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High-Sensitivity Generation 5 Cardiac Troponin T Sex- and Age-Specific 99th Percentiles in the CALIPER Cohort of Healthy Children and Adolescents.

Bohn MK, Higgins V, Kavsak P, Hoffman B, Adeli K.

Clin Chem. 2019 Feb 8. pii: clinchem.2018.299156. doi: 10.1373/clinchem.2018.299156. [Epub ahead of print] No abstract available.


Between-day versus within-day imprecision using the Abbott high-sensitivity cardiac troponin I assay at concentrations around 5 ng/l.

Kavsak PA, Millar E, McLay G, Clark L, Jaffe AS.

Clin Chim Acta. 2019 Feb;489:58-60. doi: 10.1016/j.cca.2018.11.031. Epub 2018 Nov 28. No abstract available.


Pre-analytical variables affecting discordant results on repeat sample testing for cardiac troponin I.

Kittanakom S, Ly V, Arnoldo A, Beattie A, Kavsak PA.

Clin Biochem. 2019 Jan;63:158-160. doi: 10.1016/j.clinbiochem.2018.10.014. Epub 2018 Oct 28. No abstract available.


Evaluation of the Siemens ADVIA Centaur high-sensitivity cardiac troponin I assay in serum.

Kavsak PA, Worster A, Hill SA, Jaffe AS.

Clin Chim Acta. 2018 Dec;487:216-221. doi: 10.1016/j.cca.2018.10.012. Epub 2018 Oct 6.


Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB).

Saenger AK, Jaffe AS, Body R, Collinson PO, Kavsak PA, Lam CSP, Lefèvre G, Omland T, Ordóñez-Llanos J, Pulkki K, Apple FS.

Clin Chem Lab Med. 2018 Oct 6. pii: /j/cclm.ahead-of-print/cclm-2018-0905/cclm-2018-0905.xml. doi: 10.1515/cclm-2018-0905. [Epub ahead of print]


Sex-specific, high-sensitivity cardiac troponin T cut-off concentrations for ruling out acute myocardial infarction with a single measurement.

McRae A, Graham M, Abedin T, Ji Y, Yang H, Wang D, Southern D, Andruchow J, Lang E, Innes G, Seiden-Long I, DeKoning L, Kavsak P.

CJEM. 2019 Jan;21(1):26-33. doi: 10.1017/cem.2018.435. Epub 2018 Sep 28.


The importance of tumour marker dual reporting during method transition: PSA high-dose hook effect detected.

Kittanakom S, Donohue V, Beattie J, Clark L, Kavsak PA.

Clin Biochem. 2018 Nov;61:45-46. doi: 10.1016/j.clinbiochem.2018.08.011. Epub 2018 Sep 1. No abstract available.


Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department.

Kavsak PA, Neumann JT, Cullen L, Than M, Shortt C, Greenslade JH, Pickering JW, Ojeda F, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Westermann D, Sörensen NA, Parsonage WA, Griffith L, Mehta SR, Devereaux PJ, Richards M, Troughton R, Pemberton C, Aldous S, Blankenberg S, Worster A.

CMAJ. 2018 Aug 20;190(33):E974-E984. doi: 10.1503/cmaj.180144.


Multicenter comparison of imprecision at low concentrations of two regulatory approved high-sensitivity cardiac troponin I assays.

Raizman JE, Fuezery A, Tsui AKY, Higgins T, Goudreau BL, Clark L, Hill SA, Kavsak PA.

Clin Chim Acta. 2018 Nov;486:219-220. doi: 10.1016/j.cca.2018.08.010. Epub 2018 Aug 10. No abstract available.


Perioperative heart-type fatty acid binding protein concentration cutoffs for the identification of severe acute kidney injury in patients undergoing cardiac surgery.

Kavsak PA, Whitlock R, Thiessen-Philbrook H, Parikh CR.

