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Items: 27


Drug screening approach combines epigenetic sensitization with immunochemotherapy in cancer.

Facciotto C, Casado J, Turunen L, Leivonen SK, Tumiati M, Rantanen V, Kauppi L, Lehtonen R, Leppä S, Wennerberg K, Hautaniemi S.

Clin Epigenetics. 2019 Dec 11;11(1):192. doi: 10.1186/s13148-019-0781-3.


Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR.

Pradhan B, Kauppi L.

J Vis Exp. 2019 Jul 27;(149). doi: 10.3791/59880.


Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice.

Faisal I, Cisneros-Montalvo S, Hamer G, Tuominen MM, Laurila PP, Tumiati M, Jauhiainen M, Kotaja N, Toppari J, Mäkelä JA, Kauppi L.

Endocrinology. 2019 May 1;160(5):1119-1136. doi: 10.1210/en.2018-01088.


Time to go functional! Determining tumors' DNA repair capacity ex vivo.

Tumiati M, Hietanen S, Kauppi L.

Oncotarget. 2018 Dec 7;9(96):36826-36827. doi: 10.18632/oncotarget.26419. eCollection 2018 Dec 7. No abstract available.


Meiotic spindle assembly checkpoint and aneuploidy in males versus females.

Lane S, Kauppi L.

Cell Mol Life Sci. 2019 Mar;76(6):1135-1150. doi: 10.1007/s00018-018-2986-6. Epub 2018 Dec 18. Review.


A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients.

Tumiati M, Hietanen S, Hynninen J, Pietilä E, Färkkilä A, Kaipio K, Roering P, Huhtinen K, Alkodsi A, Li Y, Lehtonen R, Erkan EP, Tuominen MM, Lehti K, Hautaniemi SK, Vähärautio A, Grénman S, Carpén O, Kauppi L.

Clin Cancer Res. 2018 Sep 15;24(18):4482-4493. doi: 10.1158/1078-0432.CCR-17-3770. Epub 2018 Jun 1.


Increasing densities of an invasive polychaete enhance bioturbation with variable effects on solute fluxes.

Kauppi L, Bernard G, Bastrop R, Norkko A, Norkko J.

Sci Rep. 2018 May 16;8(1):7619. doi: 10.1038/s41598-018-25989-2.


Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCR and Nanopore sequencing.

Pradhan B, Cajuso T, Katainen R, Sulo P, Tanskanen T, Kilpivaara O, Pitkänen E, Aaltonen LA, Kauppi L, Palin K.

Sci Rep. 2017 Nov 6;7(1):14521. doi: 10.1038/s41598-017-15076-3.


MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability.

Ylikallio E, Woldegebriel R, Tumiati M, Isohanni P, Ryan MM, Stark Z, Walsh M, Sawyer SL, Bell KM, Oshlack A, Lockhart PJ, Shcherbii M, Estrada-Cuzcano A, Atkinson D, Hartley T, Tetreault M, Cuppen I, van der Pol WL, Candayan A, Battaloglu E, Parman Y, van Gassen KLI, van den Boogaard MH, Boycott KM, Kauppi L, Jordanova A, Lönnqvist T, Tyynismaa H.

Brain. 2017 Aug 1;140(8):2093-2103. doi: 10.1093/brain/awx138.


Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy.

Faisal I, Kauppi L.

Development. 2017 Jun 1;144(11):1988-1996. doi: 10.1242/dev.149492. Epub 2017 May 15.


Detection and screening of chromosomal rearrangements in uterine leiomyomas by long-distance inverse PCR.

Pradhan B, Sarvilinna N, Matilainen J, Aska E, Sjöberg J, Kauppi L.

Genes Chromosomes Cancer. 2016 Mar;55(3):215-26. doi: 10.1002/gcc.22317. Epub 2015 Nov 26.


Sex chromosome recombination failure, apoptosis, and fertility in male mice.

Faisal I, Kauppi L.

Chromosoma. 2016 Jun;125(2):227-35. doi: 10.1007/s00412-015-0542-9. Epub 2015 Oct 6.


Meiosis: SYP up firmly and cross over evenly.

Kauppi L.

Curr Biol. 2014 Jan 6;24(1):R20-R23. doi: 10.1016/j.cub.2013.11.007.


Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.

Ontoso D, Kauppi L, Keeney S, San-Segundo PA.

Chromosoma. 2014 Mar;123(1-2):147-64. doi: 10.1007/s00412-013-0438-5. Epub 2013 Oct 9.


How much is enough? Control of DNA double-strand break numbers in mouse meiosis.

Kauppi L, Jasin M, Keeney S.

Cell Cycle. 2013 Sep 1;12(17):2719-20. doi: 10.4161/cc.26079. Epub 2013 Aug 19. No abstract available.


Numerical constraints and feedback control of double-strand breaks in mouse meiosis.

Kauppi L, Barchi M, Lange J, Baudat F, Jasin M, Keeney S.

Genes Dev. 2013 Apr 15;27(8):873-86. doi: 10.1101/gad.213652.113. Epub 2013 Apr 18.


The tricky path to recombining X and Y chromosomes in meiosis.

Kauppi L, Jasin M, Keeney S.

Ann N Y Acad Sci. 2012 Sep;1267:18-23. doi: 10.1111/j.1749-6632.2012.06593.x. Review.


Homeostatic control of recombination is implemented progressively in mouse meiosis.

Cole F, Kauppi L, Lange J, Roig I, Wang R, Keeney S, Jasin M.

Nat Cell Biol. 2012 Mar 4;14(4):424-30. doi: 10.1038/ncb2451.


Distinct properties of the XY pseudoautosomal region crucial for male meiosis.

Kauppi L, Barchi M, Baudat F, Romanienko PJ, Keeney S, Jasin M.

Science. 2011 Feb 18;331(6019):916-20. doi: 10.1126/science.1195774.


Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).

Dray E, Dunlop MH, Kauppi L, San Filippo J, Wiese C, Tsai MS, Begovic S, Schild D, Jasin M, Keeney S, Sung P.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3560-5. doi: 10.1073/pnas.1016454108. Epub 2011 Feb 9.


Analysis of meiotic recombination products from human sperm.

Kauppi L, May CA, Jeffreys AJ.

Methods Mol Biol. 2009;557:323-55. doi: 10.1007/978-1-59745-527-5_20. Review.


Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome.

Kauppi L, Jasin M, Keeney S.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13396-401. Epub 2007 Aug 9.


Where the crossovers are: recombination distributions in mammals.

Kauppi L, Jeffreys AJ, Keeney S.

Nat Rev Genet. 2004 Jun;5(6):413-24. Review. No abstract available.


Meiotic recombination hot spots and human DNA diversity.

Jeffreys AJ, Holloway JK, Kauppi L, May CA, Neumann R, Slingsby MT, Webb AJ.

Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):141-52. Review.


Recombination hotspots rather than population history dominate linkage disequilibrium in the MHC class II region.

Kauppi L, Sajantila A, Jeffreys AJ.

Hum Mol Genet. 2003 Jan 1;12(1):33-40.


Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex.

Jeffreys AJ, Kauppi L, Neumann R.

Nat Genet. 2001 Oct;29(2):217-22.


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