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Items: 1 to 50 of 127

1.

External Quality Assessment Testing Near the Limit of Detection for High-Sensitivity Cardiac Troponin Assays.

Kavsak PA.

Clin Chem. 2018 Jun 29. pii: clinchem.2018.288613. doi: 10.1373/clinchem.2018.288613. [Epub ahead of print] No abstract available.

PMID:
29959148
2.

Post-exercise cardiac troponin I release and clearance in normal Standardbred racehorses.

Rossi TM, Kavsak PA, Maxie MG, Pearl DL, Pyle WG, Physick-Sheard PW.

Equine Vet J. 2018 May 28. doi: 10.1111/evj.12967. [Epub ahead of print]

PMID:
29806966
3.

Should detectable cardiac troponin concentrations in a healthy population be the only criterion for classifying high-sensitivity cardiac troponin assays?

Kavsak PA.

Clin Biochem. 2018 Jun;56:1-3. doi: 10.1016/j.clinbiochem.2018.05.015. Epub 2018 May 24. No abstract available.

PMID:
29803619
4.

Profile of Roche's Elecsys Troponin T Gen 5 STAT blood test (a high-sensitivity cardiac troponin assay) for diagnosing myocardial infarction in the emergency department.

Kavsak PA, Andruchow JE, McRae AD, Worster A.

Expert Rev Mol Diagn. 2018 Jun;18(6):481-489. doi: 10.1080/14737159.2018.1476141. Epub 2018 May 18.

PMID:
29756512
5.

The potential role of a turbidimetric heart-type fatty acid-binding protein assay to aid in the interpretation of persistently elevated, non-changing, cardiac troponin I concentrations.

Kavsak PA, Ainsworth C, Arnold DM, Scott T, Clark L, Ivica J, Mackett K, Whitlock R, Worster A.

Clin Biochem. 2018 Aug;58:53-59. doi: 10.1016/j.clinbiochem.2018.05.006. Epub 2018 May 8.

PMID:
29750937
6.

Assessing matrix, interferences and comparability between the Abbott Diagnostics and the Beckman Coulter high-sensitivity cardiac troponin I assays.

Kavsak PA, Malinowski P, Roy C, Clark L, Lamers S.

Clin Chem Lab Med. 2018 Jun 27;56(7):1176-1181. doi: 10.1515/cclm-2017-1122.

PMID:
29533903
7.

Contemporary Emergency Department Management of Patients with Chest Pain: A Concise Review and Guide for the High-Sensitivity Troponin Era.

Andruchow JE, Kavsak PA, McRae AD.

Can J Cardiol. 2018 Feb;34(2):98-108. doi: 10.1016/j.cjca.2017.11.012. Epub 2017 Dec 2. Review.

PMID:
29407013
8.

Performance of high-sensitivity cardiac troponin in the emergency department for myocardial infarction and a composite cardiac outcome across different estimated glomerular filtration rates.

Kavsak PA, Worster A, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Griffith LE, Mehta SR, McRae AD, Devereaux PJ.

Clin Chim Acta. 2018 Apr;479:166-170. doi: 10.1016/j.cca.2018.01.034. Epub 2018 Feb 3.

PMID:
29366835
10.

Variability Between Reagent Lots for High-Sensitivity Cardiac Troponin I May Affect Performance of Early Rule Out Strategies.

Kavsak PA, Worster A, Oliver R, Clark L, Parry D, Randell E, Sarfaraz MO, Hill S, Jaffe AS.

Can J Cardiol. 2018 Feb;34(2):209.e5-209.e6. doi: 10.1016/j.cjca.2017.11.010. Epub 2017 Nov 22. No abstract available.

PMID:
29287942
11.

Analytical validation of cardiac troponin I assays in horses.

Rossi TM, Kavsak PA, Maxie MG, Pearl DL, Pyle WG, Physick-Sheard PW.

J Vet Diagn Invest. 2018 Mar;30(2):226-232. doi: 10.1177/1040638717747070. Epub 2017 Dec 10.

PMID:
29224512
12.

High-sensitivity cardiac troponin concentrations at emergency department presentation in females and males with an acute cardiac outcome.

Kavsak PA, Worster A, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Griffith L, Mehta SR, Devereaux PJ.

Ann Clin Biochem. 2017 Jan 1:4563217743997. doi: 10.1177/0004563217743997. [Epub ahead of print]

PMID:
29169258
13.

Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome.

