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Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence.

Garg S, Afzal S, Elwakeel A, Sharma D, Radhakrishnan N, Dhanjal JK, Sundar D, Kaul SC, Wadhwa R.

Mar Drugs. 2019 Jun 5;17(6). pii: E338. doi: 10.3390/md17060338.


Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential.

Garg S, Huifu H, Kumari A, Sundar D, Kaul SC, Wadhwa R.

J Gerontol A Biol Sci Med Sci. 2019 May 21. pii: glz077. doi: 10.1093/gerona/glz077. [Epub ahead of print]


Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin.

Wadhwa R, Li L, Singh R, Wang J, Gao R, Nigam N, Forestier S, Ando N, Kaul SC.

Evid Based Complement Alternat Med. 2019 Apr 14;2019:9848969. doi: 10.1155/2019/9848969. eCollection 2019.


Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence.

Garg S, Kaul SC, Wadhwa R.

Ann Neurosci. 2018 Dec;25(4):201-209. doi: 10.1159/000490693. Epub 2018 Jul 5.


Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin.

Afzal S, Garg S, Ishida Y, Terao K, Kaul SC, Wadhwa R.

Mar Drugs. 2019 Mar 23;17(3). pii: E189. doi: 10.3390/md17030189.


Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence.

Sundar D, Yu Y, Katiyar SP, Putri JF, Dhanjal JK, Wang J, Sari AN, Kolettas E, Kaul SC, Wadhwa R.

J Exp Clin Cancer Res. 2019 Feb 26;38(1):103. doi: 10.1186/s13046-019-1099-x.


Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives.

Oh E, Garg S, Liu Y, Afzal S, Gao R, Yun CO, Kaul SC, Wadhwa R.

Front Oncol. 2018 Nov 28;8:552. doi: 10.3389/fonc.2018.00552. eCollection 2018.


Integration of conventional cell viability assays for reliable and reproducible read-outs: experimental evidence.

Garg S, Huifu H, Kaul SC, Wadhwa R.

BMC Res Notes. 2018 Jun 22;11(1):403. doi: 10.1186/s13104-018-3512-5.


Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences.

Bhargava P, Kumari A, Putri JF, Ishida Y, Terao K, Kaul SC, Sundar D, Wadhwa R.

Cell Stress Chaperones. 2018 Sep;23(5):1055-1068. doi: 10.1007/s12192-018-0915-0. Epub 2018 Jun 4.


CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target.

Kalra RS, Chaudhary A, Yoon AR, Bhargava P, Omar A, Garg S, Yun CO, Kaul SC, Wadhwa R.

Oncogenesis. 2018 May 11;7(5):39. doi: 10.1038/s41389-018-0048-4.


Molecular Insights Into Withaferin-A-Induced Senescence: Bioinformatics and Experimental Evidence to the Role of NFκB and CARF.

Bhargava P, Malik V, Liu Y, Ryu J, Kaul SC, Sundar D, Wadhwa R.

J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):183-191. doi: 10.1093/gerona/gly107.


Self-assembled nanodiamond supraparticles for anticancer chemotherapy.

Yu Y, Nishikawa M, Liu M, Tei T, Kaul SC, Wadhawa R, Zhang M, Takahashi J, Miyako E.

Nanoscale. 2018 May 17;10(19):8969-8978. doi: 10.1039/c8nr00641e.


Organic cultivation of Ashwagandha with improved biomass and high content of active Withanolides: Use of Vermicompost.

Kaur A, Singh B, Ohri P, Wang J, Wadhwa R, Kaul SC, Pati PK, Kaur A.

PLoS One. 2018 Apr 16;13(4):e0194314. doi: 10.1371/journal.pone.0194314. eCollection 2018.


Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action.

Bhargava P, Grover A, Nigam N, Kaul A, Doi M, Ishida Y, Kakuta H, Kaul SC, Terao K, Wadhwa R.

