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E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.

Vuillier C, Lohard S, Fétiveau A, Allègre J, Kayaci C, King LE, Braun F, Barillé-Nion S, Gautier F, Dubrez L, Gilmore AP, Juin PP, Maillet L.

EMBO Rep. 2018 Feb;19(2):234-243. doi: 10.15252/embr.201744046. Epub 2017 Dec 12.


DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.

Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi PM, Droin N, Kayaci C, Cartier J, Gemble S, Marcion G, Gonzalez D, Boidot R, Garrido C, Michaud O, Solary E, Dubrez L.

Cell Death Dis. 2017 May 25;8(5):e2816. doi: 10.1038/cddis.2017.222.

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