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Items: 1 to 50 of 117

1.

High-throughput Measurement of Dictyostelium discoideum Macropinocytosis by Flow Cytometry.

Williams T, Kay RR.

J Vis Exp. 2018 Sep 10;(139). doi: 10.3791/58434.

PMID:
30247467
2.

Rapid and efficient genetic engineering of both wild type and axenic strains of Dictyostelium discoideum.

Paschke P, Knecht DA, Silale A, Traynor D, Williams TD, Thomason PA, Insall RH, Chubb JR, Kay RR, Veltman DM.

PLoS One. 2018 May 30;13(5):e0196809. doi: 10.1371/journal.pone.0196809. eCollection 2018.

3.

Repellent and Attractant Guidance Cues Initiate Cell Migration by Distinct Rear-Driven and Front-Driven Cytoskeletal Mechanisms.

Cramer LP, Kay RR, Zatulovskiy E.

Curr Biol. 2018 Mar 19;28(6):995-1004.e3. doi: 10.1016/j.cub.2018.02.024. Epub 2018 Mar 8.

4.

Amplification of PIP3 signalling by macropinocytic cups.

Kay RR, Williams TD, Paschke P.

Biochem J. 2018 Feb 14;475(3):643-648. doi: 10.1042/BCJ20170785.

5.

The physiological regulation of macropinocytosis during Dictyostelium growth and development.

Williams TD, Kay RR.

J Cell Sci. 2018 Mar 21;131(6). pii: jcs213736. doi: 10.1242/jcs.213736.

6.

Image based modeling of bleb site selection.

Collier S, Paschke P, Kay RR, Bretschneider T.

Sci Rep. 2017 Jul 27;7(1):6692. doi: 10.1038/s41598-017-06875-9.

7.

Method to study cell migration under uniaxial compression.

Srivastava N, Kay RR, Kabla AJ.

Mol Biol Cell. 2017 Mar 15;28(6):809-816. doi: 10.1091/mbc.E16-08-0575. Epub 2017 Jan 25.

8.

A polycystin-type transient receptor potential (Trp) channel that is activated by ATP.

Traynor D, Kay RR.

Biol Open. 2017 Feb 15;6(2):200-209. doi: 10.1242/bio.020685.

9.

A plasma membrane template for macropinocytic cups.

Veltman DM, Williams TD, Bloomfield G, Chen BC, Betzig E, Insall RH, Kay RR.

Elife. 2016 Dec 13;5. pii: e20085. doi: 10.7554/eLife.20085.

10.

Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium.

Pontel LB, Langenick J, Rosado IV, Zhang XY, Traynor D, Kay RR, Patel KJ.

J Cell Sci. 2016 Dec 15;129(24):4449-4454. Epub 2016 Nov 21.

11.

Uses and abuses of macropinocytosis.

Bloomfield G, Kay RR.

J Cell Sci. 2016 Jul 15;129(14):2697-705. doi: 10.1242/jcs.176149. Epub 2016 Jun 27. Review.

12.

Chemotactic Blebbing in Dictyostelium Cells.

Zatulovskiy E, Kay RR.

Methods Mol Biol. 2016;1407:97-105. doi: 10.1007/978-1-4939-3480-5_7.

PMID:
27271896
13.

Mechanism of eIF6 release from the nascent 60S ribosomal subunit.

Weis F, Giudice E, Churcher M, Jin L, Hilcenko C, Wong CC, Traynor D, Kay RR, Warren AJ.

Nat Struct Mol Biol. 2015 Nov;22(11):914-9. doi: 10.1038/nsmb.3112. Epub 2015 Oct 19.

14.

Chemotaxis of a model organism: progress with Dictyostelium.

Nichols JM, Veltman D, Kay RR.

Curr Opin Cell Biol. 2015 Oct;36:7-12. doi: 10.1016/j.ceb.2015.06.005. Epub 2015 Jul 14. Review.

PMID:
26183444
15.

Dictyostelium Cultivation, Transfection, Microscopy and Fractionation.

Hirst J, Kay RR, Traynor D.

Bio Protoc. 2015 Jun 5;5(11). pii: 1485.

16.

Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium.

Bloomfield G, Traynor D, Sander SP, Veltman DM, Pachebat JA, Kay RR.

Elife. 2015 Mar 27;4. doi: 10.7554/eLife.04940.

17.

Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.

Schiebler M, Brown K, Hegyi K, Newton SM, Renna M, Hepburn L, Klapholz C, Coulter S, Obregón-Henao A, Henao Tamayo M, Basaraba R, Kampmann B, Henry KM, Burgon J, Renshaw SA, Fleming A, Kay RR, Anderson KE, Hawkins PT, Ordway DJ, Rubinsztein DC, Floto RA.