Int J Oncol. 2018 Mar;52(3):925-932. doi: 10.3892/ijo.2018.4249. Epub 2018 Jan 22.


Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin.

Ishida Y, Gao R, Shah N, Bhargava P, Furune T, Kaul SC, Terao K, Wadhwa R.

Integr Cancer Ther. 2018 Sep;17(3):867-873. doi: 10.1177/1534735417753545. Epub 2018 Feb 2.


Tumor suppressor activity of miR-451: Identification of CARF as a new target.

Li L, Gao R, Yu Y, Kaul Z, Wang J, Kalra RS, Zhang Z, Kaul SC, Wadhwa R.

Sci Rep. 2018 Jan 10;8(1):375. doi: 10.1038/s41598-017-18559-5.


Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review).

Garg S, Kaul SC, Wadhwa R.

Int J Oncol. 2018 Jan;52(1):19-37. doi: 10.3892/ijo.2017.4203. Epub 2017 Nov 10. Review.


2,3-Dihydro-3β-methoxy Withaferin-A Protects Normal Cells against Stress: Molecular Evidence of Its Potent Cytoprotective Activity.

Chaudhary A, Kalra RS, Huang C, Prakash J, Kaul SC, Wadhwa R.

J Nat Prod. 2017 Oct 27;80(10):2756-2760. doi: 10.1021/acs.jnatprod.7b00573. Epub 2017 Oct 18.


Induction of senescence in cancer cells by 5'-Aza-2'-deoxycytidine: Bioinformatics and experimental insights to its targets.

Putri JF, Widodo N, Sakamoto K, Kaul SC, Wadhwa R.

Comput Biol Chem. 2017 Oct;70:49-55. doi: 10.1016/j.compbiolchem.2017.08.003. Epub 2017 Aug 2.


CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis.

Wadhwa R, Kalra RS, Kaul SC.

Mech Ageing Dev. 2017 Sep;166:64-68. doi: 10.1016/j.mad.2017.07.008. Epub 2017 Jul 25. Review.


Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences.

Yu Y, Katiyar SP, Sundar D, Kaul Z, Miyako E, Zhang Z, Kaul SC, Reddel RR, Wadhwa R.

Cell Death Dis. 2017 Apr 20;8(4):e2755. doi: 10.1038/cddis.2017.33.


Addressing Challenges to Enhance the Bioactives of Withania somnifera through Organ, Tissue, and Cell Culture Based Approaches.

Singh P, Guleri R, Angurala A, Kaur K, Kaur K, Kaul SC, Wadhwa R, Pati PK.

Biomed Res Int. 2017;2017:3278494. doi: 10.1155/2017/3278494. Epub 2017 Feb 16. Review.


Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction.

Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y.

PLoS One. 2017 Feb 16;12(2):e0172508. doi: 10.1371/journal.pone.0172508. eCollection 2017.


Relevance of mortalin to cancer cell stemness and cancer therapy.

Yun CO, Bhargava P, Na Y, Lee JS, Ryu J, Kaul SC, Wadhwa R.

Sci Rep. 2017 Feb 6;7:42016. doi: 10.1038/srep42016.


Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts.

Kaul SC, Ishida Y, Tamura K, Wada T, Iitsuka T, Garg S, Kim M, Gao R, Nakai S, Okamoto Y, Terao K, Wadhwa R.

PLoS One. 2016 Dec 9;11(12):e0166945. doi: 10.1371/journal.pone.0166945. eCollection 2016.


Molecular Characterization and Enhancement of Anticancer Activity of Caffeic Acid Phenethyl Ester by γ Cyclodextrin.

Wadhwa R, Nigam N, Bhargava P, Dhanjal JK, Goyal S, Grover A, Sundar D, Ishida Y, Terao K, Kaul SC.

J Cancer. 2016 Aug 11;7(13):1755-1771. eCollection 2016.


Loss-of-function screening to identify miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF.

Yu Y, Gao R, Kaul Z, Li L, Kato Y, Zhang Z, Groden J, Kaul SC, Wadhwa R.