Clin Chem Lab Med. 2018 Dec 19;57(2):e8-e10. doi: 10.1515/cclm-2018-0547. No abstract available.


Differences in total PSA results within and between manufacturers.

Kittanakom S, Clark L, Roy C, Malinowski P, Bamford K, Lamers S, Kavsak PA.

Clin Biochem. 2018 Sep;60:91-92. doi: 10.1016/j.clinbiochem.2018.07.009. Epub 2018 Jul 20. No abstract available.


External Quality Assessment Testing Near the Limit of Detection for High-Sensitivity Cardiac Troponin Assays.

Kavsak PA.

Clin Chem. 2018 Sep;64(9):1402-1404. doi: 10.1373/clinchem.2018.288613. Epub 2018 Jun 29. No abstract available.


Post-exercise cardiac troponin I release and clearance in normal Standardbred racehorses.

Rossi TM, Kavsak PA, Maxie MG, Pearl DL, Pyle WG, Physick-Sheard PW.

Equine Vet J. 2019 Jan;51(1):97-101. doi: 10.1111/evj.12967. Epub 2018 Jun 28.


Should detectable cardiac troponin concentrations in a healthy population be the only criterion for classifying high-sensitivity cardiac troponin assays?

Kavsak PA.

Clin Biochem. 2018 Jun;56:1-3. doi: 10.1016/j.clinbiochem.2018.05.015. Epub 2018 May 24. No abstract available.


Profile of Roche's Elecsys Troponin T Gen 5 STAT blood test (a high-sensitivity cardiac troponin assay) for diagnosing myocardial infarction in the emergency department.

Kavsak PA, Andruchow JE, McRae AD, Worster A.

Expert Rev Mol Diagn. 2018 Jun;18(6):481-489. doi: 10.1080/14737159.2018.1476141. Epub 2018 May 18.


The potential role of a turbidimetric heart-type fatty acid-binding protein assay to aid in the interpretation of persistently elevated, non-changing, cardiac troponin I concentrations.

Kavsak PA, Ainsworth C, Arnold DM, Scott T, Clark L, Ivica J, Mackett K, Whitlock R, Worster A.

Clin Biochem. 2018 Aug;58:53-59. doi: 10.1016/j.clinbiochem.2018.05.006. Epub 2018 May 8.


Assessing matrix, interferences and comparability between the Abbott Diagnostics and the Beckman Coulter high-sensitivity cardiac troponin I assays.

Kavsak PA, Malinowski P, Roy C, Clark L, Lamers S.

Clin Chem Lab Med. 2018 Jun 27;56(7):1176-1181. doi: 10.1515/cclm-2017-1122.


Contemporary Emergency Department Management of Patients with Chest Pain: A Concise Review and Guide for the High-Sensitivity Troponin Era.

Andruchow JE, Kavsak PA, McRae AD.

Can J Cardiol. 2018 Feb;34(2):98-108. doi: 10.1016/j.cjca.2017.11.012. Epub 2017 Dec 2. Review.


Performance of high-sensitivity cardiac troponin in the emergency department for myocardial infarction and a composite cardiac outcome across different estimated glomerular filtration rates.

Kavsak PA, Worster A, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Griffith LE, Mehta SR, McRae AD, Devereaux PJ.

Clin Chim Acta. 2018 Apr;479:166-170. doi: 10.1016/j.cca.2018.01.034. Epub 2018 Feb 3.


Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study.

Meisner A, Kerr KF, Thiessen-Philbrook H, Wilson FP, Garg AX, Shlipak MG, Kavsak P, Whitlock RP, Coca SG, Parikh CR.

Biomark Res. 2018 Jan 12;6:3. doi: 10.1186/s40364-018-0117-z. eCollection 2018.


Chloride and Other Electrolyte Concentrations in Commonly Available 5% Albumin Products.