EMBO Mol Med. 2015 Feb;7(2):127-39. doi: 10.15252/emmm.201404137.

18.

Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.

Clark J, Kay RR, Kielkowska A, Niewczas I, Fets L, Oxley D, Stephens LR, Hawkins PT.

EMBO J. 2014 Oct 1;33(19):2188-200. doi: 10.15252/embj.201488677. Epub 2014 Sep 1.

19.

How blebs and pseudopods cooperate during chemotaxis.

Tyson RA, Zatulovskiy E, Kay RR, Bretschneider T.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11703-8. doi: 10.1073/pnas.1322291111. Epub 2014 Jul 29.

20.

Characterization of TSET, an ancient and widespread membrane trafficking complex.

Hirst J, Schlacht A, Norcott JP, Traynor D, Bloomfield G, Antrobus R, Kay RR, Dacks JB, Robinson MS.

Elife. 2014 May 27;3:e02866. doi: 10.7554/eLife.02866.

21.

Bleb-driven chemotaxis of Dictyostelium cells.

Zatulovskiy E, Tyson R, Bretschneider T, Kay RR.

J Cell Biol. 2014 Mar 17;204(6):1027-44. doi: 10.1083/jcb.201306147. Epub 2014 Mar 10.

22.

A PIP5 kinase essential for efficient chemotactic signaling.

Fets L, Nichols JM, Kay RR.

Curr Biol. 2014 Feb 17;24(4):415-21. doi: 10.1016/j.cub.2013.12.052. Epub 2014 Jan 30.

23.

Two distinct functions for PI3-kinases in macropinocytosis.

Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR.

J Cell Sci. 2013 Sep 15;126(Pt 18):4296-307. doi: 10.1242/jcs.134015. Epub 2013 Jul 10.

24.

Identification of a eukaryotic reductive dechlorinase and characterization of its mechanism of action on its natural substrate.

Velazquez F, Peak-Chew SY, Fernández IS, Neumann CS, Kay RR.

Chem Biol. 2011 Oct 28;18(10):1252-60. doi: 10.1016/j.chembiol.2011.08.003.

25.

Defective ribosome assembly in Shwachman-Diamond syndrome.

Wong CC, Traynor D, Basse N, Kay RR, Warren AJ.

Blood. 2011 Oct 20;118(16):4305-12. doi: 10.1182/blood-2011-06-353938. Epub 2011 Jul 29.

26.

Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum.

Sucgang R, Kuo A, Tian X, Salerno W, Parikh A, Feasley CL, Dalin E, Tu H, Huang E, Barry K, Lindquist E, Shapiro H, Bruce D, Schmutz J, Salamov A, Fey P, Gaudet P, Anjard C, Babu MM, Basu S, Bushmanova Y, van der Wel H, Katoh-Kurasawa M, Dinh C, Coutinho PM, Saito T, Elias M, Schaap P, Kay RR, Henrissat B, Eichinger L, Rivero F, Putnam NH, West CM, Loomis WF, Chisholm RL, Shaulsky G, Strassmann JE, Queller DC, Kuspa A, Grigoriev IV.

Genome Biol. 2011;12(2):R20. doi: 10.1186/gb-2011-12-2-r20. Epub 2011 Feb 28.

27.

Sex determination in the social amoeba Dictyostelium discoideum.

Bloomfield G, Skelton J, Ivens A, Tanaka Y, Kay RR.

Science. 2010 Dec 10;330(6010):1533-6. doi: 10.1126/science.1197423.

28.

The exocytic gene secA is required for Dictyostelium cell motility and osmoregulation.

Zanchi R, Howard G, Bretscher MS, Kay RR.

J Cell Sci. 2010 Oct 1;123(Pt 19):3226-34. doi: 10.1242/jcs.072876. Epub 2010 Aug 31.

29.

Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.

Kay RR, Thompson CR.

Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001503. doi: 10.1101/cshperspect.a001503. Epub 2009 Jul 29. Review.

30.

A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1.

Neumann CS, Walsh CT, Kay RR.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5798-803. doi: 10.1073/pnas.1001681107. Epub 2010 Mar 15.

31.

A new Dictyostelium prestalk cell sub-type.

Yamada Y, Kay RR, Bloomfield G, Ross S, Ivens A, Williams JG.

Dev Biol. 2010 Mar 15;339(2):390-7. doi: 10.1016/j.ydbio.2009.12.045. Epub 2010 Jan 18.

32.

Xpf and not the Fanconi anaemia proteins or Rev3 accounts for the extreme resistance to cisplatin in Dictyostelium discoideum.

Zhang XY, Langenick J, Traynor D, Babu MM, Kay RR, Patel KJ.

PLoS Genet. 2009 Sep;5(9):e1000645. doi: 10.1371/journal.pgen.1000645. Epub 2009 Sep 18.

33.

