 Jul 12. Erratum in: J Am Chem Soc. 2014 Oct 15;136(41):14626.

15.

Identification of a napsamycin biosynthesis gene cluster by genome mining.

Kaysser L, Tang X, Wemakor E, Sedding K, Hennig S, Siebenberg S, Gust B.

Chembiochem. 2011 Feb 11;12(3):477-87. doi: 10.1002/cbic.201000460. Epub 2010 Dec 29.

PMID:
21290549
16.

Identification and structural elucidation of new caprazamycins from Streptomyces sp. MK730-62F2 by liquid chromatography/electrospray ionization tandem mass spectrometry.

Siebenberg S, Kaysser L, Wemakor E, Heide L, Gust B, Kammerer B.

Rapid Commun Mass Spectrom. 2011 Feb 28;25(4):495-502. doi: 10.1002/rcm.4889.

PMID:
21259358
17.

Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains.

Flinspach K, Westrich L, Kaysser L, Siebenberg S, Gomez-Escribano JP, Bibb M, Gust B, Heide L.

Biopolymers. 2010 Sep;93(9):823-32. doi: 10.1002/bip.21493.

PMID:
20578003
18.

Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.

Kaysser L, Wemakor E, Siebenberg S, Salas JA, Sohng JK, Kammerer B, Gust B.

Appl Environ Microbiol. 2010 Jun;76(12):4008-18. doi: 10.1128/AEM.02740-09. Epub 2010 Apr 23.

19.

A new arylsulfate sulfotransferase involved in liponucleoside antibiotic biosynthesis in streptomycetes.

Kaysser L, Eitel K, Tanino T, Siebenberg S, Matsuda A, Ichikawa S, Gust B.

J Biol Chem. 2010 Apr 23;285(17):12684-94. doi: 10.1074/jbc.M109.094490. Epub 2010 Feb 15.

20.

Analysis of the liposidomycin gene cluster leads to the identification of new caprazamycin derivatives.

Kaysser L, Siebenberg S, Kammerer B, Gust B.

Chembiochem. 2010 Jan 25;11(2):191-6. doi: 10.1002/cbic.200900637. No abstract available.

PMID:
20039253
21.

Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway.

Kaysser L, Lutsch L, Siebenberg S, Wemakor E, Kammerer B, Gust B.

J Biol Chem. 2009 May 29;284(22):14987-96. doi: 10.1074/jbc.M901258200. Epub 2009 Apr 7.

22.

Meeting report: the 13th International Biotechnology Symposium and Exhibition in Dalian, China.

Zhao X, Kaysser L.

Biotechnol J. 2009 Jan;4(1):23-7. doi: 10.1002/biot.200800312. No abstract available.

PMID:
19156743
23.

Preparative use of isolated CYP102 monooxygenases -- a critical appraisal.

Eiben S, Kaysser L, Maurer S, Kühnel K, Urlacher VB, Schmid RD.

J Biotechnol. 2006 Aug 5;124(4):662-9. Epub 2006 May 22. Review.

PMID:
16716428
24.

Cytochrome P450 alkane hydroxylases of the CYP153 family are common in alkane-degrading eubacteria lacking integral membrane alkane hydroxylases.

van Beilen JB, Funhoff EG, van Loon A, Just A, Kaysser L, Bouza M, Holtackers R, Röthlisberger M, Li Z, Witholt B.

Appl Environ Microbiol. 2006 Jan;72(1):59-65.

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