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Reply: LATE to the PART-y.

Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Fardo DW, Flanagan ME, Halliday G, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murray ME, Nag S, Seeley WW, Sperling RA, White CL, Schneider JA.

Brain. 2019 Sep 1;142(9):e48. doi: 10.1093/brain/awz226. No abstract available.


White Matter Hyperintensities and Hippocampal Atrophy in Relation to Cognition: The 90+ Study.

Legdeur N, Visser PJ, Woodworth DC, Muller M, Fletcher E, Maillard P, Scheltens P, DeCarli C, Kawas CH, Corrada MM.

J Am Geriatr Soc. 2019 Sep;67(9):1827-1834. doi: 10.1111/jgs.15990. Epub 2019 Jun 6.


Neuropsychological Test Norms in Cognitively Intact Oldest-Old.

Melikyan ZA, Corrada MM, Dick MB, Whittle C, Paganini-Hill A, Kawas CH.

J Int Neuropsychol Soc. 2019 May;25(5):530-545. doi: 10.1017/S1355617719000122.


Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4.

Bilousova T, Melnik M, Miyoshi E, Gonzalez BL, Poon WW, Vinters HV, Miller CA, Corrada MM, Kawas C, Hatami A, Albay R 3rd, Glabe C, Gylys KH.

Am J Pathol. 2019 Aug;189(8):1621-1636. doi: 10.1016/j.ajpath.2019.04.010. Epub 2019 May 17.


Timing of onset and rate of decline in learning and retention in the pre-dementia phase of Alzheimer's disease.

Grober E, An Y, Lipton RB, Kawas C, Resnick SM.

J Int Neuropsychol Soc. 2019 Aug;25(7):699-705. doi: 10.1017/S1355617719000304.


Blood Pressure Circadian Variation, Cognition and Brain Imaging in 90+ Year-Olds.

Paganini-Hill A, Bryant N, Corrada MM, Greenia DE, Fletcher E, Singh B, Floriolli D, Kawas CH, Fisher MJ.

Front Aging Neurosci. 2019 Apr 17;11:54. doi: 10.3389/fnagi.2019.00054. eCollection 2019.


Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.

Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White Iii CL, Yu L, Schneider JA.

Brain. 2019 Jun 1;142(6):1503-1527. doi: 10.1093/brain/awz099. Erratum in: Brain. 2019 Jul 1;142(7):e37.


Reproductive period and risk of dementia in a diverse cohort of health care members.

Gilsanz P, Lee C, Corrada MM, Kawas CH, Quesenberry CP Jr, Whitmer RA.

Neurology. 2019 Apr 23;92(17):e2005-e2014. doi: 10.1212/WNL.0000000000007326. Epub 2019 Mar 28.


Concepts for brain aging: resistance, resilience, reserve, and compensation.

Montine TJ, Cholerton BA, Corrada MM, Edland SD, Flanagan ME, Hemmy LS, Kawas CH, White LR.

Alzheimers Res Ther. 2019 Mar 11;11(1):22. doi: 10.1186/s13195-019-0479-y.


Incidence of dementia after age 90 in a multiracial cohort.

Gilsanz P, Corrada MM, Kawas CH, Mayeda ER, Glymour MM, Quesenberry CP Jr, Lee C, Whitmer RA.

Alzheimers Dement. 2019 Apr;15(4):497-505. doi: 10.1016/j.jalz.2018.12.006. Epub 2019 Feb 20.


Positive Mental Attitude Associated with Lower 35-Year Mortality: The Leisure World Cohort Study.

Paganini-Hill A, Kawas CH, Corrada MM.

J Aging Res. 2018 Nov 25;2018:2126368. doi: 10.1155/2018/2126368. eCollection 2018.


Increased longevity in older users of postmenopausal estrogen therapy: the Leisure World Cohort Study.

Paganini-Hill A, Corrada MM, Kawas CH.

Menopause. 2018 Nov;25(11):1256-1261. doi: 10.1097/GME.0000000000001227.


Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study.

Trieu T, Sajjadi SA, Kawas CH, Nelson PT, Corrada MM.

Neurology. 2018 Nov 6;91(19):e1788-e1798. doi: 10.1212/WNL.0000000000006455. Epub 2018 Oct 12.


Sleep, hippocampal volume, and cognition in adults over 90 years old.

Sabeti S, Al-Darsani Z, Mander BA, Corrada MM, Kawas CH.

Aging Clin Exp Res. 2018 Nov;30(11):1307-1318. doi: 10.1007/s40520-018-1030-x. Epub 2018 Sep 3.


Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study.

Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VM, Kawas CH, Trojanowski JQ.

Acta Neuropathol. 2018 Sep;136(3):377-388. doi: 10.1007/s00401-018-1872-5. Epub 2018 Jun 18.


Recruiting the Oldest-old for Clinical Research.

Melikyan ZA, Greenia DE, Corrada MM, Hester MM, Kawas CH, Grill JD.

Alzheimer Dis Assoc Disord. 2019 Apr-Jun;33(2):160-162. doi: 10.1097/WAD.0000000000000260. No abstract available.


Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States.

Brookmeyer R, Abdalla N, Kawas CH, Corrada MM.

Alzheimers Dement. 2018 Feb;14(2):121-129. doi: 10.1016/j.jalz.2017.10.009. Epub 2017 Dec 7.


Age-related white matter integrity differences in oldest-old without dementia.

Bennett IJ, Greenia DE, Maillard P, Sajjadi SA, DeCarli C, Corrada MM, Kawas CH.

Neurobiol Aging. 2017 Aug;56:108-114. doi: 10.1016/j.neurobiolaging.2017.04.013. Epub 2017 Apr 26.


Cancer-Incidence, prevalence and mortality in the oldest-old. A comprehensive review.

Nolen SC, Evans MA, Fischer A, Corrada MM, Kawas CH, Bota DA.

Mech Ageing Dev. 2017 Jun;164:113-126. doi: 10.1016/j.mad.2017.05.002. Epub 2017 May 11. Review.


Communicating mild cognitive impairment diagnoses with and without amyloid imaging.

Grill JD, Apostolova LG, Bullain S, Burns JM, Cox CG, Dick M, Hartley D, Kawas C, Kremen S, Lingler J, Lopez OL, Mapstone M, Pierce A, Rabinovici G, Roberts JS, Sajjadi SA, Teng E, Karlawish J.

Alzheimers Res Ther. 2017 May 4;9(1):35. doi: 10.1186/s13195-017-0261-y. Review.


Late-Onset Alzheimer Disease.

Pierce AL, Bullain SS, Kawas CH.

Neurol Clin. 2017 May;35(2):283-293. doi: 10.1016/j.ncl.2017.01.006. Review.


Lower likelihood of falling at age 90+ is associated with daily exercise a quarter of a century earlier: The 90+ Study.

Paganini-Hill A, Greenia DE, Perry S, Sajjadi SA, Kawas CH, Corrada MM.

Age Ageing. 2017 Nov 1;46(6):951-957. doi: 10.1093/ageing/afx039.


Dementia in the oldest old: Beyond Alzheimer disease.

Pierce AL, Kawas CH.

PLoS Med. 2017 Mar 21;14(3):e1002263. doi: 10.1371/journal.pmed.1002263. eCollection 2017 Mar.


Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study.

Corrada MM, Hayden KM, Paganini-Hill A, Bullain SS, DeMoss J, Aguirre C, Brookmeyer R, Kawas CH.

Alzheimers Dement. 2017 Feb;13(2):103-110. doi: 10.1016/j.jalz.2016.09.007. Epub 2017 Jan 17.


Prevalence of Frailty and Factors Associated with Frailty in Individuals Aged 90 and Older: The 90+ Study.

Lee DR, Kawas CH, Gibbs L, Corrada MM.

J Am Geriatr Soc. 2016 Nov;64(11):2257-2262. doi: 10.1111/jgs.14317. Epub 2016 Sep 2.