Migration of Dictyostelium slugs: anterior-like cells may provide the motive force for the prespore zone.

Rieu JP, Saito T, Delanoë-Ayari H, Sawada Y, Kay RR.

Cell Motil Cytoskeleton. 2009 Dec;66(12):1073-86. doi: 10.1002/cm.20411.

PMID:
19693807
34.

Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium.

Parkinson K, Bolourani P, Traynor D, Aldren NL, Kay RR, Weeks G, Thompson CR.

J Cell Sci. 2009 Feb 1;122(Pt 3):335-44. doi: 10.1242/jcs.036822. Epub 2009 Jan 6.

35.

Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains.

Carilla-Latorre S, Calvo-Garrido J, Bloomfield G, Skelton J, Kay RR, Ivens A, Martinez JL, Escalante R.

BMC Microbiol. 2008 Jun 30;8:109. doi: 10.1186/1471-2180-8-109.

36.

Changing directions in the study of chemotaxis.

Kay RR, Langridge P, Traynor D, Hoeller O.

Nat Rev Mol Cell Biol. 2008 Jun;9(6):455-63. doi: 10.1038/nrm2419. Review.

PMID:
18500256
37.

Widespread duplications in the genomes of laboratory stocks of Dictyostelium discoideum.

Bloomfield G, Tanaka Y, Skelton J, Ivens A, Kay RR.

Genome Biol. 2008 Apr 22;9(4):R75. doi: 10.1186/gb-2008-9-4-r75.

38.

DIF-1 induces the basal disc of the Dictyostelium fruiting body.

Saito T, Kato A, Kay RR.

Dev Biol. 2008 May 15;317(2):444-53. doi: 10.1016/j.ydbio.2008.02.036. Epub 2008 Feb 29.

39.

SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium.

Galardi-Castilla M, Pergolizzi B, Bloomfield G, Skelton J, Ivens A, Kay RR, Bozzaro S, Sastre L.

Dev Biol. 2008 Apr 15;316(2):260-74. doi: 10.1016/j.ydbio.2008.01.026. Epub 2008 Jan 31.

40.

My 2,000 best films: parallel phenotyping of Dictyostelium development.

Bloomfield G, Kay RR.

Genome Biol. 2007;8(7):220. Review.

41.

Possible roles of the endocytic cycle in cell motility.

Traynor D, Kay RR.

J Cell Sci. 2007 Jul 15;120(Pt 14):2318-27.

42.

Mutants in the Dictyostelium Arp2/3 complex and chemoattractant-induced actin polymerization.

Langridge PD, Kay RR.

Exp Cell Res. 2007 Jul 15;313(12):2563-74. Epub 2007 May 6.

PMID:
17553489
43.

Chemotaxis in the absence of PIP3 gradients.

Hoeller O, Kay RR.

Curr Biol. 2007 May 1;17(9):813-7.

44.

A new environmentally resistant cell type from Dictyostelium.

Serafimidis I, Bloomfield G, Skelton J, Ivens A, Kay RR.

Microbiology. 2007 Feb;153(Pt 2):619-30.

45.

Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.

Austin MB, Saito T, Bowman ME, Haydock S, Kato A, Moore BS, Kay RR, Noel JP.

Nat Chem Biol. 2006 Sep;2(9):494-502. Epub 2006 Aug 13.

46.

Blebbing of Dictyostelium cells in response to chemoattractant.

Langridge PD, Kay RR.

Exp Cell Res. 2006 Jul 1;312(11):2009-17. Epub 2006 Apr 19.

PMID:
16624291
47.

Identification of new differentiation inducing factors from Dictyostelium discoideum.

Saito T, Taylor GW, Yang JC, Neuhaus D, Stetsenko D, Kato A, Kay RR.

Biochim Biophys Acta. 2006 May;1760(5):754-61. Epub 2006 Jan 5.

PMID:
16545913
48.

Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase.

Chubb JR, Bloomfield G, Xu Q, Kaller M, Ivens A, Skelton J, Turner BM, Nellen W, Shaulsky G, Kay RR, Bickmore WA, Singer RH.

Dev Biol. 2006 Apr 15;292(2):519-32. Epub 2006 Feb 15.

49.

New prestalk and prespore inducing signals in Dictyostelium.

Serafimidis I, Kay RR.

Dev Biol. 2005 Jun 15;282(2):432-41.

50.

The genome of the social amoeba Dictyostelium discoideum.

Eichinger L, Pachebat JA, Glöckner G, Rajandream MA, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov BA, Rivero F, Bankier AT, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail MA, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox EC, Chisholm RL, Gibbs R, Loomis WF, Platzer M, Kay RR, Williams J, Dear PH, Noegel AA, Barrell B, Kuspa A.

Nature. 2005 May 5;435(7038):43-57.

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