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Items: 1 to 50 of 194

1.

Phosphodiesterase PDE2 activity, increased by isoprenaline, does not reduce β-adrenoceptor-mediated chronotropic and inotropic effects in rat heart.

Galindo-Tovar A, Vargas ML, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Jun;391(6):571-585. doi: 10.1007/s00210-018-1480-x. Epub 2018 Mar 19.

PMID:
29556684
2.

The β3 -adrenoceptor agonist mirabegron increases human atrial force through β1 -adrenoceptors: an indirect mechanism?

Mo W, Michel MC, Lee XW, Kaumann AJ, Molenaar P.

Br J Pharmacol. 2017 Aug;174(16):2706-2715. doi: 10.1111/bph.13897. Epub 2017 Jul 7.

3.

In permanent atrial fibrillation, PDE3 reduces force responses to 5-HT, but PDE3 and PDE4 do not cause the blunting of atrial arrhythmias.

Berk E, Christ T, Schwarz S, Ravens U, Knaut M, Kaumann AJ.

Br J Pharmacol. 2016 Aug;173(16):2478-89. doi: 10.1111/bph.13525. Epub 2016 Jul 18.

4.

Inhibitors of phosphodiesterases PDE2, PDE3, and PDE4 do not increase the sinoatrial tachycardia of noradrenaline and prostaglandin PGE₁ in mice.

Galindo-Tovar A, Vargas ML, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Feb;389(2):177-86. doi: 10.1007/s00210-015-1178-2. Epub 2015 Nov 3.

PMID:
26531832
5.

Mucosa of murine detrusor impairs β2 -adrenoceptor-mediated relaxation.

Propping S, Newe M, Kaumann AJ, Wirth MP, Ravens U.

Neurourol Urodyn. 2015 Aug;34(6):592-7. doi: 10.1002/nau.22627. Epub 2014 May 12.

PMID:
24820256
6.

Carvedilol induces greater control of β2- than β 1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium.

Molenaar P, Christ T, Berk E, Engel A, Gillette KT, Galindo-Tovar A, Ravens U, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Jul;387(7):629-40. doi: 10.1007/s00210-014-0974-4. Epub 2014 Mar 26.

PMID:
24668024
7.

Mucosa of human detrusor impairs contraction and β-adrenoceptor-mediated relaxation.

Propping S, Wuest M, Eichhorn B, Wirth MP, Kaumann AJ, Ravens U.

BJU Int. 2013 Dec;112(8):1215-22. doi: 10.1111/bju.12267. Epub 2013 Aug 13.

8.

PDE3, but not PDE4, reduces β₁ - and β₂-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients.

Molenaar P, Christ T, Hussain RI, Engel A, Berk E, Gillette KT, Chen L, Galindo-Tovar A, Krobert KA, Ravens U, Levy FO, Kaumann AJ.

Br J Pharmacol. 2013 Jun;169(3):528-38. doi: 10.1111/bph.12167.

9.

Surprises from a cardiac 5-HT₄TG mouse: spontaneous atrial arrhythmias by endogenous 5-HT of atrial origin? Different mechanism of arrhythmias through 5-HT₄ receptors and β-adrenoceptors?

Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2013 May;386(5):353-6. doi: 10.1007/s00210-013-0838-3. No abstract available.

PMID:
23371448
10.

Phosphodiesterases reduce spontaneous sinoatrial beating but not the 'fight or flight' tachycardia elicited by agonists through Gs-protein-coupled receptors.

Kaumann AJ.

Trends Pharmacol Sci. 2011 Jul;32(7):377-83. doi: 10.1016/j.tips.2011.03.003. Epub 2011 Apr 7.

PMID:
21481950
11.

Homology model and docking studies on porcine β₂ adrenoceptor: description of two binding sites.

Soriano-Ursúa MA, Correa-Basurto J, Trujillo-Ferrara JG, Kaumann AJ.

J Mol Model. 2011 Oct;17(10):2525-38. doi: 10.1007/s00894-010-0915-1. Epub 2011 Jan 4.

PMID:
21203789
12.

Human atrial β(1L)-adrenoceptor but not β₃-adrenoceptor activation increases force and Ca(2+) current at physiological temperature.

Christ T, Molenaar P, Klenowski PM, Ravens U, Kaumann AJ.

Br J Pharmacol. 2011 Feb;162(4):823-39. doi: 10.1111/j.1476-5381.2010.00996.x.

13.

Function of cardiac beta1- and beta2-adrenoceptors of newborn piglets: role of phosphodiesterases PDE3 and PDE4.

Galindo-Tovar A, Vargas ML, Kaumann AJ.

Eur J Pharmacol. 2010 Jul 25;638(1-3):99-107. doi: 10.1016/j.ejphar.2010.04.013. Epub 2010 Apr 18.

PMID:
20406625
14.

Phosphodiesterases do not limit beta1-adrenoceptor-mediated sinoatrial tachycardia: evidence with PDE3 and PDE4 in rabbits and PDE1-5 in rats.

Kaumann AJ, Galindo-Tovar A, Escudero E, Vargas ML.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Nov;380(5):421-30. doi: 10.1007/s00210-009-0445-5. Epub 2009 Aug 20.

PMID:
19693491
15.

Ontogenic changes of the control by phosphodiesterase-3 and -4 of 5-HT responses in porcine heart and relevance to human atrial 5-HT(4) receptors.

Galindo-Tovar A, Vargas ML, Escudero E, Kaumann AJ.

Br J Pharmacol. 2009 Jan;156(2):237-49. doi: 10.1111/j.1476-5381.2008.00023.x. Epub 2009 Jan 19.