Lai AT, Zeller MP, Millen T, Kavsak P, Szczeklik W, Elahie A, Alhazzani W, D'Aragon F, Jaeschke R, Lamontagne F, Karachi T, Cook D, Meade M, Rochwerg B; Canadian Critical Care Trials Group.

Crit Care Med. 2018 Apr;46(4):e326-e329. doi: 10.1097/CCM.0000000000002955.


Variability Between Reagent Lots for High-Sensitivity Cardiac Troponin I May Affect Performance of Early Rule Out Strategies.

Kavsak PA, Worster A, Oliver R, Clark L, Parry D, Randell E, Sarfaraz MO, Hill S, Jaffe AS.

Can J Cardiol. 2018 Feb;34(2):209.e5-209.e6. doi: 10.1016/j.cjca.2017.11.010. Epub 2017 Nov 22. No abstract available.


Analytical validation of cardiac troponin I assays in horses.

Rossi TM, Kavsak PA, Maxie MG, Pearl DL, Pyle WG, Physick-Sheard PW.

J Vet Diagn Invest. 2018 Mar;30(2):226-232. doi: 10.1177/1040638717747070. Epub 2017 Dec 10.


High-sensitivity cardiac troponin concentrations at emergency department presentation in females and males with an acute cardiac outcome.

Kavsak PA, Worster A, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Griffith L, Mehta SR, Devereaux PJ.

Ann Clin Biochem. 2018 Sep;55(5):604-607. doi: 10.1177/0004563217743997. Epub 2017 Nov 23.


Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome.

Chapman AR, Lee KK, McAllister DA, Cullen L, Greenslade JH, Parsonage W, Worster A, Kavsak PA, Blankenberg S, Neumann J, Sörensen NA, Westermann D, Buijs MM, Verdel GJE, Pickering JW, Than MP, Twerenbold R, Badertscher P, Sabti Z, Mueller C, Anand A, Adamson P, Strachan FE, Ferry A, Sandeman D, Gray A, Body R, Keevil B, Carlton E, Greaves K, Korley FK, Metkus TS, Sandoval Y, Apple FS, Newby DE, Shah ASV, Mills NL.

JAMA. 2017 Nov 21;318(19):1913-1924. doi: 10.1001/jama.2017.17488. Review. Erratum in: JAMA. 2018 Mar 20;319(11):1168. Soerensen NA [corrected to Sorensen NA].


Comprehensive Age and Sex 99th Percentiles for a High-Sensitivity Cardiac Troponin I Assay.

Estis J, Wu AHB, Todd J, Bishop J, Sandlund J, Kavsak PA.

Clin Chem. 2018 Feb;64(2):398-399. doi: 10.1373/clinchem.2017.276972. Epub 2017 Oct 18. No abstract available.


Analytical comparison of three different versions of a high-sensitivity cardiac troponin I assay over 10years.

Kavsak PA, Worster A, Hill SA, MacRae AR, Jaffe AS.

Clin Chim Acta. 2017 Dec;475:51-55. doi: 10.1016/j.cca.2017.10.006. Epub 2017 Oct 7.


4 hs-cTnI algorithms had high sensitivity and low failure rates for ruling out acute MI in the ED.

Worster A, Kavsak P.

Ann Intern Med. 2017 Sep 19;167(6):JC35. doi: 10.7326/ACPJC-2017-167-6-035. No abstract available.


High-STEACS Algorithm missed fewer patients with acute MI than the ESC Pathway in the ED.

Worster A, Kavsak P.

Ann Intern Med. 2017 Sep 19;167(6):JC34. doi: 10.7326/ACPJC-2017-167-6-034. No abstract available.


Variability and Error in Cardiac Troponin Testing: An ACLPS Critical Review.

Herman DS, Kavsak PA, Greene DN.

Am J Clin Pathol. 2017 Oct 1;148(4):281-295. doi: 10.1093/ajcp/aqx066. Review.


