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1.

The Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test Is Associated with Insulin Clearance and Muscle Insulin Sensitivity in Healthy Nonobese Men.

Kaga H, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Suzuki R, Sugimoto D, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Sato H, Kawamori R, Watada H.

J Diabetes Investig. 2020 Feb 5. doi: 10.1111/jdi.13227. [Epub ahead of print]

2.

Higher C-Peptide Level During Glucose Clamp Is Associated With Muscle Insulin Resistance in Nonobese Japanese Men.

Kaga H, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Suzuki R, Sugimoto D, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H.

J Endocr Soc. 2019 Jul 23;3(10):1847-1857. doi: 10.1210/js.2019-00167. eCollection 2019 Oct 1.

3.

Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study.

Someya Y, Tamura Y, Kaga H, Nojiri S, Shimada K, Daida H, Ishijima M, Kaneko K, Aoki S, Miida T, Hirayama S, Konishi S, Hattori N, Motoi Y, Naito H, Kawamori R, Watada H.

BMJ Open. 2019 Sep 17;9(9):e031584. doi: 10.1136/bmjopen-2019-031584.

4.

Fatty Liver Has Stronger Association With Insulin Resistance Than Visceral Fat Accumulation in Nonobese Japanese Men.

Kadowaki S, Tamura Y, Someya Y, Takeno K, Kaga H, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H.

J Endocr Soc. 2019 May 20;3(7):1409-1416. doi: 10.1210/js.2019-00052. eCollection 2019 Jul 1.

5.

Three days of a eucaloric, low-carbohydrate/high-fat diet increases insulin clearance in healthy non-obese Japanese men.

Suzuki R, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Kaga H, Sugimoto D, Kadowaki S, Someya Y, Kanazawa A, Kawamori R, Watada H.

Sci Rep. 2019 Mar 7;9(1):3857. doi: 10.1038/s41598-019-40498-6.

6.

Clinical Features of Nonobese, Apparently Healthy, Japanese Men With Reduced Adipose Tissue Insulin Sensitivity.

Sugimoto D, Tamura Y, Takeno K, Kaga H, Someya Y, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2325-2333. doi: 10.1210/jc.2018-02190.

PMID:
30689902
7.

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

Taira M, Imamura M, Takahashi A, Kamatani Y, Yamauchi T, Araki SI, Tanaka N, van Zuydam NR, Ahlqvist E, Toyoda M, Umezono T, Kawai K, Imanishi M, Watada H, Suzuki D, Maegawa H, Babazono T, Kaku K, Kawamori R; SUMMIT Consortium, Groop LC, McCarthy MI, Kadowaki T, Maeda S.

PLoS One. 2018 Dec 19;13(12):e0208654. doi: 10.1371/journal.pone.0208654. eCollection 2018.

8.

Dysfunction of muscle contraction with impaired intracellular Ca2+ handling in skeletal muscle and the effect of exercise training in male db/db mice.

Eshima H, Tamura Y, Kakehi S, Nakamura K, Kurebayashi N, Murayama T, Kakigi R, Sakurai T, Kawamori R, Watada H.

J Appl Physiol (1985). 2019 Jan 1;126(1):170-182. doi: 10.1152/japplphysiol.00048.2018. Epub 2018 Nov 15.

9.

Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes.

Shioya-Yamada M, Shimada K, Nishitani-Yokoyama M, Sai E, Takeno K, Tamura Y, Watada H, Kawamori R, Daida H, Kawai S.

J Clin Med Res. 2018 Aug;10(8):630-635. doi: 10.14740/jocmr3403w. Epub 2018 Jun 27.

10.

Empagliflozin as add-on to linagliptin in a fixed-dose combination in Japanese patients with type 2 diabetes: Glycaemic efficacy and safety profile in a 52-week, randomized, placebo-controlled trial.

Kawamori R, Haneda M, Suzaki K, Cheng G, Shiki K, Miyamoto Y, Solimando F, Lee C, Lee J, George J.

Diabetes Obes Metab. 2018 Sep;20(9):2200-2209. doi: 10.1111/dom.13352. Epub 2018 Jun 1.

11.

Characteristics of Glucose Metabolism in Underweight Japanese Women.

Someya Y, Tamura Y, Suzuki R, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Takeno K, Sato J, Kanazawa A, Kawamori R, Watada H.

J Endocr Soc. 2018 Feb 19;2(3):279-289. doi: 10.1210/js.2017-00418. eCollection 2018 Mar 1.

12.

Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism.

Osada T, Suzuki R, Ogawa A, Tanaka M, Hori M, Aoki S, Tamura Y, Watada H, Kawamori R, Konishi S.

Neuroimage. 2017 Nov 15;162:1-12. doi: 10.1016/j.neuroimage.2017.08.056. Epub 2017 Aug 24.