16.

Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart.

Christ T, Galindo-Tovar A, Thoms M, Ravens U, Kaumann AJ.

Br J Pharmacol. 2009 Jan;156(1):62-83. doi: 10.1111/j.1476-5381.2008.00015.x.

17.

Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium.

Galindo-Tovar A, Vargas ML, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr;379(4):379-84. doi: 10.1007/s00210-008-0367-7. Epub 2008 Nov 14.

PMID:
19005642
18.

Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man.

Wuest M, Eichhorn B, Grimm MO, Wirth MP, Ravens U, Kaumann AJ.

J Pharmacol Exp Ther. 2009 Jan;328(1):213-22. doi: 10.1124/jpet.108.142562. Epub 2008 Sep 26.

PMID:
18820136
19.

The low-affinity site of the beta1-adrenoceptor and its relevance to cardiovascular pharmacology.

Kaumann AJ, Molenaar P.

Pharmacol Ther. 2008 Jun;118(3):303-36. doi: 10.1016/j.pharmthera.2008.03.009. Epub 2008 Apr 11. Review.

PMID:
18501968
21.

Human heart beta-adrenoceptors: beta1-adrenoceptor diversification through 'affinity states' and polymorphism.

Molenaar P, Chen L, Semmler AB, Parsonage WA, Kaumann AJ.

Clin Exp Pharmacol Physiol. 2007 Oct;34(10):1020-8. Review.

PMID:
17714089
22.

(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling.

Molenaar P, Savarimuthu SM, Sarsero D, Chen L, Semmler AB, Carle A, Yang I, Bartel S, Vetter D, Beyerdörfer I, Krause EG, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Mar;375(1):11-28. Epub 2007 Feb 13.

PMID:
17295024
23.

The function of alpha- and beta-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice.

Neidhold S, Eichhorn B, Kasper M, Ravens U, Kaumann AJ.

Br J Pharmacol. 2007 Feb;150(3):261-70. Epub 2006 Dec 18.

24.
25.

5-hydroxytryptamine receptors in the human cardiovascular system.

Kaumann AJ, Levy FO.

Pharmacol Ther. 2006 Sep;111(3):674-706. Review.

PMID:
16960982
26.
29.

Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants.

Krobert KA, Brattelid T, Levy FO, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):473-9. Epub 2005 Jul 13.

PMID:
16012870
30.

BIBN4096BS and CGRP(8-37) antagonize the relaxant effects of alpha-CGRP more than those of beta-CGRP in human extracranial arteries.

Verheggen R, Wojtas K, Webel M, Hoffmann S, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2005 May;371(5):383-92. Epub 2005 Jun 28.

PMID:
15983761
31.

Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure.

Qvigstad E, Brattelid T, Sjaastad I, Andressen KW, Krobert KA, Birkeland JA, Sejersted OM, Kaumann AJ, Skomedal T, Osnes JB, Levy FO.

Cardiovasc Res. 2005 Mar 1;65(4):869-78.

PMID:
15721867
32.

Rolipram reduces the inotropic tachyphylaxis of glucagon in rat ventricular myocardium.

Juan-Fita MJ, Vargas ML, Kaumann AJ, Hernández Cascales J.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):324-9. Epub 2004 Sep 25.

PMID:
15452686
33.

Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure.

Brattelid T, Qvigstad E, Lynham JA, Molenaar P, Aass H, Geiran O, Skomedal T, Osnes JB, Levy FO, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Sep;370(3):157-66. Epub 2004 Sep 7.

PMID:
15365689
34.

Aspartate138 is required for the high-affinity ligand binding site but not for the low-affinity binding site of the beta1-adrenoceptor.

Joseph SS, Colledge WH, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Sep;370(3):223-6. Epub 2004 Aug 18.

PMID:
15322738
35.

Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).

Brattelid T, Kvingedal AM, Krobert KA, Andressen KW, Bach T, Hystad ME, Kaumann AJ, Levy FO.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):616-28. Epub 2004 Apr 30.

PMID:
15118808
37.

Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers.

Joseph SS, Lynham JA, Colledge WH, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):525-32. Epub 2004 Apr 2.

PMID:
15060759
38.
39.

Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptors.

Joseph SS, Lynham JA, Molenaar P, Grace AA, Colledge WH, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):496-503. Epub 2003 Nov 8.

PMID:
14608456
40.

Cardiostimulant and cardiodepressant effects through overexpressed human beta2-adrenoceptors in murine heart: regional differences and functional role of beta1-adrenoceptors.

Heubach JF, Blaschke M, Harding SE, Ravens U, Kaumann AJ.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Apr;367(4):380-90. Epub 2003 Mar 4.

PMID:
12690430
41.

(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptor.

Sarsero D, Russell FD, Lynham JA, Rabnott G, Yang I, Fong KM, Li L, Kaumann AJ, Molenaar P.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Jan;367(1):10-21. Epub 2002 Dec 7.

PMID:
12616336
44.
45.

5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.

Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Feb;363(2):146-60.

PMID:
11218067
46.
47.

Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and beta(3)-adrenoceptor knockout mice.

Oostendorp J, Preitner F, Moffatt J, Jimenez M, Giacobino JP, Molenaar P, Kaumann AJ.

Br J Pharmacol. 2000 Jun;130(4):747-58.

49.

Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: blockade with SB 209670.

Burrell KM, Molenaar P, Dawson PJ, Kaumann AJ.

J Pharmacol Exp Ther. 2000 Jan;292(1):449-59.

PMID:
10604982

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