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ADAPT: An algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis.

Daniels SJ, Leeming DJ, Eslam M, Hashem AM, Nielsen MJ, Krag A, Karsdal MA, Grove JI, Guha IN, Kawaguchi T, Torimura T, McLeod D, Akiba J, Kaye P, de Boer B, Aithal GP, Adams LA, George J.

Hepatology. 2018 Jul 16. doi: 10.1002/hep.30163. [Epub ahead of print]


VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy.

Fletcher HA, Chatterjee M, Cooper A, Hussell T, Kaye PM, Prior J, Reljic R, Vermaak S, Vordermeier M, Williams A, McShane H.

F1000Res. 2018 Apr 23;7:485. doi: 10.12688/f1000research.14386.1. eCollection 2018.


Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging.

Bradley CR, Cox EF, Scott RA, James MW, Kaye P, Aithal GP, Francis ST, Guha IN.

J Hepatol. 2018 Jun 8. pii: S0168-8278(18)32122-6. doi: 10.1016/j.jhep.2018.05.037. [Epub ahead of print]


Macrophage Transactivation for Chemokine Production Identified as a Negative Regulator of Granulomatous Inflammation Using Agent-Based Modeling.

Moyo D, Beattie L, Andrews PS, Moore JWJ, Timmis J, Sawtell A, Hoehme S, Sampson AT, Kaye PM.

Front Immunol. 2018 Mar 27;9:637. doi: 10.3389/fimmu.2018.00637. eCollection 2018.


Orbital Inflammatory Complications of Crohn's Disease: A Rare Case Series.

Monaghan TM, Albanese G, Kaye P, Thomas JD, Abercrombie LC, Moran GW.

Clin Med Insights Gastroenterol. 2018 Feb 20;11:1179552218757512. doi: 10.1177/1179552218757512. eCollection 2018.


Tegumentary leishmaniasis and coinfections other than HIV.

Martínez DY, Verdonck K, Kaye PM, Adaui V, Polman K, Llanos-Cuentas A, Dujardin JC, Boelaert M.

PLoS Negl Trop Dis. 2018 Mar 1;12(3):e0006125. doi: 10.1371/journal.pntd.0006125. eCollection 2018 Mar. Review.


Synthesis and evaluation of substituted 4-arylimino-3-hydroxybutanoic acids as potential HIV-1 integrase inhibitors.

Faridoon, Mnkandhla D, Isaacs M, Hoppe HC, Kaye PT.

Bioorg Med Chem Lett. 2018 Apr 1;28(6):1067-1070. doi: 10.1016/j.bmcl.2018.02.020. Epub 2018 Feb 12.


MDM2 expression in the progression of Barrett's oesophagus.

Robinson L, Ilyas M, Ragunath K, Card T, Abradu-Berchie B, Kaye P.

Histopathology. 2018 Jun;72(7):1230-1233. doi: 10.1111/his.13480. Epub 2018 Mar 24. No abstract available.


Immunomodulatory Therapy of Visceral Leishmaniasis in Human Immunodeficiency Virus-Coinfected Patients.

Adriaensen W, Dorlo TPC, Vanham G, Kestens L, Kaye PM, van Griensven J.

Front Immunol. 2018 Jan 12;8:1943. doi: 10.3389/fimmu.2017.01943. eCollection 2017. Review.


Primary Esophagogastric Neuroendocrine Carcinoma: a Retrospective Study from the Nottingham Upper Gastrointestinal Cancer Center.

Savva C, Kaye P, Soomro I, Parsons SL, James E, Madhusudan S.

J Gastrointest Cancer. 2018 Mar;49(1):85-92. doi: 10.1007/s12029-017-0039-2. No abstract available.


Can reference images improve interobserver agreement in reporting liver fibrosis?

German AL, Fleming K, Kaye P, Davies S, Goldin R, Hubscher SG, Tiniakos D, McGregor A, Wyatt JI.

J Clin Pathol. 2018 Apr;71(4):368-371. doi: 10.1136/jclinpath-2017-204760. Epub 2017 Nov 10.


