Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 124


Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods.

Srivastava N, Traynor D, Piel M, Kabla AJ, Kay RR.

Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2506-2512. doi: 10.1073/pnas.1905730117. Epub 2020 Jan 21.


Living on soup: macropinocytic feeding in amoebae.

Kay RR, Williams TD, Manton JD, Traynor D, Paschke P.

Int J Dev Biol. 2019;63(8-9-10):473-483. doi: 10.1387/ijdb.190220rk.


Function of small GTPases in Dictyostelium macropinocytosis.

Williams TD, Paschke PI, Kay RR.

Philos Trans R Soc Lond B Biol Sci. 2019 Feb 4;374(1765):20180150. doi: 10.1098/rstb.2018.0150. Review.


The origins and evolution of macropinocytosis.

King JS, Kay RR.

Philos Trans R Soc Lond B Biol Sci. 2019 Feb 4;374(1765):20180158. doi: 10.1098/rstb.2018.0158. Review.


Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria.

Paschke P, Knecht DA, Williams TD, Thomason PA, Insall RH, Chubb JR, Kay RR, Veltman DM.

J Vis Exp. 2019 Jan 25;(143). doi: 10.3791/58981.


Akt and SGK protein kinases are required for efficient feeding by macropinocytosis.

Williams TD, Peak-Chew SY, Paschke P, Kay RR.

J Cell Sci. 2019 Jan 24;132(2). pii: jcs224998. doi: 10.1242/jcs.224998.


The Atypical MAP Kinase ErkB Transmits Distinct Chemotactic Signals through a Core Signaling Module.

Nichols JME, Paschke P, Peak-Chew S, Williams TD, Tweedy L, Skehel M, Stephens E, Chubb JR, Kay RR.

Dev Cell. 2019 Feb 25;48(4):491-505.e9. doi: 10.1016/j.devcel.2018.12.001. Epub 2019 Jan 3.


High-throughput Measurement of Dictyostelium discoideum Macropinocytosis by Flow Cytometry.

Williams T, Kay RR.

J Vis Exp. 2018 Sep 10;(139). doi: 10.3791/58434.


Rapid and efficient genetic engineering of both wild type and axenic strains of Dictyostelium discoideum.

Paschke P, Knecht DA, Silale A, Traynor D, Williams TD, Thomason PA, Insall RH, Chubb JR, Kay RR, Veltman DM.

PLoS One. 2018 May 30;13(5):e0196809. doi: 10.1371/journal.pone.0196809. eCollection 2018.


Repellent and Attractant Guidance Cues Initiate Cell Migration by Distinct Rear-Driven and Front-Driven Cytoskeletal Mechanisms.

Cramer LP, Kay RR, Zatulovskiy E.

Curr Biol. 2018 Mar 19;28(6):995-1004.e3. doi: 10.1016/j.cub.2018.02.024. Epub 2018 Mar 8.


Amplification of PIP3 signalling by macropinocytic cups.

Kay RR, Williams TD, Paschke P.

Biochem J. 2018 Feb 14;475(3):643-648. doi: 10.1042/BCJ20170785.


The physiological regulation of macropinocytosis during Dictyostelium growth and development.

Williams TD, Kay RR.

J Cell Sci. 2018 Mar 21;131(6). pii: jcs213736. doi: 10.1242/jcs.213736.


Image based modeling of bleb site selection.

Collier S, Paschke P, Kay RR, Bretschneider T.

Sci Rep. 2017 Jul 27;7(1):6692. doi: 10.1038/s41598-017-06875-9.


Method to study cell migration under uniaxial compression.

Srivastava N, Kay RR, Kabla AJ.

Mol Biol Cell. 2017 Mar 15;28(6):809-816. doi: 10.1091/mbc.E16-08-0575. Epub 2017 Jan 25.


A polycystin-type transient receptor potential (Trp) channel that is activated by ATP.

Traynor D, Kay RR.

Biol Open. 2017 Feb 15;6(2):200-209. doi: 10.1242/bio.020685.


A plasma membrane template for macropinocytic cups.

Veltman DM, Williams TD, Bloomfield G, Chen BC, Betzig E, Insall RH, Kay RR.

Elife. 2016 Dec 13;5. pii: e20085. doi: 10.7554/eLife.20085.


Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium.

Pontel LB, Langenick J, Rosado IV, Zhang XY, Traynor D, Kay RR, Patel KJ.

J Cell Sci. 2016 Dec 15;129(24):4449-4454. Epub 2016 Nov 21.


Uses and abuses of macropinocytosis.

Bloomfield G, Kay RR.

