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Items: 35

1.

Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial.

Gandhi RT, Kwon DS, Macklin EA, Shopis JR, McLean AP, McBrine N, Flynn T, Peter L, Sbrolla A, Kaufmann DE, Porichis F, Walker BD, Bhardwaj N, Barouch DH, Kavanagh DG.

J Acquir Immune Defic Syndr. 2016 Mar 1;71(3):246-53. doi: 10.1097/QAI.0000000000000852.

2.

High-throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry.

Porichis F, Hart MG, Griesbeck M, Everett HL, Hassan M, Baxter AE, Lindqvist M, Miller SM, Soghoian DZ, Kavanagh DG, Reynolds S, Norris B, Mordecai SK, Nguyen Q, Lai C, Kaufmann DE.

Nat Commun. 2014 Dec 4;5:5641. doi: 10.1038/ncomms6641.

3.

Different antigen-processing activities in dendritic cells, macrophages, and monocytes lead to uneven production of HIV epitopes and affect CTL recognition.

Dinter J, Gourdain P, Lai NY, Duong E, Bracho-Sanchez E, Rucevic M, Liebesny PH, Xu Y, Shimada M, Ghebremichael M, Kavanagh DG, Le Gall S.

J Immunol. 2014 Nov 1;193(9):4322-4334. doi: 10.4049/jimmunol.1400491. Epub 2014 Sep 17.

4.

Evaluation of Electronic Medical Record Administrative data Linked Database (EMRALD).

Tu K, Mitiku TF, Ivers NM, Guo H, Lu H, Jaakkimainen L, Kavanagh DG, Lee DS, Tu JV.

Am J Manag Care. 2014;20(1):e15-21.

PMID:
24669409
5.

Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions.

Porichis F, Hart MG, Zupkosky J, Barblu L, Kwon DS, McMullen A, Brennan T, Ahmed R, Freeman GJ, Kavanagh DG, Kaufmann DE.

J Virol. 2014 Mar;88(5):2508-18. doi: 10.1128/JVI.02034-13. Epub 2013 Dec 18.

6.

Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells.

Pacheco Y, McLean AP, Rohrbach J, Porichis F, Kaufmann DE, Kavanagh DG.

J Immunol. 2013 Sep 1;191(5):2072-81. doi: 10.4049/jimmunol.1300435. Epub 2013 Aug 2.

7.

Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.

Zhang SC, Martin E, Shimada M, Godfrey SB, Fricke J, Locastro S, Lai NY, Liebesny P, Carlson JM, Brumme CJ, Ogbechie OA, Chen H, Walker BD, Brumme ZL, Kavanagh DG, Le Gall S.

J Immunol. 2012 Jun 15;188(12):5924-34. doi: 10.4049/jimmunol.1200219. Epub 2012 May 14.

8.

CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes.

Kwon DS, Angin M, Hongo T, Law KM, Johnson J, Porichis F, Hart MG, Pavlik DF, Tighe DP, Kavanagh DG, Streeck H, Addo MM, Kaufmann DE.

J Virol. 2012 Jun;86(12):6586-94. doi: 10.1128/JVI.06251-11. Epub 2012 Apr 11.

9.

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.

Porichis F, Kwon DS, Zupkosky J, Tighe DP, McMullen A, Brockman MA, Pavlik DF, Rodriguez-Garcia M, Pereyra F, Freeman GJ, Kavanagh DG, Kaufmann DE.

Blood. 2011 Jul 28;118(4):965-74. doi: 10.1182/blood-2010-12-328070. Epub 2011 Jun 7.

10.

In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles.

Su X, Fricke J, Kavanagh DG, Irvine DJ.

Mol Pharm. 2011 Jun 6;8(3):774-87. doi: 10.1021/mp100390w. Epub 2011 Apr 1.

11.

Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10.

Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG.

J Leukoc Biol. 2011 Apr;89(4):507-15. doi: 10.1189/jlb.0610327. Epub 2010 Nov 19.

12.

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.

Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S, Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DE.

Blood. 2009 Jul 9;114(2):346-56. doi: 10.1182/blood-2008-12-191296. Epub 2009 Apr 13.

13.

In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.

Lubong Sabado R, Kavanagh DG, Kaufmann DE, Fru K, Babcock E, Rosenberg E, Walker B, Lifson J, Bhardwaj N, Larsson M.

PLoS One. 2009;4(1):e4256. doi: 10.1371/journal.pone.0004256. Epub 2009 Jan 23.

14.

Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy.

Marzocchetti A, Lima M, Tompkins T, Kavanagh DG, Gandhi RT, O'Neill DW, Bhardwaj N, Koralnik IJ.

Virology. 2009 Jan 20;383(2):173-7. doi: 10.1016/j.virol.2008.10.046. Epub 2008 Dec 5. Erratum in: Virology. 2010 Jan 20;396(2):349-50.

15.

Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells.

Minkis K, Kavanagh DG, Alter G, Bogunovic D, O'Neill D, Adams S, Pavlick A, Walker BD, Brockman MA, Gandhi RT, Bhardwaj N.

Cancer Res. 2008 Nov 15;68(22):9441-50. doi: 10.1158/0008-5472.CAN-08-0900.

16.

Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.

Wölfl M, Rutebemberwa A, Mosbruger T, Mao Q, Li HM, Netski D, Ray SC, Pardoll D, Sidney J, Sette A, Allen T, Kuntzen T, Kavanagh DG, Kuball J, Greenberg PD, Cox AL.

