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Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells.

Bower JJ, Vance LD, Psioda M, Smith-Roe SL, Simpson DA, Ibrahim JG, Hoadley KA, Perou CM, Kaufmann WK.

NPJ Breast Cancer. 2017 Mar 31;3:9. doi: 10.1038/s41523-017-0009-7. eCollection 2017.


The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts.

Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA, Gordenin DA.

PLoS Genet. 2016 Oct 27;12(10):e1006385. doi: 10.1371/journal.pgen.1006385. eCollection 2016 Oct.


Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines.

Cordeiro-Stone M, McNulty JJ, Sproul CD, Chastain PD, Gibbs-Flournoy E, Zhou Y, Carson C, Rao S, Mitchell DL, Simpson DA, Thomas NE, Ibrahim JG, Kaufmann WK.

Pigment Cell Melanoma Res. 2016 Jan;29(1):68-80. doi: 10.1111/pcmr.12426. Epub 2015 Nov 3.


Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity.

Simpson DA, Lemonie N, Morgan DS, Gaddameedhi S, Kaufmann WK.

Cancers (Basel). 2015 Jun 17;7(2):1072-90. doi: 10.3390/cancers7020825.


A bright quantum of time in the Cleaver Laboratory; a tribute and retrospective.

Kaufmann WK.

Photochem Photobiol. 2015 Mar-Apr;91(2):501-4. doi: 10.1111/php.12384. No abstract available.


SWI/SNF complexes are required for full activation of the DNA-damage response.

Smith-Roe SL, Nakamura J, Holley D, Chastain PD 2nd, Rosson GB, Simpson DA, Ridpath JR, Kaufman DG, Kaufmann WK, Bultman SJ.

Oncotarget. 2015 Jan 20;6(2):732-45.


DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts.

Chastain PD 2nd, Brylawski BP, Zhou YC, Rao S, Chu H, Ibrahim JG, Kaufmann WK, Cordeiro-Stone M.

Photochem Photobiol. 2015 Jan-Feb;91(1):109-16. doi: 10.1111/php.12361. Epub 2014 Nov 24.


Mechanisms of chromosomal instability in melanoma.

Kaufmann WK, Carson CC, Omolo B, Filgo AJ, Sambade MJ, Simpson DA, Shields JM, Ibrahim JG, Thomas NE.

Environ Mol Mutagen. 2014 Jul;55(6):457-71. doi: 10.1002/em.21859. Epub 2014 Feb 24.


Development of DNA damage response signaling biomarkers using automated, quantitative image analysis.

Nikolaishvilli-Feinberg N, Cohen SM, Midkiff B, Zhou Y, Olorvida M, Ibrahim JG, Omolo B, Shields JM, Thomas NE, Groben PA, Kaufmann WK, Miller CR.

J Histochem Cytochem. 2014 Mar;62(3):185-96. doi: 10.1369/0022155413516469. Epub 2013 Dec 5.


Cyclobutane Pyrimidine Dimer Density as a Predictive Biomarker of the Biological Effects of Ultraviolet Radiation in Normal Human Fibroblast.

Sproul CD, Mitchell DL, Rao S, Ibrahim JG, Kaufmann WK, Cordeiro-Stone M.

Photochem Photobiol. 2014 Jan;90(1):145-54. doi: 10.1111/php.12194. Epub 2013 Nov 28.


Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?

Sproul CD, Rao S, Ibrahim JG, Kaufmann WK, Cordeiro-Stone M.

Cell Cycle. 2013 Nov 15;12(22):3555-63. doi: 10.4161/cc.26590. Epub 2013 Sep 25.


Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals.

Zhang L, Simpson DA, Innes CL, Chou J, Bushel PR, Paules RS, Kaufmann WK, Zhou T.

Physiol Genomics. 2013 Oct 1;45(19):907-16. doi: 10.1152/physiolgenomics.00064.2013. Epub 2013 Aug 13.


Compensation, crosstalk and sequestering: the currency of checkpoints in cancer.

Kaufmann WK, Anderson CW.

Cell Cycle. 2013 Apr 15;12(8):1163-4. doi: 10.4161/cc.24486. Epub 2013 Apr 2. No abstract available.


A prognostic signature of G(2) checkpoint function in melanoma cell lines.

Omolo B, Carson C, Chu H, Zhou Y, Simpson DA, Hesse JE, Paules RS, Nyhan KC, Ibrahim JG, Kaufmann WK.

Cell Cycle. 2013 Apr 1;12(7):1071-82. doi: 10.4161/cc.24067. Epub 2013 Mar 1.


Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation.

Lakhter AJ, Sahu RP, Sun Y, Kaufmann WK, Androphy EJ, Travers JB, Naidu SR.

J Invest Dermatol. 2013 Sep;133(9):2247-54. doi: 10.1038/jid.2013.56. Epub 2013 Jan 31.


