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Items: 1 to 50 of 69

1.

Suppressive and Gut Reparative Functions of Human Type 1 T-regulatory Cells.

Cook L, Stahl M, Han X, Nazli A, MacDonald KN, Wong MQ, Tsai K, Dizzell S, Jacobson K, Bressler B, Kaushic C, Vallance BA, Steiner TS, Levings MK.

Gastroenterology. 2019 Sep 9. pii: S0016-5085(19)41310-3. doi: 10.1053/j.gastro.2019.09.002. [Epub ahead of print]

PMID:
31513797
2.

IL-17 Production by γδ+ T Cells Is Critical for Inducing Th17 Responses in the Female Genital Tract and Regulated by Estradiol and Microbiota.

Anipindi VC, Bagri P, Dizzell SE, Jiménez-Saiz R, Jordana M, Snider DP, Stämpfli MR, Kaushic C.

Immunohorizons. 2019 Jul 17;3(7):317-330. doi: 10.4049/immunohorizons.1900040.

PMID:
31356161
3.

The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission.

McKinnon LR, Achilles SL, Bradshaw CS, Burgener A, Crucitti T, Fredricks DN, Jaspan HB, Kaul R, Kaushic C, Klatt N, Kwon DS, Marrazzo JM, Masson L, McClelland RS, Ravel J, van de Wijgert JHHM, Vodstrcil LA, Tachedjian G.

AIDS Res Hum Retroviruses. 2019 Mar;35(3):219-228. doi: 10.1089/AID.2018.0304.

4.

Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility.

Joag V, Obila O, Gajer P, Scott MC, Dizzell S, Humphrys M, Shahabi K, Huibner S, Shannon B, Tharao W, Mureithi M, Oyugi J, Kimani J, Kaushic C, Ravel J, Anzala O, Kaul R.

Clin Infect Dis. 2019 May 2;68(10):1675-1683. doi: 10.1093/cid/ciy762.

5.

The relationship between sex hormones, the vaginal microbiome and immunity in HIV-1 susceptibility in women.

Wessels JM, Felker AM, Dupont HA, Kaushic C.

Dis Model Mech. 2018 Aug 28;11(9). pii: dmm035147. doi: 10.1242/dmm.035147. Review.

6.

Special issue on "omics data in reproductive immunology".

Kaushic C.

Am J Reprod Immunol. 2018 Aug;80(2):e13025. doi: 10.1111/aji.13025. Epub 2018 Jul 27. No abstract available.

PMID:
30051942
7.

Hormonal influence on HIV-1 transmission in the female genital tract: New insights from systems biology.

Dupont HA, Lam J, Woods MW, Zahoor MA, Kaushic C.

Am J Reprod Immunol. 2018 Aug;80(2):e13019. doi: 10.1111/aji.13019. Epub 2018 Jul 16.

PMID:
30014538
8.

Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract.

Islam EA, Anipindi VC, Francis I, Shaik-Dasthagirisaheb Y, Xu S, Leung N, Sintsova A, Amin M, Kaushic C, Wetzler LM, Gray-Owen SD.

Infect Immun. 2018 Jul 23;86(8). pii: e00092-18. doi: 10.1128/IAI.00092-18. Print 2018 Aug.

9.

Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier.

Nazli A, Dizzell S, Zahoor MA, Ferreira VH, Kafka J, Woods MW, Ouellet M, Ashkar AA, Tremblay MJ, Bowdish DM, Kaushic C.

Cell Mol Immunol. 2019 Feb;16(2):178-194. doi: 10.1038/cmi.2017.168. Epub 2018 Mar 19.

10.

Transcriptional profiling of primary endometrial epithelial cells following acute HIV-1 exposure reveals gene signatures related to innate immunity.

Zahoor MA, Woods MW, Dizzell S, Nazli A, Mueller KM, Nguyen PV, Verschoor CP, Kaushic C.

Am J Reprod Immunol. 2018 Apr;79(4):e12822. doi: 10.1111/aji.12822. Epub 2018 Feb 8.

