Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 176


Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice.

Trivedi PM, Fynch S, Kennedy LM, Chee J, Krishnamurthy B, O'Reilly LA, Strasser A, Kay TWH, Thomas HE.

Cell Death Discov. 2019 Sep 23;5:136. doi: 10.1038/s41420-019-0217-z. eCollection 2019.


T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities.

Wiede F, Brodnicki TC, Goh PK, Leong YA, Jones GW, Yu D, Baxter AG, Jones SA, Kay TWH, Tiganis T.

Diabetes. 2019 Jun;68(6):1251-1266. doi: 10.2337/db18-1362. Epub 2019 Apr 1.


Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets.

Burzava ALS, Forget A, Harding FJ, Cockshell MP, Penko D, Rouzaud C, Ahmadi V, Marina PF, Rojas-Canales D, Bonder CS, Coates PTH, Waibel M, Thomas HE, Kay TW, Loudovaris T, Blencowe A, Voelcker NH.

Biointerphases. 2019 Jan 30;14(1):011002. doi: 10.1116/1.5087737.


IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4+ T Cell Migration.

Scott NA, Zhao Y, Krishnamurthy B, Mannering SI, Kay TWH, Thomas HE.

Front Immunol. 2018 Nov 28;9:2800. doi: 10.3389/fimmu.2018.02800. eCollection 2018.


Mortality in People With Type 1 Diabetes, Severe Hypoglycemia, and Impaired Awareness of Hypoglycemia Referred for Islet Transplantation.

Lee MH, Ward GM, MacIsaac RJ, Howe K, Holmes-Walker DJ, Anderson P, Radford T, Coates PT, Kay TW, O'Connell PJ, Goodman DJ.

Transplant Direct. 2018 Oct 23;4(11):e401. doi: 10.1097/TXD.0000000000000841. eCollection 2018 Nov. No abstract available.


Proinsulin C-peptide is an autoantigen in people with type 1 diabetes.

So M, Elso CM, Tresoldi E, Pakusch M, Pathiraja V, Wentworth JM, Harrison LC, Krishnamurthy B, Thomas HE, Rodda C, Cameron FJ, McMahon J, Kay TWH, Mannering SI.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10732-10737. doi: 10.1073/pnas.1809208115. Epub 2018 Oct 1.


Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop.

Rickels MR, Stock PG, de Koning EJP, Piemonti L, Pratschke J, Alejandro R, Bellin MD, Berney T, Choudhary P, Johnson PR, Kandaswamy R, Kay TWH, Keymeulen B, Kudva YC, Latres E, Langer RM, Lehmann R, Ludwig B, Markmann JF, Marinac M, Odorico JS, Pattou F, Senior PA, Shaw JAM, Vantyghem MC, White S.

Transplantation. 2018 Sep;102(9):1479-1486. doi: 10.1097/TP.0000000000002158. Review.


NF-κB is weakly activated in the NOD mouse model of type 1 diabetes.

Irvin AE, Jhala G, Zhao Y, Blackwell TS, Krishnamurthy B, Thomas HE, Kay TWH.

Sci Rep. 2018 Mar 9;8(1):4217. doi: 10.1038/s41598-018-22738-3.


Oxygen-permeable microwell device maintains islet mass and integrity during shipping.

Rojas-Canales DM, Waibel M, Forget A, Penko D, Nitschke J, Harding FJ, Delalat B, Blencowe A, Loudovaris T, Grey ST, Thomas HE, Kay TWH, Drogemuller CJ, Voelcker NH, Coates PT.

Endocr Connect. 2018 Mar;7(3):490-503. doi: 10.1530/EC-17-0349. Epub 2018 Feb 26.


Defining outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop.

Rickels MR, Stock PG, de Koning EJP, Piemonti L, Pratschke J, Alejandro R, Bellin MD, Berney T, Choudhary P, Johnson PR, Kandaswamy R, Kay TWH, Keymeulen B, Kudva YC, Latres E, Langer RM, Lehmann R, Ludwig B, Markmann JF, Marinac M, Odorico JS, Pattou F, Senior PA, Shaw JAM, Vantyghem MC, White S.

Transpl Int. 2018 Apr;31(4):343-352. doi: 10.1111/tri.13138. Review.


Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans.