J Immunol. 2008 Nov 1;181(9):6435-46.

17.

Quantitative effect of suboptimal codon usage on translational efficiency of mRNA encoding HIV-1 gag in intact T cells.

Ngumbela KC, Ryan KP, Sivamurthy R, Brockman MA, Gandhi RT, Bhardwaj N, Kavanagh DG.

PLoS One. 2008 Jun 4;3(6):e2356. doi: 10.1371/journal.pone.0002356.

18.

Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.

Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M.

AIDS. 2008 Mar 12;22(5):655-8. doi: 10.1097/QAD.0b013e3282f4de23.

19.

Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.

Ngumbela KC, Day CL, Mncube Z, Nair K, Ramduth D, Thobakgale C, Moodley E, Reddy S, de Pierres C, Mkhwanazi N, Bishop K, van der Stok M, Ismail N, Honeyborne I, Crawford H, Kavanagh DG, Rousseau C, Nickle D, Mullins J, Heckerman D, Korber B, Coovadia H, Kiepiela P, Goulder PJ, Walker BD.

AIDS Res Hum Retroviruses. 2008 Jan;24(1):72-82. doi: 10.1089/aid.2007.0124.

PMID:
18275350
20.

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.

Lichterfeld M, Kavanagh DG, Williams KL, Moza B, Mui SK, Miura T, Sivamurthy R, Allgaier R, Pereyra F, Trocha A, Feeney M, Gandhi RT, Rosenberg ES, Altfeld M, Allen TM, Allen R, Walker BD, Sundberg EJ, Yu XG.

J Exp Med. 2007 Nov 26;204(12):2813-24. Epub 2007 Nov 19.

21.

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.

Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A, Baker B, Zhu B, Le Gall S, Waring MT, Ahern R, Moss K, Kelleher AD, Coffin JM, Freeman GJ, Rosenberg ES, Walker BD.

Nat Immunol. 2007 Nov;8(11):1246-54. Epub 2007 Sep 30.

PMID:
17906628
22.

Extensive HLA class I allele promiscuity among viral CTL epitopes.

Frahm N, Yusim K, Suscovich TJ, Adams S, Sidney J, Hraber P, Hewitt HS, Linde CH, Kavanagh DG, Woodberry T, Henry LM, Faircloth K, Listgarten J, Kadie C, Jojic N, Sango K, Brown NV, Pae E, Zaman MT, Bihl F, Khatri A, John M, Mallal S, Marincola FM, Walker BD, Sette A, Heckerman D, Korber BT, Brander C.

Eur J Immunol. 2007 Sep;37(9):2419-33.

23.

Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1.

Sabado RL, Babcock E, Kavanagh DG, Tjomsland V, Walker BD, Lifson JD, Bhardwaj N, Larsson M.

Eur J Immunol. 2007 Jul;37(7):1752-63.

25.

Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.

Kavanagh DG, Kaufmann DE, Sunderji S, Frahm N, Le Gall S, Boczkowski D, Rosenberg ES, Stone DR, Johnston MN, Wagner BS, Zaman MT, Brander C, Gilboa E, Walker BD, Bhardwaj N.

Blood. 2006 Mar 1;107(5):1963-9. Epub 2005 Oct 25.

26.

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions.

Beignon AS, McKenna K, Skoberne M, Manches O, DaSilva I, Kavanagh DG, Larsson M, Gorelick RJ, Lifson JD, Bhardwaj N.

J Clin Invest. 2005 Nov;115(11):3265-75. Epub 2005 Oct 13.

27.

CD8 epitope escape and reversion in acute HCV infection.

Timm J, Lauer GM, Kavanagh DG, Sheridan I, Kim AY, Lucas M, Pillay T, Ouchi K, Reyor LL, Schulze zur Wiesch J, Gandhi RT, Chung RT, Bhardwaj N, Klenerman P, Walker BD, Allen TM.

J Exp Med. 2004 Dec 20;200(12):1593-604.

28.

Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response.

Gold MC, Munks MW, Wagner M, McMahon CW, Kelly A, Kavanagh DG, Slifka MK, Koszinowski UH, Raulet DH, Hill AB.

J Immunol. 2004 Jun 1;172(11):6944-53.

29.

Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells.

Fonteneau JF, Kavanagh DG, Lirvall M, Sanders C, Cover TL, Bhardwaj N, Larsson M.

Blood. 2003 Dec 15;102(13):4448-55. Epub 2003 Aug 21.

30.

Effective inhibition of K(b)- and D(b)-restricted antigen presentation in primary macrophages by murine cytomegalovirus.

LoPiccolo DM, Gold MC, Kavanagh DG, Wagner M, Koszinowski UH, Hill AB.

J Virol. 2003 Jan;77(1):301-8.

31.

A division of labor: DC subsets and HIV receptor diversity.

Kavanagh DG, Bhardwaj N.

Nat Immunol. 2002 Oct;3(10):891-3. No abstract available.

PMID:
12352961
32.
34.

Evasion of cytotoxic T lymphocytes by murine cytomegalovirus.

Kavanagh DG, Hill AB.

Semin Immunol. 2001 Feb;13(1):19-26. Review.

PMID:
11289796
35.

MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR V beta CDR2 peptides: comparison with myelin basic protein-specific T cells.

Chou YK, Weinberg AD, Buenafe A, Bourdette DN, Whitham R, Kaleeba JA, Robey IF, Kavanagh DG, Offner H, Vandenbark AA.

J Neurosci Res. 1996 Sep 15;45(6):838-51.

PMID:
8892096

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