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Items: 28

1.

Identification of 4-quinolone derivatives as inhibitors of reactive oxygen species production from human umbilical vein endothelial cells.

Onda K, Narazaki F, Ishibashi N, Nakanishi K, Sawada Y, Imamura K, Momose K, Furukawa S, Shimada Y, Moriguchi H, Yuda M, Kayakiri H, Ohta M.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6861-6. doi: 10.1016/j.bmcl.2011.09.015. Epub 2011 Sep 10.

PMID:
21963985
2.

Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.

Nakajima Y, Hamashima H, Washizuka K, Tomishima Y, Ohtake H, Imamura E, Miura T, Kayakiri H, Kato M.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):251-4.

PMID:
15603933
3.

Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614.

Minoura H, Takeshita S, Ita M, Hirosumi J, Mabuchi M, Kawamura I, Nakajima S, Nakayama O, Kayakiri H, Oku T, Ohkubo-Suzuki A, Fukagawa M, Kojo H, Hanioka K, Yamasaki N, Imoto T, Kobayashi Y, Mutoh S.

Eur J Pharmacol. 2004 Jun 28;494(2-3):273-81.

PMID:
15212984
4.

Discovery of the first non-peptide full agonists for the human bradykinin B(2) receptor incorporating 4-(2-picolyloxy)quinoline and 1-(2-picolyl)benzimidazole frameworks.

Sawada Y, Kayakiri H, Abe Y, Mizutani T, Inamura N, Asano M, Hatori C, Aramori I, Oku T, Tanaka H.

J Med Chem. 2004 May 20;47(11):2853-63.

PMID:
15139763
5.

A new class of nonpeptide bradykinin B(2) receptor ligand, incorporating a 4-aminoquinoline framework. Identification of a key pharmacophore to determine species difference and agonist/antagonist profile.

Sawada Y, Kayakiri H, Abe Y, Mizutani T, Inamura N, Asano M, Aramori I, Hatori C, Oku T, Tanaka H.

J Med Chem. 2004 May 6;47(10):2667-77.

PMID:
15115408
6.

A new series of highly potent non-peptide bradykinin B2 receptor antagonists incorporating the 4-heteroarylquinoline framework. Improvement of aqueous solubility and new insights into species difference.

Sawada Y, Kayakiri H, Abe Y, Imai K, Mizutani T, Inamura N, Asano M, Aramori I, Hatori C, Katayama A, Oku T, Tanaka H.

J Med Chem. 2004 Mar 25;47(7):1617-30.

PMID:
15027853
7.

[Bradykinin antagonist: current status and perspective].

Hirayama Y, Kayakiri H.

Nihon Yakurigaku Zasshi. 2002 Jan;119(1):45-53. Review. Japanese.

PMID:
11862756
8.

The beta-lactam antibiotics, penicillin-G and cefoselis have different mechanisms and sites of action at GABA(A) receptors.

Sugimoto M, Fukami S, Kayakiri H, Yamazaki S, Matsuoka N, Uchida I, Mashimo T.

Br J Pharmacol. 2002 Jan;135(2):427-32.

9.

[Discovery of highly potent and orally active non-peptide bradykinin B2 receptor antagonists].

Kayakiri H.

Tanpakushitsu Kakusan Koso. 2000 Apr;45(6 Suppl):996-1000. Review. Japanese. No abstract available.

PMID:
10771664
10.

Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.

Zhang X, Rice KC, Calderon SN, Kayakiri H, Smith L, Coop A, Jacobson AE, Rothman RB, Davis P, Dersch CM, Porreca F.

J Med Chem. 1999 Dec 30;42(26):5455-63.

PMID:
10639287
11.

Nonpeptide mimic of bradykinin with long-acting properties.

Aramori I, Zenkoh J, Morikawa N, Asano M, Hatori C, Sawai H, Kayakiri H, Satoh S, Inoue T, Abe Y, Sawada Y, Mizutani T, Inamura N, Iwami M, Nakahara K, Kojo H, Oku T, Notsu Y.

Immunopharmacology. 1999 Dec;45(1-3):185-90.

PMID:
10615010
12.

Discovery of orally active nonpeptide bradykinin B2 receptor antagonists.

Asano M, Inamura N, Hatori C, Sawai H, Fujiwara T, Abe Y, Kayakiri H, Satoh S, Oku T, Nakahara K.

Immunopharmacology. 1999 Sep;43(2-3):163-8. Review.

PMID:
10596849
13.
14.