J Cell Sci. 2016 Jul 15;129(14):2697-705. doi: 10.1242/jcs.176149. Epub 2016 Jun 27. Review.


Chemotactic Blebbing in Dictyostelium Cells.

Zatulovskiy E, Kay RR.

Methods Mol Biol. 2016;1407:97-105. doi: 10.1007/978-1-4939-3480-5_7.


Mechanism of eIF6 release from the nascent 60S ribosomal subunit.

Weis F, Giudice E, Churcher M, Jin L, Hilcenko C, Wong CC, Traynor D, Kay RR, Warren AJ.

Nat Struct Mol Biol. 2015 Nov;22(11):914-9. doi: 10.1038/nsmb.3112. Epub 2015 Oct 19.


Chemotaxis of a model organism: progress with Dictyostelium.

Nichols JM, Veltman D, Kay RR.

Curr Opin Cell Biol. 2015 Oct;36:7-12. doi: 10.1016/ Epub 2015 Jul 14. Review.


Dictyostelium Cultivation, Transfection, Microscopy and Fractionation.

Hirst J, Kay RR, Traynor D.

Bio Protoc. 2015 Jun 5;5(11). pii: 1485.


Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium.

Bloomfield G, Traynor D, Sander SP, Veltman DM, Pachebat JA, Kay RR.

Elife. 2015 Mar 27;4. doi: 10.7554/eLife.04940.


Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.

Schiebler M, Brown K, Hegyi K, Newton SM, Renna M, Hepburn L, Klapholz C, Coulter S, Obregón-Henao A, Henao Tamayo M, Basaraba R, Kampmann B, Henry KM, Burgon J, Renshaw SA, Fleming A, Kay RR, Anderson KE, Hawkins PT, Ordway DJ, Rubinsztein DC, Floto RA.

EMBO Mol Med. 2015 Feb;7(2):127-39. doi: 10.15252/emmm.201404137.


Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.

Clark J, Kay RR, Kielkowska A, Niewczas I, Fets L, Oxley D, Stephens LR, Hawkins PT.

EMBO J. 2014 Oct 1;33(19):2188-200. doi: 10.15252/embj.201488677. Epub 2014 Sep 1.


How blebs and pseudopods cooperate during chemotaxis.

Tyson RA, Zatulovskiy E, Kay RR, Bretschneider T.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11703-8. doi: 10.1073/pnas.1322291111. Epub 2014 Jul 29.


Characterization of TSET, an ancient and widespread membrane trafficking complex.

Hirst J, Schlacht A, Norcott JP, Traynor D, Bloomfield G, Antrobus R, Kay RR, Dacks JB, Robinson MS.

Elife. 2014 May 27;3:e02866. doi: 10.7554/eLife.02866.


Bleb-driven chemotaxis of Dictyostelium cells.

Zatulovskiy E, Tyson R, Bretschneider T, Kay RR.

J Cell Biol. 2014 Mar 17;204(6):1027-44. doi: 10.1083/jcb.201306147. Epub 2014 Mar 10.


A PIP5 kinase essential for efficient chemotactic signaling.

Fets L, Nichols JM, Kay RR.

Curr Biol. 2014 Feb 17;24(4):415-21. doi: 10.1016/j.cub.2013.12.052. Epub 2014 Jan 30.


Two distinct functions for PI3-kinases in macropinocytosis.

Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR.

J Cell Sci. 2013 Sep 15;126(Pt 18):4296-307. doi: 10.1242/jcs.134015. Epub 2013 Jul 10.


Identification of a eukaryotic reductive dechlorinase and characterization of its mechanism of action on its natural substrate.

Velazquez F, Peak-Chew SY, Fernández IS, Neumann CS, Kay RR.

Chem Biol. 2011 Oct 28;18(10):1252-60. doi: 10.1016/j.chembiol.2011.08.003.


Defective ribosome assembly in Shwachman-Diamond syndrome.

Wong CC, Traynor D, Basse N, Kay RR, Warren AJ.

Blood. 2011 Oct 20;118(16):4305-12. doi: 10.1182/blood-2011-06-353938. Epub 2011 Jul 29.


Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum.

Sucgang R, Kuo A, Tian X, Salerno W, Parikh A, Feasley CL, Dalin E, Tu H, Huang E, Barry K, Lindquist E, Shapiro H, Bruce D, Schmutz J, Salamov A, Fey P, Gaudet P, Anjard C, Babu MM, Basu S, Bushmanova Y, van der Wel H, Katoh-Kurasawa M, Dinh C, Coutinho PM, Saito T, Elias M, Schaap P, Kay RR, Henrissat B, Eichinger L, Rivero F, Putnam NH, West CM, Loomis WF, Chisholm RL, Shaulsky G, Strassmann JE, Queller DC, Kuspa A, Grigoriev IV.

