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Items: 1 to 50 of 112

1.

Intragenic antagonistic roles of protein and circRNA in tumorigenesis.

Guarnerio J, Zhang Y, Cheloni G, Panella R, Mae Katon J, Simpson M, Matsumoto A, Papa A, Loretelli C, Petri A, Kauppinen S, Garbutt C, Petur Nielsen G, Deshpande V, Castillo-Martin M, Cordon-Cardo C, Dimitrios S, Clohessy JG, Batish M, Pandolfi PP.

Cell Res. 2019 Aug;29(8):628-640. doi: 10.1038/s41422-019-0192-1. Epub 2019 Jun 17.

PMID:
31209250
2.

3D morphometric analysis of calcified cartilage properties using micro-computed tomography.

Kauppinen S, Karhula SS, Thevenot J, Ylitalo T, Rieppo L, Kestilä I, Haapea M, Hadjab I, Finnilä MA, Quenneville E, Garon M, Gahunia HK, Pritzker KPH, Buschmann MD, Saarakkala S, Nieminen HJ.

Osteoarthritis Cartilage. 2019 Jan;27(1):172-180. doi: 10.1016/j.joca.2018.09.009. Epub 2018 Oct 1.

3.

Development of Locked Nucleic Acid Antisense Oligonucleotides Targeting Ebola Viral Proteins and Host Factor Niemann-Pick C1.

Chery J, Petri A, Wagschal A, Lim SY, Cunningham J, Vasudevan S, Kauppinen S, Näär AM.

Nucleic Acid Ther. 2018 Oct;28(5):273-284. doi: 10.1089/nat.2018.0722. Epub 2018 Aug 22.

4.

Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche.

Tsukamoto S, Løvendorf MB, Park J, Salem KZ, Reagan MR, Manier S, Zavidij O, Rahmat M, Huynh D, Takagi S, Kawano Y, Kokubun K, Thrue CA, Nagano K, Petri A, Roccaro AM, Capelletti M, Baron R, Kauppinen S, Ghobrial IM.

Leukemia. 2018 Aug;32(8):1739-1750. doi: 10.1038/s41375-018-0161-6. Epub 2018 Jun 20.

PMID:
29925904
5.

In vitro method for 3D morphometry of human articular cartilage chondrons based on micro-computed tomography.

Kestilä I, Thevenot J, Finnilä MA, Karhula SS, Hadjab I, Kauppinen S, Garon M, Quenneville E, Haapea M, Rieppo L, Pritzker KP, Buschmann MD, Nieminen HJ, Saarakkala S.

Osteoarthritis Cartilage. 2018 Aug;26(8):1118-1126. doi: 10.1016/j.joca.2018.05.012. Epub 2018 May 23.

6.

Electromechanical properties of human osteoarthritic and asymptomatic articular cartilage are sensitive and early detectors of degeneration.

Hadjab I, Sim S, Karhula SS, Kauppinen S, Garon M, Quenneville E, Lavigne P, Lehenkari PP, Saarakkala S, Buschmann MD.

Osteoarthritis Cartilage. 2018 Mar;26(3):405-413. doi: 10.1016/j.joca.2017.12.002. Epub 2017 Dec 9.

7.

Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography.

Karhula SS, Finnilä MA, Lammi MJ, Ylärinne JH, Kauppinen S, Rieppo L, Pritzker KP, Nieminen HJ, Saarakkala S.

PLoS One. 2017 Jan 30;12(1):e0171075. doi: 10.1371/journal.pone.0171075. eCollection 2017.

8.

Identification of antisense long noncoding RNAs that function as SINEUPs in human cells.

Schein A, Zucchelli S, Kauppinen S, Gustincich S, Carninci P.

Sci Rep. 2016 Sep 20;6:33605. doi: 10.1038/srep33605.

9.

Micro-CT Analysis of Bone Healing in Rabbit Calvarial Critical-Sized Defects with Solid Bioactive Glass, Tricalcium Phosphate Granules or Autogenous Bone.

Lappalainen OP, Karhula SS, Haapea M, Kauppinen S, Finnilä M, Saarakkala S, Serlo W, Sándor GK.

J Oral Maxillofac Res. 2016 Jun 30;7(2):e4. doi: 10.5037/jomr.2016.7204. eCollection 2016 Apr-Jun.

10.

Association between subchondral bone structure and osteoarthritis histopathological grade.

Finnilä MAJ, Thevenot J, Aho OM, Tiitu V, Rautiainen J, Kauppinen S, Nieminen MT, Pritzker K, Valkealahti M, Lehenkari P, Saarakkala S.