PMID:
29418026
11.

CD11b+ Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10.

Lai R, Jeyanathan M, Afkhami S, Zganiacz A, Hammill JA, Yao Y, Kaushic C, Xing Z.

J Immunol. 2018 Mar 1;200(5):1746-1760. doi: 10.4049/jimmunol.1701109. Epub 2018 Jan 26.

12.

Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms.

Hapgood JP, Kaushic C, Hel Z.

Endocr Rev. 2018 Feb 1;39(1):36-78. doi: 10.1210/er.2017-00103. Review.

13.

Pathways From HIV-Related Stigma to Antiretroviral Therapy Measures in the HIV Care Cascade for Women Living With HIV in Canada.

Logie CH, Lacombe-Duncan A, Wang Y, Kaida A, Conway T, Webster K, de Pokomandy A, Loutfy MR, Anema A, Becker D, Brotto L, Carter A, Cardinal C, Colley G, Ding E, Duddy J, Gataric N, Hogg RS, Hosward T, Jabbari S, Jones E, Kestler M, Langlois A, Lima V, Lloyd-Smith E, Medjuck M, Miller C, Money D, Nicholson V, Ogilvie G, Patterson S, Pick N, Roth E, Salters K, Sanchez M, Sas J, Sereda P, Summers M, Tom C, Wang L, Webster K, Zhang W, Abdul-Noor R, Angel J, Barry F, Bauer G, Beaver K, Benoit A, Bertozzi B, Borton S, Bourque T, Brophy J, Burchell A, Carlson A, Cioppa L, Cohen J, Conway T, Cooper C, Cotnam J, Cousineau J, Fraleigh A, Gagnier B, Gasingirwa C, Greene S, Hart T, Islam S, Kaushic C, Kennedy L, Kerr D, Kiboyogo M, Kwaramba G, Leonard L, Lewis J, Logie C, Margolese S, Muchenje M, Ndungʼu M, OʼBrien K, Ouellette C, Powis J, Quan C, Raboud J, Rachlis A, Ralph E, Rourke S, Rueda S, Sandre R, Smaill F, Smith S, Tigere T, Tharao W, Walmsley S, Wobeser W, Yee J, Yudin M, Baril JG, Burke NB, Clément P, Dayle J, Dubuc D, Fernet M, Groleau D, Hot A, Klein M, Martin C, Massie L, Ménard B, OʼBrien N, Otis J, Peltier D, Pierre A, Proulx-Boucher K, Rouleau D, Savoie É, Tremblay C, Trottier B, Trottier S, Tsoukas C, Gahagan J, Hankins C, Masching R, Ogunnaike-Cooke S.

J Acquir Immune Defic Syndr. 2018 Feb 1;77(2):144-153. doi: 10.1097/QAI.0000000000001589.

14.

Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice.

Nguyen PV, Wessels JM, Mueller K, Vahedi F, Anipindi V, Verschoor CP, Chew M, Deshiere A, Karniychuk U, Mazzulli T, Tremblay MJ, Ashkar AA, Kaushic C.

Sci Rep. 2017 Nov 10;7(1):15263. doi: 10.1038/s41598-017-15630-z.

15.

Medroxyprogesterone acetate-treated human, primary endometrial epithelial cells reveal unique gene expression signature linked to innate immunity and HIV-1 susceptibility.

Woods MW, Zahoor MA, Dizzell S, Verschoor CP, Kaushic C.

Am J Reprod Immunol. 2018 Jan;79(1). doi: 10.1111/aji.12781. Epub 2017 Nov 6.

PMID:
29105931
16.

Association of high-risk sexual behaviour with diversity of the vaginal microbiota and abundance of Lactobacillus.

Wessels JM, Lajoie J, Vitali D, Omollo K, Kimani J, Oyugi J, Cheruiyot J, Kimani M, Mungai JN, Akolo M, Stearns JC, Surette MG, Fowke KR, Kaushic C.

PLoS One. 2017 Nov 2;12(11):e0187612. doi: 10.1371/journal.pone.0187612. eCollection 2017.

