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Cell-specific role of histone deacetylase 6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers.

Ma J, Trinh RT, Mahant ID, Peng B, Matthias P, Heijnen CJ, Kavelaars A.

Pain. 2019 Jul 24. doi: 10.1097/j.pain.0000000000001667. [Epub ahead of print]


Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment.

Chiang ACA, Huo X, Kavelaars A, Heijnen CJ.

Brain Behav Immun. 2019 Jul;79:319-325. doi: 10.1016/j.bbi.2019.04.005. Epub 2019 Apr 3.


Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice.

Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A.

Pain. 2019 Jun;160(6):1459-1468. doi: 10.1097/j.pain.0000000000001512.


Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin.

Boukelmoune N, Chiu GS, Kavelaars A, Heijnen CJ.

Acta Neuropathol Commun. 2018 Dec 12;6(1):139. doi: 10.1186/s40478-018-0644-8.


Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice.

Huo X, Reyes TM, Heijnen CJ, Kavelaars A.

Sci Rep. 2018 Nov 27;8(1):17400. doi: 10.1038/s41598-018-35919-x.


Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice.

Chiu GS, Boukelmoune N, Chiang ACA, Peng B, Rao V, Kingsley C, Liu HL, Kavelaars A, Kesler SR, Heijnen CJ.

Oncotarget. 2018 Oct 30;9(85):35581-35597. doi: 10.18632/oncotarget.26272. eCollection 2018 Oct 30.


Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment.

Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ.

Acta Neuropathol Commun. 2018 Oct 1;6(1):103. doi: 10.1186/s40478-018-0604-3.


Patient-reported fatigue prior to treatment is prognostic of survival in patients with acute myeloid leukemia.

Lacourt TE, Kavelaars A, Ohanian M, Shah ND, Shelburne SA, Futreal A, Kontoyiannis DP, Heijnen CJ.

Oncotarget. 2018 Jul 27;9(58):31244-31252. doi: 10.18632/oncotarget.25787. eCollection 2018 Jul 27.


Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling.

Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A.

Neuropsychopharmacology. 2018 Dec;43(13):2597-2605. doi: 10.1038/s41386-018-0154-1. Epub 2018 Jul 16.


Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor.

Wang HJ, Gu HX, Eijkelkamp N, Heijnen CJ, Kavelaars A.

Front Pharmacol. 2018 Jun 5;9:592. doi: 10.3389/fphar.2018.00592. eCollection 2018.


Transition to chronic pain: opportunities for novel therapeutics.

Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH.

Nat Rev Neurosci. 2018 Jul;19(7):383-384. doi: 10.1038/s41583-018-0012-5. No abstract available.


Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase.

Vichaya EG, Laumet G, Christian DL, Grossberg AJ, Estrada DJ, Heijnen CJ, Kavelaars A, Dantzer R.

Neuropsychopharmacology. 2019 Jan;44(2):364-371. doi: 10.1038/s41386-018-0075-z. Epub 2018 Apr 27.


Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source.

Ma J, Kavelaars A, Dougherty PM, Heijnen CJ.

Cancer. 2018 Jun 1;124(11):2289-2298. doi: 10.1002/cncr.31248. Epub 2018 Feb 20. Review.


Identification of FAM173B as a protein methyltransferase promoting chronic pain.

Willemen HLDM, Kavelaars A, Prado J, Maas M, Versteeg S, Nellissen LJJ, Tromp J, Gonzalez Cano R, Zhou W, Jakobsson ME, Małecki J, Posthuma G, Habib AM, Heijnen CJ, Falnes PØ, Eijkelkamp N.

PLoS Biol. 2018 Feb 14;16(2):e2003452. doi: 10.1371/journal.pbio.2003452. eCollection 2018 Feb.


Associations of inflammation with symptom burden in patients with acute myeloid leukemia.

Lacourt TE, Kavelaars A, Galloway-Peña JR, Sahasrabhojane PV, Shah ND, Futreal A, Kontoyiannis DP, Shelburne SA, Heijnen CJ.

Psychoneuroendocrinology. 2018 Mar;89:203-208. doi: 10.1016/j.psyneuen.2018.01.018.


Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy.

Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A.

Pain. 2018 May;159(5):884-893. doi: 10.1097/j.pain.0000000000001160.


Longitudinal changes in glucocorticoid receptor exon 1F methylation and psychopathology after military deployment.

Schür RR, Boks MP, Rutten BPF, Daskalakis NP, de Nijs L, van Zuiden M, Kavelaars A, Heijnen CJ, Joëls M, Kahn RS, Geuze E, Vermetten E, Vinkers CH.

Transl Psychiatry. 2017 Jul 25;7(7):e1181. doi: 10.1038/tp.2017.150.


Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.

Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O'Connor JC, Lee AW, Heijnen CJ, Kavelaars A.