J Orthop Res. 2017 Apr;35(4):785-792. doi: 10.1002/jor.23312. Epub 2016 Jun 22.

11.

Transcriptome dynamics of the microRNA inhibition response.

Wen J, Leucci E, Vendramin R, Kauppinen S, Lund AH, Krogh A, Parker BJ.

Nucleic Acids Res. 2016 May 19;44(9):4486. doi: 10.1093/nar/gkw091. Epub 2016 Feb 9. No abstract available.

12.

Long Noncoding RNA Expression during Human B-Cell Development.

Petri A, Dybkær K, Bøgsted M, Thrue CA, Hagedorn PH, Schmitz A, Bødker JS, Johnsen HE, Kauppinen S.

PLoS One. 2015 Sep 22;10(9):e0138236. doi: 10.1371/journal.pone.0138236. eCollection 2015.

13.

Transcriptome dynamics of the microRNA inhibition response.

Wen J, Leucci E, Vendramin R, Kauppinen S, Lund AH, Krogh A, Parker BJ.

Nucleic Acids Res. 2015 Jul 27;43(13):6207-21. doi: 10.1093/nar/gkv603. Epub 2015 Jun 18. Erratum in: Nucleic Acids Res. 2016 May 19;44(9):4486.

14.

Determining collagen distribution in articular cartilage using contrast-enhanced micro-computed tomography.

Nieminen HJ, Ylitalo T, Karhula S, Suuronen JP, Kauppinen S, Serimaa R, Hæggström E, Pritzker KP, Valkealahti M, Lehenkari P, Finnilä M, Saarakkala S.

Osteoarthritis Cartilage. 2015 Sep;23(9):1613-21. doi: 10.1016/j.joca.2015.05.004. Epub 2015 May 21.

15.

Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-convergence on axonal guidance.

Kaalund SS, Venø MT, Bak M, Møller RS, Laursen H, Madsen F, Broholm H, Quistorff B, Uldall P, Tommerup N, Kauppinen S, Sabers A, Fluiter K, Møller LB, Nossent AY, Silahtaroglu A, Kjems J, Aronica E, Tümer Z.

Epilepsia. 2014 Dec;55(12):2017-27. doi: 10.1111/epi.12839. Epub 2014 Nov 19.

16.

Development of microRNA therapeutics is coming of age.

van Rooij E, Kauppinen S.

EMBO Mol Med. 2014 Jul;6(7):851-64. doi: 10.15252/emmm.201100899. Review.

17.

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Bernardo BC, Gao XM, Tham YK, Kiriazis H, Winbanks CE, Ooi JY, Boey EJ, Obad S, Kauppinen S, Gregorevic P, Du XJ, Lin RC, McMullen JR.

PLoS One. 2014 Feb 27;9(2):e90337. doi: 10.1371/journal.pone.0090337. eCollection 2014.

18.

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM.

Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840.

19.

Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.

Murphy BL, Obad S, Bihannic L, Ayrault O, Zindy F, Kauppinen S, Roussel MF.

Cancer Res. 2013 Dec 1;73(23):7068-78. doi: 10.1158/0008-5472.CAN-13-0927. Epub 2013 Oct 21.

20.

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus.

Leucci E, Patella F, Waage J, Holmstrøm K, Lindow M, Porse B, Kauppinen S, Lund AH.

Sci Rep. 2013;3:2535. doi: 10.1038/srep02535.

21.

HCV infection and miravirsen.

Janssen HL, Kauppinen S, Hodges MR.

N Engl J Med. 2013 Aug 29;369(9):878. doi: 10.1056/NEJMc1307787. No abstract available.

PMID:
23984739
22.

Treatment of HCV infection by targeting microRNA.

Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, Persson R, King BD, Kauppinen S, Levin AA, Hodges MR.

N Engl J Med. 2013 May 2;368(18):1685-94. doi: 10.1056/NEJMoa1209026. Epub 2013 Mar 27.

23.

Discovering the first microRNA-targeted drug.

Lindow M, Kauppinen S.

J Cell Biol. 2012 Oct 29;199(3):407-12. doi: 10.1083/jcb.201208082.

24.

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.

Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9.

25.

LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas.

Zhang Y, Roccaro AM, Rombaoa C, Flores L, Obad S, Fernandes SM, Sacco A, Liu Y, Ngo H, Quang P, Azab AK, Azab F, Maiso P, Reagan M, Brown JR, Thai TH, Kauppinen S, Ghobrial IM.

Blood. 2012 Aug 23;120(8):1678-86. doi: 10.1182/blood-2012-02-410647. Epub 2012 Jul 13.

PMID:
22797699
26.

MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.

Corsten MF, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, Summer G, Coort SL, Hazebroek M, van Leeuwen R, Gijbels MJ, Wijnands E, Biessen EA, De Winther MP, Stassen FR, Carmeliet P, Kauppinen S, Schroen B, Heymans S.

Circ Res. 2012 Aug 3;111(4):415-25. doi: 10.1161/CIRCRESAHA.112.267443. Epub 2012 Jun 19.

PMID:
22715471
27.

The therapeutic potential of microRNAs in cancer.

Thorsen SB, Obad S, Jensen NF, Stenvang J, Kauppinen S.

Cancer J. 2012 May-Jun;18(3):275-84. doi: 10.1097/PPO.0b013e318258b5d6.

PMID:
22647365
28.

MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis.

Meisgen F, Xu N, Wei T, Janson PC, Obad S, Broom O, Nagy N, Kauppinen S, Kemény L, Ståhle M, Pivarcsi A, Sonkoly E.

Exp Dermatol. 2012 Apr;21(4):312-4. doi: 10.1111/j.1600-0625.2012.01462.x.

PMID:
22417311
29.

Regulation of acute graft-versus-host disease by microRNA-155.

Ranganathan P, Heaphy CE, Costinean S, Stauffer N, Na C, Hamadani M, Santhanam R, Mao C, Taylor PA, Sandhu S, He G, Shana'ah A, Nuovo GJ, Lagana A, Cascione L, Obad S, Broom O, Kauppinen S, Byrd JC, Caligiuri M, Perrotti D, Hadley GA, Marcucci G, Devine SM, Blazar BR, Croce CM, Garzon R.

Blood. 2012 May 17;119(20):4786-97. doi: 10.1182/blood-2011-10-387522. Epub 2012 Mar 9.

30.

Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients.

Pesonen S, Diaconu I, Kangasniemi L, Ranki T, Kanerva A, Pesonen SK, Gerdemann U, Leen AM, Kairemo K, Oksanen M, Haavisto E, Holm SL, Karioja-Kallio A, Kauppinen S, Partanen KP, Laasonen L, Joensuu T, Alanko T, Cerullo V, Hemminki A.

Cancer Res. 2012 Apr 1;72(7):1621-31. doi: 10.1158/0008-5472.CAN-11-3001. Epub 2012 Feb 9.

31.

Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model.

Mercader JM, González JR, Lozano JJ, Bak M, Kauppinen S, Sumoy L, Dierssen M, Fernández-Aranda F, Visa J, Gratacòs M, Estivill X.

Gene. 2012 Apr 15;497(2):181-90. doi: 10.1016/j.gene.2012.01.057. Epub 2012 Jan 30.

PMID:
22310387
32.

Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo.

Leucci E, Zriwil A, Gregersen LH, Jensen KT, Obad S, Bellan C, Leoncini L, Kauppinen S, Lund AH.

Oncogene. 2012 Dec 6;31(49):5081-9. doi: 10.1038/onc.2012.15. Epub 2012 Feb 6.

PMID:
22310293
33.

Inhibition of microRNA function by antimiR oligonucleotides.

Stenvang J, Petri A, Lindow M, Obad S, Kauppinen S.

Silence. 2012 Jan 9;3(1):1. doi: 10.1186/1758-907X-3-1.

34.

Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation.

Taipaleenmäki H, Bjerre Hokland L, Chen L, Kauppinen S, Kassem M.

Eur J Endocrinol. 2012 Mar;166(3):359-71. doi: 10.1530/EJE-11-0646. Epub 2011 Nov 14. Review.

PMID:
22084154
35.

Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice.

Garchow BG, Bartulos Encinas O, Leung YT, Tsao PY, Eisenberg RA, Caricchio R, Obad S, Petri A, Kauppinen S, Kiriakidou M.

EMBO Mol Med. 2011 Oct;3(10):605-15. doi: 10.1002/emmm.201100171. Epub 2011 Sep 1.

36.

mRNA expression profiling reveals conserved and non-conserved miR-140 targets.

Nicolas FE, Pais H, Schwach F, Lindow M, Kauppinen S, Moulton V, Dalmay T.

RNA Biol. 2011 Jul-Aug;8(4):607-15. doi: 10.4161/rna.8.4.15390. Epub 2011 Jul 1.

PMID:
21720209
37.

Immunological effects of low-dose cyclophosphamide in cancer patients treated with oncolytic adenovirus.