PMID:
28844890
13.

Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver.

Furukawa Y, Tamura Y, Takeno K, Funayama T, Kaga H, Suzuki R, Watanabe T, Kakehi S, Kanazawa A, Kawamori R, Watada H.

J Diabetes Investig. 2017 Aug 24. doi: 10.1111/jdi.12731. [Epub ahead of print]

14.

Correlates of insulin clearance in apparently healthy non-obese Japanese men.

Kaga H, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H.

Sci Rep. 2017 May 3;7(1):1462. doi: 10.1038/s41598-017-01469-x.

15.

Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle.

Eshima H, Tamura Y, Kakehi S, Kurebayashi N, Murayama T, Nakamura K, Kakigi R, Okada T, Sakurai T, Kawamori R, Watada H.

Physiol Rep. 2017 Apr;5(7). pii: e13250. doi: 10.14814/phy2.13250.

16.

Long-term treatment study of global standard dose metformin in Japanese patients with type 2 diabetes mellitus.

Odawara M, Kawamori R, Tajima N, Iwamoto Y, Kageyama S, Yodo Y, Ueki F, Hotta N.

Diabetol Int. 2017 Feb 24;8(3):286-295. doi: 10.1007/s13340-017-0309-z. eCollection 2017 Aug.

17.

Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study.

Funayama T, Tamura Y, Takeno K, Kawaguchi M, Kakehi S, Watanabe T, Furukawa Y, Kaga H, Yamamoto R, Kanazawa A, Fujitani Y, Kawamori R, Watada H.

Sci Rep. 2017 Jan 9;7:40277. doi: 10.1038/srep40277.

18.

The Glycated Albumin (GA) to HbA1c Ratio Reflects Shorter-Term Glycemic Control than GA: Analysis of Patients with Fulminant Type 1 Diabetes.

Koga M, Inada S, Nakao T, Kawamori R, Kasayama S.

J Clin Lab Anal. 2017 Jan;31(1). doi: 10.1002/jcla.22023. Epub 2016 Jul 8.

19.

Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m2.

Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H.

J Clin Endocrinol Metab. 2016 Oct;101(10):3676-3684. Epub 2016 Jul 6.

PMID:
27383116
20.

[Role of sportology for the prevention and treatment of diabetes mellitus].

Kawamori R.

Nihon Rinsho. 2016 Apr;74 Suppl 2:687-92. Japanese. No abstract available.

PMID:
27266175
21.

Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy.

Sai E, Shimada K, Yokoyama T, Hiki M, Sato S, Hamasaki N, Maruyama M, Morimoto R, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.

Heart Vessels. 2017 Feb;32(2):166-174. doi: 10.1007/s00380-016-0844-8. Epub 2016 May 3.

PMID:
27142065
22.

Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies.

Matsuba R, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S.

PLoS One. 2016 Apr 26;11(4):e0154093. doi: 10.1371/journal.pone.0154093. eCollection 2016.

23.

Clinical study of repaglinide efficacy and safety in type 2 diabetes mellitus patients with blood glucose levels inadequately controlled by sitagliptin.

Kawamori R, Kaku K, Hanafusa T, Ioriya K, Kageyama S, Hotta N.

J Diabetes Investig. 2016 Mar;7(2):253-9. doi: 10.1111/jdi.12384. Epub 2015 Jul 19.

24.

Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle.

Ikeda SI, Tamura Y, Kakehi S, Sanada H, Kawamori R, Watada H.

Biochem Biophys Res Commun. 2016 May 13;473(4):947-952. doi: 10.1016/j.bbrc.2016.03.159. Epub 2016 Apr 1.

PMID:
27040770
25.

Does the treatment of type 2 diabetes mellitus with the DPP-4 inhibitor vildagliptin reduce HbA1c to a greater extent in Japanese patients than in Caucasian patients?

Foley JE, Bhosekar V, Kawamori R.

Vasc Health Risk Manag. 2016 Jan 21;12:9-12. doi: 10.2147/VHRM.S96971. eCollection 2016.

26.

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A, Hu C, Moon S, Long J, Kwak SH, Rasheed A, Saxena R, Ma RC, Okada Y, Iwata M, Hosoe J, Shojima N, Iwasaki M, Fujita H, Suzuki K, Danesh J, Jørgensen T, Jørgensen ME, Witte DR, Brandslund I, Christensen C, Hansen T, Mercader JM, Flannick J, Moreno-Macías H, Burtt NP, Zhang R, Kim YJ, Zheng W, Singh JR, Tam CH, Hirose H, Maegawa H, Ito C, Kaku K, Watada H, Tanaka Y, Tobe K, Kawamori R, Kubo M, Cho YS, Chan JC, Sanghera D, Frossard P, Park KS, Shu XO, Kim BJ, Florez JC, Tusié-Luna T, Jia W, Tai ES, Pedersen O, Saleheen D, Maeda S, Kadowaki T.

