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Items: 24

1.

p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells.

Ihry RJ, Worringer KA, Salick MR, Frias E, Ho D, Theriault K, Kommineni S, Chen J, Sondey M, Ye C, Randhawa R, Kulkarni T, Yang Z, McAllister G, Russ C, Reece-Hoyes J, Forrester W, Hoffman GR, Dolmetsch R, Kaykas A.

Nat Med. 2018 Jul;24(7):939-946. doi: 10.1038/s41591-018-0050-6. Epub 2018 Jun 11.

PMID:
29892062
2.

Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids.

Salick MR, Wells MF, Eggan K, Kaykas A.

J Vis Exp. 2017 Sep 19;(127). doi: 10.3791/56404.

3.

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.

Feuerbach D, Schindler P, Barske C, Joller S, Beng-Louka E, Worringer KA, Kommineni S, Kaykas A, Ho DJ, Ye C, Welzenbach K, Elain G, Klein L, Brzak I, Mir AK, Farady CJ, Aichholz R, Popp S, George N, Neumann U.

Neurosci Lett. 2017 Nov 1;660:109-114. doi: 10.1016/j.neulet.2017.09.034. Epub 2017 Sep 18.

PMID:
28923481
4.

A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development.

Yao Z, Mich JK, Ku S, Menon V, Krostag AR, Martinez RA, Furchtgott L, Mulholland H, Bort S, Fuqua MA, Gregor BW, Hodge RD, Jayabalu A, May RC, Melton S, Nelson AM, Ngo NK, Shapovalova NV, Shehata SI, Smith MW, Tait LJ, Thompson CL, Thomsen ER, Ye C, Glass IA, Kaykas A, Yao S, Phillips JW, Grimley JS, Levi BP, Wang Y, Ramanathan S.

Cell Stem Cell. 2017 Jan 5;20(1):120-134. doi: 10.1016/j.stem.2016.09.011. Epub 2016 Oct 27.

5.

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection.

Wells MF, Salick MR, Wiskow O, Ho DJ, Worringer KA, Ihry RJ, Kommineni S, Bilican B, Klim JR, Hill EJ, Kane LT, Ye C, Kaykas A, Eggan K.

Cell Stem Cell. 2016 Dec 1;19(6):703-708. doi: 10.1016/j.stem.2016.11.011.

6.

A viral strategy for targeting and manipulating interneurons across vertebrate species.

Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Grimley JS, Krostag AR, Kaykas A, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G.

Nat Neurosci. 2016 Dec;19(12):1743-1749. doi: 10.1038/nn.4430. Epub 2016 Oct 31. Erratum in: Nat Neurosci. 2017 Jun 27;20(7):1033. Update in: Nat Neurosci. 2017 Jun 27;20(7):1033.

7.

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.

8.

Genome engineering of isogenic human ES cells to model autism disorders.

Martinez RA, Stein JL, Krostag AR, Nelson AM, Marken JS, Menon V, May RC, Yao Z, Kaykas A, Geschwind DH, Grimley JS.

Nucleic Acids Res. 2015 May 26;43(10):e65. doi: 10.1093/nar/gkv164. Epub 2015 Mar 11.

9.

CORTECON: a temporal transcriptome analysis of in vitro human cerebral cortex development from human embryonic stem cells.

van de Leemput J, Boles NC, Kiehl TR, Corneo B, Lederman P, Menon V, Lee C, Martinez RA, Levi BP, Thompson CL, Yao S, Kaykas A, Temple S, Fasano CA.

Neuron. 2014 Jul 2;83(1):51-68. doi: 10.1016/j.neuron.2014.05.013.

10.

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.

Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR.

Neuron. 2014 Jul 16;83(2):309-323. doi: 10.1016/j.neuron.2014.05.033. Epub 2014 Jun 19.

11.

Improving reliability and absolute quantification of human brain microarray data by filtering and scaling probes using RNA-Seq.

Miller JA, Menon V, Goldy J, Kaykas A, Lee CK, Smith KA, Shen EH, Phillips JW, Lein ES, Hawrylycz MJ.

BMC Genomics. 2014 Feb 24;15:154. doi: 10.1186/1471-2164-15-154.

12.

Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6.

Kategaya LS, Changkakoty B, Biechele T, Conrad WH, Kaykas A, Dasgupta R, Moon RT.

PLoS One. 2009 Jul 2;4(7):e6129. doi: 10.1371/journal.pone.0006129.

13.

Functional genomic analysis of the Wnt-wingless signaling pathway.

DasGupta R, Kaykas A, Moon RT, Perrimon N.

Science. 2005 May 6;308(5723):826-33. Epub 2005 Apr 7.

14.

WNT and beta-catenin signalling: diseases and therapies.

Moon RT, Kohn AD, De Ferrari GV, Kaykas A.

Nat Rev Genet. 2004 Sep;5(9):691-701. Review.

PMID:
15372092
15.
16.

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization.

Kaykas A, Yang-Snyder J, Héroux M, Shah KV, Bouvier M, Moon RT.

Nat Cell Biol. 2004 Jan;6(1):52-8. Epub 2003 Dec 14.

PMID:
14688793
17.

Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT.

Curr Biol. 2003 Apr 15;13(8):680-5.

18.
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Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.

Robitaille J, MacDonald ML, Kaykas A, Sheldahl LC, Zeisler J, Dubé MP, Zhang LH, Singaraja RR, Guernsey DL, Zheng B, Siebert LF, Hoskin-Mott A, Trese MT, Pimstone SN, Shastry BS, Moon RT, Hayden MR, Goldberg YP, Samuels ME.

Nat Genet. 2002 Oct;32(2):326-30. Epub 2002 Aug 12.

PMID:
12172548
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The R27080 glycoprotein is abundantly secreted from human cytomegalovirus-infected fibroblasts.

Müllberg J, Hsu ML, Rauch CT, Gerhart MJ, Kaykas A, Cosman D.

J Gen Virol. 1999 Feb;80 ( Pt 2):437-40.

PMID:
10073705

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