Sound Body Sound Mind? Physical Performance and the Risk of Dementia in the Oldest-Old: The 90+ Study.

Bullain SS, Corrada MM, Perry SM, Kawas CH.

J Am Geriatr Soc. 2016 Jul;64(7):1408-15. doi: 10.1111/jgs.14224. Epub 2016 Jul 5.


Microinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study.

Corrada MM, Sonnen JA, Kim RC, Kawas CH.

Alzheimers Dement. 2016 Aug;12(8):900-8. doi: 10.1016/j.jalz.2016.04.006. Epub 2016 May 28.


ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups.

Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung KS, Corrada MM, Crawford JD, Daly C, Gondo Y, Hagberg B, Hirose N, Holstege H, Kawas C, Kaye J, Kochan NA, Lau BH, Lucca U, Marcon G, Martin P, Poon LW, Richmond R, Robine JM, Skoog I, Slavin MJ, Szewieczek J, Tettamanti M, Viña J, Perls T, Sachdev PS.

BMC Neurol. 2016 Apr 21;16:52. doi: 10.1186/s12883-016-0569-4.


Impact of interventions to reduce Alzheimer's disease pathology on the prevalence of dementia in the oldest-old.

Brookmeyer R, Kawas CH, Abdallah N, Paganini-Hill A, Kim RC, Corrada MM.

Alzheimers Dement. 2016 Mar;12(3):225-32. doi: 10.1016/j.jalz.2016.01.004. Epub 2016 Feb 17.


Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases.

Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R 3rd, Cole GM, Teng E, Gylys KH.

Am J Pathol. 2016 Jan;186(1):185-98. doi: 10.1016/j.ajpath.2015.09.018.


Brain-derived neurotrophic factor and TrkB expression in the "oldest-old," the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta.

Michalski B, Corrada MM, Kawas CH, Fahnestock M.

Neurobiol Aging. 2015 Dec;36(12):3130-3139. doi: 10.1016/j.neurobiolaging.2015.08.022. Epub 2015 Aug 29.


Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study.

Kawas CH, Kim RC, Sonnen JA, Bullain SS, Trieu T, Corrada MM.

Neurology. 2015 Aug 11;85(6):535-42. doi: 10.1212/WNL.0000000000001831. Epub 2015 Jul 15.


Lifestyle Factors and Dementia in the Oldest-old: The 90+ Study.

Paganini-Hill A, Kawas CH, Corrada MM.

Alzheimer Dis Assoc Disord. 2016 Jan-Mar;30(1):21-6. doi: 10.1097/WAD.0000000000000087.


Antioxidant vitamin intake and mortality: the Leisure World Cohort Study.

Paganini-Hill A, Kawas CH, Corrada MM.

Am J Epidemiol. 2015 Jan 15;181(2):120-6. doi: 10.1093/aje/kwu294. Epub 2014 Dec 29.


2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.

Alzheimer's Association National Plan Milestone Workgroup, Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC.

Alzheimers Dement. 2014 Oct;10(5 Suppl):S430-52. doi: 10.1016/j.jalz.2014.08.103.


Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.

Pensalfini A, Albay R 3rd, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG.

Neurobiol Dis. 2014 Nov;71:53-61. doi: 10.1016/j.nbd.2014.07.011. Epub 2014 Aug 1.


Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old.

Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ.

Brain. 2014 Sep;137(Pt 9):2578-87. doi: 10.1093/brain/awu190. Epub 2014 Jul 9.


Exponential increases in the prevalence of disability in the oldest old: a Canadian national survey.

Guay M, Dubois MF, Corrada M, Lapointe-Garant MP, Kawas C.

Gerontology. 2014;60(5):395-401. doi: 10.1159/000358059. Epub 2014 May 7.


Author Response.

Yasar S, Furberg C, Kawas C, Carlson M.

Neurology. 2014 Apr 1;82(13):1192-3. No abstract available.


ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.

Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE; Alzheimer’ Disease Genetic Consortium, Schellenberg GD, Fardo DW.

Acta Neuropathol. 2014;127(6):825-43. doi: 10.1007/s00401-014-1282-2. Epub 2014 Apr 27.


Plasma phospholipids identify antecedent memory impairment in older adults.

Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ.

Nat Med. 2014 Apr;20(4):415-8. doi: 10.1038/nm.3466. Epub 2014 Mar 9.


Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study.

Yasar S, Xia J, Yao W, Furberg CD, Xue QL, Mercado CI, Fitzpatrick AL, Fried LP, Kawas CH, Sink KM, Williamson JD, DeKosky ST, Carlson MC; Ginkgo Evaluation of Memory (GEM) Study Investigators.

Neurology. 2013 Sep 3;81(10):896-903. doi: 10.1212/WNL.0b013e3182a35228. Epub 2013 Aug 2.


Neocortical β-amyloid area is associated with dementia and APOE in the oldest-old.

Berlau DJ, Corrada MM, Robinson JL, Geser F, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ.

Alzheimers Dement. 2013 Nov;9(6):699-705. doi: 10.1016/j.jalz.2012.11.011. Epub 2013 Mar 7.


DRD4 genotype predicts longevity in mouse and human.

Grady DL, Thanos PK, Corrada MM, Barnett JC Jr, Ciobanu V, Shustarovich D, Napoli A, Moyzis AG, Grandy D, Rubinstein M, Wang GJ, Kawas CH, Chen C, Dong Q, Wang E, Volkow ND, Moyzis RK.

J Neurosci. 2013 Jan 2;33(1):286-91. doi: 10.1523/JNEUROSCI.3515-12.2013.


Amyloid imaging and cognitive decline in nondemented oldest-old: the 90+ Study.

Kawas CH, Greenia DE, Bullain SS, Clark CM, Pontecorvo MJ, Joshi AD, Corrada MM.

Alzheimers Dement. 2013 Mar;9(2):199-203. doi: 10.1016/j.jalz.2012.06.005. Epub 2012 Nov 16.


Apolipoprotein E genotype, dementia, and mortality in the oldest old: the 90+ Study.

Corrada MM, Paganini-Hill A, Berlau DJ, Kawas CH.

Alzheimers Dement. 2013 Jan;9(1):12-8. doi: 10.1016/j.jalz.2011.12.004. Epub 2012 Nov 2.


Poor physical performance and dementia in the oldest old: the 90+ study.

Bullain SS, Corrada MM, Shah BA, Mozaffar FH, Panzenboeck M, Kawas CH.

JAMA Neurol. 2013 Jan;70(1):107-13. doi: 10.1001/jamaneurol.2013.583.


Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.

Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, Feinberg LF, Frisoni G, Green C, Guimaraes RM, Gwyther LP, Hefti FF, Hutton M, Kawas C, Kent DM, Kuller L, Langa KM, Mahley RW, Maslow K, Masters CL, Meier DE, Neumann PJ, Paul SM, Petersen RC, Sager MA, Sano M, Schenk D, Soares H, Sperling RA, Stahl SM, van Deerlin V, Stern Y, Weir D, Wolk DA, Trojanowski JQ.

Alzheimers Dement. 2012 Sep;8(5):445-52. doi: 10.1016/j.jalz.2012.08.001.


Alzheimer disease pathology and longitudinal cognitive performance in the oldest-old with no dementia.

Balasubramanian AB, Kawas CH, Peltz CB, Brookmeyer R, Corrada MM.

Neurology. 2012 Aug 28;79(9):915-21. doi: 10.1212/WNL.0b013e318266fc77. Epub 2012 Aug 15.


Session II: Mechanisms of age-related cognitive change and targets for intervention: neural circuits, networks, and plasticity.

DeCarli C, Kawas C, Morrison JH, Reuter-Lorenz PA, Sperling RA, Wright CB.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):747-53. doi: 10.1093/gerona/gls111. Epub 2012 May 8. Review.

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