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Thiol-Reactive Star Polymers Functionalized with Short Ethoxy-Containing Moieties Exhibit Enhanced Uptake in Acute Lymphoblastic Leukemia Cells.

Bayat N, McOrist N, Ariotti N, Lai M, Sia KC, Li Y, Grace JL, Quinn JF, Whittaker MR, Kavallaris M, Davis TP, Lock RB.

Int J Nanomedicine. 2019 Dec 11;14:9795-9808. doi: 10.2147/IJN.S220326. eCollection 2019.


Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration.

Po'uha ST, Le Grand M, Brandl MB, Gifford AJ, Goodall GJ, Khew-Goodall Y, Kavallaris M.

Br J Cancer. 2019 Dec 6. doi: 10.1038/s41416-019-0669-1. [Epub ahead of print]


Modeling the Distribution of Diprotic Basic Drugs in Liposomal Systems: Perspectives on Malaria Nanotherapy.

Moles E, Kavallaris M, Fernàndez-Busquets X.

Front Pharmacol. 2019 Sep 25;10:1064. doi: 10.3389/fphar.2019.01064. eCollection 2019.


When polymers meet carbon nanostructures: expanding horizons in cancer therapy.

Cirillo G, Peitzsch C, Vittorio O, Curcio M, Farfalla A, Voli F, Dubrovska A, Iemma F, Kavallaris M, Hampel S.

Future Med Chem. 2019 Aug;11(16):2205-2231. doi: 10.4155/fmc-2018-0540.


Identification of Novel Medulloblastoma Cell-Targeting Peptides for Use in Selective Chemotherapy Drug Delivery.

Tjandra KC, McCarthy N, Yang L, Laos AJ, Sharbeen G, Phillips PA, Forgham H, Sagnella SM, Whan RM, Kavallaris M, Thordarson P, McCarroll JA.

J Med Chem. 2019 Aug 1. doi: 10.1021/acs.jmedchem.9b00851. [Epub ahead of print]


The Use of Star Polymer Nanoparticles for the Delivery of siRNA to Mouse Orthotopic Pancreatic Tumor Models.

McCarroll JA, Sharbeen G, Kavallaris M, Phillips PA.

Methods Mol Biol. 2019;1974:329-353. doi: 10.1007/978-1-4939-9220-1_23.


A potent targeted cancer nanotherapeutic.

Moles E, Kavallaris M.

Nat Biomed Eng. 2019 Apr;3(4):248-250. doi: 10.1038/s41551-019-0390-7. No abstract available.


A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.

Somers K, Wen VW, Middlemiss SMC, Osborne B, Forgham H, Jung M, Karsa M, Clifton M, Bongers A, Gao J, Mayoh C, Raoufi-Rad N, Kusnadi EP, Hannan KM, Scott DA, Kwek A, Liu B, Flemming C, Chudakova DA, Pandher R, Failes TW, Lim J, Angeli A, Osterman AL, Imamura T, Kees UR, Supuran CT, Pearson RB, Hannan RD, Davis TP, McCarroll J, Kavallaris M, Turner N, Gudkov AV, Haber M, Norris MD, Henderson MJ.

Oncogene. 2019 May;38(20):3824-3842. doi: 10.1038/s41388-018-0666-5. Epub 2019 Jan 22.


In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis.

Parmar A, Pascali G, Voli F, Lerra L, Yee E, Ahmed-Cox A, Kimpton K, Cirillo G, Arthur A, Zahra D, Rahardjo G, Liu GJ, Lengkeek N, Saletta F, Charil A, Kavallaris M, Vittorio O.

Theranostics. 2018 Nov 9;8(20):5645-5659. doi: 10.7150/thno.29840. eCollection 2018.


Minimum information reporting in bio-nano experimental literature.

Faria M, Björnmalm M, Thurecht KJ, Kent SJ, Parton RG, Kavallaris M, Johnston APR, Gooding JJ, Corrie SR, Boyd BJ, Thordarson P, Whittaker AK, Stevens MM, Prestidge CA, Porter CJH, Parak WJ, Davis TP, Crampin EJ, Caruso F.

Nat Nanotechnol. 2018 Sep;13(9):777-785. doi: 10.1038/s41565-018-0246-4. Epub 2018 Sep 6. Review.


Nucleic acid hybridization on an electrically reconfigurable network of gold-coated magnetic nanoparticles enables microRNA detection in blood.

Tavallaie R, McCarroll J, Le Grand M, Ariotti N, Schuhmann W, Bakker E, Tilley RD, Hibbert DB, Kavallaris M, Gooding JJ.

Nat Nanotechnol. 2018 Nov;13(11):1066-1071. doi: 10.1038/s41565-018-0232-x. Epub 2018 Aug 27.


Biologically Targeted Magnetic Hyperthermia: Potential and Limitations.