Application of the Morita-Baylis-Hillman reaction in the synthesis of 3-[(N-cycloalkylbenzamido)methyl]-2-quinolones as potential HIV-1 integrase inhibitors.

Sekgota KC, Majumder S, Isaacs M, Mnkandhla D, Hoppe HC, Khanye SD, Kriel FH, Coates J, Kaye PT.

Bioorg Chem. 2017 Dec;75:310-316. doi: 10.1016/j.bioorg.2017.09.015. Epub 2017 Sep 22.


Characterizing ice particles using two-dimensional reflections of a lidar beam.

Goerke M, Ulanowski Z, Ritter G, Hesse E, Neely RR, Taylor L, Stillwell RA, Kaye PH.

Appl Opt. 2017 Jul 1;56(19):G188-G196. doi: 10.1364/AO.56.00G188.


Technical aspects of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Technical Guideline - March 2017.

Polkowski M, Jenssen C, Kaye P, Carrara S, Deprez P, Gines A, Fernández-Esparrach G, Eisendrath P, Aithal GP, Arcidiacono P, Barthet M, Bastos P, Fornelli A, Napoleon B, Iglesias-Garcia J, Seicean A, Larghi A, Hassan C, van Hooft JE, Dumonceau JM.

Endoscopy. 2017 Oct;49(10):989-1006. doi: 10.1055/s-0043-119219. Epub 2017 Sep 12.


Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS).

Beg S, Ragunath K, Wyman A, Banks M, Trudgill N, Pritchard DM, Riley S, Anderson J, Griffiths H, Bhandari P, Kaye P, Veitch A.

Gut. 2017 Nov;66(11):1886-1899. doi: 10.1136/gutjnl-2017-314109. Epub 2017 Aug 18. Erratum in: Gut. 2017 Dec;66(12 ):2188.


Skin parasite landscape determines host infectiousness in visceral leishmaniasis.

Doehl JSP, Bright Z, Dey S, Davies H, Magson J, Brown N, Romano A, Dalton JE, Pinto AI, Pitchford JW, Kaye PM.

Nat Commun. 2017 Jul 5;8(1):57. doi: 10.1038/s41467-017-00103-8.


TNF signalling drives expansion of bone marrow CD4+ T cells responsible for HSC exhaustion in experimental visceral leishmaniasis.

Pinto AI, Brown N, Preham O, Doehl JSP, Ashwin H, Kaye PM.

PLoS Pathog. 2017 Jul 3;13(7):e1006465. doi: 10.1371/journal.ppat.1006465. eCollection 2017 Jul.


A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH.

Osman M, Mistry A, Keding A, Gabe R, Cook E, Forrester S, Wiggins R, Di Marco S, Colloca S, Siani L, Cortese R, Smith DF, Aebischer T, Kaye PM, Lacey CJ.

PLoS Negl Trop Dis. 2017 May 12;11(5):e0005527. doi: 10.1371/journal.pntd.0005527. eCollection 2017 May.


Postoperative survival following perioperative MAGIC versus neoadjuvant OE02-type chemotherapy in oesophageal adenocarcinoma.

Reece-Smith AM, Saunders JH, Soomro IN, Bowman CR, Duffy JP, Kaye PV, Welch NT, Madhusudan S, Parsons SL.

Ann R Coll Surg Engl. 2017 May;99(5):378-384. doi: 10.1308/rcsann.2017.0024.


Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study.

Ross-Innes CS, Chettouh H, Achilleos A, Galeano-Dalmau N, Debiram-Beecham I, MacRae S, Fessas P, Walker E, Varghese S, Evan T, Lao-Sirieix PS, O'Donovan M, Malhotra S, Novelli M, Disep B, Kaye PV, Lovat LB, Haidry R, Griffin M, Ragunath K, Bhandari P, Haycock A, Morris D, Attwood S, Dhar A, Rees C, Rutter MD, Ostler R, Aigret B, Sasieni PD, Fitzgerald RC; BEST2 study group.

Lancet Gastroenterol Hepatol. 2017 Jan;2(1):23-31. doi: 10.1016/S2468-1253(16)30118-2. Epub 2016 Nov 11. Erratum in: Lancet Gastroenterol Hepatol. 2017 Jul;2(7):e4.