Simeonovic CJ, Popp SK, Starrs LM, Brown DJ, Ziolkowski AF, Ludwig B, Bornstein SR, Wilson JD, Pugliese A, Kay TWH, Thomas HE, Loudovaris T, Choong FJ, Freeman C, Parish CR.

PLoS One. 2018 Feb 7;13(2):e0191360. doi: 10.1371/journal.pone.0191360. eCollection 2018.


Shuffling peptides to create T-cell epitopes: does the immune system play cards?

Mannering SI, So M, Elso CM, Kay TWH.

Immunol Cell Biol. 2018 Jan;96(1):34-40. doi: 10.1111/imcb.1015. Epub 2017 Dec 7. Review.


Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells.

Augstein P, Loudovaris T, Bandala-Sanchez E, Heinke P, Naselli G, Lee L, Hawthorne WJ, Góñez LJ, Neale AM, Vaillant F, Thomas HE, Kay TW, Banakh I, Harrison LC.

Pancreas. 2018 Jan;47(1):25-34. doi: 10.1097/MPA.0000000000000950.


Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice.

Wali JA, Galic S, Tan CY, Gurzov EN, Frazier AE, Connor T, Ge J, Pappas EG, Stroud D, Varanasi LC, Selck C, Ryan MT, Thorburn DR, Kemp BE, Krishnamurthy B, Kay TW, McGee SL, Thomas HE.

Cell Death Differ. 2018 Jan;25(1):217-225. doi: 10.1038/cdd.2017.168. Epub 2017 Oct 20.


Erratum to: Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

Battaglia M, Anderson MS, Buckner JH, Geyer SM, Gottlieb PA, Kay TWH, Lernmark Å, Muller S, Pugliese A, Roep BO, Greenbaum CJ, Peakman M.

Diabetologia. 2017 Dec;60(12):2540. doi: 10.1007/s00125-017-4446-5. No abstract available.


Inhibition of Y1 receptor signaling improves islet transplant outcome.

Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, Laybutt DR, Grey ST, Herzog H.

Nat Commun. 2017 Sep 8;8(1):490. doi: 10.1038/s41467-017-00624-2.


Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

Battaglia M, Anderson MS, Buckner JH, Geyer SM, Gottlieb PA, Kay TWH, Lernmark Å, Muller S, Pugliese A, Roep BO, Greenbaum CJ, Peakman M.

Diabetologia. 2017 Nov;60(11):2139-2147. doi: 10.1007/s00125-017-4384-2. Epub 2017 Aug 2. Review. Erratum in: Diabetologia. 2017 Sep 26;:.


Transplantation sites for human and murine islets.

Stokes RA, Cheng K, Lalwani A, Swarbrick MM, Thomas HE, Loudovaris T, Kay TW, Hawthorne WJ, O'Connell PJ, Gunton JE.

Diabetologia. 2017 Oct;60(10):1961-1971. doi: 10.1007/s00125-017-4362-8. Epub 2017 Jul 22.


Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.

Mollah ZUA, Quah HS, Graham KL, Jhala G, Krishnamurthy B, Dharma JFM, Chee J, Trivedi PM, Pappas EG, Mackin L, Chu EPF, Akazawa S, Fynch S, Hodson C, Deans AJ, Trapani JA, Chong MMW, Bird PI, Brodnicki TC, Thomas HE, Kay TWH.

Diabetes. 2017 Dec;66(12):3041-3050. doi: 10.2337/db17-0517. Epub 2017 Jul 21.


Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ.

Sutherland RM, Londrigan SL, Brady JL, Carrington EM, Marchingo JM, Heinzel S, Hodgkin PD, Graham KL, Kay TW, Zhan Y, Lew AM.

Nat Commun. 2017 Apr 12;8:14809. doi: 10.1038/ncomms14809.


Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.

Trivedi PM, Graham KL, Scott NA, Jenkins MR, Majaw S, Sutherland RM, Fynch S, Lew AM, Burns CJ, Krishnamurthy B, Brodnicki TC, Mannering SI, Kay TW, Thomas HE.

Diabetes. 2017 Jun;66(6):1650-1660. doi: 10.2337/db16-1250. Epub 2017 Mar 14.


First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia.

Geyer MC, Coates PT, Khurana S, Chen JW, Kay TW, Balamurugan AN, Couper JJ, Radford T, Drogemuller CJ, Loudovaris T, Pathi R, Wilks MJ, Couper RT.

Pancreas. 2017 Mar;46(3):e18-e20. doi: 10.1097/MPA.0000000000000769. No abstract available.


Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In't Veld PA.

Diabetologia. 2017 Apr;60(4):753-755. doi: 10.1007/s00125-016-4195-x. Epub 2017 Jan 9. No abstract available.


Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility.

Chu EP, Elso CM, Pollock AH, Alsayb MA, Mackin L, Thomas HE, Kay TW, Silveira PA, Mansell AS, Gaus K, Brodnicki TC.

Mol Immunol. 2017 Feb;82:19-33. doi: 10.1016/j.molimm.2016.12.007. Epub 2016 Dec 19.


Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes.

Jhala G, Chee J, Trivedi PM, Selck C, Gurzov EN, Graham KL, Thomas HE, Kay TW, Krishnamurthy B.

JCI Insight. 2016 Jul 7;1(10):e86065. doi: 10.1172/jci.insight.86065.


Long-term effects of islet transplantation.

Holmes-Walker DJ, Kay TW.

Curr Opin Organ Transplant. 2016 Oct;21(5):497-502. doi: 10.1097/MOT.0000000000000355. Review.


Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin Injections.

Holmes-Walker DJ, Gunton JE, Hawthorne W, Payk M, Anderson P, Donath S, Loudovaris T, Ward GM, Kay TW, OʼConnell PJ.

Transplantation. 2017 Jun;101(6):1268-1275. doi: 10.1097/TP.0000000000001381.


Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling.

Pane JA, Fleming FE, Graham KL, Thomas HE, Kay TW, Coulson BS.

Sci Rep. 2016 Jul 13;6:29697. doi: 10.1038/srep29697.


How to Make Mice Tell the Truth.

Thomas HE, Brodnicki TC, Kay TW.

Diabetes. 2016 May;65(5):1161-3. doi: 10.2337/dbi16-0001. No abstract available.


Analysis of antigen specific T cells in diabetes - Lessons from pre-clinical studies and early clinical trials.

Krishnamurthy B, Selck C, Chee J, Jhala G, Kay TW.

J Autoimmun. 2016 Jul;71:35-43. doi: 10.1016/j.jaut.2016.03.018. Epub 2016 Apr 12. Review.


Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement.

Markmann JF, Bartlett ST, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, OʼConnell PJ, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Khovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T.

Transplantation. 2016 Jul;100(7):e25-31. doi: 10.1097/TP.0000000000001054. Review.


Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement.

Bartlett ST, Markmann JF, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, OʼConnell P, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Kovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T.

Transplantation. 2016 Feb;100 Suppl 2:S1-44. doi: 10.1097/TP.0000000000001055. No abstract available.


Human islet cells are killed by BID-independent mechanisms in response to FAS ligand.

Joglekar MV, Trivedi PM, Kay TW, Hawthorne WJ, O'Connell PJ, Jenkins AJ, Hardikar AA, Thomas HE.

Apoptosis. 2016 Apr;21(4):379-89. doi: 10.1007/s10495-016-1212-y.


Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets.

Kim KW, Ho A, Alshabee-Akil A, Hardikar AA, Kay TW, Rawlinson WD, Craig ME.

Diabetes. 2016 Apr;65(4):996-1003. doi: 10.2337/db15-0956. Epub 2015 Nov 11.


Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells.

Augstein P, Naselli G, Loudovaris T, Hawthorne WJ, Campbell P, Bandala-Sanchez E, Rogers K, Heinke P, Thomas HE, Kay TW, Harrison LC.

Diabetes Res Clin Pract. 2015 Dec;110(3):291-300. doi: 10.1016/j.diabres.2015.10.010. Epub 2015 Oct 26.


Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.

Trivedi P, Graham KL, Krishnamurthy B, Fynch S, Slattery RM, Kay TW, Thomas HE.

Immunol Cell Biol. 2016 Apr;94(4):334-41. doi: 10.1038/icb.2015.89. Epub 2015 Oct 8.


The case for an autoimmune aetiology of type 1 diabetes.

Mannering SI, Pathiraja V, Kay TW.

Clin Exp Immunol. 2016 Jan;183(1):8-15. doi: 10.1111/cei.12699. Epub 2015 Oct 21. Review.


Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE, Kay TW, Birnberg NC, Steinberg GR, Kemp BE, Oakhill JS.

Chem Biol. 2015 Jun 18;22(6):705-11. doi: 10.1016/j.chembiol.2015.05.011.


Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.