Brain Behav Immun. 2017 Nov;66:94-102. doi: 10.1016/j.bbi.2017.07.008. Epub 2017 Jul 11.


Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy.

Maj MA, Ma J, Krukowski KN, Kavelaars A, Heijnen CJ.

Front Mol Neurosci. 2017 Apr 18;10:108. doi: 10.3389/fnmol.2017.00108. eCollection 2017.


HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy.

Krukowski K, Ma J, Golonzhka O, Laumet GO, Gutti T, van Duzer JH, Mazitschek R, Jarpe MB, Heijnen CJ, Kavelaars A.

Pain. 2017 Jun;158(6):1126-1137. doi: 10.1097/j.pain.0000000000000893.


Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function.

Chiu GS, Maj MA, Rizvi S, Dantzer R, Vichaya EG, Laumet G, Kavelaars A, Heijnen CJ.

Cancer Res. 2017 Feb 1;77(3):742-752. doi: 10.1158/0008-5472.CAN-16-1817. Epub 2016 Nov 22.


Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.

Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A.

Sci Rep. 2016 Nov 3;6:36370. doi: 10.1038/srep36370.


CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain.

Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A.

J Neurosci. 2016 Oct 26;36(43):11074-11083.


IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.

Eijkelkamp N, Steen-Louws C, Hartgring SA, Willemen HL, Prado J, Lafeber FP, Heijnen CJ, Hack CE, van Roon JA, Kavelaars A.

J Neurosci. 2016 Jul 13;36(28):7353-63. doi: 10.1523/JNEUROSCI.0092-16.2016.


Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice.

Zhou W, Kavelaars A, Heijnen CJ.

PLoS One. 2016 Mar 28;11(3):e0151890. doi: 10.1371/journal.pone.0151890. eCollection 2016.


Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy.

Zhang H, Li Y, de Carvalho-Barbosa M, Kavelaars A, Heijnen CJ, Albrecht PJ, Dougherty PM.

J Pain. 2016 Jul;17(7):775-86. doi: 10.1016/j.jpain.2016.02.011. Epub 2016 Mar 12.


Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F Jr, Murga C, Heijnen CJ, Kavelaars A.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41. doi: 10.1073/pnas.1516036113. Epub 2016 Feb 29.


Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression.

Vichaya EG, Molkentine JM, Vermeer DW, Walker AK, Feng R, Holder G, Luu K, Mason RM, Saligan L, Heijnen CJ, Kavelaars A, Mason KA, Lee JH, Dantzer R.

Behav Brain Res. 2016 Jan 15;297:241-50. doi: 10.1016/j.bbr.2015.10.024. Epub 2015 Oct 22.


Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.

Krukowski K, Nijboer CH, Huo X, Kavelaars A, Heijnen CJ.

Pain. 2015 Nov;156(11):2184-92. doi: 10.1097/j.pain.0000000000000290.


Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse.

Donega V, Nijboer CH, van Velthoven CT, Youssef SA, de Bruin A, van Bel F, Kavelaars A, Heijnen CJ.

Pediatr Res. 2015 Nov;78(5):520-6. doi: 10.1038/pr.2015.145. Epub 2015 Aug 13.


Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

Vila-Bedmar R, Cruces-Sande M, Lucas E, Willemen HL, Heijnen CJ, Kavelaars A, Mayor F Jr, Murga C.

Sci Signal. 2015 Jul 21;8(386):ra73. doi: 10.1126/scisignal.aaa4374.


Mechanisms of chemotherapy-induced behavioral toxicities.

Vichaya EG, Chiu GS, Krukowski K, Lacourt TE, Kavelaars A, Dantzer R, Heijnen CJ, Walker AK.

Front Neurosci. 2015 Apr 21;9:131. doi: 10.3389/fnins.2015.00131. eCollection 2015. Review.


Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.

Zhou W, Dantzer R, Budac DP, Walker AK, Mao-Ying QL, Lee AW, Heijnen CJ, Kavelaars A.

Brain Behav Immun. 2015 May;46:147-53. doi: 10.1016/j.bbi.2015.01.013. Epub 2015 Jan 28.


Neonatal glucocorticoid treatment: long-term effects on the hypothalamus-pituitary-adrenal axis, immune system, and problem behavior in 14-17 year old adolescents.

Ter Wolbeek M, Kavelaars A, de Vries WB, Tersteeg-Kamperman M, Veen S, Kornelisse RF, van Weissenbruch M, Baerts W, Liem KD, van Bel F, Heijnen CJ.

Brain Behav Immun. 2015 Mar;45:128-38. doi: 10.1016/j.bbi.2014.10.017. Epub 2014 Nov 8.


Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions.

Donega V, Nijboer CH, Braccioli L, Slaper-Cortenbach I, Kavelaars A, van Bel F, Heijnen CJ.