Nat Commun. 2016 Jan 28;7:10531. doi: 10.1038/ncomms10531.

27.

Efficacy and safety of 40 mg or 60 mg duloxetine in Japanese adults with diabetic neuropathic pain: Results from a randomized, 52-week, open-label study.

Yasuda H, Hotta N, Kasuga M, Kashiwagi A, Kawamori R, Yamada T, Baba Y, Alev L, Nakajo K.

J Diabetes Investig. 2016 Jan;7(1):100-8. doi: 10.1111/jdi.12361. Epub 2015 May 18.

28.

Dynamic prediction model and risk assessment chart for cardiovascular disease based on on-treatment blood pressure and baseline risk factors.

Teramukai S, Okuda Y, Miyazaki S, Kawamori R, Shirayama M, Teramoto T.

Hypertens Res. 2016 Feb;39(2):113-8. doi: 10.1038/hr.2015.120. Epub 2015 Nov 26.

29.

Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet.

Kakehi S, Tamura Y, Takeno K, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, Watada H.

Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E32-40. doi: 10.1152/ajpendo.00220.2015. Epub 2015 Oct 20.

30.

Effects of Pioglitazone for Secondary Stroke Prevention in Patients with Impaired Glucose Tolerance and Newly Diagnosed Diabetes: The J-SPIRIT Study.

Tanaka R, Yamashiro K, Okuma Y, Shimura H, Nakamura S, Ueno Y, Tanaka Y, Miyamoto N, Tomizawa Y, Nakahara T, Furukawa Y, Watada H, Kawamori R, Hattori N, Urabe T.

J Atheroscler Thromb. 2015;22(12):1305-16. doi: 10.5551/jat.30007. Epub 2015 Aug 11.

31.

Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes.

Matsuba R, Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S.

PLoS One. 2015 May 7;10(5):e0126363. doi: 10.1371/journal.pone.0126363. eCollection 2015.

32.

Four-year evolution of insulin regimens, glycaemic control, hypoglycaemia and body weight after starting insulin therapy in type 2 diabetes across three continents.

Home PD, Dain MP, Freemantle N, Kawamori R, Pfohl M, Brette S, Pilorget V, Scherbaum WA, Vespasiani G, Vincent M, Balkau B.

Diabetes Res Clin Pract. 2015 May;108(2):350-9. doi: 10.1016/j.diabres.2015.01.030. Epub 2015 Jan 23.

33.

[What is the natural history of type 2 diabetes mellitus].

Kawamori R.

Nihon Rinsho. 2015 Mar;73(3):363-72. Japanese.

PMID:
25812360
34.

Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study.

Watanabe T, Tamura Y, Kakehi S, Funayama T, Gastaldelli A, Takeno K, Kawaguchi M, Yamamoto R, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R, Watada H.

J Diabetes Investig. 2015 Mar;6(2):164-72. doi: 10.1111/jdi.12262. Epub 2014 Aug 6.

35.

Evaluation of myocardial triglyceride accumulation assessed on 1H-magnetic resonance spectroscopy in apparently healthy Japanese subjects.

Sai E, Shimada K, Yokoyama T, Sato S, Nishizaki Y, Miyazaki T, Hiki M, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.

Intern Med. 2015;54(4):367-73. doi: 10.2169/internalmedicine.54.3024.

36.

Lipid and blood pressure control for the prevention of cardiovascular disease in hypertensive patients: a subanalysis of the OMEGA study.

Teramoto T, Kawamori R, Miyazaki S, Teramukai S, Sato Y, Okuda Y, Shirayama M.

J Atheroscler Thromb. 2015;22(1):62-75. doi: 10.5551/jat.25304. Epub 2014 Aug 29.

37.

Can intensive lipid-lowering therapy improve the carotid intima-media thickness in Japanese subjects under primary prevention for cardiovascular disease?: The JART and JART extension subanalysis.

Daida H, Nohara R, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yokoi H, Yoshida M; Justification for Atherosclerosis Regression Treatment (JART) Investigators.

J Atheroscler Thromb. 2014;21(7):739-54. Epub 2014 Jun 20.

38.

Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular lipid-accumulated nonobese men.

Kawaguchi M, Tamura Y, Kakehi S, Takeno K, Sakurai Y, Watanabe T, Funayama T, Sato F, Ikeda S, Ogura Y, Saga N, Naito H, Fujitani Y, Kanazawa A, Kawamori R, Watada H.

J Clin Endocrinol Metab. 2014 Sep;99(9):3343-52. doi: 10.1210/jc.2014-1896. Epub 2014 Jun 17.

PMID:
24937540
39.