Effect of a low glycemic index diet versus a high-cereal fibre diet on markers of subclinical cardiac injury in healthy individuals with type 2 diabetes mellitus: An exploratory analysis of a randomized dietary trial.

Ha V, Viguiliouk E, Kendall CWC, Balachandran B, Jenkins DJA, Kavsak PA, Sievenpiper JL.

Clin Biochem. 2017 Dec;50(18):1104-1109. doi: 10.1016/j.clinbiochem.2017.09.021. Epub 2017 Sep 25.


Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study.

Roshanov PS, Eikelboom JW, Crowther M, Tandon V, Borges FK, Kearon C, Lamy A, Whitlock R, Biccard BM, Szczeklik W, Guyatt GH, Panju M, Spence J, Garg AX, McGillion M, VanHelder T, Kavsak PA, de Beer J, Winemaker M, Sessler DI, Le Manach Y, Sheth T, Pinthus JH, Thabane L, Simunovic MRI, Mizera R, Ribas S, Devereaux PJ; Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (VISION) Investigators.

CMAJ Open. 2017 Aug 4;5(3):E594-E603. doi: 10.9778/cmajo.20160106.


Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations.

Kavsak PA, Roy C, Malinowski P, Mark CT, Scott T, Clark L, Lamers S, Ainsworth C.

Ann Clin Biochem. 2018 Jul;55(4):500-504. doi: 10.1177/0004563217734883. Epub 2017 Nov 8.


Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery.

Parikh CR, Puthumana J, Shlipak MG, Koyner JL, Thiessen-Philbrook H, McArthur E, Kerr K, Kavsak P, Whitlock RP, Garg AX, Coca SG.

J Am Soc Nephrol. 2017 Dec;28(12):3699-3707. doi: 10.1681/ASN.2017010055. Epub 2017 Aug 14.


Comparative Evaluation of 2-Hour Rapid Diagnostic Algorithms for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin T.

McRae AD, Innes G, Graham M, Lang E, Andruchow JE, Yang H, Ji Y, Vatanpour S, Southern DA, Wang D, Seiden-Long I, DeKoning L, Kavsak P.

Can J Cardiol. 2017 Aug;33(8):1006-1012. doi: 10.1016/j.cjca.2017.04.010. Epub 2017 May 3.


High-Sensitivity Cardiac Troponin Risk Cutoffs for Acute Cardiac Outcomes at Emergency Department Presentation.

Kavsak PA, Worster A, Ma J, Shortt C, Clayton N, Sherbino J, Hill SA, McQueen M, Mehta SR, Devereaux PJ.

Can J Cardiol. 2017 Jul;33(7):898-903. doi: 10.1016/j.cjca.2017.04.011. Epub 2017 May 3.


Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine.

Jerzak KJ, Laureano M, Elsharawi R, Kavsak P, Chan KK, Dhesy-Thind SK, Zbuk K.

Hypoxia (Auckl). 2017 May 24;5:61-66. doi: 10.2147/HP.S127560. eCollection 2017.


Undetectable Concentrations of a Food and Drug Administration-approved High-sensitivity Cardiac Troponin T Assay to Rule Out Acute Myocardial Infarction at Emergency Department Arrival.

McRae AD, Innes G, Graham M, Lang E, Andruchow JE, Ji Y, Vatanpour S, Abedin T, Yang H, Southern DA, Wang D, Seiden-Long I, DeKoning L, Kavsak P.

Acad Emerg Med. 2017 Oct;24(10):1267-1277. doi: 10.1111/acem.13229. Epub 2017 Aug 11.


Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery.