Genome Biol. 2011;12(2):R20. doi: 10.1186/gb-2011-12-2-r20. Epub 2011 Feb 28.


Sex determination in the social amoeba Dictyostelium discoideum.

Bloomfield G, Skelton J, Ivens A, Tanaka Y, Kay RR.

Science. 2010 Dec 10;330(6010):1533-6. doi: 10.1126/science.1197423.


The exocytic gene secA is required for Dictyostelium cell motility and osmoregulation.

Zanchi R, Howard G, Bretscher MS, Kay RR.

J Cell Sci. 2010 Oct 1;123(Pt 19):3226-34. doi: 10.1242/jcs.072876. Epub 2010 Aug 31.


Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.

Kay RR, Thompson CR.

Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001503. doi: 10.1101/cshperspect.a001503. Epub 2009 Jul 29. Review.


A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1.

Neumann CS, Walsh CT, Kay RR.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5798-803. doi: 10.1073/pnas.1001681107. Epub 2010 Mar 15.


A new Dictyostelium prestalk cell sub-type.

Yamada Y, Kay RR, Bloomfield G, Ross S, Ivens A, Williams JG.

Dev Biol. 2010 Mar 15;339(2):390-7. doi: 10.1016/j.ydbio.2009.12.045. Epub 2010 Jan 18.


Xpf and not the Fanconi anaemia proteins or Rev3 accounts for the extreme resistance to cisplatin in Dictyostelium discoideum.

Zhang XY, Langenick J, Traynor D, Babu MM, Kay RR, Patel KJ.

PLoS Genet. 2009 Sep;5(9):e1000645. doi: 10.1371/journal.pgen.1000645. Epub 2009 Sep 18.


Migration of Dictyostelium slugs: anterior-like cells may provide the motive force for the prespore zone.

Rieu JP, Saito T, Delanoë-Ayari H, Sawada Y, Kay RR.

Cell Motil Cytoskeleton. 2009 Dec;66(12):1073-86. doi: 10.1002/cm.20411.


Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium.

Parkinson K, Bolourani P, Traynor D, Aldren NL, Kay RR, Weeks G, Thompson CR.

J Cell Sci. 2009 Feb 1;122(Pt 3):335-44. doi: 10.1242/jcs.036822. Epub 2009 Jan 6.


Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains.

Carilla-Latorre S, Calvo-Garrido J, Bloomfield G, Skelton J, Kay RR, Ivens A, Martinez JL, Escalante R.

BMC Microbiol. 2008 Jun 30;8:109. doi: 10.1186/1471-2180-8-109.


Changing directions in the study of chemotaxis.

Kay RR, Langridge P, Traynor D, Hoeller O.

Nat Rev Mol Cell Biol. 2008 Jun;9(6):455-63. doi: 10.1038/nrm2419. Review.


Widespread duplications in the genomes of laboratory stocks of Dictyostelium discoideum.

Bloomfield G, Tanaka Y, Skelton J, Ivens A, Kay RR.

Genome Biol. 2008 Apr 22;9(4):R75. doi: 10.1186/gb-2008-9-4-r75.


DIF-1 induces the basal disc of the Dictyostelium fruiting body.

Saito T, Kato A, Kay RR.

Dev Biol. 2008 May 15;317(2):444-53. doi: 10.1016/j.ydbio.2008.02.036. Epub 2008 Feb 29.


SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium.

Galardi-Castilla M, Pergolizzi B, Bloomfield G, Skelton J, Ivens A, Kay RR, Bozzaro S, Sastre L.

Dev Biol. 2008 Apr 15;316(2):260-74. doi: 10.1016/j.ydbio.2008.01.026. Epub 2008 Jan 31.


My 2,000 best films: parallel phenotyping of Dictyostelium development.

Bloomfield G, Kay RR.

Genome Biol. 2007;8(7):220. Review.


Possible roles of the endocytic cycle in cell motility.

Traynor D, Kay RR.

J Cell Sci. 2007 Jul 15;120(Pt 14):2318-27.


Mutants in the Dictyostelium Arp2/3 complex and chemoattractant-induced actin polymerization.

Langridge PD, Kay RR.

Exp Cell Res. 2007 Jul 15;313(12):2563-74. Epub 2007 May 6.


Chemotaxis in the absence of PIP3 gradients.

Hoeller O, Kay RR.

Curr Biol. 2007 May 1;17(9):813-7.

Supplemental Content

Support Center