Accumulation of oxidative stress-related gene polymorphisms and the risk of coronary heart disease events in patients with type 2 diabetes--an 8-year prospective study.

Katakami N, Kaneto H, Matsuoka TA, Takahara M, Osonoi T, Saitou M, Kawai K, Ishibashi F, Kashiwagi A, Kawamori R, Shimomura I, Yamasaki Y.

Atherosclerosis. 2014 Aug;235(2):408-14. doi: 10.1016/j.atherosclerosis.2014.05.936. Epub 2014 Jun 3.

PMID:
24933031
40.

Effect of combination therapy with repaglinide and metformin hydrochloride on glycemic control in Japanese patients with type 2 diabetes mellitus.

Kawamori R, Kaku K, Hanafusa T, Oikawa T, Kageyama S, Hotta N.

J Diabetes Investig. 2014 Feb 12;5(1):72-9. doi: 10.1111/jdi.12121. Epub 2013 Aug 2.

41.

Morningness-eveningness questionnaire score correlates with glycated hemoglobin in middle-aged male workers with type 2 diabetes mellitus.

Iwasaki M, Hirose T, Mita T, Sato F, Ito C, Yamamoto R, Someya Y, Yoshihara T, Tamura Y, Kanazawa A, Kawamori R, Fujitani Y, Watada H.

J Diabetes Investig. 2013 Jul 8;4(4):376-81. doi: 10.1111/jdi.12047. Epub 2013 Feb 13.

42.

Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia.

Mita T, Nakayama S, Abe H, Gosho M, Iida H, Hirose T, Kawamori R, Watada H.

J Diabetes Investig. 2013 May 6;4(3):297-303. doi: 10.1111/jdi.12032. Epub 2013 Feb 13.

43.

Repetitive hypoglycemia increases circulating adrenaline level with resultant worsening of intimal thickening after vascular injury in male Goto-Kakizaki rat carotid artery.

Yasunari E, Mita T, Osonoi Y, Azuma K, Goto H, Ohmura C, Kanazawa A, Kawamori R, Fujitani Y, Watada H.

Endocrinology. 2014 Jun;155(6):2244-53. doi: 10.1210/en.2013-1628. Epub 2014 Mar 31.

PMID:
24684300
44.

Change in carotid intima-media thickness in a high-risk group of patients by intensive lipid-lowering therapy with rosuvastatin: subanalysis of the JART study.

Yokoi H, Nohara R, Daida H, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yoshida M.

Int Heart J. 2014;55(2):146-52. Epub 2014 Mar 14.

45.

Effects of pioglitazone on macrovascular events in patients with type 2 diabetes mellitus at high risk of stroke: the PROFIT-J study.

Yoshii H, Onuma T, Yamazaki T, Watada H, Matsuhisa M, Matsumoto M, Kitagawa K, Kitakaze M, Yamasaki Y, Kawamori R; PROFIT-J Study Group.

J Atheroscler Thromb. 2014;21(6):563-73. Epub 2014 Jan 29.

46.

Diffusional kurtosis imaging analysis in patients with hypertension.

Shimoji K, Uka T, Tamura Y, Yoshida M, Kamagata K, Hori M, Motoi Y, Watada H, Kawamori R, Aoki S.

Jpn J Radiol. 2014 Feb;32(2):98-104. doi: 10.1007/s11604-013-0275-8. Epub 2014 Jan 11.

PMID:
24414884
47.

Painful diabetic neuropathy in Japanese diabetic patients is common but underrecognized.

Tsuji M, Yasuda T, Kaneto H, Matsuoka TA, Hirose T, Kawamori R, Iseki M, Shimomura I, Shibata M.

Pain Res Treat. 2013;2013:318352. doi: 10.1155/2013/318352. Epub 2013 Nov 26.

48.

Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle.

Ikeda S, Tamura Y, Kakehi S, Takeno K, Kawaguchi M, Watanabe T, Sato F, Ogihara T, Kanazawa A, Fujitani Y, Kawamori R, Watada H.

Biochem Biophys Res Commun. 2013 Nov 8;441(1):36-41. doi: 10.1016/j.bbrc.2013.10.005. Epub 2013 Oct 10.

PMID:
24120496
49.

Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice.

Ishibashi K, Hara A, Fujitani Y, Uchida T, Komiya K, Tamaki M, Abe H, Ogihara T, Kanazawa A, Kawamori R, Watada H.

Biochem Biophys Res Commun. 2013 Nov 1;440(4):570-5. doi: 10.1016/j.bbrc.2013.09.110. Epub 2013 Oct 5.

PMID:
24103756
50.

Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population.

Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S.

PLoS One. 2013 Sep 25;8(9):e76317. doi: 10.1371/journal.pone.0076317. eCollection 2013.

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