The role of adjuvant platinum-based chemotherapy in esophagogastric cancer patients who received neoadjuvant chemotherapy prior to definitive surgery.

Saunders JH, Bowman CR, Reece-Smith AM, Pang V, Dorrington MS, Mumtaz E, Soomro I, Kaye P, Madhusudan S, Parsons SL.

J Surg Oncol. 2017 Jun;115(7):821-829. doi: 10.1002/jso.24601. Epub 2017 Mar 2.


Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: Results of a randomized controlled trial using 2 dietary approaches.

Baldry EL, Aithal GP, Kaye P, Idris IR, Bennett A, Leeder PC, Macdonald IA.

Diabetes Obes Metab. 2017 Aug;19(8):1179-1183. doi: 10.1111/dom.12918. Epub 2017 Mar 31.


Salmonella enterica Serovar Typhi Lipopolysaccharide O-Antigen Modification Impact on Serum Resistance and Antibody Recognition.

Kintz E, Heiss C, Black I, Donohue N, Brown N, Davies MR, Azadi P, Baker S, Kaye PM, van der Woude M.

Infect Immun. 2017 Mar 23;85(4). pii: e01021-16. doi: 10.1128/IAI.01021-16. Print 2017 Apr.


Economic evaluation of HIV testing for men who have sex with men in community-based organizations - results from six European cities.

Perelman J, Rosado R, Amri O, Morel S, Rojas Castro D, Chanos S, Cigan B, Lobnik M, Fuertes R, Pichon F, Kaye PS, Agustí C, Fernàndez-López L, Lorente N, Casabona J.

AIDS Care. 2017 Aug;29(8):985-989. doi: 10.1080/09540121.2016.1271392. Epub 2016 Dec 27.


In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.

Reif R, Ghallab A, Beattie L, Günther G, Kuepfer L, Kaye PM, Hengstler JG.

Arch Toxicol. 2017 Mar;91(3):1335-1352. doi: 10.1007/s00204-016-1906-5. Epub 2016 Dec 20.


Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis.

Fraser SD, Sadofsky LR, Kaye PM, Hart SP.

Sci Rep. 2016 Dec 8;6:38689. doi: 10.1038/srep38689.


Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development.

Timmis J, Alden K, Andrews P, Clark E, Nellis A, Naylor B, Coles M, Kaye P.

CPT Pharmacometrics Syst Pharmacol. 2017 Mar;6(3):156-167. doi: 10.1002/psp4.12157. Epub 2017 Feb 9. Review.


Synthesis and antimalarial activity of N-benzylated (N-arylcarbamoyl)alkylphosphonic acid derivatives.

Adeyemi CM, Faridoon, Isaacs M, Mnkandhla D, Hoppe HC, Krause RW, Kaye PT.

Bioorg Med Chem. 2016 Dec 1;24(23):6131-6138. doi: 10.1016/j.bmc.2016.04.021. Epub 2016 Apr 9.


CD4+ Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production.

Moore JW, Beattie L, Osman M, Owens BM, Brown N, Dalton JE, Maroof A, Kaye PM.

PLoS One. 2016 Sep 22;11(9):e0163604. doi: 10.1371/journal.pone.0163604. eCollection 2016.


Visual morphometry and three non-invasive markers in the evaluation of liver fibrosis in chronic liver disease.

Agrawal S, Hoad CL, Francis ST, Guha IN, Kaye P, Aithal GP.

Scand J Gastroenterol. 2017 Jan;52(1):107-115. doi: 10.1080/00365521.2016.1233578. Epub 2016 Sep 23.


Recombinant polymorphic membrane protein D in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal Chlamydia trachomatis infection in mice.

Paes W, Brown N, Brzozowski AM, Coler R, Reed S, Carter D, Bland M, Kaye PM, Lacey CJN.

Vaccine. 2016 Jul 29;34(35):4123-4131. doi: 10.1016/j.vaccine.2016.06.081. Epub 2016 Jul 4.


Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors.