PLoS One. 2014 Nov 14;9(11):e112339. doi: 10.1371/journal.pone.0112339. eCollection 2014.


Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return from military deployment.

van Zuiden M, Kavelaars A, Vermetten E, Olff M, Geuze E, Heijnen C.

Psychoneuroendocrinology. 2015 Jan;51:513-24. doi: 10.1016/j.psyneuen.2014.09.014. Epub 2014 Sep 28.


Cytokine production as a putative biological mechanism underlying stress sensitization in high combat exposed soldiers.

Smid GE, van Zuiden M, Geuze E, Kavelaars A, Heijnen CJ, Vermetten E.

Psychoneuroendocrinology. 2015 Jan;51:534-46. doi: 10.1016/j.psyneuen.2014.07.010. Epub 2014 Jul 23.


The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.

Mao-Ying QL, Kavelaars A, Krukowski K, Huo XJ, Zhou W, Price TJ, Cleeland C, Heijnen CJ.

PLoS One. 2014 Jun 23;9(6):e100701. doi: 10.1371/journal.pone.0100701. eCollection 2014.


Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury.

Donega V, Nijboer CH, van Tilborg G, Dijkhuizen RM, Kavelaars A, Heijnen CJ.

Exp Neurol. 2014 Nov;261:53-64. doi: 10.1016/j.expneurol.2014.06.009. Epub 2014 Jun 16.


Monocytes/Macrophages control resolution of transient inflammatory pain.

Willemen HL, Eijkelkamp N, Garza Carbajal A, Wang H, Mack M, Zijlstra J, Heijnen CJ, Kavelaars A.

J Pain. 2014 May;15(5):496-506. doi: 10.1016/j.jpain.2014.01.491.


Association between brain natriuretic peptide, markers of inflammation and the objective and subjective response to cardiac resynchronization therapy.

Brouwers C, Versteeg H, Meine M, Heijnen CJ, Kavelaars AM, Pedersen SS, Mommersteeg PM.

Brain Behav Immun. 2014 Aug;40:211-8. doi: 10.1016/j.bbi.2014.03.017. Epub 2014 Apr 1.


A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia.

Willemen HL, Campos PM, Lucas E, Morreale A, Gil-Redondo R, Agut J, González FV, Ramos P, Heijnen C, Mayor F Jr, Kavelaars A, Murga C.

Biochem J. 2014 May 1;459(3):427-39. doi: 10.1042/BJ20130172.


The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies.

Kooijman E, Nijboer CH, van Velthoven CT, Kavelaars A, Kesecioglu J, Heijnen CJ.

J Neuroinflammation. 2014 Jan 3;11:2. doi: 10.1186/1742-2094-11-2. Review.


Neuroinflammation and comorbidity of pain and depression.

Walker AK, Kavelaars A, Heijnen CJ, Dantzer R.

Pharmacol Rev. 2013 Dec 11;66(1):80-101. doi: 10.1124/pr.113.008144. Print 2014. Review.


The neuroimmune basis of fatigue.

Dantzer R, Heijnen CJ, Kavelaars A, Laye S, Capuron L.

Trends Neurosci. 2014 Jan;37(1):39-46. doi: 10.1016/j.tins.2013.10.003. Epub 2013 Nov 13. Review.


Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

Wang H, Heijnen CJ, van Velthoven CT, Willemen HL, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, Kavelaars A.

J Clin Invest. 2013 Dec;123(12):5023-34. doi: 10.1172/JCI66241. Epub 2013 Nov 15.


Therapeutic potential of genetically modified mesenchymal stem cells after neonatal hypoxic-ischemic brain damage.

van Velthoven CT, Braccioli L, Willemen HL, Kavelaars A, Heijnen CJ.

Mol Ther. 2014 Mar;22(3):645-654. doi: 10.1038/mt.2013.260. Epub 2013 Oct 31.


Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination.

Nessler J, Bénardais K, Gudi V, Hoffmann A, Salinas Tejedor L, Janßen S, Prajeeth CK, Baumgärtner W, Kavelaars A, Heijnen CJ, van Velthoven C, Hansmann F, Skripuletz T, Stangel M.

PLoS One. 2013 Jul 26;8(7):e69795. doi: 10.1371/journal.pone.0069795. Print 2013.


Cerebral and hepatic inflammatory response after neonatal hypoxia-ischemia in newborn rats.

Bonestroo HJ, Nijboer CH, van Velthoven CT, Kavelaars A, Hack CE, van Bel F, Heijnen CJ.

Dev Neurosci. 2013;35(2-3):197-211. doi: 10.1159/000346685. Epub 2013 May 8.


Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke.

van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM.

Stroke. 2013 May;44(5):1426-32. doi: 10.1161/STROKEAHA.111.000326. Epub 2013 Mar 28.

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