Chapman AR, Lee KK, McAllister DA, Cullen L, Greenslade JH, Parsonage W, Worster A, Kavsak PA, Blankenberg S, Neumann J, Sörensen NA, Westermann D, Buijs MM, Verdel GJE, Pickering JW, Than MP, Twerenbold R, Badertscher P, Sabti Z, Mueller C, Anand A, Adamson P, Strachan FE, Ferry A, Sandeman D, Gray A, Body R, Keevil B, Carlton E, Greaves K, Korley FK, Metkus TS, Sandoval Y, Apple FS, Newby DE, Shah ASV, Mills NL.

JAMA. 2017 Nov 21;318(19):1913-1924. doi: 10.1001/jama.2017.17488. Review. Erratum in: JAMA. 2018 Mar 20;319(11):1168. Soerensen NA [corrected to Sorensen NA].

14.

Comprehensive Age and Sex 99th Percentiles for a High-Sensitivity Cardiac Troponin I Assay.

Estis J, Wu AHB, Todd J, Bishop J, Sandlund J, Kavsak PA.

Clin Chem. 2018 Feb;64(2):398-399. doi: 10.1373/clinchem.2017.276972. Epub 2017 Oct 18. No abstract available.

PMID:
29046331
15.

Analytical comparison of three different versions of a high-sensitivity cardiac troponin I assay over 10years.

Kavsak PA, Worster A, Hill SA, MacRae AR, Jaffe AS.

Clin Chim Acta. 2017 Dec;475:51-55. doi: 10.1016/j.cca.2017.10.006. Epub 2017 Oct 7.

PMID:
29017768
16.

Variability and Error in Cardiac Troponin Testing: An ACLPS Critical Review.

Herman DS, Kavsak PA, Greene DN.

Am J Clin Pathol. 2017 Oct 1;148(4):281-295. doi: 10.1093/ajcp/aqx066. Review.

PMID:
28967956
17.

Effect of a low glycemic index diet versus a high-cereal fibre diet on markers of subclinical cardiac injury in healthy individuals with type 2 diabetes mellitus: An exploratory analysis of a randomized dietary trial.

Ha V, Viguiliouk E, Kendall CWC, Balachandran B, Jenkins DJA, Kavsak PA, Sievenpiper JL.

Clin Biochem. 2017 Dec;50(18):1104-1109. doi: 10.1016/j.clinbiochem.2017.09.021. Epub 2017 Sep 25.

PMID:
28958804
18.

Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study.

Roshanov PS, Eikelboom JW, Crowther M, Tandon V, Borges FK, Kearon C, Lamy A, Whitlock R, Biccard BM, Szczeklik W, Guyatt GH, Panju M, Spence J, Garg AX, McGillion M, VanHelder T, Kavsak PA, de Beer J, Winemaker M, Sessler DI, Le Manach Y, Sheth T, Pinthus JH, Thabane L, Simunovic MRI, Mizera R, Ribas S, Devereaux PJ; Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (VISION) Investigators.

CMAJ Open. 2017 Aug 4;5(3):E594-E603. doi: 10.9778/cmajo.20160106.

19.

Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations.

Kavsak PA, Roy C, Malinowski P, Mark CT, Scott T, Clark L, Lamers S, Ainsworth C.

Ann Clin Biochem. 2018 Jul;55(4):500-504. doi: 10.1177/0004563217734883. Epub 2017 Nov 8.

PMID:
28920468
20.

High-Sensitivity Cardiac Troponin Risk Cutoffs for Acute Cardiac Outcomes at Emergency Department Presentation.

Kavsak PA, Worster A, Ma J, Shortt C, Clayton N, Sherbino J, Hill SA, McQueen M, Mehta SR, Devereaux PJ.

Can J Cardiol. 2017 Jul;33(7):898-903. doi: 10.1016/j.cjca.2017.04.011. Epub 2017 May 3.

PMID:
28668141
21.
22.

Response by Than et al to Letter Regarding Article, "Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction".

Than MP, Pickering JW, Cullen L, Kavsak PA.

Circulation. 2017 Apr 18;135(16):e923-e924. doi: 10.1161/CIRCULATIONAHA.117.027479. No abstract available.

23.

A laboratory score at presentation to rule-out serious cardiac outcomes or death in patients presenting with symptoms suggestive of acute coronary syndrome.

Kavsak PA, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Mehta SR, Devereaux PJ, Worster A.

Clin Chim Acta. 2017 Jun;469:69-74. doi: 10.1016/j.cca.2017.03.021. Epub 2017 Mar 23.