Chang D, Lim M, Goos JACM, Qiao R, Ng YY, Mansfeld FM, Jackson M, Davis TP, Kavallaris M.

Front Pharmacol. 2018 Aug 2;9:831. doi: 10.3389/fphar.2018.00831. eCollection 2018. Review.


β-tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells.

Parker AL, Teo WS, Pandzic E, Vicente JJ, McCarroll JA, Wordeman L, Kavallaris M.

Life Sci Alliance. 2018;1(2). pii: e201800059. doi: 10.26508/lsa.201800059. Epub 2018 Apr 19.


A photoelectrochemical platform for the capture and release of rare single cells.

Parker SG, Yang Y, Ciampi S, Gupta B, Kimpton K, Mansfeld FM, Kavallaris M, Gaus K, Gooding JJ.

Nat Commun. 2018 Jun 12;9(1):2288. doi: 10.1038/s41467-018-04701-y.


Targeted Doxorubicin-Loaded Bacterially Derived Nano-Cells for the Treatment of Neuroblastoma.

Sagnella SM, Trieu J, Brahmbhatt H, MacDiarmid JA, MacMillan A, Whan RM, Fife CM, McCarroll JA, Gifford AJ, Ziegler DS, Kavallaris M.

Mol Cancer Ther. 2018 May;17(5):1012-1023. doi: 10.1158/1535-7163.MCT-17-0738. Epub 2018 Feb 28.


Water Soluble Antioxidant Dextran-Quercetin Conjugate with Potential Anticancer Properties.

Oliver S, Yee E, Kavallaris M, Vittorio O, Boyer C.

Macromol Biosci. 2018 Apr;18(4):e1700239. doi: 10.1002/mabi.201700239. Epub 2018 Feb 7.


Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells.

Yee EMH, Brandl MB, Pasquier E, Cirillo G, Kimpton K, Kavallaris M, Kumar N, Vittorio O.

Sci Rep. 2017 Aug 9;7(1):7638. doi: 10.1038/s41598-017-07452-w.


Discovery of thalicthuberine as a novel antimitotic agent from nature that disrupts microtubule dynamics and induces apoptosis in prostate cancer cells.

Levrier C, Rockstroh A, Gabrielli B, Kavallaris M, Lehman M, Davis RA, Sadowski MC, Nelson CC.

Cell Cycle. 2018;17(5):652-668. doi: 10.1080/15384101.2017.1356512.


An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance.

Parker AL, Teo WS, McCarroll JA, Kavallaris M.

Int J Mol Sci. 2017 Jul 4;18(7). pii: E1434. doi: 10.3390/ijms18071434. Review.


Tuneable catechin functionalisation of carbohydrate polymers.

Oliver S, Jofri A, Thomas DS, Vittorio O, Kavallaris M, Boyer C.

Carbohydr Polym. 2017 Aug 1;169:480-494. doi: 10.1016/j.carbpol.2017.04.032. Epub 2017 Apr 23.


The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.

Lovelace MD, Powter EE, Coleman PR, Zhao Y, Parker A, Chang GH, Lay AJ, Hunter J, McGrath AP, Jormakka M, Bertolino P, McCaughan G, Kavallaris M, Vadas MA, Gamble JR.

Mol Biol Cell. 2017 Apr 15;28(8):1066-1078. doi: 10.1091/mbc.E16-05-0285. Epub 2017 Mar 1.


Nanoparticles for radiooncology: Mission, vision, challenges.

Kunz-Schughart LA, Dubrovska A, Peitzsch C, Ewe A, Aigner A, Schellenburg S, Muders MH, Hampel S, Cirillo G, Iemma F, Tietze R, Alexiou C, Stephan H, Zarschler K, Vittorio O, Kavallaris M, Parak WJ, Mädler L, Pokhrel S.

Biomaterials. 2017 Mar;120:155-184. doi: 10.1016/j.biomaterials.2016.12.010. Epub 2016 Dec 14. Review.


Delineating the Role of βIV-Tubulins in Pancreatic Cancer: βIVb-Tubulin Inhibition Sensitizes Pancreatic Cancer Cells to Vinca Alkaloids.

Sharbeen G, McCarroll J, Liu J, Youkhana J, Limbri LF, Biankin AV, Johns A, Kavallaris M, Goldstein D, Phillips PA.

Neoplasia. 2016 Dec;18(12):753-764. doi: 10.1016/j.neo.2016.10.011. Epub 2016 Nov 24.


The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs.

Liu PY, Sokolowski N, Guo ST, Siddiqi F, Atmadibrata B, Telfer TJ, Sun Y, Zhang L, Yu D, Mccarroll J, Liu B, Yang RH, Guo XY, Tee AE, Itoh K, Wang J, Kavallaris M, Haber M, Norris MD, Cheung BB, Byrne JA, Ziegler DS, Marshall GM, Dinger ME, Codd R, Zhang XD, Liu T.