Litwak SA, Wali JA, Pappas EG, Saadi H, Stanley WJ, Varanasi LC, Kay TW, Thomas HE, Gurzov EN.

J Diabetes Res. 2015;2015:280615. doi: 10.1155/2015/280615. Epub 2015 May 6.


A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy.

Farr RJ, Januszewski AS, Joglekar MV, Liang H, McAulley AK, Hewitt AW, Thomas HE, Loudovaris T, Kay TW, Jenkins A, Hardikar AA.

Sci Rep. 2015 Jun 2;5:10375. doi: 10.1038/srep10375.


Evidence-informed clinical practice recommendations for treatment of type 1 diabetes complicated by problematic hypoglycemia.

Choudhary P, Rickels MR, Senior PA, Vantyghem MC, Maffi P, Kay TW, Keymeulen B, Inagaki N, Saudek F, Lehmann R, Hering BJ.

Diabetes Care. 2015 Jun;38(6):1016-29. doi: 10.2337/dc15-0090. Review.


Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.

Zhao Y, Scott NA, Quah HS, Krishnamurthy B, Bond F, Loudovaris T, Mannering SI, Kay TW, Thomas HE.

Eur J Immunol. 2015 Sep;45(9):2494-503. doi: 10.1002/eji.201445378. Epub 2015 May 28.


BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells.

Krishnamurthy B, Chee J, Jhala G, Trivedi P, Catterall T, Selck C, Gurzov EN, Brodnicki TC, Graham KL, Wali JA, Zhan Y, Gray D, Strasser A, Allison J, Thomas HE, Kay TW.

Diabetes. 2015 Sep;64(9):3229-38. doi: 10.2337/db14-1851. Epub 2015 May 6.


Measuring death of pancreatic beta cells in response to stress and cytotoxic T cells.

Wali JA, Trivedi P, Kay TW, Thomas HE.

Methods Mol Biol. 2015;1292:165-76. doi: 10.1007/978-1-4939-2522-3_12.


Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets.

Stanley WJ, Litwak SA, Quah HS, Tan SM, Kay TW, Tiganis T, de Haan JB, Thomas HE, Gurzov EN.

Diabetes. 2015 Jul;64(7):2489-96. doi: 10.2337/db14-1575. Epub 2015 Mar 2.


Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.

Wali JA, Gurzov EN, Fynch S, Elkerbout L, Kay TW, Masters SL, Thomas HE.

PLoS One. 2014 Nov 18;9(11):e113128. doi: 10.1371/journal.pone.0113128. eCollection 2014.


Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.

Hasnain SZ, Borg DJ, Harcourt BE, Tong H, Sheng YH, Ng CP, Das I, Wang R, Chen AC, Loudovaris T, Kay TW, Thomas HE, Whitehead JP, Forbes JM, Prins JB, McGuckin MA.

Nat Med. 2014 Dec;20(12):1417-26. doi: 10.1038/nm.3705. Epub 2014 Nov 2.


Islet cell transplantation in Australia: screening, remote transplantation, and incretin hormone secretion in insulin independent patients.

Marathe CS, Drogemuller CJ, Marathe JA, Loudavaris T, Hawthorne WJ, O'Connell PJ, Radford T, Kay TW, Horowitz M, Coates PT, Torpy DJ.

Horm Metab Res. 2015 Jan;47(1):16-23. doi: 10.1055/s-0034-1389941. Epub 2014 Oct 28. Review.


Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes.

Zhao Y, Scott NA, Fynch S, Elkerbout L, Wong WW, Mason KD, Strasser A, Huang DC, Kay TW, Thomas HE.

Diabetologia. 2015 Jan;58(1):140-8. doi: 10.1007/s00125-014-3407-5. Epub 2014 Oct 10.


Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010.

Balamurugan AN, Naziruddin B, Lockridge A, Tiwari M, Loganathan G, Takita M, Matsumoto S, Papas K, Trieger M, Rainis H, Kin T, Kay TW, Wease S, Messinger S, Ricordi C, Alejandro R, Markmann J, Kerr-Conti J, Rickels MR, Liu C, Zhang X, Witkowski P, Posselt A, Maffi P, Secchi A, Berney T, O'Connell PJ, Hering BJ, Barton FB.

Am J Transplant. 2014 Nov;14(11):2595-606. doi: 10.1111/ajt.12872. Epub 2014 Oct 2.

Supplemental Content

Support Center