PMID:
28342713
24.

Total Analytic Error for Low Cardiac Troponin Concentrations (≤10 ng/L) by Use of a High-Sensitivity Cardiac Troponin Assay.

Kavsak PA, Jaffe AS, Greene DN, Christenson RH, Apple FS, Wu AHB.

Clin Chem. 2017 May;63(5):1043-1045. doi: 10.1373/clinchem.2017.271361. Epub 2017 Mar 21. No abstract available.

25.

Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations.

Moledina DG, Isguven S, McArthur E, Thiessen-Philbrook H, Garg AX, Shlipak M, Whitlock R, Kavsak PA, Coca SG, Parikh CR; Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) Consortium.

Ann Thorac Surg. 2017 Aug;104(2):613-620. doi: 10.1016/j.athoracsur.2016.11.036. Epub 2017 Feb 21.

PMID:
28223055
26.

Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome.

Shortt C, Ma J, Clayton N, Sherbino J, Whitlock R, Pare G, Hill SA, McQueen M, Mehta SR, Devereaux PJ, Worster A, Kavsak PA.

Clin Chem. 2017 Jan;63(1):403-414. doi: 10.1373/clinchem.2016.261545. Epub 2016 Nov 10.

27.

Simulation Models of Misclassification Error for Single Thresholds of High-Sensitivity Cardiac Troponin I Due to Assay Bias and Imprecision.

Lyon AW, Kavsak PA, Lyon OA, Worster A, Lyon ME.

Clin Chem. 2017 Feb;63(2):585-592. doi: 10.1373/clinchem.2016.265058. Epub 2016 Dec 14.

28.

Can 100 papers over 50years tell the story of a scientific journal?

Kavsak PA.

Clin Biochem. 2017 Jan;50(1-2):1-5. doi: 10.1016/j.clinbiochem.2016.12.001. Epub 2016 Dec 6. No abstract available.

PMID:
27940140
29.

Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction.

Pickering JW, Greenslade JH, Cullen L, Flaws D, Parsonage W, Aldous S, George P, Worster A, Kavsak PA, Than MP.

Circulation. 2016 Nov 15;134(20):1532-1541. Epub 2016 Oct 17.

30.

Reality check for cardiac troponin testing - Sometimes the result is wrong.

Kavsak PA, Saenger AK, Hickman PE.

Clin Biochem. 2016 Oct;49(15):1107-1108. doi: 10.1016/j.clinbiochem.2016.09.007. Epub 2016 Sep 17. No abstract available.

PMID:
27645499
31.

Statistical issues with the determination of the troponin 99th percentile - Not just a problem for troponin?

Hickman PE, Koerbin G, Saenger AK, Kavsak PA.

Clin Biochem. 2016 Oct;49(15):1105-1106. doi: 10.1016/j.clinbiochem.2016.09.013. Epub 2016 Sep 13. No abstract available.

PMID:
27637295
32.

Commutable samples with assigned target concentrations may help us harmonise general chemistry results.

Don-Wauchope AC, Kavsak PA.

Clin Chem Lab Med. 2017 Feb 1;55(2):165-166. doi: 10.1515/cclm-2016-0558. No abstract available.

33.

Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer.

Henderson MP, Hirte H, Hotte SJ, Kavsak PA.

Heliyon. 2016 Jan 22;2(1):e00059. doi: 10.1016/j.heliyon.2015.e00059. eCollection 2016 Jan.

34.

Editorial commentary: High-sensitivity cardiac troponin: Like every new tool there is a learning curve.

Kavsak PA.

Trends Cardiovasc Med. 2017 Jan;27(1):48-50. doi: 10.1016/j.tcm.2016.06.008. Epub 2016 Jun 24. No abstract available.

PMID:
27425561
35.

Carryover: More than just a major hangover for the clinical laboratory.

Kavsak PA, Zeidler J.

Clin Biochem. 2016 Jul;49(10-11):735-6. doi: 10.1016/j.clinbiochem.2016.05.020. Epub 2016 May 21. No abstract available.

PMID:
27220058
36.
37.

Acceptable Analytical Variation May Exceed High-Sensitivity Cardiac Troponin I Cutoffs in Early Rule-Out and Rule-In Acute Myocardial Infarction Algorithms.

Kavsak PA, Don-Wauchope AC, Hill SA, Worster A.

Clin Chem. 2016 Jun;62(6):887-9. doi: 10.1373/clinchem.2016.255448. Epub 2016 Apr 26. No abstract available.