Sci Rep. 2016 Jul 26;6:30185. doi: 10.1038/srep30185.


Molecular dynamics-based identification of novel natural mortalin-p53 abrogators as anticancer agents.

Nagpal N, Goyal S, Dhanjal JK, Ye L, Kaul SC, Wadhwa R, Chaturvedi R, Grover A.

J Recept Signal Transduct Res. 2017 Feb;37(1):8-16. doi: 10.3109/10799893.2016.1141952. Epub 2016 Jul 5.


Stress chaperone mortalin regulates human melanogenesis.

Wadhwa R, Priyandoko D, Gao R, Widodo N, Nigam N, Li L, Ahn HM, Yun CO, Ando N, Mahe C, Kaul SC.

Cell Stress Chaperones. 2016 Jul;21(4):631-44. doi: 10.1007/s12192-016-0688-2. Epub 2016 Apr 7.


Functional Characterisation of Anticancer Activity in the Aqueous Extract of Helicteres angustifolia L. Roots.

Li K, Yu Y, Sun S, Liu Y, Garg S, Kaul SC, Lei Z, Gao R, Wadhwa R, Zhang Z.

PLoS One. 2016 Mar 24;11(3):e0152017. doi: 10.1371/journal.pone.0152017. eCollection 2016.


Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.

Na Y, Kaul SC, Ryu J, Lee JS, Ahn HM, Kaul Z, Kalra RS, Li L, Widodo N, Yun CO, Wadhwa R.

Cancer Res. 2016 May;76(9):2754-2765. doi: 10.1158/0008-5472.CAN-15-2704. Epub 2016 Mar 9.


Fate of bone marrow mesenchymal stromal cells following autologous transplantation in a rabbit model of osteonecrosis.

Sugaya H, Mishima H, Gao R, Kaul SC, Wadhwa R, Aoto K, Li M, Yoshioka T, Ogawa T, Ochiai N, Yamazaki M.

Cytotherapy. 2016 Feb;18(2):198-204. doi: 10.1016/j.jcyt.2015.10.016.


Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells.

Nigam N, Grover A, Goyal S, Katiyar SP, Bhargava P, Wang PC, Sundar D, Kaul SC, Wadhwa R.

PLoS One. 2015 Sep 16;10(9):e0138192. doi: 10.1371/journal.pone.0138192. eCollection 2015.


Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts.

Wadhwa R, Konar A, Kaul SC.

Neurochem Int. 2016 May;95:109-18. doi: 10.1016/j.neuint.2015.09.001. Epub 2015 Sep 8. Review.


CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis.

Kalra RS, Cheung CT, Chaudhary A, Prakash J, Kaul SC, Wadhwa R.

Mol Oncol. 2015 Nov;9(9):1877-89. doi: 10.1016/j.molonc.2015.07.003. Epub 2015 Aug 4.


Circulating mortalin autoantibody--a new serological marker of liver cirrhosis.

Lu WJ, Saxena N, Luk JM, Kaul SC, Wadhwa R.

Cell Stress Chaperones. 2015 Jul;20(4):715-9. doi: 10.1007/s12192-015-0592-1. Epub 2015 Apr 24.


Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation.

Shah N, Singh R, Sarangi U, Saxena N, Chaudhary A, Kaur G, Kaul SC, Wadhwa R.

PLoS One. 2015 Mar 19;10(3):e0120554. doi: 10.1371/journal.pone.0120554. eCollection 2015.


Biotechnological interventions in Withania somnifera (L.) Dunal.

Singh P, Guleri R, Singh V, Kaur G, Kataria H, Singh B, Kaur G, Kaul SC, Wadhwa R, Pati PK.

Biotechnol Genet Eng Rev. 2015 Apr-Oct;31(1-2):1-20. doi: 10.1080/02648725.2015.1020467. Epub 2015 Mar 19. Review.