Oncotarget. 2016 Nov 29;7(48):79217-79232. doi: 10.18632/oncotarget.12640.


6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells.

Levrier C, Sadowski MC, Rockstroh A, Gabrielli B, Kavallaris M, Lehman M, Davis RA, Nelson CC.

Mol Cancer Ther. 2017 Jan;16(1):3-15. doi: 10.1158/1535-7163.MCT-16-0325. Epub 2016 Oct 19.


Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth.

Vittorio O, Brandl M, Cirillo G, Kimpton K, Hinde E, Gaus K, Yee E, Kumar N, Duong H, Fleming C, Haber M, Norris M, Boyer C, Kavallaris M.

Oncotarget. 2016 Jul 26;7(30):47479-47493. doi: 10.18632/oncotarget.10201.


Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.

Fife CM, Sagnella SM, Teo WS, Po'uha ST, Byrne FL, Yeap YY, Ng DC, Davis TP, McCarroll JA, Kavallaris M.

Oncogene. 2017 Jan 26;36(4):501-511. doi: 10.1038/onc.2016.220. Epub 2016 Jun 20.


A Rationally Optimized Nanoparticle System for the Delivery of RNA Interference Therapeutics into Pancreatic Tumors in Vivo.

Teo J, McCarroll JA, Boyer C, Youkhana J, Sagnella SM, Duong HT, Liu J, Sharbeen G, Goldstein D, Davis TP, Kavallaris M, Phillips PA.

Biomacromolecules. 2016 Jul 11;17(7):2337-51. doi: 10.1021/acs.biomac.6b00185. Epub 2016 Jun 28.


Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-based Metronomic Chemotherapy: A Bench to Bedside Study.

Pasquier E, André N, Street J, Chougule A, Rekhi B, Ghosh J, Philip DSJ, Meurer M, MacKenzie KL, Kavallaris M, Banavali SD.

EBioMedicine. 2016 Apr;6:87-95. doi: 10.1016/j.ebiom.2016.02.026. Epub 2016 Feb 17.


βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells.

Parker AL, Turner N, McCarroll JA, Kavallaris M.

Carcinogenesis. 2016 Aug;37(8):787-798. doi: 10.1093/carcin/bgw058. Epub 2016 May 4.


Gamma-actin is involved in regulating centrosome function and mitotic progression in cancer cells.

Po'uha ST, Kavallaris M.

Cell Cycle. 2015;14(24):3908-19. doi: 10.1080/15384101.2015.1120920.


Macromolecular Hydrogen Sulfide Donors Trigger Spatiotemporally Confined Changes in Cell Signaling.

Ercole F, Mansfeld FM, Kavallaris M, Whittaker MR, Quinn JF, Halls ML, Davis TP.

Biomacromolecules. 2016 Jan 11;17(1):371-83. doi: 10.1021/acs.biomac.5b01469. Epub 2015 Dec 23.


Analyses of Tumor Burden In Vivo and Metastasis Ex Vivo Using Luciferase-Expressing Cancer Cells in an Orthotopic Mouse Model of Neuroblastoma.

Byrne FL, McCarroll JA, Kavallaris M.

Methods Mol Biol. 2016;1372:61-77. doi: 10.1007/978-1-4939-3148-4_5.


The endocytic pathway and therapeutic efficiency of doxorubicin conjugated cholesterol-derived polymers.

Sevimli S, Sagnella S, Macmillan A, Whan R, Kavallaris M, Bulmus V, Davis TP.

Biomater Sci. 2015 Feb;3(2):323-35. doi: 10.1039/c4bm00224e. Epub 2014 Sep 25.


Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma.

Cheung BB, Tan O, Koach J, Liu B, Shum MS, Carter DR, Sutton S, Po'uha ST, Chesler L, Haber M, Norris MD, Kavallaris M, Liu T, O'Neill GM, Marshall GM.

Mol Oncol. 2015 Aug;9(7):1484-500. doi: 10.1016/j.molonc.2015.04.005. Epub 2015 Apr 29.


γ-Actin plays a key role in endothelial cell motility and neovessel maintenance.

Pasquier E, Tuset MP, Sinnappan S, Carnell M, Macmillan A, Kavallaris M.

Vasc Cell. 2015 Feb 6;7:2. doi: 10.1186/s13221-014-0027-2. eCollection 2015.


Correction to "effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers".

Boyer C, Teo J, Phillips P, Erlich RB, Sagnella S, Sharbeen G, Dwarte T, Duong HT, Goldstein D, Davis TP, Kavallaris M, McCarroll J.