Writing Committee for the VISION Study Investigators, Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M, Abraham V, Pearse R, Wang CY, Sessler DI, Kurz A, Szczeklik W, Berwanger O, Villar JC, Malaga G, Garg AX, Chow CK, Ackland G, Patel A, Borges FK, Belley-Cote EP, Duceppe E, Spence J, Tandon V, Williams C, Sapsford RJ, Polanczyk CA, Tiboni M, Alonso-Coello P, Faruqui A, Heels-Ansdell D, Lamy A, Whitlock R, LeManach Y, Roshanov PS, McGillion M, Kavsak P, McQueen MJ, Thabane L, Rodseth RN, Buse GAL, Bhandari M, Garutti I, Jacka MJ, Schünemann HJ, Cortes OL, Coriat P, Dvirnik N, Botto F, Pettit S, Jaffe AS, Guyatt GH.

JAMA. 2017 Apr 25;317(16):1642-1651. doi: 10.1001/jama.2017.4360.


Response by Than et al to Letter Regarding Article, "Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction".

Than MP, Pickering JW, Cullen L, Kavsak PA.

Circulation. 2017 Apr 18;135(16):e923-e924. doi: 10.1161/CIRCULATIONAHA.117.027479. No abstract available.


A laboratory score at presentation to rule-out serious cardiac outcomes or death in patients presenting with symptoms suggestive of acute coronary syndrome.

Kavsak PA, Shortt C, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Mehta SR, Devereaux PJ, Worster A.

Clin Chim Acta. 2017 Jun;469:69-74. doi: 10.1016/j.cca.2017.03.021. Epub 2017 Mar 23.


Total Analytic Error for Low Cardiac Troponin Concentrations (≤10 ng/L) by Use of a High-Sensitivity Cardiac Troponin Assay.

Kavsak PA, Jaffe AS, Greene DN, Christenson RH, Apple FS, Wu AHB.

Clin Chem. 2017 May;63(5):1043-1045. doi: 10.1373/clinchem.2017.271361. Epub 2017 Mar 21. No abstract available.


Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations.

Moledina DG, Isguven S, McArthur E, Thiessen-Philbrook H, Garg AX, Shlipak M, Whitlock R, Kavsak PA, Coca SG, Parikh CR; Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) Consortium.

Ann Thorac Surg. 2017 Aug;104(2):613-620. doi: 10.1016/j.athoracsur.2016.11.036. Epub 2017 Feb 21.


Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome.

Shortt C, Ma J, Clayton N, Sherbino J, Whitlock R, Pare G, Hill SA, McQueen M, Mehta SR, Devereaux PJ, Worster A, Kavsak PA.

Clin Chem. 2017 Jan;63(1):403-414. doi: 10.1373/clinchem.2016.261545. Epub 2016 Nov 10.


Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury.

Apple FS, Jaffe AS, Sharkey S, Kavsak P, Kontos MC, Saenger AK, Smith S.

Clin Chem. 2017 Jan;63(1):37-44. doi: 10.1373/clinchem.2016.257428. Epub 2016 Oct 6. No abstract available.


Simulation Models of Misclassification Error for Single Thresholds of High-Sensitivity Cardiac Troponin I Due to Assay Bias and Imprecision.

Lyon AW, Kavsak PA, Lyon OA, Worster A, Lyon ME.

Clin Chem. 2017 Feb;63(2):585-592. doi: 10.1373/clinchem.2016.265058. Epub 2016 Dec 14.


Can 100 papers over 50years tell the story of a scientific journal?

Kavsak PA.

Clin Biochem. 2017 Jan;50(1-2):1-5. doi: 10.1016/j.clinbiochem.2016.12.001. Epub 2016 Dec 6. No abstract available.


Economic Considerations of Early Rule-In/Rule-Out Algorithms for The Diagnosis of Myocardial Infarction in The Emergency Department Using Cardiac Troponin and Glycemic Biomarkers.

Shortt C, Xie F, Whitlock R, Ma J, Clayton N, Sherbino J, Hill SA, Pare G, McQueen M, Mehta SR, Devereaux PJ, Worster A, Kavsak P.

Clin Chem. 2017 Feb;63(2):593-602. doi: 10.1373/clinchem.2016.261776. Epub 2016 Nov 3.

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