17.

Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination.

Bagri P, Anipindi VC, Nguyen PV, Vitali D, Stämpfli MR, Kaushic C.

J Virol. 2017 Nov 14;91(23). pii: e01234-17. doi: 10.1128/JVI.01234-17. Print 2017 Dec 1.

18.

Role of sex hormones and the vaginal microbiome in susceptibility and mucosal immunity to HIV-1 in the female genital tract.

Vitali D, Wessels JM, Kaushic C.

AIDS Res Ther. 2017 Sep 12;14(1):39. doi: 10.1186/s12981-017-0169-4. Review.

19.

Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine.

Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z.

J Infect Dis. 2017 Jul 1;216(1):135-145. doi: 10.1093/infdis/jix252.

20.

Considerations for the rational design of a Chlamydia vaccine.

Liang S, Bulir D, Kaushic C, Mahony J.

Hum Vaccin Immunother. 2017 Apr 3;13(4):831-835. doi: 10.1080/21645515.2016.1252886. Epub 2016 Nov 11. Review.

21.

Effects of Female Sex Hormones on Susceptibility to HSV-2 in Vaginal Cells Grown in Air-Liquid Interface.

Lee Y, Dizzell SE, Leung V, Nazli A, Zahoor MA, Fichorova RN, Kaushic C.

Viruses. 2016 Aug 30;8(9). pii: E241. doi: 10.3390/v8090241.

22.

Immunization with chlamydial type III secretion antigens reduces vaginal shedding and prevents fallopian tube pathology following live C. muridarum challenge.

Bulir DC, Liang S, Lee A, Chong S, Simms E, Stone C, Kaushic C, Ashkar A, Mahony JB.

Vaccine. 2016 Jul 25;34(34):3979-85. doi: 10.1016/j.vaccine.2016.06.046. Epub 2016 Jun 17.

PMID:
27325352
23.

Correction: Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway.

Anipindi VC, Bagri P, Roth K, Dizzell SE, Nguyen PV, Shaler CR, Chu DK, Jiménez-Saiz R, Liang H, Swift SL, Nazli A, Kafka JK, Bramson J, Xing Z, Jordana M, Wan Y, Snider DP, Stampfli MR, Kaushic C.

PLoS Pathog. 2016 Jun 8;12(6):e1005706. doi: 10.1371/journal.ppat.1005706. eCollection 2016 Jun.

24.

Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway.

Anipindi VC, Bagri P, Roth K, Dizzell SE, Nguyen PV, Shaler CR, Chu DK, Jiménez-Saiz R, Liang H, Swift S, Nazli A, Kafka JK, Bramson J, Xing Z, Jordana M, Wan Y, Snider DP, Stampfli MR, Kaushic C.

PLoS Pathog. 2016 May 5;12(5):e1005589. doi: 10.1371/journal.ppat.1005589. eCollection 2016 May. Erratum in: PLoS Pathog. 2016 Jun;12(6):e1005706.

25.

High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells.

Xiu F, Anipindi VC, Nguyen PV, Boudreau J, Liang H, Wan Y, Snider DP, Kaushic C.

PLoS One. 2016 Apr 11;11(4):e0153304. doi: 10.1371/journal.pone.0153304. eCollection 2016.

26.

The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.

Islam EA, Shaik-Dasthagirisaheb Y, Kaushic C, Wetzler LM, Gray-Owen SD.

Mucosal Immunol. 2016 Jul;9(4):1051-64. doi: 10.1038/mi.2015.122. Epub 2015 Dec 23.

27.

The anti-inflammatory activity of curcumin protects the genital mucosal epithelial barrier from disruption and blocks replication of HIV-1 and HSV-2.

Ferreira VH, Nazli A, Dizzell SE, Mueller K, Kaushic C.

PLoS One. 2015 Apr 9;10(4):e0124903. doi: 10.1371/journal.pone.0124903. eCollection 2015.

28.

Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection.