A predictive mathematical model of the DNA damage G2 checkpoint.

Kesseler KJ, Blinov ML, Elston TC, Kaufmann WK, Simpson DA.

J Theor Biol. 2013 Mar 7;320:159-69. doi: 10.1016/j.jtbi.2012.12.011. Epub 2012 Dec 22.


Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts.

Smith-Roe SL, Patel SS, Zhou Y, Simpson DA, Rao S, Ibrahim JG, Cordeiro-Stone M, Kaufmann WK.

Cell Cycle. 2013 Jan 15;12(2):332-45. doi: 10.4161/cc.23177. Epub 2012 Jan 15.


Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts.

Prasad RY, Chastain PD, Nikolaishvili-Feinberg N, Smeester L, Kaufmann WK, Fry RC.

Nanotoxicology. 2013 Sep;7(6):1111-9. doi: 10.3109/17435390.2012.710659. Epub 2012 Aug 23.


Mutational showers during carcinogenesis.

Kaufmann WK.

Pigment Cell Melanoma Res. 2012 Sep;25(5):566-8. doi: 10.1111/j.1755-148X.2012.01034.x. Epub 2012 Aug 6. No abstract available.


A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects.

Jeffries CD, Johnson CR, Zhou T, Simpson DA, Kaufmann WK.

Gene Regul Syst Bio. 2012;6:55-66. doi: 10.4137/GRSB.S8476. Epub 2012 Apr 11.


A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines.

Carson C, Omolo B, Chu H, Zhou Y, Sambade MJ, Peters EC, Tompkins P, Simpson DA, Thomas NE, Fan C, Sarasin A, Dessen P, Shields JM, Ibrahim JG, Kaufmann WK.

Pigment Cell Melanoma Res. 2012 Jul;25(4):514-26. doi: 10.1111/j.1755-148X.2012.01010.x. Epub 2012 Jun 1.


Control of skin cancer by the circadian rhythm.

Gaddameedhi S, Selby CP, Kaufmann WK, Smart RC, Sancar A.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18790-5. doi: 10.1073/pnas.1115249108. Epub 2011 Oct 24.


What's going on at stalled forks?

Kaufmann WK.

Cell Cycle. 2011 Sep 15;10(18):3048. Epub 2011 Sep 15. No abstract available.


Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts.

Smith-Roe SL, Patel SS, Simpson DA, Zhou YC, Rao S, Ibrahim JG, Kaiser-Rogers KA, Cordeiro-Stone M, Kaufmann WK.

Cell Cycle. 2011 May 15;10(10):1618-24. Epub 2011 May 15.


Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032.

Sambade MJ, Peters EC, Thomas NE, Kaufmann WK, Kimple RJ, Shields JM.

Radiother Oncol. 2011 Mar;98(3):394-9. doi: 10.1016/j.radonc.2010.12.017. Epub 2011 Feb 4.


Topoisomerase IIalpha maintains genomic stability through decatenation G(2) checkpoint signaling.

Bower JJ, Karaca GF, Zhou Y, Simpson DA, Cordeiro-Stone M, Kaufmann WK.

Oncogene. 2010 Aug 26;29(34):4787-99. doi: 10.1038/onc.2010.232. Epub 2010 Jun 21.


Similar nucleotide excision repair capacity in melanocytes and melanoma cells.

Gaddameedhi S, Kemp MG, Reardon JT, Shields JM, Smith-Roe SL, Kaufmann WK, Sancar A.

Cancer Res. 2010 Jun 15;70(12):4922-30. doi: 10.1158/0008-5472.CAN-10-0095. Epub 2010 May 25.


Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.

Bower JJ, Zhou Y, Zhou T, Simpson DA, Arlander SJ, Paules RS, Cordeiro-Stone M, Kaufmann WK.

Cell Cycle. 2010 Apr 15;9(8):1617-28. Epub 2010 Apr 15.


Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.

Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang TH, Cordeiro-Stone M, Kaufmann WK, Abraham RT, Sancar A, Unsal-Kaçmaz K.

J Biol Chem. 2010 May 28;285(22):16562-71. doi: 10.1074/jbc.M110.110304. Epub 2010 Mar 15.


The human intra-S checkpoint response to UVC-induced DNA damage.

Kaufmann WK.

Carcinogenesis. 2010 May;31(5):751-65. doi: 10.1093/carcin/bgp230. Epub 2009 Sep 30. Review.


Analysis of the topoisomerase II-dependent decatenation G2 checkpoint and checkpoint kinases in human cells.

Kaufmann WK.

Methods Mol Biol. 2009;582:155-66. doi: 10.1007/978-1-60761-340-4_13.


Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53.

Chen B, Simpson DA, Zhou Y, Mitra A, Mitchell DL, Cordeiro-Stone M, Kaufmann WK.

Cell Cycle. 2009 Jun 1;8(11):1775-87. Epub 2009 Jun 10.