Mol Pharm. 2015 Mar 2;12(3):1004. doi: 10.1021/acs.molpharmaceut.5b00092. Epub 2015 Feb 18. No abstract available.


Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer.

McCarroll JA, Dwarte T, Baigude H, Dang J, Yang L, Erlich RB, Kimpton K, Teo J, Sagnella SM, Akerfeldt MC, Liu J, Phillips PA, Rana TM, Kavallaris M.

Oncotarget. 2015 May 20;6(14):12020-34.


βIII-tubulin: a novel mediator of chemoresistance and metastases in pancreatic cancer.

McCarroll JA, Sharbeen G, Liu J, Youkhana J, Goldstein D, McCarthy N, Limbri LF, Dischl D, Ceyhan GO, Erkan M, Johns AL, Biankin AV, Kavallaris M, Phillips PA.

Oncotarget. 2015 Feb 10;6(4):2235-49.


Graphene oxide - gelatin nanohybrids as functional tools for enhanced Carboplatin activity in neuroblastoma cells.

Makharza S, Vittorio O, Cirillo G, Oswald S, Hinde E, Kavallaris M, Büchner B, Mertig M, Hampel S.

Pharm Res. 2015 Jun;32(6):2132-43. doi: 10.1007/s11095-014-1604-z. Epub 2014 Dec 24.


TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer.

McCarroll JA, Gan PP, Erlich RB, Liu M, Dwarte T, Sagnella SS, Akerfeldt MC, Yang L, Parker AL, Chang MH, Shum MS, Byrne FL, Kavallaris M.

Cancer Res. 2015 Jan 15;75(2):415-25. doi: 10.1158/0008-5472.CAN-14-2740. Epub 2014 Nov 20.


Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes.

Eiffe E, Pasquier E, Kavallaris M, Herbert C, StC Black D, Kumar N.

Bioorg Med Chem. 2014 Oct 1;22(19):5182-93. doi: 10.1016/j.bmc.2014.08.010. Epub 2014 Aug 17.


Computational analysis of image-based drug profiling predicts synergistic drug combinations: applications in triple-negative breast cancer.

Brandl MB, Pasquier E, Li F, Beck D, Zhang S, Zhao H, Kavallaris M, Wong ST.

Mol Oncol. 2014 Dec;8(8):1548-60. doi: 10.1016/j.molonc.2014.06.007. Epub 2014 Jun 19.


Microtubules and their role in cellular stress in cancer.

Parker AL, Kavallaris M, McCarroll JA.

Front Oncol. 2014 Jun 18;4:153. doi: 10.3389/fonc.2014.00153. eCollection 2014. Review.


Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression.

Liu PY, Erriquez D, Marshall GM, Tee AE, Polly P, Wong M, Liu B, Bell JL, Zhang XD, Milazzo G, Cheung BB, Fox A, Swarbrick A, Hüttelmaier S, Kavallaris M, Perini G, Mattick JS, Dinger ME, Liu T.

J Natl Cancer Inst. 2014 Jun 6;106(7). pii: dju113. doi: 10.1093/jnci/dju113. Print 2014 Jul. Erratum in: J Natl Cancer Inst. 2015 Jan;107(1):doi/10.1093/jnci/dju359.


Drug delivery: beyond active tumour targeting.

Sagnella SM, McCarroll JA, Kavallaris M.

Nanomedicine. 2014 Aug;10(6):1131-7. doi: 10.1016/j.nano.2014.04.012. Epub 2014 May 10. Review.


Role of pancreatic stellate cells in chemoresistance in pancreatic cancer.

McCarroll JA, Naim S, Sharbeen G, Russia N, Lee J, Kavallaris M, Goldstein D, Phillips PA.

Front Physiol. 2014 Apr 9;5:141. doi: 10.3389/fphys.2014.00141. eCollection 2014. Review.


Movers and shakers: cell cytoskeleton in cancer metastasis.

Fife CM, McCarroll JA, Kavallaris M.

Br J Pharmacol. 2014 Dec;171(24):5507-23. doi: 10.1111/bph.12704. Epub 2014 Jul 2. Review. Erratum in: Br J Pharmacol. 2017 Jan;174(1):116.


Potential applications of nanotechnology for the diagnosis and treatment of pancreatic cancer.

McCarroll J, Teo J, Boyer C, Goldstein D, Kavallaris M, Phillips PA.

Front Physiol. 2014 Jan 24;5:2. doi: 10.3389/fphys.2014.00002. eCollection 2014. Review.


Magnetic catechin-dextran conjugate as targeted therapeutic for pancreatic tumour cells.

Vittorio O, Voliani V, Faraci P, Karmakar B, Iemma F, Hampel S, Kavallaris M, Cirillo G.

J Drug Target. 2014 Jun;22(5):408-15. doi: 10.3109/1061186X.2013.878941. Epub 2014 Jan 16.


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