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 4. Discovery of novel frameworks mimicking the active conformation.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Inamura N, Asano M, Aramori I, Hatori C, Sawai H, Oku T, Tanaka H.

J Med Chem. 1998 Nov 5;41(23):4587-98.

PMID:
9804698
15.

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a] pyridine moiety.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Inamura N, Asano M, Aramori I, Hatori C, Sawai H, Oku T, Tanaka H.

J Med Chem. 1998 Oct 8;41(21):4062-79.

PMID:
9767643
16.

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 2. Overcoming the species difference between guinea pig and man.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Inamura N, Asano M, Hatori C, Sawai H, Oku T, Tanaka H.

J Med Chem. 1998 Oct 8;41(21):4053-61.

PMID:
9767642
17.

Pharmacological characterization of a nonpeptide bradykinin B2 receptor antagonist, FR165649, and agonist, FR190997.

Asano M, Hatori C, Sawai H, Johki S, Inamura N, Kayakiri H, Satoh S, Abe Y, Inoue T, Sawada Y, Mizutani T, Oku T, Nakahara K.

Br J Pharmacol. 1998 Jun;124(3):441-6.

18.

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 1. Construction of the basic framework.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Imai K, Inamura N, Asano M, Hatori C, Katayama A, Oku T, Tanaka H.

J Med Chem. 1998 Feb 12;41(4):564-78.

PMID:
9484506
19.

Pharmacological characterization of a novel, orally active, nonpeptide bradykinin B2 receptor antagonist, FR167344.

Inamura N, Asano M, Hatori C, Sawai H, Hirosumi J, Fujiwara T, Kayakiri H, Satoh S, Abe Y, Inoue T, Sawada Y, Oku T, Nakahara K.

Eur J Pharmacol. 1997 Aug 20;333(1):79-86.

PMID:
9311664
20.

Nonpeptide mimic of bradykinin with long-acting properties at the bradykinin B2 receptor.

Aramori I, Zenkoh J, Morikawa N, Asano M, Hatori C, Sawai H, Kayakiri H, Satoh S, Inoue T, Abe Y, Sawada Y, Mizutani T, Inamura N, Nakahara K, Kojo H, Oku T, Notsu Y.

Mol Pharmacol. 1997 Jul;52(1):16-20.

PMID:
9224807
21.

Characterization of FR173657, a novel nonpeptide B2 antagonist: in vitro and in vivo studies.

Inamura N, Asano M, Kayakiri H, Hatori C, Oku T, Nakahara K.

Can J Physiol Pharmacol. 1997 Jun;75(6):622-8.

PMID:
9276139
23.

The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657.

Asano M, Inamura N, Hatori C, Sawai H, Fujiwara T, Katayama A, Kayakiri H, Satoh S, Abe Y, Inoue T, Sawada Y, Nakahara K, Oku T, Okuhara M.

Br J Pharmacol. 1997 Feb;120(4):617-24.

24.

Ligand selectivity of cloned human and rat opioid mu receptors.

Rothman RB, Xu H, Wang JB, Partilla JS, Kayakiri H, Rice KC, Uhl GR.

Synapse. 1995 Sep;21(1):60-4.

PMID:
8525463
25.

6 beta-[125iodo]-3, 14-dihydroxy-17-methyl-4, 5 alpha-epoxymorphinan ([125I]IOXY-AGO): a potent and selective radioligand for opioid mu receptors.

Xu H, Goodman CB, Partilla JS, Ni Q, Kayakiri H, Rice KC, Rothman RB.

Synapse. 1995 Feb;19(2):105-11.

PMID:
7725239
26.

Opioid peptide receptor studies. 3. Interaction of opioid peptides and other drugs with four subtypes of the kappa 2 receptor in guinea pig brain.

Ni Q, Xu H, Partilla JS, de Costa BR, Rice KC, Kayakiri H, Rothman RB.

Peptides. 1995;16(6):1083-95.

PMID:
8532593
27.

Structure and synthesis of nectrisine, a new immunomodulator isolated from a fungus.

Kayakiri H, Nakamura K, Takase S, Setoi H, Uchida I, Terano H, Hashimoto M, Tada T, Koda S.

Chem Pharm Bull (Tokyo). 1991 Nov;39(11):2807-12.

PMID:
1799935
28.

Synthesis of some polyhydroxylated pyrrolidine derivatives.

Setoi H, Kayakiri H, Takeno H, Hashimoto M.

Chem Pharm Bull (Tokyo). 1987 Oct;35(10):3995-9. No abstract available.

PMID:
3435934

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