Living with reduced replicative helicase protein.

Kaufmann WK.

Cell Cycle. 2009 May 15;8(10):1468-9. Epub 2009 May 15. No abstract available.


Toxicogenomics: transcription profiling for toxicology assessment.

Zhou T, Chou J, Watkins PB, Kaufmann WK.

EXS. 2009;99:325-66. Review.


In silico construction of a protein interaction landscape for nucleotide excision repair.

Tran N, Qu PP, Simpson DA, Lindsey-Boltz L, Guan X, Schmitt CP, Ibrahim JG, Kaufmann WK.

Cell Biochem Biophys. 2009;53(2):101-14. doi: 10.1007/s12013-009-9042-y.


Ubiquitylation of proliferating cell nuclear antigen and recruitment of human DNA polymerase eta.

Nikolaishvili-Feinberg N, Jenkins GS, Nevis KR, Staus DP, Scarlett CO, Unsal-Kaçmaz K, Kaufmann WK, Cordeiro-Stone M.

Biochemistry. 2008 Apr 1;47(13):4141-50. doi: 10.1021/bi702329h. Epub 2008 Mar 6.


A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading.

Kesseler KJ, Kaufmann WK, Reardon JT, Elston TC, Sancar A.

J Theor Biol. 2007 Nov 21;249(2):361-75. Epub 2007 Aug 8.


Ataxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts.

Zhou T, Chou J, Zhou Y, Simpson DA, Cao F, Bushel PR, Paules RS, Kaufmann WK.

Mol Cancer Res. 2007 Aug;5(8):813-22.


Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression.

Kaufmann WK, Nevis KR, Qu P, Ibrahim JG, Zhou T, Zhou Y, Simpson DA, Helms-Deaton J, Cordeiro-Stone M, Moore DT, Thomas NE, Hao H, Liu Z, Shields JM, Scott GA, Sharpless NE.

J Invest Dermatol. 2008 Jan;128(1):175-87. Epub 2007 Jun 28.


Initiating the uninitiated: replication of damaged DNA and carcinogenesis.

Kaufmann WK.

Cell Cycle. 2007 Jun 15;6(12):1460-7. Epub 2007 May 17. Review.


Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.

Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Kerr KF, Kosyk O, Lobenhofer EK, Sieber SO, Vliet PA, Weis BK, Wolfinger R, Woods CG, Freedman JH, Linney E, Kaufmann WK, Kavanagh TJ, Paules RS, Rusyn I, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H; Members of the Toxicogenomics Research Consortium.

Toxicol Sci. 2007 Sep;99(1):326-37. Epub 2007 Jun 11.


Identification of primary transcriptional regulation of cell cycle-regulated genes upon DNA damage.

Zhou T, Chou J, Mullen TE, Elkon R, Zhou Y, Simpson DA, Bushel PR, Paules RS, Lobenhofer EK, Hurban P, Kaufmann WK.

Cell Cycle. 2007 Apr 15;6(8):972-81. Epub 2007 Apr 19.


Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.

Shields JM, Thomas NE, Cregger M, Berger AJ, Leslie M, Torrice C, Hao H, Penland S, Arbiser J, Scott G, Zhou T, Bar-Eli M, Bear JE, Der CJ, Kaufmann WK, Rimm DL, Sharpless NE.

Cancer Res. 2007 Feb 15;67(4):1502-12.


The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.

Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK.

Mol Cell Biol. 2007 Apr;27(8):3131-42. Epub 2007 Feb 12.


Cdc7-Dbf4 and the human S checkpoint response to UVC.

Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, Simpson DA, Paules RS, Sancar A, Cordeiro-Stone M, Kaufmann WK.

J Biol Chem. 2007 Mar 30;282(13):9458-68. Epub 2007 Feb 2.


Clonal evolution of lymphoblastoid cell lines.

Ryan JL, Kaufmann WK, Raab-Traub N, Oglesbee SE, Carey LA, Gulley ML.

Lab Invest. 2006 Nov;86(11):1193-200. Epub 2006 Oct 2.


Checkpoint regulation of replication dynamics in UV-irradiated human cells.

Chastain PD 2nd, Heffernan TP, Nevis KR, Lin L, Kaufmann WK, Kaufman DG, Cordeiro-Stone M.

Cell Cycle. 2006 Sep;5(18):2160-7. Epub 2006 Sep 15.


Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk.

Kaufmann WK, Filatov L, Oglesbee SE, Simpson DA, Lotano MA, McKeen HD, Sawyer LR, Moore DT, Millikan RC, Cordeiro-Stone M, Carey LA.

Carcinogenesis. 2006 Dec;27(12):2519-27. Epub 2006 Jun 15.


Dangerous entanglements.

Kaufmann WK.

Trends Mol Med. 2006 Jun;12(6):235-7. Epub 2006 May 2.


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