Cerullo V, Diaconu I, Kangasniemi L, Rajecki M, Escutenaire S, Koski A, Romano V, Rouvinen N, Tuuminen T, Laasonen L, Partanen K, Kauppinen S, Joensuu T, Oksanen M, Holm SL, Haavisto E, Karioja-Kallio A, Kanerva A, Pesonen S, Arstila PT, Hemminki A.

Mol Ther. 2011 Sep;19(9):1737-46. doi: 10.1038/mt.2011.113. Epub 2011 Jun 14.

38.

Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry.

Schneider M, Andersen DC, Silahtaroglu A, Lyngbæk S, Kauppinen S, Hansen JL, Sheikh SP.

J Mol Histol. 2011 Aug;42(4):289-99. doi: 10.1007/s10735-011-9332-8. Epub 2011 Jun 5.

PMID:
21643937
39.

Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors.

Pesonen S, Diaconu I, Cerullo V, Escutenaire S, Raki M, Kangasniemi L, Nokisalmi P, Dotti G, Guse K, Laasonen L, Partanen K, Karli E, Haavisto E, Oksanen M, Karioja-Kallio A, Hannuksela P, Holm SL, Kauppinen S, Joensuu T, Kanerva A, Hemminki A.

Int J Cancer. 2012 Apr 15;130(8):1937-47. doi: 10.1002/ijc.26216. Epub 2011 Aug 8.

40.

MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo.

Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent AY, Bak M, Kauppinen S, Kassem M.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6139-44. doi: 10.1073/pnas.1016758108. Epub 2011 Mar 28.

41.

Silencing of microRNA families by seed-targeting tiny LNAs.

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S.

Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786.

42.

Involvement of microRNAs in lung cancer biology and therapy.

Liu X, Sempere LF, Guo Y, Korc M, Kauppinen S, Freemantle SJ, Dmitrovsky E.

Transl Res. 2011 Apr;157(4):200-8. doi: 10.1016/j.trsl.2011.01.001. Epub 2011 Feb 4. Review.

43.

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU.

J Clin Invest. 2011 Apr;121(4):1386-96. doi: 10.1172/JCI44883.

44.

In vivo and in vitro distribution of type 5 and fiber-modified oncolytic adenoviruses in human blood compartments.

Escutenaire S, Cerullo V, Diaconu I, Ahtiainen L, Hannuksela P, Oksanen M, Haavisto E, Karioja-Kallio A, Holm SL, Kangasniemi L, Ribacka C, Kauppinen S, Joensuu T, Arstila TP, Pesonen S, Kanerva A, Hemminki A.

Ann Med. 2011 Mar;43(2):151-63. doi: 10.3109/07853890.2010.538079. Epub 2011 Jan 25.

PMID:
21261555
45.

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice.

Patrick DM, Montgomery RL, Qi X, Obad S, Kauppinen S, Hill JA, van Rooij E, Olson EN.

J Clin Invest. 2010 Nov;120(11):3912-6. doi: 10.1172/JCI43604. Epub 2010 Oct 18.

46.

Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors.

Sempere LF, Preis M, Yezefski T, Ouyang H, Suriawinata AA, Silahtaroglu A, Conejo-Garcia JR, Kauppinen S, Wells W, Korc M.

Clin Cancer Res. 2010 Aug 15;16(16):4246-55. doi: 10.1158/1078-0432.CCR-10-1152. Epub 2010 Aug 3.

47.

MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4.

Sonkoly E, Janson P, Majuri ML, Savinko T, Fyhrquist N, Eidsmo L, Xu N, Meisgen F, Wei T, Bradley M, Stenvang J, Kauppinen S, Alenius H, Lauerma A, Homey B, Winqvist O, Ståhle M, Pivarcsi A.

J Allergy Clin Immunol. 2010 Sep;126(3):581-9.e1-20. doi: 10.1016/j.jaci.2010.05.045. Epub 2010 Jul 31.

PMID:
20673989
48.

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors.

Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, Kauppinen S, Dmitrovsky E.

J Clin Invest. 2010 Apr;120(4):1298-309. doi: 10.1172/JCI39566. Epub 2010 Mar 8.

49.

Recombinant Adeno-Associated Virus-Mediated microRNA Delivery into the Postnatal Mouse Brain Reveals a Role for miR-134 in Dendritogenesis in Vivo.

Christensen M, Larsen LA, Kauppinen S, Schratt G.

Front Neural Circuits. 2010 Jan 12;3:16. doi: 10.3389/neuro.04.016.2009. eCollection 2010.

50.

miRMaid: a unified programming interface for microRNA data resources.

Jacobsen A, Krogh A, Kauppinen S, Lindow M.

BMC Bioinformatics. 2010 Jan 14;11:29. doi: 10.1186/1471-2105-11-29.

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