Ferreira VH, Dizzell S, Nazli A, Kafka JK, Mueller K, Nguyen PV, Tremblay MJ, Cochrane A, Kaushic C.

J Infect Dis. 2015 Jun 1;211(11):1745-56. doi: 10.1093/infdis/jiu832. Epub 2014 Dec 23.

PMID:
25538276
29.

MicroRNA-155 is required for clearance of Streptococcus pneumoniae from the nasopharynx.

Verschoor CP, Dorrington MG, Novakowski KE, Kaiser J, Radford K, Nair P, Anipindi V, Kaushic C, Surette MG, Bowdish DM.

Infect Immun. 2014 Nov;82(11):4824-33. doi: 10.1128/IAI.02251-14. Epub 2014 Aug 25.

30.

Latent TGF-β1 is compartmentalized between blood and seminal plasma of HIV-positive men and its activation in semen is negatively correlated with viral load and immune activation.

Kafka JK, Osborne BJ, Sheth PM, Nazli A, Dizzell S, Huibner S, Kovacs C, Verschoor CP, Bowdish DM, Kaul R, Kaushic C.

Am J Reprod Immunol. 2015 Feb;73(2):151-61. doi: 10.1111/aji.12300. Epub 2014 Jul 23.

PMID:
25052241
31.

Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection.

Nguyen PV, Kafka JK, Ferreira VH, Roth K, Kaushic C.

Cell Mol Immunol. 2014 Sep;11(5):410-27. doi: 10.1038/cmi.2014.41. Epub 2014 Jun 30. Review.

32.

Influence of common mucosal co-factors on HIV infection in the female genital tract.

Ferreira VH, Kafka JK, Kaushic C.

Am J Reprod Immunol. 2014 Jun;71(6):543-54. doi: 10.1111/aji.12221. Epub 2014 Mar 12. Review.

PMID:
24617528
33.

HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.

Nazli A, Kafka JK, Ferreira VH, Anipindi V, Mueller K, Osborne BJ, Dizzell S, Chauvin S, Mian MF, Ouellet M, Tremblay MJ, Mossman KL, Ashkar AA, Kovacs C, Bowdish DM, Snider DP, Kaul R, Kaushic C.

J Immunol. 2013 Oct 15;191(8):4246-58. doi: 10.4049/jimmunol.1301482. Epub 2013 Sep 16.

34.
35.

Herpes simplex virus type 2 coinfection does not accelerate CD4 count decline in untreated HIV infection.

Tan DH, Raboud JM, Kaul R, Brunetta J, Kaushic C, Kovacs C, Lee E, Luetkehoelter J, Rachlis A, Smaill F, Smieja M, Walmsley SL.

Clin Infect Dis. 2013 Aug;57(3):448-57. doi: 10.1093/cid/cit208. Epub 2013 Apr 9.

PMID:
23572481
36.

HSV-2 vaccine: current state and insights into development of a vaccine that targets genital mucosal protection.

Roth K, Ferreira VH, Kaushic C.

Microb Pathog. 2013 May;58:45-54. doi: 10.1016/j.micpath.2012.11.001. Epub 2012 Nov 15. Review.

PMID:
23159485
37.

A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis.

Kim CJ, Nazli A, Rojas OL, Chege D, Alidina Z, Huibner S, Mujib S, Benko E, Kovacs C, Shin LY, Grin A, Kandel G, Loutfy M, Ostrowski M, Gommerman JL, Kaushic C, Kaul R.

Mucosal Immunol. 2012 Nov;5(6):670-80. doi: 10.1038/mi.2012.72. Epub 2012 Aug 1.

PMID:
22854709
38.

Delayed but effective induction of mucosal memory immune responses against genital HSV-2 in the absence of secondary lymphoid organs.

Roth KL, Bhavanam S, Jiang H, Gillgrass A, Ho K, Ferreira VH, Kaushic C.

Mucosal Immunol. 2013 Jan;6(1):56-68. doi: 10.1038/mi.2012.48. Epub 2012 Jun 20.

PMID:
22718264
39.

