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Items: 33


Identification of Extracellular DNA-Binding Proteins in the Biofilm Matrix.

Kavanaugh JS, Flack CE, Lister J, Ricker EB, Ibberson CB, Jenul C, Moormeier DE, Delmain EA, Bayles KW, Horswill AR.

MBio. 2019 Jun 25;10(3). pii: e01137-19. doi: 10.1128/mBio.01137-19.


Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense.

Parlet CP, Kavanaugh JS, Crosby HA, Raja HA, El-Elimat T, Todd DA, Pearce CJ, Cech NB, Oberlies NH, Horswill AR.

Cell Rep. 2019 Apr 2;27(1):187-198.e6. doi: 10.1016/j.celrep.2019.03.018.


Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models.

Muhs A, Lyles JT, Parlet CP, Nelson K, Kavanaugh JS, Horswill AR, Quave CL.

Sci Rep. 2017 Feb 10;7:42275. doi: 10.1038/srep42275.


Correction: Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance.

Quave CL, Lyles JT, Kavanaugh JS, Nelson K, Parlet CP, Crosby HA, Heilmann KP, Horswill AR.

PLoS One. 2016 Sep 22;11(9):e0163655. doi: 10.1371/journal.pone.0163655. eCollection 2016.


Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing.

Gordon CP, Olson SD, Lister JL, Kavanaugh JS, Horswill AR.

J Med Chem. 2016 Oct 13;59(19):8879-8888. Epub 2016 Sep 15.


Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition.

Todd DA, Zich DB, Ettefagh KA, Kavanaugh JS, Horswill AR, Cech NB.

J Microbiol Methods. 2016 Aug;127:89-94. doi: 10.1016/j.mimet.2016.05.024. Epub 2016 May 26.


Impact of Environmental Cues on Staphylococcal Quorum Sensing and Biofilm Development.

Kavanaugh JS, Horswill AR.

J Biol Chem. 2016 Jun 10;291(24):12556-64. doi: 10.1074/jbc.R116.722710. Epub 2016 Apr 21. Review.


Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance.

Quave CL, Lyles JT, Kavanaugh JS, Nelson K, Parlet CP, Crosby HA, Heilmann KP, Horswill AR.

PLoS One. 2015 Aug 21;10(8):e0136486. doi: 10.1371/journal.pone.0136486. eCollection 2015. Erratum in: PLoS One. 2016;11(9):e0163655.


ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.

Daly SM, Elmore BO, Kavanaugh JS, Triplett KD, Figueroa M, Raja HA, El-Elimat T, Crosby HA, Femling JK, Cech NB, Horswill AR, Oberlies NH, Hall PR.

Antimicrob Agents Chemother. 2015 Apr;59(4):2223-35. doi: 10.1128/AAC.04564-14. Epub 2015 Feb 2.


Rot is a key regulator of Staphylococcus aureus biofilm formation.

Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR.

Mol Microbiol. 2015 Apr;96(2):388-404. doi: 10.1111/mmi.12943. Epub 2015 Feb 26.


Chronic ethanol feeding increases the severity of Staphylococcus aureus skin infections by altering local host defenses.

Parlet CP, Kavanaugh JS, Horswill AR, Schlueter AJ.

J Leukoc Biol. 2015 Apr;97(4):769-78. doi: 10.1189/jlb.4A0214-092R. Epub 2015 Jan 20.


Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry.

Figueroa M, Jarmusch AK, Raja HA, El-Elimat T, Kavanaugh JS, Horswill AR, Cooks RG, Cech NB, Oberlies NH.

J Nat Prod. 2014 Jun 27;77(6):1351-8. doi: 10.1021/np5000704. Epub 2014 Jun 9.


Analysis of autoinducer-2 quorum sensing in Yersinia pestis.

Yu J, Madsen ML, Carruthers MD, Phillips GJ, Kavanaugh JS, Boyd JM, Horswill AR, Minion FC.

Infect Immun. 2013 Nov;81(11):4053-62. doi: 10.1128/IAI.00880-13. Epub 2013 Aug 19.


Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry.

Junio HA, Todd DA, Ettefagh KA, Ehrmann BM, Kavanaugh JS, Horswill AR, Cech NB.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 1;930:7-12. doi: 10.1016/j.jchromb.2013.04.019. Epub 2013 Apr 19.


Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor.

Olson ME, Nygaard TK, Ackermann L, Watkins RL, Zurek OW, Pallister KB, Griffith S, Kiedrowski MR, Flack CE, Kavanaugh JS, Kreiswirth BN, Horswill AR, Voyich JM.

Infect Immun. 2013 Apr;81(4):1316-24. doi: 10.1128/IAI.01242-12. Epub 2013 Feb 4.


Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA).

Cech NB, Junio HA, Ackermann LW, Kavanaugh JS, Horswill AR.

Planta Med. 2012 Sep;78(14):1556-61. Epub 2012 Jul 18.


The structure of LsrB from Yersinia pestis complexed with autoinducer-2.

Kavanaugh JS, Gakhar L, Horswill AR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1501-5. doi: 10.1107/S1744309111042953. Epub 2011 Nov 29.


Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus.

Kiedrowski MR, Kavanaugh JS, Malone CL, Mootz JM, Voyich JM, Smeltzer MS, Bayles KW, Horswill AR.

PLoS One. 2011;6(11):e26714. doi: 10.1371/journal.pone.0026714. Epub 2011 Nov 11.


Peptide signaling in the staphylococci.

Thoendel M, Kavanaugh JS, Flack CE, Horswill AR.

Chem Rev. 2011 Jan 12;111(1):117-51. doi: 10.1021/cr100370n. Epub 2010 Dec 21. Review. No abstract available.


Fluorescent reporters for Staphylococcus aureus.

Malone CL, Boles BR, Lauderdale KJ, Thoendel M, Kavanaugh JS, Horswill AR.

J Microbiol Methods. 2009 Jun;77(3):251-60. doi: 10.1016/j.mimet.2009.02.011. Epub 2009 Mar 3.


A role for type I signal peptidase in Staphylococcus aureus quorum sensing.

Kavanaugh JS, Thoendel M, Horswill AR.

Mol Microbiol. 2007 Aug;65(3):780-98. Epub 2007 Jul 3.


Intersubunit interactions associated with Tyr42 alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin.

Kavanaugh JS, Rogers PH, Arnone A, Hui HL, Wierzba A, DeYoung A, Kwiatkowski LD, Noble RW, Juszczak LJ, Peterson ES, Friedman JM.

Biochemistry. 2005 Mar 15;44(10):3806-20.


Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.

Chan NL, Kavanaugh JS, Rogers PH, Arnone A.

Biochemistry. 2004 Jan 13;43(1):118-32.


Site-directed mutations of human hemoglobin at residue 35beta: a residue at the intersection of the alpha1beta1, alpha1beta2, and alpha1alpha2 interfaces.

Kavanaugh JS, Weydert JA, Rogers PH, Arnone A, Hui HL, Wierzba AM, Kwiatkowski LD, Paily P, Noble RW, Bruno S, Mozzarelli A.

Protein Sci. 2001 Sep;10(9):1847-55.


Structural and functional properties of human hemoglobins reassembled after synthesis in Escherichia coli.

Hui HL, Kavanaugh JS, Doyle ML, Wierzba A, Rogers PH, Arnone A, Holt JM, Ackers GK, Noble RW.

Biochemistry. 1999 Jan 19;38(3):1040-9.


Structure and oxygen affinity of crystalline des-his-146beta human hemoglobin in the T state.

Bettati S, Kwiatkowski LD, Kavanaugh JS, Mozzarelli A, Arnone A, Rossi GL, Noble RW.

J Biol Chem. 1997 Dec 26;272(52):33077-84.


Structure and oxygen affinity of crystalline desArg141 alpha human hemoglobin A in the T state.

Kavanaugh JS, Chafin DR, Arnone A, Mozzarelli A, Rivetti C, Rossi GL, Kwiatkowski LD, Noble RW.

J Mol Biol. 1995 Apr 21;248(1):136-50.


Hemoglobin Thionville. An alpha-chain variant with a substitution of a glutamate for valine at NA-1 and having an acetylated methionine NH2 terminus.

Vasseur C, Blouquit Y, Kister J, Promé D, Kavanaugh JS, Rogers PH, Guillemin C, Arnone A, Galacteros F, Poyart C, et al.

J Biol Chem. 1992 Jun 25;267(18):12682-91.


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