Faridoon, Edkins AL, Isaacs M, Mnkandhla D, Hoppe HC, Kaye PT.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3810-2. doi: 10.1016/j.bmcl.2016.05.023. Epub 2016 May 9.


Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions.

Beattie L, Sawtell A, Mann J, Frame TCM, Teal B, de Labastida Rivera F, Brown N, Walwyn-Brown K, Moore JWJ, MacDonald S, Lim EK, Dalton JE, Engwerda CR, MacDonald KP, Kaye PM.

J Hepatol. 2016 Oct;65(4):758-768. doi: 10.1016/j.jhep.2016.05.037. Epub 2016 Jun 1.


Dysplasia in Barrett's oesophagus: p53 immunostaining is more reproducible than haematoxylin and eosin diagnosis and improves overall reliability, while grading is poorly reproducible.

Kaye PV, Ilyas M, Soomro I, Haider SA, Atwal G, Menon S, Gill S, Richards C, Harrison R, West K, Ragunath K.

Histopathology. 2016 Sep;69(3):431-40. doi: 10.1111/his.12956. Epub 2016 Apr 6.


Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate ester–AZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors.

Manyeruke MH, Olomola TO, Majumder S, Abrahams S, Isaacs M, Mautsa N, Mosebi S, Mnkandhla D, Hewer R, Hoppe HC, Klein R, Kaye PT.

Bioorg Med Chem. 2015 Dec 15;23(24):7521-8.


Lessons from other diseases: granulomatous inflammation in leishmaniasis.

Kaye PM, Beattie L.

Semin Immunopathol. 2016 Mar;38(2):249-60. doi: 10.1007/s00281-015-0548-7. Epub 2015 Dec 17. Review.


Elucidating Latent Mechanistic Complexity in Competing Acid-Catalyzed Reactions of Salicylaldehyde-Derived Baylis-Hillman Adducts.

Olomola TO, Klein R, Caira MR, Kaye PT.

J Org Chem. 2016 Jan 4;81(1):109-20. doi: 10.1021/acs.joc.5b02372. Epub 2015 Dec 14.


M2 Polarization of Monocytes-Macrophages Is a Hallmark of Indian Post Kala-Azar Dermal Leishmaniasis.

Mukhopadhyay D, Mukherjee S, Roy S, Dalton JE, Kundu S, Sarkar A, Das NK, Kaye PM, Chatterjee M.

PLoS Negl Trop Dis. 2015 Oct 23;9(10):e0004145. doi: 10.1371/journal.pntd.0004145. eCollection 2015 Oct.


Bile canalicular dynamics in hepatocyte sandwich cultures.

Reif R, Karlsson J, Günther G, Beattie L, Wrangborg D, Hammad S, Begher-Tibbe B, Vartak A, Melega S, Kaye PM, Hengstler JG, Jirstrand M.

Arch Toxicol. 2015 Oct;89(10):1861-70. doi: 10.1007/s00204-015-1575-9. Epub 2015 Aug 18.


Routine non-thyroid head and neck cytology in a large UK centre: clinical utility and pitfalls.

Kaye PV, Pigera M, Khan MM, Hollows P, Beasley N.

J Laryngol Otol. 2015 Jul;129(7):682-7. doi: 10.1017/S0022215115000092.


Addendum: BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia.

Bennett C, Moayyedi P, Corley DA, DeCaestecker J, Falck-Ytter Y, Falk G, Vakil N, Sanders S, Vieth M, Inadomi J, Aldulaimi D, Ho KY, Odze R, Meltzer SJ, Quigley E, Gittens S, Watson P, Zaninotto G, Iyer PG, Alexandre L, Ang Y, Callaghan J, Harrison R, Singh R, Bhandari P, Bisschops R, Geramizadeh B, Kaye P, Krishnadath S, Brian Fennerty M, Manner H, Nason KS, Pech O, Konda V, Ragunath K, Rahman I, Romero Y, Sampliner R, Siersema PD, Tack J, Tham TC, Trudgill N, Weinberg DS, Wang J, Wang K, Wong JY, Attwood S, Malfertheiner P, MacDonald D, Barr H, Ferguson MK, Jankowski J; BOB CAT Consortium.