Endometrial epithelial cell response to semen from HIV-infected men during different stages of infection is distinct and can drive HIV-1-long terminal repeat.

Kafka JK, Sheth PM, Nazli A, Osborne BJ, Kovacs C, Kaul R, Kaushic C.

AIDS. 2012 Jan 2;26(1):27-36. doi: 10.1097/QAD.0b013e32834e57b2.

PMID:
22095191
40.

Primary human epithelial cell culture system for studying interactions between female upper genital tract and sexually transmitted viruses, HSV-2 and HIV-1.

Kaushic C, Nazli A, Ferreira VH, Kafka JK.

Methods. 2011 Oct;55(2):114-21. doi: 10.1016/j.ymeth.2011.09.022. Epub 2011 Oct 4. Review.

PMID:
21996033
41.

Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner.

Ferreira VH, Nazli A, Khan G, Mian MF, Ashkar AA, Gray-Owen S, Kaul R, Kaushic C.

J Infect Dis. 2011 Jul 15;204(2):299-308. doi: 10.1093/infdis/jir260.

PMID:
21673042
42.

Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in regulating susceptibility and immune responses.

Kaushic C, Roth KL, Anipindi V, Xiu F.

J Reprod Immunol. 2011 Mar;88(2):204-9. doi: 10.1016/j.jri.2010.12.004. Epub 2011 Feb 5. Review.

PMID:
21296427
43.

HIV-1 infection in the female reproductive tract: role of interactions between HIV-1 and genital epithelial cells.

Kaushic C.

Am J Reprod Immunol. 2011 Mar;65(3):253-60. doi: 10.1111/j.1600-0897.2010.00965.x. Epub 2011 Jan 12. Review.

PMID:
21223427
44.

Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation.

Nazli A, Chan O, Dobson-Belaire WN, Ouellet M, Tremblay MJ, Gray-Owen SD, Arsenault AL, Kaushic C.

PLoS Pathog. 2010 Apr 8;6(4):e1000852. doi: 10.1371/journal.ppat.1000852.

45.

HIV infection in the female genital tract: discrete influence of the local mucosal microenvironment.

Kaushic C, Ferreira VH, Kafka JK, Nazli A.

Am J Reprod Immunol. 2010 Jun;63(6):566-75. doi: 10.1111/j.1600-0897.2010.00843.x. Epub 2010 Mar 29. Review.

PMID:
20384619
46.

Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung.

Small CL, Shaler CR, McCormick S, Jeyanathan M, Damjanovic D, Brown EG, Arck P, Jordana M, Kaushic C, Ashkar AA, Xing Z.

J Immunol. 2010 Feb 15;184(4):2048-56. doi: 10.4049/jimmunol.0902772. Epub 2010 Jan 18.

47.

Estradiol limits viral replication following intravaginal immunization leading to diminished mucosal IgG response and non-sterile protection against genital herpes challenge.

Gillgrass A, Chege D, Bhavanam S, Kaushic C.

Am J Reprod Immunol. 2010 Apr 1;63(4):299-309. doi: 10.1111/j.1600-0897.2009.00796.x. Epub 2010 Jan 11.

PMID:
20070285
48.

The role of the local microenvironment in regulating susceptibility and immune responses to sexually transmitted viruses in the female genital tract.

Kaushic C.

J Reprod Immunol. 2009 Dec;83(1-2):168-72. doi: 10.1016/j.jri.2009.08.010. Epub 2009 Oct 25. Review.

PMID:
19857903
49.

Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women.

Nazli A, Yao XD, Smieja M, Rosenthal KL, Ashkar AA, Kaushic C.

Antiviral Res. 2009 Feb;81(2):103-12. doi: 10.1016/j.antiviral.2008.10.005. Epub 2008 Nov 12.

PMID:
19013198
50.

Intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesterone.

Bhavanam S, Snider DP, Kaushic C.

Vaccine. 2008 Nov 11;26(48):6165-72. doi: 10.1016/j.vaccine.2008.08.045. Epub 2008 Sep 18.

PMID:
18804503

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