Evaluation and selection of candidate reference genes for normalization of quantitative RT-PCR in Withania somnifera (L.) Dunal.

Singh V, Kaul SC, Wadhwa R, Pati PK.

PLoS One. 2015 Mar 13;10(3):e0118860. doi: 10.1371/journal.pone.0118860. eCollection 2015.


Alcoholic Extract of Ashwagandha Leaves Protects Against Amnesia by Regulation of Arc Function.

Gautam A, Kaul SC, Thakur MK.

Mol Neurobiol. 2016 Apr;53(3):1760-1769. doi: 10.1007/s12035-015-9117-2. Epub 2015 Mar 7.


Functional significance of point mutations in stress chaperone mortalin and their relevance to Parkinson disease.

Wadhwa R, Ryu J, Ahn HM, Saxena N, Chaudhary A, Yun CO, Kaul SC.

J Biol Chem. 2015 Mar 27;290(13):8447-56. doi: 10.1074/jbc.M114.627463. Epub 2015 Feb 2.


Serum-free isolation and culture system to enhance the proliferation and bone regeneration of adipose tissue-derived mesenchymal stem cells.

Sato K, Itoh T, Kato T, Kitamura Y, Kaul SC, Wadhwa R, Sato F, Ohneda O.

In Vitro Cell Dev Biol Anim. 2015 May;51(5):515-29. doi: 10.1007/s11626-014-9860-0. Epub 2015 Jan 15.


Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence.

Dhanjal JK, Nigam N, Sharma S, Chaudhary A, Kaul SC, Grover A, Wadhwa R.

BMC Cancer. 2014 Oct 22;14:775. doi: 10.1186/1471-2407-14-775.


Withanone-rich combination of Ashwagandha withanolides restricts metastasis and angiogenesis through hnRNP-K.

Gao R, Shah N, Lee JS, Katiyar SP, Li L, Oh E, Sundar D, Yun CO, Wadhwa R, Kaul SC.

Mol Cancer Ther. 2014 Dec;13(12):2930-40. doi: 10.1158/1535-7163.MCT-14-0324. Epub 2014 Sep 18.


Identification and functional characterization of nuclear mortalin in human carcinogenesis.

Ryu J, Kaul Z, Yoon AR, Liu Y, Yaguchi T, Na Y, Ahn HM, Gao R, Choi IK, Yun CO, Kaul SC, Wadhwa R.

J Biol Chem. 2014 Sep 5;289(36):24832-44. doi: 10.1074/jbc.M114.565929. Epub 2014 Jul 10.


Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.

Cheung CT, Singh R, Kalra RS, Kaul SC, Wadhwa R.

J Biol Chem. 2014 Jun 27;289(26):18258-69. doi: 10.1074/jbc.M114.547208. Epub 2014 May 13.


Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells.

Gao R, Singh R, Kaul Z, Kaul SC, Wadhwa R.

J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):701-13. doi: 10.1093/gerona/glu019. Epub 2014 Apr 18.


Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein.

Singh R, Kalra RS, Hasan K, Kaul Z, Cheung CT, Huschtscha L, Reddel RR, Kaul SC, Wadhwa R.

Exp Cell Res. 2014 Apr 1;322(2):324-34. doi: 10.1016/j.yexcr.2014.01.022. Epub 2014 Jan 28.


Water extract of Ashwagandha leaves has anticancer activity: identification of an active component and its mechanism of action.

Wadhwa R, Singh R, Gao R, Shah N, Widodo N, Nakamoto T, Ishida Y, Terao K, Kaul SC.

PLoS One. 2013 Oct 10;8(10):e77189. doi: 10.1371/journal.pone.0077189. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/b7059f27-5970-4734-8601-9913adcce984.


Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.

Saxena N, Katiyar SP, Liu Y, Grover A, Gao R, Sundar D, Kaul SC, Wadhwa R.

Biosci Rep. 2013 Oct 16;33(5). pii: e00073. doi: 10.1042/BSR20130034.

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