Am J Gastroenterol. 2015 Jun;110(6):943. doi: 10.1038/ajg.2015.151. No abstract available.


Pathologists are able to differentiate reliably the lamina propria associated with Barrett's musculofibrous anomaly from submucosa in oesophageal endoscopic resections.

Kaye PV, O'Donovan M, Mapstone N, Disep B, Novelli M, Ragunath K.

Histopathology. 2015 Dec;67(6):914-7. doi: 10.1111/his.12736. Epub 2015 Jun 19.


A study of T₁ relaxation time as a measure of liver fibrosis and the influence of confounding histological factors.

Hoad CL, Palaniyappan N, Kaye P, Chernova Y, James MW, Costigan C, Austin A, Marciani L, Gowland PA, Guha IN, Francis ST, Aithal GP.

NMR Biomed. 2015 Jun;28(6):706-14. doi: 10.1002/nbm.3299. Epub 2015 Apr 24.


BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia.

Bennett C, Moayyedi P, Corley DA, DeCaestecker J, Falck-Ytter Y, Falk G, Vakil N, Sanders S, Vieth M, Inadomi J, Aldulaimi D, Ho KY, Odze R, Meltzer SJ, Quigley E, Gittens S, Watson P, Zaninotto G, Iyer PG, Alexandre L, Ang Y, Callaghan J, Harrison R, Singh R, Bhandari P, Bisschops R, Geramizadeh B, Kaye P, Krishnadath S, Fennerty MB, Manner H, Nason KS, Pech O, Konda V, Ragunath K, Rahman I, Romero Y, Sampliner R, Siersema PD, Tack J, Tham TC, Trudgill N, Weinberg DS, Wang J, Wang K, Wong JY, Attwood S, Malfertheiner P, MacDonald D, Barr H, Ferguson MK, Jankowski J; BOB CAT Consortium.

Am J Gastroenterol. 2015 May;110(5):662-82; quiz 683. doi: 10.1038/ajg.2015.55. Epub 2015 Apr 14. Review. Erratum in: Am J Gastroenterol. 2015 Jun;110(6):943.


The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection.

Dalton JE, Glover AC, Hoodless L, Lim EK, Beattie L, Kirby A, Kaye PM.

PLoS Pathog. 2015 Feb 24;11(2):e1004681. doi: 10.1371/journal.ppat.1004681. eCollection 2015 Feb.


Evaluation of a minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression for diagnosing Barrett's esophagus: a multi-center case-control study.

Ross-Innes CS, Debiram-Beecham I, O'Donovan M, Walker E, Varghese S, Lao-Sirieix P, Lovat L, Griffin M, Ragunath K, Haidry R, Sami SS, Kaye P, Novelli M, Disep B, Ostler R, Aigret B, North BV, Bhandari P, Haycock A, Morris D, Attwood S, Dhar A, Rees C, Rutter MD, Sasieni PD, Fitzgerald RC; BEST2 Study Group.

PLoS Med. 2015 Jan 29;12(1):e1001780. doi: 10.1371/journal.pmed.1001780. eCollection 2015 Jan.


Cervico-vaginal immunoglobulin G levels increase post-ovulation independently of neutrophils.

Schaefer K, Brown N, Kaye PM, Lacey CJ.

PLoS One. 2014 Dec 5;9(12):e114824. doi: 10.1371/journal.pone.0114824. eCollection 2014.


Mixed periampullary adenocarcinoma and somatostatinoma with small bowel gastrointestinal stromal tumour in neurofibromatosis type 1.

Tewari N, Rollins K, Gandhi N, Kaye P, Lobo DN.

JOP. 2014 Nov 28;15(6):600-3. doi: 10.6092/1590-8577/2844.


Lymphoepithelial cyst of the pancreas and elevated cyst fluid carcinoembryonic antigen: a diagnostic challenge.

Tewari N, Rollins K, Wu J, Kaye P, Lobo DN.

JOP. 2014 Sep 28;15(5):504-7. doi: 10.6092/1590-8577/2799.

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