38.

Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction.

Pickering JW, Greenslade JH, Cullen L, Flaws D, Parsonage W, George P, Worster A, Kavsak PA, Than MP.

Heart. 2016 Aug 15;102(16):1270-8. doi: 10.1136/heartjnl-2015-308505. Epub 2016 Mar 8.

PMID:
26955848
39.

A STAR-Document for those interested in evaluating diagnostic research studies.

Kavsak PA.

Ann Transl Med. 2016 Feb;4(3):45. doi: 10.3978/j.issn.2305-5839.2015.12.43. No abstract available.

40.

Error detection in routine clinical chemistry laboratory test results.

Don-Wauchope AC, Kavsak PA.

Clin Biochem. 2016 Feb;49(3):199-200. doi: 10.1016/j.clinbiochem.2016.01.013. Epub 2016 Jan 19. No abstract available.

PMID:
26794026
41.

Adopting 'ng/L' as the units for high-sensitivity cardiac troponin assays and commitment by the entire health-care team could be the key for adopting recommendations.

Kufaishi H, Pardhan A, Krizmanich W, Worster A, Hill S, Kavsak PA.

Ann Clin Biochem. 2016 Jul;53(Pt 4):516-7. doi: 10.1177/0004563215613533. Epub 2016 Jan 7. No abstract available.

PMID:
26746409
42.

Clinical Biochemistry 2015 year in review: Material not for the faint of heart.

Kavsak PA, Lai L, Langman L, Jones PM, Hammett-Stabler CA.

Clin Biochem. 2015 Dec;48(18):1211-2. doi: 10.1016/j.clinbiochem.2015.11.013. Epub 2015 Nov 18. No abstract available.

PMID:
26601569
43.

Troponin in Stable Ischemic Heart Disease and Diabetes.

Kavsak PA.

N Engl J Med. 2015 Nov 12;373(20):1976-7. doi: 10.1056/NEJMc1511645. No abstract available.

PMID:
26559579
44.

Negative interference of N-acetyl cysteine (NAC) on selected chemistries on the Abbott architect platform.

Agbor TA, Brown M, Clark L, Kavsak PA.

Clin Chim Acta. 2015 Dec 7;451(Pt B):219-21. doi: 10.1016/j.cca.2015.09.032. Epub 2015 Oct 3. No abstract available.

PMID:
26434549
45.

Hospital Admission and Myocardial Injury Prevalence after the Clinical Introduction of a High-Sensitivity Cardiac Troponin I Assay.

Kavsak PA, Pardhan A, Krizmanich W, Worster A.

Clin Chem. 2015 Sep;61(9):1209-10. doi: 10.1373/clinchem.2015.243345. Epub 2015 Jul 16. No abstract available.

46.

Sex-specific cutoffs for cardiac troponin using high-sensitivity assays--Is there clinical equipoise?

Mueller C, Kavsak PA.

Clin Biochem. 2015 Aug;48(12):749-50. doi: 10.1016/j.clinbiochem.2015.07.005. Epub 2015 Jul 8. No abstract available.

PMID:
26162492
47.

What is in that sample ? A pertinent question when assessing quality for patient laboratory results and beyond.

Kavsak PA.

Clin Biochem. 2015 May;48(7-8):465-6. doi: 10.1016/j.clinbiochem.2015.04.010. Epub 2015 Apr 16. No abstract available.

PMID:
25891022
48.

Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery.

Greenberg JH, Whitlock R, Zhang WR, Thiessen-Philbrook HR, Zappitelli M, Devarajan P, Eikelboom J, Kavsak PA, Devereaux PJ, Shortt C, Garg AX, Parikh CR; TRIBE-AKI Consortium.

Pediatr Nephrol. 2015 Sep;30(9):1519-27. doi: 10.1007/s00467-015-3088-4. Epub 2015 Apr 15.

49.

Presenting characteristics of patients undergoing cardiac troponin measurements in the emergency department.

Goodman DA, Kavsak PA, Hill SA, Worster A.

CJEM. 2015 Jan;17(1):62-6. doi: 10.2310/8000.2013.131298.

PMID:
25781385
50.

A practical approach for the validation and clinical implementation of a high-sensitivity cardiac troponin I assay across a North American city.

Kavsak PA, Beattie J, Pickersgill R, Ford L, Caruso N, Clark L.

Pract Lab Med. 2015 Mar 3;1:28-34. doi: 10.1016/j.plabm.2015.02.001. eCollection 2015 Apr 1.

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